Project

PRJNA195909:zebrafish embryo and larva development

Navigation
Downloads

Results for irx6a

Z-value: 1.11

Motif logo

logo of

Transcription factors associated with irx6a

Gene Symbol Gene ID Gene Info
irx6a
ENSDARG00000034420 iroquois homeobox 6a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irx6adr11_v1_chr7_-_35516251_355162510.742.2e-02Click!

Activity profile of irx6a motif

Sorted Z-values of irx6a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_2908764 2.06 ENSDART00000162362
wu:fj16a03
wu:fj16a03
chr16_+_25316973 1.93 ENSDART00000086409
dync1i1
dynein, cytoplasmic 1, intermediate chain 1
chr13_+_43247936 1.88 ENSDART00000126850
ENSDART00000165331
smoc2
SPARC related modular calcium binding 2
chr1_-_59287410 1.81 ENSDART00000158011
ENSDART00000170580
col5a3b
collagen, type V, alpha 3b
chr19_+_3653976 1.55 ENSDART00000125673
nedd9
neural precursor cell expressed, developmentally down-regulated 9
chr20_+_35382482 1.35 ENSDART00000135284
vsnl1a
visinin-like 1a
chr8_+_29986265 1.34 ENSDART00000148258
ptch1
patched 1
chr10_+_45345574 1.29 ENSDART00000166085
ppiab
peptidylprolyl isomerase Ab (cyclophilin A)
chr15_+_33991928 1.22 ENSDART00000170177
vwde
von Willebrand factor D and EGF domains
chr16_-_45398408 1.21 ENSDART00000004052
rgl2
ral guanine nucleotide dissociation stimulator-like 2
chr6_+_3827751 1.14 ENSDART00000003008
ENSDART00000122348
gad1b
glutamate decarboxylase 1b
chr9_-_14108896 1.05 ENSDART00000135209
prkag3b
protein kinase, AMP-activated, gamma 3b non-catalytic subunit
chr18_+_8346920 1.01 ENSDART00000083421
cpt1b
carnitine palmitoyltransferase 1B (muscle)
chr3_-_12970418 0.97 ENSDART00000158747
pdgfab
platelet-derived growth factor alpha polypeptide b
chr5_-_48268049 0.95 ENSDART00000187454
mef2cb
myocyte enhancer factor 2cb
chr5_-_33460959 0.94 ENSDART00000085636
si:ch211-182d3.1
si:ch211-182d3.1
chr5_+_13427826 0.94 ENSDART00000083359
sec14l8
SEC14-like lipid binding 8
chr13_+_23677949 0.87 ENSDART00000144215
pcnxl2
pecanex-like 2 (Drosophila)
chr12_+_36891483 0.86 ENSDART00000048927
cox10
COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
chr8_-_6943155 0.81 ENSDART00000139545
ENSDART00000033294
wdr13
WD repeat domain 13
chr15_-_29573267 0.80 ENSDART00000099947
samsn1a
SAM domain, SH3 domain and nuclear localisation signals 1a
chr4_+_22613625 0.75 ENSDART00000131161
sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr7_-_44672095 0.75 ENSDART00000073745
cmtm4
CKLF-like MARVEL transmembrane domain containing 4
chr8_+_28259347 0.71 ENSDART00000110857
fam212b
family with sequence similarity 212, member B
chr19_-_17526735 0.68 ENSDART00000189391
thrb
thyroid hormone receptor beta
chr15_-_14375452 0.67 ENSDART00000160675
ENSDART00000164028
ENSDART00000171642
dpf1
D4, zinc and double PHD fingers family 1
chr20_-_7072487 0.67 ENSDART00000145954
si:ch211-121a2.2
si:ch211-121a2.2
chr11_+_14284866 0.64 ENSDART00000163729
si:ch211-262i1.3
si:ch211-262i1.3
chr3_-_18792492 0.63 ENSDART00000134208
ENSDART00000034373
hagh
hydroxyacylglutathione hydrolase
chr4_-_75175407 0.62 ENSDART00000180125
CABZ01043953.1

chr21_-_12036134 0.61 ENSDART00000031658
tpgs2
tubulin polyglutamylase complex subunit 2
chr5_+_37517800 0.60 ENSDART00000048107
FP102018.1
Danio rerio latent transforming growth factor beta binding protein 3 (ltbp3), mRNA.
chr12_-_35095414 0.48 ENSDART00000153229
si:dkey-21e13.3
si:dkey-21e13.3
chr22_+_2937485 0.43 ENSDART00000082222
ENSDART00000135507
ENSDART00000143258
cep19
centrosomal protein 19
chr15_-_23522653 0.42 ENSDART00000144685
hmbsb
hydroxymethylbilane synthase, b
chr16_-_44709832 0.41 ENSDART00000156784
si:ch211-151m7.6
si:ch211-151m7.6
chr18_-_40884087 0.41 ENSDART00000059194
snrpd2
small nuclear ribonucleoprotein D2 polypeptide
chr13_-_12389748 0.39 ENSDART00000141606
commd8
COMM domain containing 8
chr25_+_7671640 0.39 ENSDART00000145367
kcnj11l
potassium inwardly-rectifying channel, subfamily J, member 11, like
chr5_-_24238733 0.38 ENSDART00000138170
plscr3a
phospholipid scramblase 3a
chr16_+_22649855 0.38 ENSDART00000143043
chrnb2b
cholinergic receptor, nicotinic, beta 2b
chr21_+_23108420 0.37 ENSDART00000192394
ENSDART00000088459
htr3b
5-hydroxytryptamine (serotonin) receptor 3B
chr17_+_8899016 0.37 ENSDART00000150214
psmc1a
proteasome 26S subunit, ATPase 1a
chr21_+_26991198 0.36 ENSDART00000065397
fkbp2
FK506 binding protein 2
chr1_+_961607 0.35 ENSDART00000184660
n6amt1
N-6 adenine-specific DNA methyltransferase 1
chr2_+_54804385 0.31 ENSDART00000172309
twsg1a
twisted gastrulation BMP signaling modulator 1a
chr20_-_38610360 0.31 ENSDART00000168783
ENSDART00000164638
slc30a2
solute carrier family 30 (zinc transporter), member 2
chr20_+_23440632 0.30 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
si:dkey-90m5.4
chr19_+_27342479 0.30 ENSDART00000184687
ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr22_-_2937503 0.28 ENSDART00000092991
ENSDART00000131110
pigx
phosphatidylinositol glycan anchor biosynthesis, class X
chr13_-_34683370 0.28 ENSDART00000113661
kif16bb
kinesin family member 16Bb
chr23_+_45027263 0.26 ENSDART00000058364
hmgb2b
high mobility group box 2b
chr4_+_9028819 0.25 ENSDART00000102893
aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr21_+_20549395 0.25 ENSDART00000181633
efna5a
ephrin-A5a
chr23_-_32944796 0.23 ENSDART00000190388
plxna2
plexin A2
chr15_-_2857961 0.23 ENSDART00000033263
ankrd49
ankyrin repeat domain 49
chr13_+_12389849 0.20 ENSDART00000086525
atp10d
ATPase phospholipid transporting 10D
chr15_-_3976035 0.20 ENSDART00000168061
si:ch73-309g22.1
si:ch73-309g22.1
chr6_+_27304503 0.19 ENSDART00000154759
espnla
espin like a
chr23_-_7594723 0.18 ENSDART00000115298
plagl2
pleiomorphic adenoma gene-like 2
chr14_+_10567104 0.18 ENSDART00000160723
gpr174
G protein-coupled receptor 174
chr15_+_11381532 0.18 ENSDART00000124172
si:ch73-321d9.2
si:ch73-321d9.2
chr20_-_13774826 0.18 ENSDART00000063831
opn8c
opsin 8, group member c
chr14_+_45471642 0.16 ENSDART00000126979
ENSDART00000172952
ENSDART00000173284
ubxn1
UBX domain protein 1
chr6_-_131401 0.15 ENSDART00000151251
LRRC8E
si:zfos-323e3.4
chr7_-_31830936 0.13 ENSDART00000052514
ENSDART00000129720
cars
cysteinyl-tRNA synthetase
chr14_-_8625845 0.12 ENSDART00000054760
zgc:162144
zgc:162144
chr6_+_6802582 0.10 ENSDART00000189422
dtd1
D-tyrosyl-tRNA deacylase 1
chr22_+_2492397 0.10 ENSDART00000181596
CU570894.2

chr25_-_34281411 0.09 ENSDART00000189932
gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr14_-_30747686 0.08 ENSDART00000008373
fosl1a
FOS-like antigen 1a
chr19_-_26923273 0.06 ENSDART00000089609
skiv2l
SKI2 homolog, superkiller viralicidic activity 2-like
chr18_+_33652976 0.06 ENSDART00000143833
si:dkey-47k20.7
si:dkey-47k20.7
chr4_+_62341346 0.06 ENSDART00000160601
znf1079
zinc finger protein 1079
chr21_+_21702623 0.03 ENSDART00000136840
or125-2
odorant receptor, family E, subfamily 125, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of irx6a

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.3 0.9 GO:1904088 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.3 1.5 GO:0090527 actin filament reorganization(GO:0090527)
0.2 0.6 GO:0006089 lactate metabolic process(GO:0006089)
0.2 0.7 GO:0042706 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.1 1.3 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.1 1.0 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 0.4 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.1 0.3 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.1 0.2 GO:0003403 optic vesicle formation(GO:0003403)
0.1 0.3 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 0.4 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.1 1.0 GO:0009437 carnitine metabolic process(GO:0009437)
0.1 1.9 GO:0042476 odontogenesis(GO:0042476)
0.0 1.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.9 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.6 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 1.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 1.0 GO:0060914 heart formation(GO:0060914)
0.0 1.9 GO:0010970 establishment of localization by movement along microtubule(GO:0010970)
0.0 0.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.8 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.4 GO:0017121 phospholipid scrambling(GO:0017121)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.2 GO:0031362 intrinsic component of external side of plasma membrane(GO:0031233) anchored component of external side of plasma membrane(GO:0031362)
0.0 3.7 GO:0005604 basement membrane(GO:0005604)
0.0 0.7 GO:0071565 nBAF complex(GO:0071565)
0.0 0.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.4 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.3 1.3 GO:0097108 hedgehog family protein binding(GO:0097108)
0.3 0.9 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.2 0.7 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 1.9 GO:0045503 dynein light chain binding(GO:0045503)
0.1 1.0 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.0 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 0.3 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.1 1.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.4 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.1 0.4 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.4 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 1.1 GO:0016208 AMP binding(GO:0016208)
0.0 0.1 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.0 0.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 1.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.3 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.6 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 0.4 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 1.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.4 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway