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PRJNA195909:zebrafish embryo and larva development
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Results for irf5
Z-value: 2.58
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Transcription factors associated with irf5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| irf5 | dr11_v1_chr4_-_13614797_13614936 | 0.85 | 3.6e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_69187585 Show fit | 5.26 |
ENSDART00000160499
ENSDART00000166258 |
MARVEL domain containing 3 |
|
| chr20_-_43743700 Show fit | 3.53 |
ENSDART00000100620
|
si:dkeyp-50f7.2 |
|
| chr15_+_44201056 Show fit | 3.40 |
ENSDART00000162433
ENSDART00000148336 |
|
|
| chr5_-_30382925 Show fit | 3.36 |
ENSDART00000125381
|
grass carp reovirus (GCRV)-induced gene 2o |
|
| chr22_+_24623936 Show fit | 3.30 |
ENSDART00000160924
|
mucolipin 2 |
|
| chr7_+_46020508 Show fit | 3.03 |
ENSDART00000170294
|
cyclin E1 |
|
| chr15_-_29162193 Show fit | 2.85 |
ENSDART00000138449
ENSDART00000099885 |
XIAP associated factor 1 |
|
| chr15_-_33964897 Show fit | 2.83 |
ENSDART00000172075
ENSDART00000158126 ENSDART00000160456 |
lipolysis stimulated lipoprotein receptor |
|
| chr17_+_22381215 Show fit | 2.82 |
ENSDART00000162670
ENSDART00000128875 |
solute carrier family 8 (sodium/calcium exchanger), member 1b |
|
| chr18_+_44532668 Show fit | 2.78 |
ENSDART00000140672
|
suppression of tumorigenicity 14 (colon carcinoma) a |
Network of associatons between targets according to the STRING database.
First level regulatory network of irf5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | GO:0008544 | epidermis development(GO:0008544) |
| 1.8 | 5.3 | GO:0010633 | negative regulation of epithelial cell migration(GO:0010633) |
| 0.1 | 3.8 | GO:0071166 | ribonucleoprotein complex localization(GO:0071166) |
| 0.4 | 3.6 | GO:0070475 | rRNA base methylation(GO:0070475) |
| 0.1 | 3.0 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
| 0.2 | 2.8 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.1 | 2.8 | GO:0098703 | calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035) |
| 0.1 | 2.7 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.1 | 2.6 | GO:0048920 | posterior lateral line neuromast primordium migration(GO:0048920) |
| 0.0 | 2.6 | GO:0002573 | myeloid leukocyte differentiation(GO:0002573) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.1 | 3.5 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 3.4 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.8 | 3.0 | GO:0097134 | cyclin E1-CDK2 complex(GO:0097134) |
| 0.0 | 2.8 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.2 | 2.6 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.3 | 2.5 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 2.3 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 2.3 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
| 0.0 | 2.3 | GO:0048786 | presynaptic active zone(GO:0048786) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 4.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 4.3 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 3.5 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.1 | 3.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.4 | 3.3 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
| 0.0 | 3.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.2 | 2.8 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.2 | 2.8 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.4 | 2.6 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 3.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 2.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 2.3 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 2.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 1.7 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 1.2 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.0 | 1.1 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 3.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 3.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 2.6 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 2.6 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 2.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 2.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 2.2 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 2.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 1.9 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |