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PRJNA195909:zebrafish embryo and larva development

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Results for irf4a+irf4b

Z-value: 0.76

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Transcription factors associated with irf4a+irf4b

Gene Symbol Gene ID Gene Info
irf4a
ENSDARG00000006560 interferon regulatory factor 4a
irf4b
ENSDARG00000055374 interferon regulatory factor 4b
irf4b
ENSDARG00000115381 interferon regulatory factor 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf4bdr11_v1_chr20_+_26556372_265563720.363.4e-01Click!
irf4adr11_v1_chr2_-_879800_879800-0.059.0e-01Click!

Activity profile of irf4a+irf4b motif

Sorted Z-values of irf4a+irf4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr25_+_15997957 1.03 ENSDART00000140047
ppfibp2b
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr22_+_25236657 1.02 ENSDART00000138012
zgc:172218
zgc:172218
chr15_-_1835189 0.75 ENSDART00000154369
taf15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr21_+_21010786 0.69 ENSDART00000079692
ndr1
nodal-related 1
chr25_+_28862660 0.66 ENSDART00000154681
si:ch211-106e7.2
si:ch211-106e7.2
chr9_+_23765587 0.66 ENSDART00000145120
si:ch211-219a4.3
si:ch211-219a4.3
chr18_+_44532668 0.66 ENSDART00000140672
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr25_+_16646113 0.65 ENSDART00000110426
cecr2
cat eye syndrome chromosome region, candidate 2
chr10_-_17550931 0.58 ENSDART00000145077
ska1
spindle and kinetochore associated complex subunit 1
chr5_+_28260158 0.56 ENSDART00000181434
ncaph
non-SMC condensin I complex, subunit H
chr9_-_23765480 0.55 ENSDART00000027212
si:ch211-219a4.6
si:ch211-219a4.6
chr16_+_19637384 0.54 ENSDART00000184773
ENSDART00000191895
ENSDART00000182020
ENSDART00000135359
macc1
metastasis associated in colon cancer 1
chr21_+_17301790 0.54 ENSDART00000145057
tsc1b
TSC complex subunit 1b
chr1_-_55750208 0.52 ENSDART00000142244
dnajb1b
DnaJ (Hsp40) homolog, subfamily B, member 1b
chr19_+_43669122 0.51 ENSDART00000139151
si:ch211-193k19.1
si:ch211-193k19.1
chr19_-_15420678 0.49 ENSDART00000151454
ENSDART00000027697
serinc2
serine incorporator 2
chr16_-_41667101 0.49 ENSDART00000084528
atp2c1
ATPase secretory pathway Ca2+ transporting 1
chr18_+_44532199 0.46 ENSDART00000135386
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr6_-_1566407 0.46 ENSDART00000112118
trim107
tripartite motif containing 107
chr3_+_15773991 0.45 ENSDART00000089923
znf652
zinc finger protein 652
chr15_+_34069746 0.44 ENSDART00000163513
arl4aa
ADP-ribosylation factor-like 4aa
chr18_+_44532370 0.42 ENSDART00000086952
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr15_+_31911989 0.42 ENSDART00000111472
brca2
breast cancer 2, early onset
chr5_+_31959954 0.42 ENSDART00000142826
myo1hb
myosin IHb
chr17_-_40879108 0.41 ENSDART00000010362
supt7l
SPT7-like STAGA complex gamma subunit
chr23_-_29553430 0.41 ENSDART00000157773
ENSDART00000126384
ube4b
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr17_+_40879331 0.40 ENSDART00000046003
slc4a1ap
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr13_+_24263049 0.40 ENSDART00000135992
ENSDART00000088005
abcb10
ATP-binding cassette, sub-family B (MDR/TAP), member 10
chr15_-_17071328 0.39 ENSDART00000122617
si:ch211-24o10.6
si:ch211-24o10.6
chr19_+_791538 0.39 ENSDART00000146554
ENSDART00000138406
tmem79a
transmembrane protein 79a
chr11_-_30508843 0.38 ENSDART00000101667
ENSDART00000179930
map4k3a
mitogen-activated protein kinase kinase kinase kinase 3a
chr4_+_68562464 0.38 ENSDART00000192954
BX548011.4

chr6_-_1566581 0.38 ENSDART00000192993
trim107
tripartite motif containing 107
chr18_+_44532883 0.38 ENSDART00000121994
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr2_+_2818645 0.36 ENSDART00000163587
rock1
Rho-associated, coiled-coil containing protein kinase 1
chr16_+_27383717 0.36 ENSDART00000132329
ENSDART00000136256
stx17
syntaxin 17
chr3_+_36127287 0.35 ENSDART00000058605
ENSDART00000182500
scpep1
serine carboxypeptidase 1
chr24_-_11467004 0.34 ENSDART00000144316
pxdc1b
PX domain containing 1b
chr24_-_26885897 0.34 ENSDART00000180512
fndc3bb
fibronectin type III domain containing 3Bb
chr14_-_31814149 0.34 ENSDART00000173393
arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr6_-_1566186 0.32 ENSDART00000156305
trim107
tripartite motif containing 107
chr3_-_26171668 0.32 ENSDART00000113890
rabep2
rabaptin, RAB GTPase binding effector protein 2
chr12_-_28975705 0.32 ENSDART00000129173
znf646
zinc finger protein 646
chr20_+_13781779 0.32 ENSDART00000142999
ENSDART00000152471
lpgat1
lysophosphatidylglycerol acyltransferase 1
chr23_-_29553691 0.31 ENSDART00000053804
ube4b
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr16_+_35661331 0.31 ENSDART00000161725
map7d1a
MAP7 domain containing 1a
chr20_-_51547464 0.31 ENSDART00000099486
disp1
dispatched homolog 1 (Drosophila)
chr2_+_30489846 0.30 ENSDART00000145732
march6
membrane-associated ring finger (C3HC4) 6
chr2_-_43739740 0.30 ENSDART00000113849
kif5ba
kinesin family member 5B, a
chr4_-_12795436 0.30 ENSDART00000131026
ENSDART00000075127
b2m
beta-2-microglobulin
chr23_-_35396845 0.30 ENSDART00000142038
ENSDART00000049373
ENSDART00000181978
ENSDART00000171357
cmtr1
cap methyltransferase 1
chr10_+_4046448 0.28 ENSDART00000123086
ENSDART00000052268
pitpnb
phosphatidylinositol transfer protein, beta
chr22_-_10605045 0.28 ENSDART00000184812
bap1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr15_-_43995028 0.27 ENSDART00000172485
ENSDART00000186320
nlrc3l
NLR family, CARD domain containing 3-like
chr6_-_10728057 0.25 ENSDART00000002247
sp3b
Sp3b transcription factor
chr11_+_24804556 0.25 ENSDART00000082761
ENSDART00000186283
adipor1a
adiponectin receptor 1a
chr7_+_17908235 0.23 ENSDART00000077113
mta2
metastasis associated 1 family, member 2
chr10_+_8101729 0.23 ENSDART00000138875
ENSDART00000123447
ENSDART00000185333
pstpip2
proline-serine-threonine phosphatase interacting protein 2
chr8_-_51340773 0.23 ENSDART00000060633
kansl3
KAT8 regulatory NSL complex subunit 3
chr1_+_38153944 0.23 ENSDART00000135666
galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr6_+_11250316 0.21 ENSDART00000137122
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr1_-_7582859 0.21 ENSDART00000110696
mxb
myxovirus (influenza) resistance B
chr4_-_17669881 0.21 ENSDART00000066997
dram1
DNA-damage regulated autophagy modulator 1
chr20_-_38525467 0.20 ENSDART00000061417
si:ch211-245h14.1
si:ch211-245h14.1
chr20_-_6476705 0.20 ENSDART00000077095
trappc8
trafficking protein particle complex 8
chr10_+_28160265 0.20 ENSDART00000022484
rnft1
ring finger protein, transmembrane 1
chr1_-_7570181 0.19 ENSDART00000103588
mxa
myxovirus (influenza) resistance A
chr1_-_36771712 0.19 ENSDART00000148386
prmt9
protein arginine methyltransferase 9
chr9_+_23003208 0.19 ENSDART00000021060
eaf2
ELL associated factor 2
chr8_+_20157798 0.18 ENSDART00000124809
acsbg2
acyl-CoA synthetase bubblegum family member 2
chr25_+_36045072 0.18 ENSDART00000126326
rpgrip1l
RPGRIP1-like
chr13_+_17694845 0.18 ENSDART00000079778
ifit8
interferon-induced protein with tetratricopeptide repeats 8
chr21_-_40049642 0.17 ENSDART00000124416
med31
mediator complex subunit 31
chr23_-_12906228 0.17 ENSDART00000138807
ndnl2
necdin-like 2
chr3_-_4501026 0.17 ENSDART00000163052
zgc:162198
zgc:162198
chr10_+_7703251 0.16 ENSDART00000165134
ggcx
gamma-glutamyl carboxylase
chr5_-_69716501 0.15 ENSDART00000158956
mob1a
MOB kinase activator 1A
chr18_-_24988645 0.15 ENSDART00000136434
ENSDART00000085735
chd2
chromodomain helicase DNA binding protein 2
chr6_-_18560190 0.15 ENSDART00000168636
tefm
transcription elongation factor, mitochondrial
chr8_-_18229169 0.15 ENSDART00000131764
ENSDART00000143036
ENSDART00000145986
si:ch211-241d21.5
si:ch211-241d21.5
chr7_+_19738665 0.14 ENSDART00000089333
tkfc
triokinase/FMN cyclase
chr1_-_1885516 0.13 ENSDART00000122187
ENSDART00000131675
si:ch211-132g1.3
si:ch211-132g1.3
chr22_-_17474781 0.13 ENSDART00000186817
si:ch211-197g15.8
si:ch211-197g15.8
chr4_-_12795030 0.13 ENSDART00000150427
b2m
beta-2-microglobulin
chr22_-_17474583 0.13 ENSDART00000148027
si:ch211-197g15.8
si:ch211-197g15.8
chr6_-_52235118 0.13 ENSDART00000191243
tomm34
translocase of outer mitochondrial membrane 34
chr14_-_33585809 0.13 ENSDART00000023540
sash3
SAM and SH3 domain containing 3
chr13_-_50200348 0.12 ENSDART00000038391
pkz
protein kinase containing Z-DNA binding domains
chr19_-_791016 0.12 ENSDART00000037515
msto1
misato 1, mitochondrial distribution and morphology regulator
chr11_-_6206520 0.12 ENSDART00000150199
ENSDART00000148246
ENSDART00000019440
pole4
polymerase (DNA-directed), epsilon 4, accessory subunit
chr21_-_38031038 0.11 ENSDART00000179483
ENSDART00000076238
rbm41
RNA binding motif protein 41
chr22_+_38914983 0.11 ENSDART00000085701
senp5
SUMO1/sentrin specific peptidase 5
chr12_-_27242498 0.10 ENSDART00000152609
ENSDART00000152170
si:dkey-11c5.11
si:dkey-11c5.11
chr24_-_11467549 0.10 ENSDART00000082264
pxdc1b
PX domain containing 1b
chr4_-_26107841 0.10 ENSDART00000172012
si:ch211-244b2.4
si:ch211-244b2.4
chr6_-_18400548 0.10 ENSDART00000179797
ENSDART00000164891
trim25
tripartite motif containing 25
chr8_-_51340931 0.09 ENSDART00000178209
kansl3
KAT8 regulatory NSL complex subunit 3
chr18_-_25905574 0.09 ENSDART00000143899
ENSDART00000163369
sema4ba
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ba
chr6_+_41554794 0.08 ENSDART00000165424
srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr21_+_11535304 0.08 ENSDART00000158901
ENSDART00000081600
cd8b
cd8 beta
chr7_-_20464133 0.07 ENSDART00000078192
cnpy4
canopy4
chr12_+_48319221 0.07 ENSDART00000126362
anapc16
anaphase promoting complex subunit 16
chr5_+_59397739 0.07 ENSDART00000148659
clip2
CAP-GLY domain containing linker protein 2
chr1_+_31674297 0.07 ENSDART00000044214
wbp1lb
WW domain binding protein 1-like b
chr11_-_575786 0.06 ENSDART00000019997
mkrn2
makorin, ring finger protein, 2
chr17_+_30448452 0.06 ENSDART00000153939
lpin1
lipin 1
chr5_+_66063807 0.06 ENSDART00000122405
jak2b
Janus kinase 2b
chr9_-_32837860 0.06 ENSDART00000142227
mxe
myxovirus (influenza virus) resistance E
chr4_+_11464255 0.05 ENSDART00000008584
gdi2
GDP dissociation inhibitor 2
chr12_-_35936329 0.05 ENSDART00000166634
rnf213b
ring finger protein 213b
chr22_-_30999000 0.04 ENSDART00000109841
ssuh2.3
ssu-2 homolog, tandem duplicate 3
chr6_+_15762647 0.04 ENSDART00000127133
ENSDART00000128939
iqca1
IQ motif containing with AAA domain 1
chr8_+_47897734 0.04 ENSDART00000140266
mfn2
mitofusin 2
chr21_+_25793970 0.04 ENSDART00000101217
CLDN4 (1 of many)
zgc:136892
chr4_+_54948890 0.04 ENSDART00000166873
si:dkey-56m15.7
si:dkey-56m15.7
chr19_-_7110617 0.03 ENSDART00000104838
psmb8a
proteasome subunit beta 8A
chr22_-_7778895 0.03 ENSDART00000125489
si:ch73-44m9.3
si:ch73-44m9.3
chr5_+_21922534 0.02 ENSDART00000148092
si:ch73-92i20.1
si:ch73-92i20.1
chr22_-_10604526 0.02 ENSDART00000091777
bap1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr25_-_3034668 0.02 ENSDART00000053405
scamp2
secretory carrier membrane protein 2
chr18_+_17624295 0.01 ENSDART00000151865
ENSDART00000190408
ENSDART00000189204
ENSDART00000188894
ENSDART00000033762
ENSDART00000193471
nlrc5
NLR family, CARD domain containing 5
chr17_+_43895158 0.01 ENSDART00000111123
msh4
mutS homolog 4
chr6_+_22068589 0.01 ENSDART00000151205
aldh1l1
aldehyde dehydrogenase 1 family, member L1
chr15_+_2421729 0.01 ENSDART00000082294
ENSDART00000156428
hephl1a
hephaestin-like 1a
chr12_+_36109507 0.01 ENSDART00000175409
map2k6
mitogen-activated protein kinase kinase 6
chr3_+_25191467 0.00 ENSDART00000156956
ENSDART00000154799
il2rb
interleukin 2 receptor, beta

Network of associatons between targets according to the STRING database.

First level regulatory network of irf4a+irf4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0003347 epicardial cell to mesenchymal cell transition(GO:0003347) negative regulation of adherens junction organization(GO:1903392)
0.1 0.5 GO:0055071 manganese ion homeostasis(GO:0055071)
0.1 0.3 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.1 0.3 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 0.3 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 0.3 GO:0014005 microglia development(GO:0014005)
0.0 0.7 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.3 GO:0098971 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.0 0.6 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.2 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.0 0.5 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0 0.3 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0039535 RIG-I signaling pathway(GO:0039529) regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039531) regulation of RIG-I signaling pathway(GO:0039535)
0.0 0.4 GO:0007530 sex determination(GO:0007530)
0.0 0.4 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.0 0.2 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.3 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.5 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 0.1 GO:0019563 glycerol catabolic process(GO:0019563)
0.0 0.3 GO:0042694 muscle cell fate specification(GO:0042694)
0.0 0.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.2 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.4 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 1.0 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 1.9 GO:0016485 protein processing(GO:0016485)
0.0 0.9 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.4 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.7 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 0.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.3 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 0.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.6 GO:0000796 condensin complex(GO:0000796)
0.1 0.2 GO:1990072 TRAPPIII protein complex(GO:1990072)
0.1 0.4 GO:0030914 STAGA complex(GO:0030914)
0.1 0.7 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.3 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.2 GO:0070847 core mediator complex(GO:0070847)
0.0 0.5 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.2 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.3 GO:0044545 NSL complex(GO:0044545)
0.0 0.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.4 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.7 GO:0070698 type I activin receptor binding(GO:0070698)
0.1 0.5 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.1 0.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.4 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.0 0.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.0 0.3 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.6 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.2 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.1 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.1 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0 0.2 GO:0016405 CoA-ligase activity(GO:0016405)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.5 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.6 PID AURORA B PATHWAY Aurora B signaling
0.0 1.1 PID P73PATHWAY p73 transcription factor network
0.0 0.4 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins