ISMARA results: irf1b+irf2+irf2a

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PRJNA195909:zebrafish embryo and larva development

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Results for irf1b+irf2+irf2a

Z-value: 1.68

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Transcription factors associated with irf1b+irf2+irf2a

Gene Symbol	Gene ID	Gene Info
irf2a NCBI UniProt	ENSDARG00000007387	interferon regulatory factor 2a
irf2 NCBI UniProt	ENSDARG00000040465	interferon regulatory factor 2
irf1b NCBI UniProt	ENSDARG00000043249	interferon regulatory factor 1b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
irf2a	dr11_v1_chr1_+_39865748_39865753	0.97	2.1e-05	Click!
irf2	dr11_v1_chr14_-_4121052_4121052	-0.85	3.6e-03	Click!
irf1b	dr11_v1_chr21_+_45626136_45626136	-0.61	7.9e-02	Click!

Activity profile of irf1b+irf2+irf2a motif

Sorted Z-values of irf1b+irf2+irf2a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr23_+_43668756 Show fit	5.08	ENSDART00000112598	otud4 NCBI UniProt Show fit	OTU deubiquitinase 4
chr20_+_54295213 Show fit	3.23	ENSDART00000074085	zp2.3 NCBI UniProt Show fit	zona pellucida glycoprotein 2, tandem duplicate 3
chr4_+_279669 Show fit	2.70	ENSDART00000184884	CABZ01085275.1 NCBI UniProt Show fit
chr11_+_37638873 Show fit	2.18	ENSDART00000186384 ENSDART00000184291 ENSDART00000131782 ENSDART00000140502	sh2d5 NCBI UniProt Show fit	SH2 domain containing 5
chr20_+_54309148 Show fit	2.08	ENSDART00000099360	zp2.1 NCBI UniProt Show fit	zona pellucida glycoprotein 2, tandem duplicate 1
chr9_-_35633827 Show fit	2.00	ENSDART00000077745	zp2l1 NCBI UniProt Show fit	zona pellucida glycoprotein 2, like 1
chr10_-_21542702 Show fit	1.90	ENSDART00000146761 ENSDART00000134502	zgc:165539 NCBI UniProt Show fit	zgc:165539
chr18_-_38270430 Show fit	1.89	ENSDART00000139519	caprin1b NCBI UniProt Show fit	cell cycle associated protein 1b
chr9_+_8401796 Show fit	1.89	ENSDART00000180047 ENSDART00000132339 ENSDART00000137527	si:ch1073-75o15.3 NCBI UniProt Show fit	si:ch1073-75o15.3
chr14_-_45967712 Show fit	1.88	ENSDART00000043751 ENSDART00000141357	macrod1 NCBI UniProt Show fit	MACRO domain containing 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of irf1b+irf2+irf2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.7	GO:0016567	protein ubiquitination(GO:0016567)
1.3	5.1	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0	3.6	GO:0017148	negative regulation of translation(GO:0017148)
0.0	3.1	GO:0000209	protein polyubiquitination(GO:0000209)
0.3	2.8	GO:0015886	heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.0	2.8	GO:0071166	ribonucleoprotein complex localization(GO:0071166)
0.0	2.4	GO:0042147	retrograde transport, endosome to Golgi(GO:0042147)
0.2	2.3	GO:0019883	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	2.3	GO:0090630	activation of GTPase activity(GO:0090630)
0.1	2.0	GO:0000076	DNA replication checkpoint(GO:0000076)

Showing 1 to 10 of 146 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	GO:0043296	apical junction complex(GO:0043296)
0.1	2.1	GO:0005940	septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1	2.0	GO:0000145	exocyst(GO:0000145)
0.1	1.8	GO:0005579	membrane attack complex(GO:0005579)
0.0	1.8	GO:0030496	midbody(GO:0030496)
0.0	1.6	GO:0016607	nuclear speck(GO:0016607)
0.0	1.6	GO:0005802	trans-Golgi network(GO:0005802)
0.1	1.5	GO:0015030	Cajal body(GO:0015030)
0.0	1.5	GO:0008021	synaptic vesicle(GO:0008021)
0.1	1.4	GO:0031211	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)

Showing 1 to 10 of 61 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.3	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.3	5.1	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.1	4.4	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	4.0	GO:0060090	binding, bridging(GO:0060090)
0.4	2.8	GO:0015232	heme transporter activity(GO:0015232)
0.1	2.0	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.1	2.0	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0	2.0	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.0	2.0	GO:0019901	protein kinase binding(GO:0019901)
0.0	1.9	GO:0051539	4 iron, 4 sulfur cluster binding(GO:0051539)

Showing 1 to 10 of 100 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.8	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	1.8	PID P73PATHWAY	p73 transcription factor network
0.0	1.3	PID BARD1 PATHWAY	BARD1 signaling events
0.0	1.3	PID ATR PATHWAY	ATR signaling pathway
0.1	1.2	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	1.2	PID IL12 2PATHWAY	IL12-mediated signaling events
0.1	0.9	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	0.9	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.9	PID ARF 3PATHWAY	Arf1 pathway
0.0	0.9	PID AURORA B PATHWAY	Aurora B signaling

Showing 1 to 10 of 19 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2	2.0	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	2.0	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.1	1.6	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	1.2	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	1.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	1.2	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	1.1	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	0.9	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.9	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis

Showing 1 to 10 of 39 entries

Results for irf1b+irf2+irf2a

Z-value: 1.68

Motif logo

Transcription factors associated with irf1b+irf2+irf2a

Activity-expression correlation:

Activity profile of irf1b+irf2+irf2a motif

Sorted Z-values of irf1b+irf2+irf2a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of irf1b+irf2+irf2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: