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PRJNA195909:zebrafish embryo and larva development

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Results for hoxd10a

Z-value: 0.69

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Transcription factors associated with hoxd10a

Gene Symbol Gene ID Gene Info
ENSDARG00000057859 homeobox D10a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxd10adr11_v1_chr9_-_1970071_1970071-0.932.6e-04Click!

Activity profile of hoxd10a motif

Sorted Z-values of hoxd10a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr23_+_28322986 1.52 ENSDART00000134710
baculoviral IAP repeat containing 5b
chr1_-_18811517 1.40 ENSDART00000142026
si:dkey-167i21.2
chr2_-_1486023 1.08 ENSDART00000113774
si:ch211-188c16.1
chr6_-_25165693 1.03 ENSDART00000167259
zinc finger protein 326
chr22_-_38819603 0.97 ENSDART00000104437
si:ch211-262h13.5
chr21_+_5192016 0.88 ENSDART00000139288
si:dkey-121h17.7
chr11_-_39118882 0.82 ENSDART00000113185
ENSDART00000156526
adaptor-related protein complex 5, beta 1 subunit
chr24_+_17069420 0.82 ENSDART00000014787
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a
chr19_+_13994563 0.76 ENSDART00000164696
transmembrane protein 222b
chr3_-_40768548 0.75 ENSDART00000004923
SMAD specific E3 ubiquitin protein ligase 1
chr3_-_26191960 0.73 ENSDART00000113843
yippee-like 3
chr24_+_15655233 0.73 ENSDART00000143160
F-box protein 15
chr9_+_29643036 0.72 ENSDART00000023210
ENSDART00000175160
tripartite motif containing 13
chr25_-_12412704 0.71 ENSDART00000168275
DET1, COP1 ubiquitin ligase partner
chr1_-_55068941 0.71 ENSDART00000152143
ENSDART00000152590
pellino E3 ubiquitin protein ligase 1a
chr19_-_3056235 0.70 ENSDART00000137020
block of proliferation 1
chr5_-_23805387 0.69 ENSDART00000133805
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4
chr12_+_30788912 0.68 ENSDART00000160422
aldehyde dehydrogenase 18 family, member A1
chr25_+_18436301 0.67 ENSDART00000056180
centrosomal protein 41
chr24_+_15655069 0.66 ENSDART00000042943
ENSDART00000181296
F-box protein 15
chr18_-_20458412 0.65 ENSDART00000012241
kinesin family member 23
chr18_-_39200557 0.64 ENSDART00000132367
ENSDART00000183672
si:ch211-235f12.2
mitogen-activated protein kinase 6
chr25_+_34915762 0.63 ENSDART00000191776
syntrophin, beta 2
chr10_+_41986685 0.63 ENSDART00000086165
ENSDART00000171983
SET domain containing 1B, a
chr22_-_15010688 0.62 ENSDART00000139892
extracellular leucine-rich repeat and fibronectin type III domain containing 2a
chr21_+_34167178 0.60 ENSDART00000158308
transient receptor potential cation channel, subfamily C, member 5b
chr21_+_3796196 0.59 ENSDART00000146754
SPOUT domain containing methyltransferase 1
chr13_-_31017960 0.57 ENSDART00000145287
WDFY family member 4
chr2_+_21356242 0.57 ENSDART00000145670
ENSDART00000146600
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like b
chr21_+_3796620 0.57 ENSDART00000099535
ENSDART00000144515
SPOUT domain containing methyltransferase 1
chr9_-_19489264 0.54 ENSDART00000122894
WD repeat domain 4
chr9_-_3519717 0.53 ENSDART00000145043
ddb1 and cul4 associated factor 17
chr19_-_35450661 0.52 ENSDART00000113574
ENSDART00000136895
anillin, actin binding protein
chr11_+_14104417 0.49 ENSDART00000059752
ENSDART00000186575
mediator complex subunit 16
chr11_-_35970966 0.49 ENSDART00000188805
inositol 1,4,5-trisphosphate receptor, type 1b
chr19_+_4051535 0.48 ENSDART00000167084
bloodthirsty-related gene family, member 24
chr25_-_3217115 0.48 ENSDART00000032390
general transcription factor IIH, polypeptide 1
chr19_+_43828104 0.48 ENSDART00000166031
elongin A
chr9_+_3519191 0.47 ENSDART00000008606
methyltransferase like 8
chr11_-_27953135 0.47 ENSDART00000168338
endothelin converting enzyme 1
chr9_+_45605410 0.46 ENSDART00000136444
ENSDART00000007189
ENSDART00000158713
ENSDART00000182671
TNF receptor-associated factor 3 interacting protein 1
chr21_+_21279159 0.45 ENSDART00000148346
inositol-trisphosphate 3-kinase Ca
chr5_+_6672870 0.44 ENSDART00000126598
paxillin a
chr25_-_2723682 0.43 ENSDART00000113382
ADP-dependent glucokinase
chr3_-_43954343 0.43 ENSDART00000157580
ubiquitin family domain containing 1
chr15_-_10455438 0.42 ENSDART00000158958
ENSDART00000192971
ENSDART00000162133
ENSDART00000185071
ENSDART00000192444
ENSDART00000165668
ENSDART00000175825
teneurin transmembrane protein 4
chr10_+_44692272 0.42 ENSDART00000157458
ubiquitin C
chr14_+_23184517 0.41 ENSDART00000181410
ecto-NOX disulfide-thiol exchanger 2
chr16_+_41060161 0.38 ENSDART00000141130
SREBF chaperone
chr1_+_54199406 0.38 ENSDART00000176578
TSC complex subunit 2
chr14_+_44804326 0.36 ENSDART00000079866
ENSDART00000172974
solute carrier family 30 (zinc transporter), member 9
chr3_-_11828206 0.36 ENSDART00000018159
si:ch211-262e15.1
chr6_-_39521832 0.36 ENSDART00000065038
activating transcription factor 1
chr13_-_24669258 0.36 ENSDART00000000831
zinc finger protein 511
chr3_+_29600917 0.33 ENSDART00000048867
somatostatin receptor 3
chr14_-_32959851 0.33 ENSDART00000075157
cysteine-rich hydrophobic domain 1
chr1_+_32341734 0.32 ENSDART00000135078
pseudouridine 5'-phosphatase
chr11_-_23687158 0.31 ENSDART00000189599
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr6_-_40921412 0.31 ENSDART00000076097
ENSDART00000188364
SFI1 centrin binding protein
chr1_-_19764038 0.31 ENSDART00000005733
translation machinery associated 16 homolog
chr13_+_2442841 0.31 ENSDART00000114456
ENSDART00000137124
ENSDART00000193737
ENSDART00000189722
ENSDART00000187485
ARFGEF family member 3
chr16_-_43233509 0.30 ENSDART00000025877
claudin 12
chr10_-_2788668 0.30 ENSDART00000131749
ENSDART00000124356
ENSDART00000085031
ash2 (absent, small, or homeotic)-like (Drosophila)
chr5_+_50912729 0.28 ENSDART00000190837
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a
chr1_+_26105141 0.28 ENSDART00000102379
ENSDART00000127154
topoisomerase I binding, arginine/serine-rich a
chr3_-_26184018 0.28 ENSDART00000191604
si:ch211-11k18.4
chr6_+_9793791 0.28 ENSDART00000149896
amyotrophic lateral sclerosis 2b (juvenile)
chr5_+_30986512 0.27 ENSDART00000005893
ubiquitin-conjugating enzyme E2G 1a (UBC7 homolog, yeast)
chr14_+_20941038 0.27 ENSDART00000182539
zgc:66433
chr5_+_35458346 0.27 ENSDART00000141239
ER lipid raft associated 2
chr5_+_22459087 0.26 ENSDART00000134781

chr25_-_2723902 0.25 ENSDART00000143721
ENSDART00000175224
ADP-dependent glucokinase
chr13_-_18069421 0.25 ENSDART00000146772
ENSDART00000134477
zinc finger, AN1-type domain 4
chr16_-_42186093 0.25 ENSDART00000076030
fibrillarin
chr5_+_10084100 0.24 ENSDART00000109236
si:ch211-207k7.4
chr19_-_10324182 0.24 ENSDART00000151352
ENSDART00000151162
ENSDART00000023571
U2 small nuclear RNA auxiliary factor 2b
chr6_-_14040136 0.23 ENSDART00000065361
ENSDART00000179765
ets variant 5b
chr18_+_23218980 0.23 ENSDART00000185014
myocyte enhancer factor 2aa
chr3_-_36246899 0.22 ENSDART00000141106
ENSDART00000059506
ENSDART00000158701
G protein pathway suppressor 1
chr19_-_10324573 0.22 ENSDART00000171795
U2 small nuclear RNA auxiliary factor 2b
chr13_+_24717880 0.22 ENSDART00000147713
cilia and flagella associated protein 43
chr25_+_34915576 0.20 ENSDART00000073441
syntrophin, beta 2
chr21_-_3770636 0.19 ENSDART00000053596
secretory carrier membrane protein 1
chr23_+_12852655 0.19 ENSDART00000183015
structural maintenance of chromosomes 1A, like
chr18_-_42395161 0.19 ENSDART00000098641
contactin 5
chr8_-_53166975 0.17 ENSDART00000114683
rabenosyn, RAB effector
chr8_-_15292197 0.15 ENSDART00000140867
spermatogenesis associated 6
chr20_-_25445237 0.13 ENSDART00000145034
ENSDART00000018049
mitochondrial ribosomal protein L19
chr1_-_17711636 0.12 ENSDART00000148322
ENSDART00000122670
ufm1-specific peptidase 2
chr6_+_29386728 0.12 ENSDART00000104303
actin-like 6A
chr18_-_2222128 0.10 ENSDART00000171402
phosphatidylinositol glycan anchor biosynthesis, class B
chr23_-_17451264 0.10 ENSDART00000190748
tumor protein D52-like 2b
chr5_+_19094462 0.10 ENSDART00000190596
unc-13 homolog Ba (C. elegans)
chr22_+_22302614 0.10 ENSDART00000049434
secretory carrier membrane protein 4
chr20_-_30931139 0.09 ENSDART00000006778
ENSDART00000146376
acetyl-CoA acetyltransferase 2
chr2_-_42628028 0.09 ENSDART00000179866
myosin X
chr7_+_17973269 0.09 ENSDART00000079969
potassium channel, subfamily K, member 7
chr10_-_3138403 0.09 ENSDART00000183365
ubiquitin-conjugating enzyme E2L 3a
chr9_+_19489304 0.09 ENSDART00000151920
si:ch211-140m22.7
chr4_-_16824556 0.08 ENSDART00000165289
ENSDART00000185839
glycogen synthase 2
chr17_+_31621788 0.08 ENSDART00000111629
ENSDART00000157148
cyclin-dependent kinase 2 interacting protein
chr9_-_3519253 0.07 ENSDART00000169586
ddb1 and cul4 associated factor 17
chr19_+_47299212 0.07 ENSDART00000158262
thiopurine S-methyltransferase, tandem duplicate 1
chr10_-_26985231 0.06 ENSDART00000050585
zinc finger, HIT-type containing 2
chr21_-_11654422 0.06 ENSDART00000081614
ENSDART00000132699
calpastatin
chr18_+_15644559 0.06 ENSDART00000061794
nuclear receptor subfamily 1, group H, member 4
chr6_+_12316438 0.05 ENSDART00000156854
si:dkey-276j7.2
chr22_-_36750589 0.05 ENSDART00000010824
aminoacylase 1
chr15_+_3674765 0.04 ENSDART00000081802
NIMA related kinase 3
chr11_-_42752884 0.04 ENSDART00000186025
si:ch73-106k19.5
chr10_-_36244864 0.04 ENSDART00000123748
odorant receptor, family D, subfamily 109, member 1
chr20_+_13894123 0.03 ENSDART00000007744
solute carrier family 30 (zinc transporter), member 1a
chr2_-_23349116 0.03 ENSDART00000099690
family with sequence similarity 129, member Ab
chr17_-_19344999 0.02 ENSDART00000138315
goosecoid
chr7_+_5007310 0.02 ENSDART00000146083
si:ch211-272h9.3
chr5_+_19094153 0.02 ENSDART00000186525
ENSDART00000064752
unc-13 homolog Ba (C. elegans)
chr10_-_45379831 0.02 ENSDART00000186205

chr22_+_21950838 0.00 ENSDART00000143075
guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4
chr23_-_41585748 0.00 ENSDART00000102879
ENSDART00000188689
signal peptide, CUB domain, EGF-like 3
chr18_+_7543347 0.00 ENSDART00000103467
ADP-ribosylation factor 5

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxd10a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0000212 meiotic spindle organization(GO:0000212)
0.3 1.2 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.7 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.1 0.5 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.1 0.5 GO:0008356 asymmetric cell division(GO:0008356)
0.1 0.7 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.7 GO:0040016 embryonic cleavage(GO:0040016)
0.1 0.4 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 0.4 GO:0007624 ultradian rhythm(GO:0007624)
0.1 0.7 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.1 0.5 GO:0090660 regulation of microtubule polymerization(GO:0031113) cerebrospinal fluid circulation(GO:0090660)
0.1 0.2 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.6 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.7 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.7 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.4 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.9 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.7 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.5 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.2 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.5 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.4 GO:0061055 myotome development(GO:0061055)
0.0 0.5 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 0.2 GO:0031126 snoRNA 3'-end processing(GO:0031126)
0.0 1.0 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784)
0.0 0.5 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.6 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.4 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 1.1 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.8 GO:0048634 regulation of muscle organ development(GO:0048634)
0.0 0.1 GO:0016081 synaptic vesicle docking(GO:0016081) presynaptic dense core granule exocytosis(GO:0099525)
0.0 0.3 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.2 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.7 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.5 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 1.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.7 GO:0006096 glycolytic process(GO:0006096)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0044609 DBIRD complex(GO:0044609)
0.2 0.7 GO:0070545 PeBoW complex(GO:0070545)
0.1 1.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.5 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.1 0.4 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 0.5 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.5 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.9 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 0.5 GO:0089701 U2AF(GO:0089701)
0.0 0.5 GO:0070449 elongin complex(GO:0070449)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.8 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.5 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.1 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.4 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.8 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.5 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.7 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.7 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.1 0.7 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.5 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.1 1.5 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 1.2 GO:0035198 miRNA binding(GO:0035198)
0.1 0.6 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.7 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.5 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 1.0 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 1.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0 0.5 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.5 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 0.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.4 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0008119 thiopurine S-methyltransferase activity(GO:0008119)
0.0 0.1 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.2 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.7 PID BMP PATHWAY BMP receptor signaling
0.0 0.7 PID AURORA B PATHWAY Aurora B signaling
0.0 0.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 0.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 0.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.4 REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 0.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes