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PRJNA195909:zebrafish embryo and larva development
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Results for hoxc11a
Z-value: 1.87
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Transcription factors associated with hoxc11a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hoxc11a | dr11_v1_chr23_+_36074798_36074880 | 0.65 | 6.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_+_10146542 Show fit | 5.33 |
ENSDART00000048073
|
zgc:171775 |
|
| chr22_-_4644484 Show fit | 5.20 |
ENSDART00000167748
|
fibrillin 2b |
|
| chr1_+_44439661 Show fit | 4.66 |
ENSDART00000100309
|
crystallin, beta B1, like 2 |
|
| chr10_-_29903165 Show fit | 4.15 |
ENSDART00000078800
|
lens intrinsic membrane protein 2.1 |
|
| chr17_+_52822831 Show fit | 3.81 |
ENSDART00000193368
|
Meis homeobox 2a |
|
| chr23_+_39606108 Show fit | 3.70 |
ENSDART00000109464
|
G0/G1 switch 2 |
|
| chr12_-_25916530 Show fit | 3.68 |
ENSDART00000186386
|
synuclein, gamma b (breast cancer-specific protein 1) |
|
| chr11_+_25257022 Show fit | 3.67 |
ENSDART00000156052
|
tumor protein p53 inducible nuclear protein 2 |
|
| chr12_+_27117609 Show fit | 3.44 |
ENSDART00000076154
|
homeobox B8b |
|
| chr11_+_30244356 Show fit | 3.42 |
ENSDART00000036050
ENSDART00000150080 |
retinoschisin 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of hoxc11a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | GO:0009880 | embryonic pattern specification(GO:0009880) |
| 0.0 | 5.7 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 1.7 | 5.2 | GO:0003250 | cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) endocardial cell development(GO:0060958) cell proliferation involved in heart valve development(GO:2000793) |
| 0.1 | 5.1 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.0 | 4.7 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.0 | 4.0 | GO:0043062 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.1 | 3.7 | GO:0071542 | dopaminergic neuron differentiation(GO:0071542) |
| 0.1 | 3.7 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
| 0.4 | 3.6 | GO:0006833 | water transport(GO:0006833) |
| 0.1 | 3.6 | GO:0006096 | glycolytic process(GO:0006096) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.2 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 5.1 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 4.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 3.7 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 3.7 | GO:0044306 | axon terminus(GO:0043679) neuron projection terminus(GO:0044306) |
| 0.0 | 3.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.2 | 3.3 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.6 | 2.3 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.0 | 2.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.3 | 2.1 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 28.0 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.1 | 13.5 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 9.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 8.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.6 | 5.6 | GO:0015250 | water channel activity(GO:0015250) |
| 0.1 | 5.3 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 4.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.2 | 3.7 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 0.0 | 3.4 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.3 | 3.3 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.6 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 1.5 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 1.0 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.2 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 3.8 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 2.9 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 2.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 1.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 1.7 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.2 | 1.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 1.6 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.1 | 1.5 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 1.2 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |