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PRJNA195909:zebrafish embryo and larva development
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Results for hoxb9a
Z-value: 0.92
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Transcription factors associated with hoxb9a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hoxb9a | dr11_v1_chr3_+_23677351_23677351 | 0.50 | 1.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_+_7379728 Show fit | 1.96 |
ENSDART00000012194
|
GATA binding protein 5 |
|
| chr23_+_39606108 Show fit | 1.41 |
ENSDART00000109464
|
G0/G1 switch 2 |
|
| chr6_+_35362225 Show fit | 1.32 |
ENSDART00000133783
ENSDART00000102483 |
regulator of G protein signaling 4 |
|
| chr8_+_4697764 Show fit | 1.18 |
ENSDART00000064197
|
claudin 5a |
|
| chr5_-_40510397 Show fit | 1.18 |
ENSDART00000146237
ENSDART00000051065 |
follistatin a |
|
| chr2_-_40135942 Show fit | 0.98 |
ENSDART00000176951
ENSDART00000098632 ENSDART00000148563 ENSDART00000149895 |
eph receptor A4a |
|
| chr2_+_52847049 Show fit | 0.97 |
ENSDART00000121980
|
cAMP responsive element binding protein 3-like 3b |
|
| chr24_-_17029374 Show fit | 0.95 |
ENSDART00000039267
|
prostaglandin D2 synthase b, tandem duplicate 1 |
|
| chr10_+_506538 Show fit | 0.95 |
ENSDART00000141713
|
si:ch211-242f23.3 |
|
| chr13_+_22295905 Show fit | 0.90 |
ENSDART00000180133
ENSDART00000181125 |
ubiquitin specific peptidase 54a |
Network of associatons between targets according to the STRING database.
First level regulatory network of hoxb9a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.0 | GO:0048618 | post-embryonic foregut morphogenesis(GO:0048618) |
| 0.2 | 2.0 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.0 | 1.4 | GO:0031018 | endocrine pancreas development(GO:0031018) |
| 0.0 | 1.2 | GO:0061028 | establishment of endothelial barrier(GO:0061028) |
| 0.1 | 1.0 | GO:0003404 | optic vesicle morphogenesis(GO:0003404) |
| 0.0 | 1.0 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 0.3 | 0.9 | GO:0060958 | cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) endocardial cell development(GO:0060958) cell proliferation involved in heart valve development(GO:2000793) |
| 0.0 | 0.7 | GO:0006414 | translational elongation(GO:0006414) |
| 0.1 | 0.6 | GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) |
| 0.1 | 0.6 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 0.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 0.6 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 0.6 | GO:0098835 | presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894) |
| 0.0 | 0.5 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 0.2 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.0 | 0.2 | GO:0070390 | transcription export complex 2(GO:0070390) |
| 0.0 | 0.2 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.2 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 0.1 | GO:1990072 | TRAPPIII protein complex(GO:1990072) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 1.2 | GO:0048185 | activin binding(GO:0048185) |
| 0.1 | 1.0 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 1.0 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.1 | 1.0 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 0.7 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.6 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 0.6 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.0 | 0.6 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 0.5 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.3 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.2 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 1.4 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 1.3 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 0.6 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.6 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.5 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.4 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.4 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 0.3 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.0 | 0.3 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |