ISMARA results: hoxb8a+hoxb8b

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PRJNA195909:zebrafish embryo and larva development

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Results for hoxb8a+hoxb8b

Z-value: 1.41

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Transcription factors associated with hoxb8a+hoxb8b

Gene Symbol	Gene ID	Gene Info
hoxb8b NCBI UniProt	ENSDARG00000054025	homeobox B8b
hoxb8a NCBI UniProt	ENSDARG00000056027	homeobox B8a
hoxb8b NCBI UniProt	ENSDARG00000111056	homeobox B8b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
hoxb8b	dr11_v1_chr12_+_27117609_27117609	0.47	2.1e-01	Click!
hoxb8a	dr11_v1_chr3_+_23687909_23687909	0.45	2.2e-01	Click!

Activity profile of hoxb8a+hoxb8b motif

Sorted Z-values of hoxb8a+hoxb8b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr24_+_38301080 Show fit	3.48	ENSDART00000105672	mybpc2b NCBI UniProt Show fit	myosin binding protein C, fast type b
chr2_+_33368414 Show fit	2.09	ENSDART00000077462	slc6a9 NCBI UniProt Show fit	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr3_+_33300522 Show fit	1.88	ENSDART00000114023	hspb9 NCBI UniProt Show fit	heat shock protein, alpha-crystallin-related, 9
chr10_-_39011514 Show fit	1.82	ENSDART00000075123	pcp4a NCBI UniProt Show fit	Purkinje cell protein 4a
chr1_+_17676745 Show fit	1.68	ENSDART00000030665	slc25a4 NCBI UniProt Show fit	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr12_-_26406323 Show fit	1.56	ENSDART00000131896	myoz1b NCBI UniProt Show fit	myozenin 1b
chr6_+_52804267 Show fit	1.55	ENSDART00000065681	matn4 NCBI UniProt Show fit	matrilin 4
chr19_-_3123963 Show fit	1.48	ENSDART00000122816	si:ch211-80h18.1 NCBI UniProt Show fit	si:ch211-80h18.1
chr4_-_4387012 Show fit	1.28	ENSDART00000191836	CU468826.3 NCBI UniProt Show fit	Danio rerio U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1-like (LOC100331497), mRNA.
chr7_+_31879649 Show fit	1.19	ENSDART00000099789	mybpc3 NCBI UniProt Show fit	myosin binding protein C, cardiac

Showing 1 to 10 of 189 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb8a+hoxb8b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.2	GO:0003210	cardiac atrium formation(GO:0003210)
0.5	2.1	GO:0060092	regulation of synaptic transmission, glycinergic(GO:0060092)
0.1	1.9	GO:0072554	endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.4	1.7	GO:0015867	intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.1	1.2	GO:0015693	magnesium ion transport(GO:0015693)
0.1	1.0	GO:0042983	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.1	1.0	GO:0060088	auditory receptor cell stereocilium organization(GO:0060088)
0.0	1.0	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	1.0	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.2	0.9	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)

Showing 1 to 10 of 53 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	GO:0030018	Z disc(GO:0030018)
0.1	1.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.9	GO:0005871	kinesin complex(GO:0005871)
0.0	0.8	GO:0031901	early endosome membrane(GO:0031901)
0.0	0.8	GO:0034705	voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1	0.7	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.1	0.7	GO:0016586	RSC complex(GO:0016586)
0.1	0.6	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.0	0.5	GO:0031105	septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.4	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)

Showing 1 to 10 of 13 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.2	GO:0032036	myosin heavy chain binding(GO:0032036)
0.1	2.1	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.4	1.7	GO:0005471	ATP:ADP antiporter activity(GO:0005471)
0.2	1.6	GO:0031433	telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.1	1.2	GO:0008143	poly(A) binding(GO:0008143)
0.1	1.0	GO:0016838	carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0	1.0	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2	0.9	GO:0032896	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1	0.9	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.9	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)

Showing 1 to 10 of 33 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
2.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.6	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.2	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events

Showing 1 to 3 of 3 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.1	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	1.7	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
0.1	0.6	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.6	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.4	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	0.3	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.3	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation

Showing 1 to 8 of 8 entries

Results for hoxb8a+hoxb8b

Z-value: 1.41

Motif logo

Transcription factors associated with hoxb8a+hoxb8b

Activity-expression correlation:

Activity profile of hoxb8a+hoxb8b motif

Sorted Z-values of hoxb8a+hoxb8b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb8a+hoxb8b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: