ISMARA results: hoxb6a+hoxb6b

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PRJNA195909:zebrafish embryo and larva development

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Results for hoxb6a+hoxb6b

Z-value: 4.06

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Transcription factors associated with hoxb6a+hoxb6b

Gene Symbol	Gene ID	Gene Info
hoxb6a NCBI UniProt	ENSDARG00000010630	homeobox B6a
hoxb6b NCBI UniProt	ENSDARG00000026513	homeobox B6b
hoxb6b NCBI UniProt	ENSDARG00000111786	homeobox B6b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
hoxb6b	dr11_v1_chr12_+_27127139_27127139	0.62	7.2e-02	Click!
hoxb6a	dr11_v1_chr3_+_23703704_23703704	0.54	1.3e-01	Click!

Activity profile of hoxb6a+hoxb6b motif

Sorted Z-values of hoxb6a+hoxb6b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr21_+_7582036 Show fit	4.17	ENSDART00000135485 ENSDART00000027268	otpa NCBI UniProt Show fit	orthopedia homeobox a
chr11_+_30244356 Show fit	3.81	ENSDART00000036050 ENSDART00000150080	rs1a NCBI UniProt Show fit	retinoschisin 1a
chr3_-_32817274 Show fit	3.66	ENSDART00000142582	mylpfa NCBI UniProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle a
chr21_+_6556635 Show fit	3.61	ENSDART00000139598	col5a1 NCBI UniProt Show fit	procollagen, type V, alpha 1
chr1_+_44439661 Show fit	3.51	ENSDART00000100309	crybb1l2 NCBI UniProt Show fit	crystallin, beta B1, like 2
chr15_+_32711663 Show fit	3.07	ENSDART00000157854 ENSDART00000167515	postnb NCBI UniProt Show fit	periostin, osteoblast specific factor b
chr7_+_29954709 Show fit	2.93	ENSDART00000173904	tpma NCBI UniProt Show fit	alpha-tropomyosin
chr1_+_17676745 Show fit	2.82	ENSDART00000030665	slc25a4 NCBI UniProt Show fit	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr12_-_25916530 Show fit	2.73	ENSDART00000186386	sncgb NCBI UniProt Show fit	synuclein, gamma b (breast cancer-specific protein 1)
chr6_+_52790049 Show fit	2.66	ENSDART00000002571	matn4 NCBI UniProt Show fit	matrilin 4

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb6a+hoxb6b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	15.0	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1	10.2	GO:0007601	visual perception(GO:0007601)
0.0	7.5	GO:0099536	synaptic signaling(GO:0099536)
1.2	6.9	GO:0021767	mammillary body development(GO:0021767)
0.2	6.9	GO:0030199	collagen fibril organization(GO:0030199)
0.1	6.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.3	5.0	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208)
0.1	5.0	GO:0030514	negative regulation of BMP signaling pathway(GO:0030514)
0.2	4.8	GO:0006942	regulation of striated muscle contraction(GO:0006942)
0.2	4.3	GO:0016203	muscle attachment(GO:0016203)

Showing 1 to 10 of 435 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	59.8	GO:0005576	extracellular region(GO:0005576)
0.0	29.5	GO:0031226	intrinsic component of plasma membrane(GO:0031226)
0.2	9.6	GO:0005861	troponin complex(GO:0005861)
0.0	8.7	GO:0098794	postsynapse(GO:0098794)
0.1	8.5	GO:0005884	actin filament(GO:0005884)
0.1	7.6	GO:0005604	basement membrane(GO:0005604)
0.2	7.3	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.2	6.8	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0	6.5	GO:0030424	axon(GO:0030424)
0.1	5.0	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)

Showing 1 to 10 of 141 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	93.6	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0	36.2	GO:0005509	calcium ion binding(GO:0005509)
0.0	14.6	GO:0051015	actin filament binding(GO:0051015)
0.1	9.8	GO:0008201	heparin binding(GO:0008201)
0.2	7.8	GO:0017075	syntaxin-1 binding(GO:0017075)
0.1	7.7	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.6	6.8	GO:0031013	troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1	6.8	GO:0005212	structural constituent of eye lens(GO:0005212)
0.4	6.7	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.4	5.0	GO:0022851	benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)

Showing 1 to 10 of 292 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	12.7	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.1	10.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	7.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	4.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	4.2	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.0	3.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	3.2	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.2	2.9	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.2	2.4	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	2.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.

Showing 1 to 10 of 45 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.9	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.4	5.6	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
1.0	4.0	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.3	3.7	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.3	3.6	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	3.6	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.8	3.4	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.0	3.3	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	3.2	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.2	3.0	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells

Showing 1 to 10 of 86 entries

Results for hoxb6a+hoxb6b

Z-value: 4.06

Motif logo

Transcription factors associated with hoxb6a+hoxb6b

Activity-expression correlation:

Activity profile of hoxb6a+hoxb6b motif

Sorted Z-values of hoxb6a+hoxb6b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb6a+hoxb6b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: