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PRJNA195909:zebrafish embryo and larva development

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Results for hoxb5a+hoxb5b

Z-value: 0.63

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Transcription factors associated with hoxb5a+hoxb5b

Gene Symbol Gene ID Gene Info
hoxb5a
ENSDARG00000013057 homeobox B5a
hoxb5b
ENSDARG00000054030 homeobox B5b
hoxb5b
ENSDARG00000113174 homeobox B5b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb5adr11_v1_chr3_+_23707691_23707691-0.853.7e-03Click!
hoxb5bdr11_v1_chr12_+_27129659_27129659-0.853.9e-03Click!

Activity profile of hoxb5a+hoxb5b motif

Sorted Z-values of hoxb5a+hoxb5b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_29387215 1.10 ENSDART00000148787
s100a1
S100 calcium binding protein A1
chr4_-_77551860 1.02 ENSDART00000188176
AL935186.6

chr4_-_77563411 1.00 ENSDART00000186841
AL935186.8

chr21_-_9769500 0.77 ENSDART00000170710
arhgap24
Rho GTPase activating protein 24
chr13_+_534453 0.70 ENSDART00000147909
wu:fc17b08
wu:fc17b08
chr6_+_4255319 0.62 ENSDART00000170351
nbeal1
neurobeachin-like 1
chr15_-_25099679 0.58 ENSDART00000154628
rflnb
refilin B
chr19_-_27827744 0.57 ENSDART00000181620
papd7
PAP associated domain containing 7
chr22_+_25352530 0.52 ENSDART00000176742
ENSDART00000113186
si:dkey-240e12.6
si:dkey-240e12.6
chr19_+_15441022 0.52 ENSDART00000098970
ENSDART00000140276
lin28a
lin-28 homolog A (C. elegans)
chr5_-_16791223 0.52 ENSDART00000192744
atad1a
ATPase family, AAA domain containing 1a
chr11_-_2297832 0.51 ENSDART00000158266
znf740a
zinc finger protein 740a
chr2_-_15324837 0.50 ENSDART00000015655
tecrl2b
trans-2,3-enoyl-CoA reductase-like 2b
chr23_+_22293682 0.48 ENSDART00000187304
CR354612.1

chr20_+_48543492 0.48 ENSDART00000175480
LO018254.1

chr10_+_18557102 0.47 ENSDART00000160157
CR388008.1

chr8_-_36554675 0.46 ENSDART00000132804
ENSDART00000078746
ccdc157
coiled-coil domain containing 157
chr22_+_12477996 0.42 ENSDART00000177704
CR847870.3

chr4_+_77966055 0.40 ENSDART00000174203
ENSDART00000130100
ENSDART00000080665
ENSDART00000174317
ENSDART00000190123
zgc:113921
zgc:113921
chr9_+_48755638 0.39 ENSDART00000047401
abcb11a
ATP-binding cassette, sub-family B (MDR/TAP), member 11a
chr19_+_43341424 0.38 ENSDART00000134815
sesn2
sestrin 2
chr22_+_17536989 0.34 ENSDART00000149531
hnrnpm
heterogeneous nuclear ribonucleoprotein M
chr15_-_952891 0.34 ENSDART00000153780
alox5b.1
arachidonate 5-lipoxygenase b, tandem duplicate 1
chr19_+_43341115 0.33 ENSDART00000145846
ENSDART00000102384
sesn2
sestrin 2
chr13_-_36134317 0.32 ENSDART00000015664
ENSDART00000188301
ENSDART00000191073
ENSDART00000184192
ENSDART00000139593
pcnx
pecanex homolog (Drosophila)
chr17_+_20569806 0.32 ENSDART00000113936
SAMD8
zgc:162183
chr13_-_44819254 0.30 ENSDART00000131673
si:dkeyp-2e4.8
si:dkeyp-2e4.8
chr14_-_25078569 0.30 ENSDART00000172802
ENSDART00000173345
ENSDART00000135004
matr3l1.1
matrin 3-like 1.1
chr9_+_6082793 0.29 ENSDART00000192045
st6gal2a
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2a
chr13_-_86847 0.29 ENSDART00000158062
pole2
polymerase (DNA directed), epsilon 2
chr19_+_48060464 0.27 ENSDART00000123163
zgc:85936
zgc:85936
chr8_+_25962833 0.26 ENSDART00000086583
si:dkey-72l14.4
si:dkey-72l14.4
chr3_-_4911989 0.25 ENSDART00000158197
si:dkey-73p2.2
si:dkey-73p2.2
chr9_-_41817712 0.25 ENSDART00000182657
si:dkeyp-30e7.2
si:dkeyp-30e7.2
chr19_+_17642356 0.25 ENSDART00000176431
CR382334.1

chr5_-_9625459 0.24 ENSDART00000143347
sh2b3
SH2B adaptor protein 3
chr9_-_12034444 0.24 ENSDART00000038651
znf804a
zinc finger protein 804A
chr15_-_684911 0.24 ENSDART00000161685
zgc:171901
zgc:171901
chr6_-_15603675 0.24 ENSDART00000143502
lrrfip1b
leucine rich repeat (in FLII) interacting protein 1b
chr22_-_7461603 0.23 ENSDART00000170630
BX511034.6

chr11_-_44030962 0.23 ENSDART00000171910
FP016005.1

chr19_+_46259619 0.22 ENSDART00000158032
grinaa
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding)
chr8_+_247163 0.21 ENSDART00000122378
cep120
centrosomal protein 120
chr25_+_35212919 0.21 ENSDART00000180127
ano5a
anoctamin 5a
chr8_-_43847138 0.20 ENSDART00000148358
adgrd1
adhesion G protein-coupled receptor D1
chr12_+_17436904 0.20 ENSDART00000079130
atad1b
ATPase family, AAA domain containing 1b
chr5_-_33769211 0.19 ENSDART00000133504
dab2ipb
DAB2 interacting protein b
chr25_+_36316280 0.18 ENSDART00000152735
si:ch211-113a14.11
si:ch211-113a14.11
chr9_+_16854121 0.18 ENSDART00000110866
cln5
CLN5, intracellular trafficking protein
chr3_+_54776475 0.16 ENSDART00000142710
si:ch211-74m13.1
si:ch211-74m13.1
chr3_+_54776117 0.15 ENSDART00000189047
ENSDART00000115076
si:ch211-74m13.1
si:ch211-74m13.1
chr23_-_41965557 0.14 ENSDART00000144183
slc1a7b
solute carrier family 1 (glutamate transporter), member 7b
chr6_+_41191482 0.13 ENSDART00000000877
opn1mw3
opsin 1 (cone pigments), medium-wave-sensitive, 3
chr8_+_36554816 0.13 ENSDART00000126687
sf3a1
splicing factor 3a, subunit 1
chr18_-_506082 0.13 ENSDART00000169974
sdr42e1
short chain dehydrogenase/reductase family 42E, member 1
chr22_-_15385442 0.13 ENSDART00000090975
tmem264
transmembrane protein 264
chr5_-_41142467 0.12 ENSDART00000129415
zfr
zinc finger RNA binding protein
chr6_+_54888493 0.12 ENSDART00000113331
nav1b
neuron navigator 1b
chr21_-_308852 0.11 ENSDART00000151613
lhfpl2a
LHFPL tetraspan subfamily member 2a
chr3_-_1520657 0.11 ENSDART00000053201
polr2f
polymerase (RNA) II (DNA directed) polypeptide F
chr2_-_42065069 0.10 ENSDART00000140188
cspp1b
centrosome and spindle pole associated protein 1b
chr14_+_8476769 0.10 ENSDART00000131773
dnajc4
DnaJ (Hsp40) homolog, subfamily C, member 4
chr20_+_51730658 0.10 ENSDART00000010271
aida
axin interactor, dorsalization associated
chr10_+_26944418 0.10 ENSDART00000135493
frmd8
FERM domain containing 8
chr23_+_3513201 0.10 ENSDART00000092258
spata2
spermatogenesis associated 2
chr22_+_1680628 0.09 ENSDART00000166672
si:dkey-1b17.6
si:dkey-1b17.6
chr3_+_28831450 0.08 ENSDART00000055422
flr
fleer
chr7_+_62320134 0.07 ENSDART00000012089
stim2b
stromal interaction molecule 2b
chr6_-_10927766 0.07 ENSDART00000134327
ccr7
chemokine (C-C motif) receptor 7
chr1_-_56596701 0.07 ENSDART00000133693
LO018605.1

chr7_+_56889879 0.07 ENSDART00000039810
myo9aa
myosin IXAa
chr4_+_38547203 0.07 ENSDART00000171349
si:ch211-209n20.1
si:ch211-209n20.1
chr4_-_25812329 0.07 ENSDART00000146658
tmcc3
transmembrane and coiled-coil domain family 3
chr24_-_29822913 0.06 ENSDART00000160929
aglb
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase b
chr4_+_42295479 0.06 ENSDART00000162279
znf1118
zinc finger protein 1118
chr3_-_5413018 0.05 ENSDART00000063138
vmo1a
vitelline membrane outer layer 1 homolog a
chr5_+_59392183 0.05 ENSDART00000082983
ENSDART00000180882
clip2
CAP-GLY domain containing linker protein 2
chr20_+_53181017 0.05 ENSDART00000189692
ENSDART00000177109
FIG4
FIG4 phosphoinositide 5-phosphatase
chr22_-_17729778 0.05 ENSDART00000192132
si:ch73-63e15.2
si:ch73-63e15.2
chr11_-_6070192 0.05 ENSDART00000162776
babam1
BRISC and BRCA1 A complex member 1
chr4_-_59094319 0.05 ENSDART00000162560
si:dkey-28i19.1
si:dkey-28i19.1
chr2_+_22823952 0.04 ENSDART00000147935
aire
autoimmune regulator
chr1_+_55703120 0.04 ENSDART00000141089
adgre6
adhesion G protein-coupled receptor E6
chr4_-_9549693 0.04 ENSDART00000160242
FQ377934.1

chr3_+_39579393 0.03 ENSDART00000055170
cln3
ceroid-lipofuscinosis, neuronal 3
chr16_+_16826504 0.03 ENSDART00000108691
kcnj14
potassium inwardly-rectifying channel, subfamily J, member 14
chr15_-_42283830 0.01 ENSDART00000015979
farsb
phenylalanyl-tRNA synthetase, beta subunit
chr15_-_35031523 0.01 ENSDART00000154848
si:ch211-272b8.6
si:ch211-272b8.6
chr23_+_39331216 0.00 ENSDART00000160957
kcng1
potassium voltage-gated channel, subfamily G, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb5a+hoxb5b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:1900158 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.1 0.8 GO:1900028 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.1 0.7 GO:1901031 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.1 0.4 GO:0032782 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.1 0.3 GO:0010610 regulation of mRNA stability involved in response to stress(GO:0010610) regulation of mRNA stability involved in response to oxidative stress(GO:2000815)
0.1 0.2 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.0 0.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.3 GO:0051122 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.2 GO:0038026 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) reelin-mediated signaling pathway(GO:0038026)
0.0 0.0 GO:0002513 tolerance induction(GO:0002507) tolerance induction to self antigen(GO:0002513)
0.0 0.2 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.0 0.1 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.1 GO:0010939 regulation of necrotic cell death(GO:0010939) regulation of necroptotic process(GO:0060544)
0.0 0.3 GO:0032418 lysosome localization(GO:0032418)
0.0 0.5 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 0.1 GO:0098529 neuromuscular junction development, skeletal muscle fiber(GO:0098529)
0.0 0.1 GO:0046546 development of primary male sexual characteristics(GO:0046546)
0.0 0.1 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0036372 opsin transport(GO:0036372)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.3 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.1 GO:0043194 axon initial segment(GO:0043194)
0.0 0.1 GO:0005879 axonemal microtubule(GO:0005879)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0031005 filamin binding(GO:0031005)
0.1 0.7 GO:0070728 leucine binding(GO:0070728)
0.1 0.4 GO:0015126 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.0 0.3 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.0 0.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 1.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.3 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.1 GO:0070735 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.0 0.1 GO:0004134 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.0 0.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling