Project

PRJNA195909:zebrafish embryo and larva development

Navigation
Downloads

Results for hoxb1a+hoxb1b-2

Z-value: 0.90

Motif logo

logo of

Transcription factors associated with hoxb1a+hoxb1b-2

Gene Symbol Gene ID Gene Info
hoxb1a
ENSDARG00000008174 homeobox B1a
hoxb1b-2
ENSDARG00000112663 homeobox B1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb1adr11_v1_chr3_+_23768898_237688980.265.0e-01Click!

Activity profile of hoxb1a+hoxb1b-2 motif

Sorted Z-values of hoxb1a+hoxb1b-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_29952719 2.02 ENSDART00000173737
tpma
alpha-tropomyosin
chr16_+_1383914 1.97 ENSDART00000185089
cers2b
ceramide synthase 2b
chr6_+_29791164 1.73 ENSDART00000017424
ptmaa
prothymosin, alpha a
chr25_+_20215964 1.62 ENSDART00000139235
tnnt2d
troponin T2d, cardiac
chr14_-_36378494 1.52 ENSDART00000058503
gpm6aa
glycoprotein M6Aa
chr25_+_20216159 1.46 ENSDART00000048642
tnnt2d
troponin T2d, cardiac
chr1_-_38709551 1.42 ENSDART00000128794
gpm6ab
glycoprotein M6Ab
chr21_-_28920245 1.34 ENSDART00000132884
cxxc5a
CXXC finger protein 5a
chr14_+_34547554 1.31 ENSDART00000074819
gabrp
gamma-aminobutyric acid (GABA) A receptor, pi
chr2_+_55984788 1.22 ENSDART00000183599
nmrk2
nicotinamide riboside kinase 2
chr12_-_25916530 1.12 ENSDART00000186386
sncgb
synuclein, gamma b (breast cancer-specific protein 1)
chr7_-_13381129 1.06 ENSDART00000164326
si:ch73-119p20.1
si:ch73-119p20.1
chr9_+_22003942 0.96 ENSDART00000091013
si:dkey-57a22.15
si:dkey-57a22.15
chr1_-_20911297 0.93 ENSDART00000078271
cpe
carboxypeptidase E
chr3_+_23768898 0.93 ENSDART00000110682
hoxb1a
homeobox B1a
chr2_+_27010439 0.91 ENSDART00000030547
cdh7a
cadherin 7a
chr8_+_6954984 0.89 ENSDART00000145610
si:ch211-255g12.6
si:ch211-255g12.6
chr20_-_35841570 0.89 ENSDART00000037855
tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr7_+_31879649 0.85 ENSDART00000099789
mybpc3
myosin binding protein C, cardiac
chr16_-_31188715 0.85 ENSDART00000058829
scrt1b
scratch family zinc finger 1b
chr14_-_7888748 0.83 ENSDART00000166293
ppp3cb
protein phosphatase 3, catalytic subunit, beta isozyme
chr8_+_44703864 0.77 ENSDART00000016225
star
steroidogenic acute regulatory protein
chr16_+_46111849 0.74 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr1_-_8428736 0.72 ENSDART00000138435
ENSDART00000121823
syngr3b
synaptogyrin 3b
chr3_-_57744323 0.70 ENSDART00000101829
lgals3bpb
lectin, galactoside-binding, soluble, 3 binding protein b
chr22_-_600016 0.68 ENSDART00000086434
tmcc2
transmembrane and coiled-coil domain family 2
chr10_+_439692 0.68 ENSDART00000147740
zdhhc8a
zinc finger, DHHC-type containing 8a
chr22_+_3223489 0.66 ENSDART00000082011
lim2.2
lens intrinsic membrane protein 2.2
chr4_+_21129752 0.62 ENSDART00000169764
syt1a
synaptotagmin Ia
chr12_-_10220036 0.60 ENSDART00000134619
mpp2b
membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2)
chr23_+_36178104 0.60 ENSDART00000103131
hoxc1a
homeobox C1a
chr8_-_39903803 0.59 ENSDART00000012391
cabp1a
calcium binding protein 1a
chr10_+_1396940 0.58 ENSDART00000150096
gdnfa
glial cell derived neurotrophic factor a
chr25_+_7461624 0.56 ENSDART00000170569
syt12
synaptotagmin XII
chr11_+_37201483 0.56 ENSDART00000160930
ENSDART00000173439
ENSDART00000171273
zgc:112265
zgc:112265
chr24_-_20016817 0.56 ENSDART00000082201
ENSDART00000189448
slc22a13b
solute carrier family 22 member 13b
chr18_+_40354998 0.55 ENSDART00000098791
ENSDART00000049171
sema6dl
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr2_+_2223837 0.55 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr24_+_34113424 0.54 ENSDART00000105572
gbx1
gastrulation brain homeobox 1
chr23_-_11870962 0.51 ENSDART00000143481
si:dkey-178k16.1
si:dkey-178k16.1
chr7_+_25036188 0.51 ENSDART00000163957
ENSDART00000169749
sb:cb1058
sb:cb1058
chr10_-_44305180 0.50 ENSDART00000187552
CDK2AP1
cyclin dependent kinase 2 associated protein 1
chr18_+_24922125 0.48 ENSDART00000180385
rgma
repulsive guidance molecule family member a
chr6_-_13401133 0.47 ENSDART00000151206
fmnl2b
formin-like 2b
chr25_-_13842618 0.46 ENSDART00000160258
mapk8ip1a
mitogen-activated protein kinase 8 interacting protein 1a
chr22_-_16997475 0.46 ENSDART00000090237
nfia
nuclear factor I/A
chr7_-_52842007 0.44 ENSDART00000182710
map1aa
microtubule-associated protein 1Aa
chr20_-_25369767 0.44 ENSDART00000180278
itsn2a
intersectin 2a
chr10_-_27049170 0.42 ENSDART00000143451
cnih2
cornichon family AMPA receptor auxiliary protein 2
chr16_+_10422836 0.41 ENSDART00000161568
ino80e
INO80 complex subunit E
chr16_-_37964325 0.38 ENSDART00000148801
mrap2a
melanocortin 2 receptor accessory protein 2a
chr4_+_26496489 0.38 ENSDART00000160652
iqsec3a
IQ motif and Sec7 domain 3a
chr17_+_51764310 0.38 ENSDART00000157171
si:ch211-168d23.3
si:ch211-168d23.3
chr4_-_8014463 0.38 ENSDART00000036153
ccdc3a
coiled-coil domain containing 3a
chr13_-_31829786 0.37 ENSDART00000138667
sertad4
SERTA domain containing 4
chr1_+_26071869 0.36 ENSDART00000059264
mxd4
MAX dimerization protein 4
chr23_+_20408227 0.36 ENSDART00000134727
si:rp71-17i16.4
si:rp71-17i16.4
chr7_-_33350082 0.36 ENSDART00000008785
anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr4_+_4272622 0.36 ENSDART00000164810
ano2
anoctamin 2
chr18_+_28102620 0.34 ENSDART00000132342
kiaa1549lb
KIAA1549-like b
chr2_-_53525896 0.34 ENSDART00000057053
im:7138239
im:7138239
chr22_-_16997246 0.32 ENSDART00000090242
nfia
nuclear factor I/A
chr21_-_31290582 0.32 ENSDART00000065362
ca4c
carbonic anhydrase IV c
chr5_-_22544151 0.31 ENSDART00000006474
glra4b
glycine receptor, alpha 4b
chr3_+_15805917 0.31 ENSDART00000055834
phospho1
phosphatase, orphan 1
chr11_-_25213651 0.31 ENSDART00000097316
ENSDART00000152186
myh7ba
myosin, heavy chain 7B, cardiac muscle, beta a
chr20_-_49650293 0.31 ENSDART00000151239
col12a1b
collagen, type XII, alpha 1b
chr17_-_20897250 0.30 ENSDART00000088106
ank3b
ankyrin 3b
chr8_-_7440364 0.29 ENSDART00000180659
hdac6
histone deacetylase 6
chr11_-_27702778 0.28 ENSDART00000045942
ENSDART00000125352
phf2
PHD finger protein 2
chr3_-_35800221 0.28 ENSDART00000031390
caskin1
CASK interacting protein 1
chr5_-_66028371 0.27 ENSDART00000183012
nrarpb
NOTCH regulated ankyrin repeat protein b
chr5_-_52921532 0.25 ENSDART00000160566
CU695117.1

chr22_-_13544244 0.23 ENSDART00000110136
cntnap5b
contactin associated protein-like 5b
chr24_+_28528000 0.23 ENSDART00000155924
arhgap29a
Rho GTPase activating protein 29a
chr8_+_6410933 0.23 ENSDART00000168789
lrrtm4l2
leucine rich repeat transmembrane neuronal 4 like 2
chr10_-_25591194 0.23 ENSDART00000131640
tiam1a
T cell lymphoma invasion and metastasis 1a
chr16_-_1502699 0.22 ENSDART00000187189
sim1a
single-minded family bHLH transcription factor 1a
chr19_+_816208 0.22 ENSDART00000093304
nrm
nurim
chr8_-_5220125 0.21 ENSDART00000035676
bnip3la
BCL2 interacting protein 3 like a
chr18_+_26899316 0.20 ENSDART00000050230
tspan3a
tetraspanin 3a
chr1_+_34181581 0.19 ENSDART00000146042
epha6
eph receptor A6
chr5_-_52277643 0.19 ENSDART00000010757
rgmb
repulsive guidance molecule family member b
chr3_-_18675688 0.19 ENSDART00000048218
slc5a11
solute carrier family 5 (sodium/inositol cotransporter), member 11
chr7_+_16835218 0.19 ENSDART00000173580
nav2a
neuron navigator 2a
chr12_+_22580579 0.18 ENSDART00000171725
ENSDART00000192290
capgb
capping protein (actin filament), gelsolin-like b
chr8_-_44015210 0.17 ENSDART00000186879
ENSDART00000188965
ENSDART00000001313
ENSDART00000188902
ENSDART00000185935
ENSDART00000147869
rimbp2
rimbp2
RIMS binding protein 2
RIMS binding protein 2
chr23_+_642001 0.17 ENSDART00000030643
ENSDART00000124850
irf10
interferon regulatory factor 10
chr1_-_681116 0.17 ENSDART00000165894
adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr16_-_17175731 0.16 ENSDART00000183057
opn9
opsin 9
chr17_-_20394566 0.14 ENSDART00000154667
sorcs3b
sortilin related VPS10 domain containing receptor 3b
chr14_-_26377044 0.14 ENSDART00000022236
emx3
empty spiracles homeobox 3
chr14_+_5383060 0.13 ENSDART00000187825
lbx2
ladybird homeobox 2
chr24_+_32472155 0.11 ENSDART00000098859
neurod6a
neuronal differentiation 6a
chr1_-_20826023 0.11 ENSDART00000054472
tll1
tolloid-like 1
chr7_+_36898850 0.11 ENSDART00000113342
tox3
TOX high mobility group box family member 3
chr2_-_45630823 0.10 ENSDART00000183553
CR450720.1

chr17_+_40684 0.10 ENSDART00000164231
CABZ01111555.1

chr17_-_20897407 0.09 ENSDART00000149481
ank3b
ankyrin 3b
chr9_+_22351443 0.07 ENSDART00000080054
crygs3
crystallin, gamma S3
chr10_-_31175744 0.06 ENSDART00000191728
pknox2
pbx/knotted 1 homeobox 2
chr13_-_51065048 0.05 ENSDART00000168085
CABZ01078663.1

chr19_+_28256076 0.04 ENSDART00000133354
irx4b
iroquois homeobox 4b
chr23_+_642395 0.04 ENSDART00000186995
irf10
interferon regulatory factor 10
chr6_+_3640381 0.04 ENSDART00000172078
col28a2b
collagen, type XXVIII, alpha 2b
chr5_+_35398745 0.03 ENSDART00000098010
ptger4b
prostaglandin E receptor 4 (subtype EP4) b
chr18_+_41542542 0.03 ENSDART00000087445
tsen34
TSEN34 tRNA splicing endonuclease subunit
chr17_-_19626357 0.03 ENSDART00000011432
reep3a
receptor accessory protein 3a
chr16_+_25196572 0.02 ENSDART00000141956
tyrobp
TYRO protein tyrosine kinase binding protein
chr16_-_20932896 0.02 ENSDART00000180646
tax1bp1b
Tax1 (human T-cell leukemia virus type I) binding protein 1b
chr2_-_26563978 0.02 ENSDART00000150016
glis1a
GLIS family zinc finger 1a
chr10_+_7564106 0.01 ENSDART00000159042
purg
purine-rich element binding protein G
chr16_-_1503023 0.01 ENSDART00000036348
sim1a
single-minded family bHLH transcription factor 1a
chr1_+_26626824 0.00 ENSDART00000158193
coro2a
coronin, actin binding protein, 2A

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb1a+hoxb1b-2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0031645 negative regulation of myelination(GO:0031642) negative regulation of neurological system process(GO:0031645)
0.2 0.6 GO:0090189 regulation of neurotransmitter uptake(GO:0051580) regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.2 0.8 GO:0003210 cardiac atrium formation(GO:0003210)
0.1 0.9 GO:0021661 rhombomere 4 development(GO:0021570) rhombomere 4 morphogenesis(GO:0021661)
0.1 0.8 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.1 0.5 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 0.3 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 0.5 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.1 0.2 GO:0072020 proximal straight tubule development(GO:0072020)
0.1 0.7 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 3.4 GO:0006937 regulation of muscle contraction(GO:0006937)
0.1 1.4 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 0.8 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 1.1 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.7 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.9 GO:0060034 notochord cell differentiation(GO:0060034)
0.0 0.4 GO:0097009 protein localization to cell surface(GO:0034394) energy homeostasis(GO:0097009)
0.0 2.0 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.5 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.0 0.1 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.0 0.2 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.3 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.3 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 1.9 GO:0061515 myeloid cell development(GO:0061515)
0.0 0.4 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 0.3 GO:0070570 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 1.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.6 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 1.1 GO:0021549 cerebellum development(GO:0021549)
0.0 1.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.3 GO:0070167 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.8 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.6 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 3.4 GO:0005861 troponin complex(GO:0005861)
0.0 1.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.7 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.1 GO:0043679 axon terminus(GO:0043679)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.9 GO:0016342 catenin complex(GO:0016342)
0.0 1.5 GO:0005884 actin filament(GO:0005884)
0.0 0.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.4 GO:0016514 SWI/SNF complex(GO:0016514)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:1903136 cuprous ion binding(GO:1903136)
0.3 3.1 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.2 1.7 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.2 1.2 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.1 0.8 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 2.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.6 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.1 0.4 GO:0031782 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1 1.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.3 GO:0047611 tubulin deacetylase activity(GO:0042903) acetylspermidine deacetylase activity(GO:0047611)
0.0 0.7 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 1.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.7 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.3 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237) extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 1.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 1.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.8 GO:0015485 cholesterol binding(GO:0015485)
0.0 2.0 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.3 GO:0004089 carbonate dehydratase activity(GO:0004089)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.9 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.7 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.8 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling