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PRJNA195909:zebrafish embryo and larva development

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Results for hoxb13a

Z-value: 1.10

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Transcription factors associated with hoxb13a

Gene Symbol Gene ID Gene Info
hoxb13a
ENSDARG00000056015 homeobox B13a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb13adr11_v1_chr3_+_23654233_236542330.942.0e-04Click!

Activity profile of hoxb13a motif

Sorted Z-values of hoxb13a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_22675802 2.95 ENSDART00000145538
ENSDART00000143312
zgc:193505
zgc:193505
chr19_-_5380770 2.35 ENSDART00000000221
krt91
keratin 91
chr7_+_39401388 2.26 ENSDART00000144750
tnni2b.1
troponin I type 2b (skeletal, fast), tandem duplicate 1
chr20_-_48485354 2.03 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr21_-_25741411 2.02 ENSDART00000101211
cldnh
claudin h
chr10_-_7785930 1.84 ENSDART00000043961
ENSDART00000111058
mpx
myeloid-specific peroxidase
chr16_-_21785261 1.83 ENSDART00000078858
si:ch73-86n18.1
si:ch73-86n18.1
chr11_-_18253111 1.81 ENSDART00000125984
mustn1b
musculoskeletal, embryonic nuclear protein 1b
chr22_+_15624371 1.71 ENSDART00000124868
lpl
lipoprotein lipase
chr20_+_40150612 1.61 ENSDART00000143680
ENSDART00000109681
ENSDART00000101041
ENSDART00000121818
trdn
triadin
chr14_-_24761132 1.57 ENSDART00000146299
slit3
slit homolog 3 (Drosophila)
chr6_+_35362225 1.50 ENSDART00000133783
ENSDART00000102483
rgs4
regulator of G protein signaling 4
chr17_-_15382704 1.38 ENSDART00000005313
zgc:85722
zgc:85722
chr2_-_59145027 1.37 ENSDART00000128320
FO834803.1

chr20_+_29743904 1.30 ENSDART00000146366
ENSDART00000153154
kidins220b
kinase D-interacting substrate 220b
chr5_-_46980651 1.29 ENSDART00000181022
ENSDART00000168038
edil3a
EGF-like repeats and discoidin I-like domains 3a
chr1_-_44940830 1.28 ENSDART00000097500
ENSDART00000134464
ENSDART00000137216
tmem176
transmembrane protein 176
chr18_+_44649804 1.18 ENSDART00000059063
ehd2b
EH-domain containing 2b
chr7_-_30367650 1.17 ENSDART00000075519
aldh1a2
aldehyde dehydrogenase 1 family, member A2
chr20_-_25709247 1.16 ENSDART00000146711
si:dkeyp-117h8.2
si:dkeyp-117h8.2
chr22_+_11857356 1.11 ENSDART00000179540
mras
muscle RAS oncogene homolog
chr8_+_25351863 1.10 ENSDART00000034092
dnase1l1l
deoxyribonuclease I-like 1-like
chr23_-_7799184 1.04 ENSDART00000190946
ENSDART00000165427
myt1b
myelin transcription factor 1b
chr5_+_22510639 1.02 ENSDART00000080919
rpl36a
ribosomal protein L36A
chr17_-_52587598 1.00 ENSDART00000061497
si:ch211-173a9.6
si:ch211-173a9.6
chr5_+_27434601 0.99 ENSDART00000064701
loxl2b
lysyl oxidase-like 2b
chr15_-_28596507 0.94 ENSDART00000156800
si:ch211-225b7.5
si:ch211-225b7.5
chr4_-_4387012 0.85 ENSDART00000191836
CU468826.3
Danio rerio U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1-like (LOC100331497), mRNA.
chr7_+_33130639 0.84 ENSDART00000142450
ENSDART00000173967
ENSDART00000173832
zgc:153219
si:ch211-194p6.7
zgc:153219
si:ch211-194p6.7
chr24_-_23323526 0.83 ENSDART00000112256
ENSDART00000176903
zfhx4
zinc finger homeobox 4
chr19_-_42557416 0.82 ENSDART00000163217
ENSDART00000128278
ENSDART00000162304
ENSDART00000166556
si:dkey-267n13.1
si:dkey-267n13.1
chr25_+_25453221 0.80 ENSDART00000176822
rassf7a
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr16_-_27628994 0.73 ENSDART00000157407
nacad
NAC alpha domain containing
chr17_-_23412705 0.72 ENSDART00000126995
si:ch211-149k12.3
si:ch211-149k12.3
chr21_-_37733287 0.69 ENSDART00000157826
mpp1
membrane protein, palmitoylated 1
chr1_+_44941031 0.69 ENSDART00000141145
si:dkey-9i23.16
si:dkey-9i23.16
chr13_-_49802194 0.68 ENSDART00000148722
b3galnt2
beta-1,3-N-acetylgalactosaminyltransferase 2
chr5_+_34622320 0.67 ENSDART00000141338
enc1
ectodermal-neural cortex 1
chr1_-_1627487 0.66 ENSDART00000166094
clic6
chloride intracellular channel 6
chr1_-_19079957 0.66 ENSDART00000141795
phox2ba
paired-like homeobox 2ba
chr17_+_21295132 0.65 ENSDART00000103845
eno4
enolase family member 4
chr12_+_41697664 0.65 ENSDART00000162302
bnip3
BCL2 interacting protein 3
chr2_-_31735142 0.63 ENSDART00000130903
ralyl
RALY RNA binding protein like
chr16_-_563235 0.62 ENSDART00000016303
irx2a
iroquois homeobox 2a
chr25_-_35599887 0.62 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr8_-_25120231 0.60 ENSDART00000147308
amigo1
adhesion molecule with Ig-like domain 1
chr5_-_26181863 0.56 ENSDART00000098500
ccdc125
coiled-coil domain containing 125
chr5_-_14390445 0.55 ENSDART00000026120
ap3m2
adaptor-related protein complex 3, mu 2 subunit
chr24_-_23675446 0.53 ENSDART00000066644
hnf4g
hepatocyte nuclear factor 4, gamma
chr19_-_17526735 0.53 ENSDART00000189391
thrb
thyroid hormone receptor beta
chr25_+_19106574 0.51 ENSDART00000067332
rlbp1b
retinaldehyde binding protein 1b
chr10_+_39164638 0.51 ENSDART00000188997
CU633908.1

chr23_+_30048849 0.49 ENSDART00000126027
uts2a
urotensin 2, alpha
chr25_+_28823952 0.48 ENSDART00000067072
nfybb
nuclear transcription factor Y, beta b
chr13_+_1182257 0.47 ENSDART00000033528
ENSDART00000183702
ENSDART00000147959
tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr18_+_1154189 0.45 ENSDART00000135090
si:ch1073-75f15.2
si:ch1073-75f15.2
chr9_+_2333550 0.45 ENSDART00000016417
atp5mc3a
ATP synthase membrane subunit c locus 3a
chr20_-_27733683 0.45 ENSDART00000103317
ENSDART00000138139
zgc:153157
zgc:153157
chr15_+_45586471 0.44 ENSDART00000165699
cldn15lb
claudin 15-like b
chr23_+_35759843 0.44 ENSDART00000047082
gdap1l1
ganglioside induced differentiation associated protein 1-like 1
chr8_+_25352268 0.44 ENSDART00000187829
dnase1l1l
deoxyribonuclease I-like 1-like
chr2_+_45548890 0.38 ENSDART00000113994
fndc7a
fibronectin type III domain containing 7a
chr12_-_7253270 0.37 ENSDART00000035762
ube2d1b
ubiquitin-conjugating enzyme E2D 1b
chr3_+_32443395 0.35 ENSDART00000188447
prr12b
proline rich 12b
chr12_-_34758474 0.30 ENSDART00000153418
bahcc1b
BAH domain and coiled-coil containing 1b
chr22_+_18187857 0.29 ENSDART00000166300
mef2b
myocyte enhancer factor 2b
chr24_+_1042594 0.29 ENSDART00000109117
si:dkey-192l18.9
si:dkey-192l18.9
chr16_+_21738194 0.28 ENSDART00000163688
FP085428.1
Danio rerio si:ch211-154o6.4 (si:ch211-154o6.4), mRNA.
chr1_+_8111009 0.26 ENSDART00000152192
SLC5A10
si:dkeyp-9d4.5
chr1_-_58561963 0.23 ENSDART00000165040
slc27a1b
solute carrier family 27 (fatty acid transporter), member 1b
chr24_-_20808283 0.23 ENSDART00000143759
vipr1b
vasoactive intestinal peptide receptor 1b
chr15_+_11381532 0.23 ENSDART00000124172
si:ch73-321d9.2
si:ch73-321d9.2
chr7_+_27251376 0.22 ENSDART00000173521
ENSDART00000173962
sox6
SRY (sex determining region Y)-box 6
chr8_+_30709685 0.20 ENSDART00000133989
upb1
ureidopropionase, beta
chr22_+_18188045 0.20 ENSDART00000140106
mef2b
myocyte enhancer factor 2b
chr2_-_40196547 0.19 ENSDART00000168098
ccl34a.3
chemokine (C-C motif) ligand 34a, duplicate 3
chr1_+_19515228 0.16 ENSDART00000103091
clrn2
clarin 2
chr11_-_29623380 0.16 ENSDART00000162587
ENSDART00000193935
ENSDART00000191646
chd5
chromodomain helicase DNA binding protein 5
chr5_-_67750907 0.15 ENSDART00000172097
b4galt4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
chr7_-_8324927 0.12 ENSDART00000102535
f13a1b
coagulation factor XIII, A1 polypeptide b
chr18_-_9046805 0.11 ENSDART00000134224
grm3
glutamate receptor, metabotropic 3
chr4_-_49987980 0.11 ENSDART00000150428
si:dkey-156k2.4
si:dkey-156k2.4
chr20_-_52338782 0.11 ENSDART00000109735
ENSDART00000132941
si:ch1073-287p18.1
si:ch1073-287p18.1
chr1_+_47486104 0.09 ENSDART00000114746
lrrc58a
leucine rich repeat containing 58a
chr1_-_58562129 0.09 ENSDART00000159070
slc27a1b
solute carrier family 27 (fatty acid transporter), member 1b
chr17_-_45150763 0.09 ENSDART00000155043
ENSDART00000156786
ENSDART00000191147
tmed8
transmembrane p24 trafficking protein 8
chr1_+_8110562 0.09 ENSDART00000112160
SLC5A10
si:dkeyp-9d4.5
chr20_+_34717403 0.09 ENSDART00000034252
pnocb
prepronociceptin b
chr20_-_46085840 0.08 ENSDART00000133714
taar12a
trace amine associated receptor 12a
chr19_-_40776267 0.07 ENSDART00000189038
calcr
calcitonin receptor
chr4_+_34418211 0.04 ENSDART00000160070
si:ch211-246b8.2
si:ch211-246b8.2
chr17_+_31820401 0.04 ENSDART00000192607
ENSDART00000157490
eef1akmt2
EEF1A lysine methyltransferase 2
chr10_-_22249444 0.01 ENSDART00000148831
fgf11b
fibroblast growth factor 11b

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb13a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0035988 chondrocyte proliferation(GO:0035988)
0.3 1.2 GO:0061113 pancreas morphogenesis(GO:0061113)
0.3 2.0 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.3 1.0 GO:0003322 pancreatic A cell development(GO:0003322)
0.2 1.0 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.1 1.8 GO:2000377 regulation of reactive oxygen species metabolic process(GO:2000377)
0.1 0.5 GO:0042706 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.1 1.7 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 0.5 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1 1.5 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.1 0.6 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.1 0.6 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.1 0.3 GO:0071072 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.1 1.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.6 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 2.3 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.2 GO:0019483 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
0.0 0.6 GO:0035778 pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014)
0.0 0.6 GO:0007413 axonal fasciculation(GO:0007413)
0.0 1.2 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.2 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.7 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.5 GO:0007634 optokinetic behavior(GO:0007634)
0.0 0.5 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.4 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 1.5 GO:0031018 endocrine pancreas development(GO:0031018)
0.0 0.4 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.7 GO:0048484 enteric nervous system development(GO:0048484)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0042627 chylomicron(GO:0042627)
0.1 0.7 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 0.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 2.3 GO:0005861 troponin complex(GO:0005861)
0.1 2.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 2.4 GO:0005882 intermediate filament(GO:0005882)
0.0 0.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.3 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.0 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.2 1.5 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.1 0.5 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 1.6 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 0.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 1.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 1.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.2 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.8 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 1.1 GO:0019003 GDP binding(GO:0019003)
0.0 1.8 GO:0004601 peroxidase activity(GO:0004601)
0.0 2.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.3 GO:0005178 integrin binding(GO:0005178)
0.0 0.1 GO:0097643 amylin receptor activity(GO:0097643)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.7 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 0.5 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 1.0 GO:0051082 unfolded protein binding(GO:0051082)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.5 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.1 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.5 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.1 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway