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PRJNA195909:zebrafish embryo and larva development
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Results for hoxb10a+hoxc10a
Z-value: 0.62
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Transcription factors associated with hoxb10a+hoxc10a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hoxb10a | dr11_v1_chr3_+_23669267_23669267 | 0.90 | 9.0e-04 | Click! |
| hoxc10a | dr11_v1_chr23_+_36083529_36083617 | 0.85 | 3.7e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_+_10146542 Show fit | 1.58 |
ENSDART00000048073
|
zgc:171775 |
|
| chr3_-_31804481 Show fit | 1.46 |
ENSDART00000028270
|
glial fibrillary acidic protein |
|
| chr23_+_27068225 Show fit | 1.41 |
ENSDART00000054238
|
major intrinsic protein of lens fiber a |
|
| chr16_-_45917322 Show fit | 1.19 |
ENSDART00000060822
|
antifreeze protein type IV |
|
| chr2_+_2223837 Show fit | 1.17 |
ENSDART00000101038
ENSDART00000129354 |
transmembrane inner ear |
|
| chr25_+_20089986 Show fit | 1.15 |
ENSDART00000143441
ENSDART00000184073 |
troponin I4b, tandem duplicate 2 |
|
| chr6_+_52790049 Show fit | 1.15 |
ENSDART00000002571
|
matrilin 4 |
|
| chr2_-_35566938 Show fit | 1.09 |
ENSDART00000029006
ENSDART00000077178 ENSDART00000125298 |
tenascin N |
|
| chr23_+_39606108 Show fit | 1.09 |
ENSDART00000109464
|
G0/G1 switch 2 |
|
| chr10_-_29903165 Show fit | 1.01 |
ENSDART00000078800
|
lens intrinsic membrane protein 2.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of hoxb10a+hoxc10a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 0.2 | 1.4 | GO:0006833 | water transport(GO:0006833) |
| 0.0 | 1.4 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.2 | 1.2 | GO:0060017 | parathyroid gland development(GO:0060017) |
| 0.1 | 1.2 | GO:0060088 | auditory receptor cell stereocilium organization(GO:0060088) |
| 0.0 | 1.2 | GO:0060030 | dorsal convergence(GO:0060030) |
| 0.0 | 1.0 | GO:0099500 | synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500) |
| 0.0 | 1.0 | GO:0031018 | endocrine pancreas development(GO:0031018) |
| 0.2 | 0.9 | GO:0071908 | determination of intestine left/right asymmetry(GO:0071908) |
| 0.3 | 0.8 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.4 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 0.9 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.1 | 0.8 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 0.8 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.0 | 0.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 0.5 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 0.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.4 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 0.3 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | GO:0015250 | water channel activity(GO:0015250) |
| 0.0 | 1.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 1.2 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 1.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 1.0 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 1.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 0.8 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 0.8 | GO:0031433 | telethonin binding(GO:0031433) FATZ binding(GO:0051373) |
| 0.1 | 0.8 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.0 | 0.8 | GO:0031593 | polyubiquitin binding(GO:0031593) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.4 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 0.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.2 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.1 | 0.8 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.7 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 0.6 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 0.4 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.4 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.0 | 0.4 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 0.3 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.0 | 0.3 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |