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PRJNA195909:zebrafish embryo and larva development
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Results for hoxa1a+hoxb1b-1+hoxc1a
Z-value: 1.47
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Transcription factors associated with hoxa1a+hoxb1b-1+hoxc1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hoxc1a | dr11_v1_chr23_+_36178104_36178104 | 0.89 | 1.2e-03 | Click! |
| hoxa1a | dr11_v1_chr19_+_19786117_19786213 | 0.88 | 2.0e-03 | Click! |
| hoxb1b | dr11_v1_chr12_+_27141140_27141140 | 0.75 | 2.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_1383914 Show fit | 4.88 |
ENSDART00000185089
|
ceramide synthase 2b |
|
| chr3_-_55147731 Show fit | 4.66 |
ENSDART00000155871
ENSDART00000109016 ENSDART00000122904 |
hemoglobin alpha embryonic-3 |
|
| chr12_-_25916530 Show fit | 4.31 |
ENSDART00000186386
|
synuclein, gamma b (breast cancer-specific protein 1) |
|
| chr7_+_29952719 Show fit | 3.28 |
ENSDART00000173737
|
alpha-tropomyosin |
|
| chr25_+_20215964 Show fit | 2.77 |
ENSDART00000139235
|
troponin T2d, cardiac |
|
| chr6_+_29791164 Show fit | 2.67 |
ENSDART00000017424
|
prothymosin, alpha a |
|
| chr21_-_26495700 Show fit | 2.60 |
ENSDART00000109379
|
CD248 molecule, endosialin b |
|
| chr20_-_32446406 Show fit | 2.52 |
ENSDART00000026635
|
nuclear receptor subfamily 2, group E, member 1 |
|
| chr19_-_45985989 Show fit | 2.49 |
ENSDART00000165897
|
si:ch211-153f2.3 |
|
| chr25_+_20216159 Show fit | 2.43 |
ENSDART00000048642
|
troponin T2d, cardiac |
Network of associatons between targets according to the STRING database.
First level regulatory network of hoxa1a+hoxb1b-1+hoxc1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.4 | GO:0060843 | lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845) |
| 0.1 | 5.2 | GO:0006937 | regulation of muscle contraction(GO:0006937) |
| 0.2 | 4.7 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.1 | 4.4 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.2 | 4.3 | GO:0071542 | dopaminergic neuron differentiation(GO:0071542) |
| 0.1 | 3.6 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.0 | 3.2 | GO:0061515 | myeloid cell development(GO:0061515) |
| 0.0 | 3.1 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter(GO:0000122) |
| 0.5 | 2.7 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.1 | 2.6 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.8 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 5.2 | GO:0005861 | troponin complex(GO:0005861) |
| 0.4 | 4.7 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.1 | 4.5 | GO:0043679 | axon terminus(GO:0043679) |
| 0.1 | 3.2 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 2.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 2.2 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 2.2 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.3 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.4 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.5 | 5.2 | GO:0030172 | troponin C binding(GO:0030172) troponin I binding(GO:0031013) |
| 0.3 | 4.9 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.4 | 4.7 | GO:0031720 | haptoglobin binding(GO:0031720) |
| 1.4 | 4.3 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 0.2 | 3.2 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.0 | 2.9 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 0.0 | 2.9 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) |
| 0.4 | 2.7 | GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) |
| 0.9 | 2.6 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 3.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 1.1 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.1 | 1.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.8 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 0.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 3.2 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 2.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.3 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 1.1 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 1.0 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.8 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.8 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 0.7 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 0.7 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |