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PRJNA195909:zebrafish embryo and larva development
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Results for hoxa13a+hoxa13b
Z-value: 1.34
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Transcription factors associated with hoxa13a+hoxa13b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hoxa13a | dr11_v1_chr19_+_19729506_19729506 | -0.23 | 5.5e-01 | Click! |
| hoxa13b | dr11_v1_chr16_+_20895904_20895904 | -0.22 | 5.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_14191592 Show fit | 2.08 |
ENSDART00000164594
|
T-box transcription factor Ta |
|
| chr13_+_22675802 Show fit | 1.67 |
ENSDART00000145538
ENSDART00000143312 |
zgc:193505 |
|
| chr16_-_45917322 Show fit | 1.54 |
ENSDART00000060822
|
antifreeze protein type IV |
|
| chr23_+_39606108 Show fit | 1.32 |
ENSDART00000109464
|
G0/G1 switch 2 |
|
| chr7_-_30367650 Show fit | 1.21 |
ENSDART00000075519
|
aldehyde dehydrogenase 1 family, member A2 |
|
| chr13_-_50614639 Show fit | 1.20 |
ENSDART00000170527
|
ventral expressed homeobox |
|
| chr19_-_24555623 Show fit | 1.19 |
ENSDART00000176022
|
polymerase (RNA) III (DNA directed) polypeptide G like a |
|
| chr22_+_25590391 Show fit | 1.00 |
ENSDART00000178133
|
alanyl-tRNA synthetase 2, mitochondrial (putative) |
|
| chr14_-_21123551 Show fit | 0.89 |
ENSDART00000171679
ENSDART00000165882 |
si:dkey-74k8.4 |
|
| chr7_-_69025306 Show fit | 0.86 |
ENSDART00000180796
|
|
Network of associatons between targets according to the STRING database.
First level regulatory network of hoxa13a+hoxa13b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.5 | 2.1 | GO:0072045 | convergent extension involved in nephron morphogenesis(GO:0072045) |
| 0.1 | 1.7 | GO:0060030 | dorsal convergence(GO:0060030) |
| 0.1 | 1.5 | GO:0035778 | pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014) |
| 0.5 | 1.4 | GO:0039015 | spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111) |
| 0.0 | 1.3 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.3 | 1.2 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 0.1 | 1.2 | GO:0042661 | regulation of mesodermal cell fate specification(GO:0042661) |
| 0.3 | 1.0 | GO:0006419 | alanyl-tRNA aminoacylation(GO:0006419) |
| 0.0 | 1.0 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.5 | 1.4 | GO:0097189 | apoptotic body(GO:0097189) |
| 0.0 | 1.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.7 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 0.6 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 0.5 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 0.5 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.0 | 0.5 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.0 | 0.5 | GO:0000145 | exocyst(GO:0000145) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 1.4 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 1.2 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.3 | 1.0 | GO:0004813 | alanine-tRNA ligase activity(GO:0004813) |
| 0.1 | 0.9 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.1 | 0.9 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.0 | 0.8 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.8 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 0.8 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.2 | 0.7 | GO:1990699 | palmitoleyl hydrolase activity(GO:1990699) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.7 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.6 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.5 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.5 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 0.5 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 0.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.4 | PID TNF PATHWAY | TNF receptor signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 1.4 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 1.0 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 0.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 0.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.7 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 0.6 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.6 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 0.6 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.5 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |