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PRJNA195909:zebrafish embryo and larva development
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Results for hoxa11b
Z-value: 2.43
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Transcription factors associated with hoxa11b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hoxa11b | dr11_v1_chr16_+_20904754_20904754 | -0.86 | 3.0e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr24_-_10014512 Show fit | 4.73 |
ENSDART00000124341
ENSDART00000191630 |
zgc:171474 |
|
| chr19_-_27550768 Show fit | 4.65 |
ENSDART00000142313
|
si:dkeyp-46h3.8 |
|
| chr6_+_28208973 Show fit | 3.92 |
ENSDART00000171216
ENSDART00000171377 ENSDART00000167389 ENSDART00000166988 |
si:ch73-14h10.2 |
|
| chr14_+_34490445 Show fit | 3.77 |
ENSDART00000132193
ENSDART00000148044 |
wingless-type MMTV integration site family, member 8a |
|
| chr10_-_10969596 Show fit | 3.61 |
ENSDART00000092011
|
exonuclease 3'-5' domain containing 3 |
|
| chr10_-_10969444 Show fit | 3.30 |
ENSDART00000138041
|
exonuclease 3'-5' domain containing 3 |
|
| chr11_+_18130300 Show fit | 3.22 |
ENSDART00000169146
|
zgc:175135 |
|
| chr20_-_34028967 Show fit | 3.19 |
ENSDART00000153408
ENSDART00000033817 |
SCY1-like, kinase-like 3 |
|
| chr14_+_32918172 Show fit | 3.18 |
ENSDART00000182867
|
ligand of numb-protein X 2b |
|
| chr21_+_20396858 Show fit | 3.14 |
ENSDART00000003299
ENSDART00000146615 |
zgc:103482 |
Network of associatons between targets according to the STRING database.
First level regulatory network of hoxa11b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | GO:0016197 | endosomal transport(GO:0016197) |
| 0.0 | 6.1 | GO:0006644 | phospholipid metabolic process(GO:0006644) |
| 0.3 | 4.8 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.1 | 4.7 | GO:0034504 | protein localization to nucleus(GO:0034504) |
| 0.1 | 4.4 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.2 | 4.3 | GO:0035459 | cargo loading into vesicle(GO:0035459) |
| 1.3 | 3.8 | GO:0021512 | spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111) |
| 0.4 | 3.6 | GO:0045948 | positive regulation of translational initiation(GO:0045948) |
| 0.3 | 3.5 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.0 | 3.4 | GO:0000819 | sister chromatid segregation(GO:0000819) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.7 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 5.3 | GO:0005813 | centrosome(GO:0005813) |
| 0.2 | 4.3 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.1 | 4.0 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 1.3 | 3.8 | GO:0097189 | apoptotic body(GO:0097189) |
| 0.0 | 3.7 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.1 | 3.6 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.2 | 3.5 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 3.5 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 3.5 | GO:0005802 | trans-Golgi network(GO:0005802) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.9 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 8.6 | GO:0042393 | histone binding(GO:0042393) |
| 0.2 | 8.1 | GO:0008408 | 3'-5' exonuclease activity(GO:0008408) |
| 0.1 | 5.9 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.0 | 5.4 | GO:0003712 | transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712) |
| 0.4 | 4.8 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
| 0.0 | 4.4 | GO:0004518 | nuclease activity(GO:0004518) |
| 0.1 | 3.8 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.5 | 3.5 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.2 | 3.5 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 4.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 4.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 3.6 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 3.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 2.3 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.1 | 2.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 2.1 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 2.0 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 3.5 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.6 | 3.1 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.2 | 3.0 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.2 | 2.8 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.1 | 2.8 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 2.7 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.1 | 2.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 2.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 2.4 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |