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PRJNA195909:zebrafish embryo and larva development
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Results for hnf1ba+hnf1bb
Z-value: 2.39
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Transcription factors associated with hnf1ba+hnf1bb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hnf1ba | dr11_v1_chr15_-_16012963_16012963 | 0.60 | 9.0e-02 | Click! |
| hnf1bb | dr11_v1_chr21_+_38817785_38817843 | 0.52 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_32345187 Show fit | 6.87 |
ENSDART00000147132
|
complement component 9 |
|
| chr2_+_55984788 Show fit | 5.31 |
ENSDART00000183599
|
nicotinamide riboside kinase 2 |
|
| chr22_-_23668356 Show fit | 5.11 |
ENSDART00000167106
ENSDART00000159622 ENSDART00000163228 |
complement factor H |
|
| chr6_+_60055168 Show fit | 4.73 |
ENSDART00000008752
|
phosphoenolpyruvate carboxykinase 1 (soluble) |
|
| chr15_+_28202170 Show fit | 4.70 |
ENSDART00000077736
|
vitronectin a |
|
| chr20_+_10538025 Show fit | 4.67 |
ENSDART00000129762
|
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like |
|
| chr1_+_10051763 Show fit | 4.43 |
ENSDART00000011701
|
fibrinogen beta chain |
|
| chr19_+_19772765 Show fit | 4.37 |
ENSDART00000182028
ENSDART00000161019 |
homeobox A3a |
|
| chr24_-_39610585 Show fit | 4.29 |
ENSDART00000066506
|
cytochrome c oxidase subunit VIb polypeptide 1 |
|
| chr16_-_42894628 Show fit | 4.26 |
ENSDART00000045600
|
hemochromatosis type 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of hnf1ba+hnf1bb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.3 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 2.3 | 6.9 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.3 | 6.7 | GO:0019835 | cytolysis(GO:0019835) |
| 0.1 | 5.8 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 1.2 | 4.7 | GO:0071548 | glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548) |
| 0.0 | 4.7 | GO:0006814 | sodium ion transport(GO:0006814) |
| 0.6 | 4.4 | GO:0060017 | parathyroid gland development(GO:0060017) |
| 0.3 | 4.4 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 0.8 | 3.9 | GO:0003261 | cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261) |
| 0.9 | 3.7 | GO:2000252 | positive regulation of epithelial cell differentiation(GO:0030858) negative regulation of behavior(GO:0048521) negative regulation of feeding behavior(GO:2000252) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.5 | GO:0005576 | extracellular region(GO:0005576) |
| 2.3 | 6.9 | GO:0044215 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
| 0.4 | 6.7 | GO:0005579 | membrane attack complex(GO:0005579) |
| 1.5 | 4.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.2 | 3.3 | GO:0031430 | M band(GO:0031430) |
| 0.2 | 2.9 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 2.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.3 | 2.7 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 2.6 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 2.5 | GO:0032587 | ruffle membrane(GO:0032587) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 11.3 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.1 | 7.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 5.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.8 | 5.3 | GO:0050262 | ribosylnicotinamide kinase activity(GO:0050262) |
| 0.1 | 5.1 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
| 0.8 | 4.9 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.2 | 4.7 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 4.7 | GO:0030145 | manganese ion binding(GO:0030145) |
| 0.4 | 3.9 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.0 | 3.6 | GO:0005179 | hormone activity(GO:0005179) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 7.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 5.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 4.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 4.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 3.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.5 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.1 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 17.9 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 1.3 | 5.1 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 1.6 | 4.7 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.4 | 4.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 4.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 3.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 3.7 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.4 | 3.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 3.5 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.2 | 2.7 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |