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PRJNA195909:zebrafish embryo and larva development

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Results for hnf1ba+hnf1bb

Z-value: 2.39

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Transcription factors associated with hnf1ba+hnf1bb

Gene Symbol Gene ID Gene Info
hnf1ba
ENSDARG00000006615 HNF1 homeobox Ba
hnf1bb
ENSDARG00000022295 HNF1 homeobox Bb
hnf1ba
ENSDARG00000115522 HNF1 homeobox Ba

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hnf1badr11_v1_chr15_-_16012963_160129630.609.0e-02Click!
hnf1bbdr11_v1_chr21_+_38817785_388178430.521.5e-01Click!

Activity profile of hnf1ba+hnf1bb motif

Sorted Z-values of hnf1ba+hnf1bb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_32345187 6.87 ENSDART00000147132
c9
complement component 9
chr2_+_55984788 5.31 ENSDART00000183599
nmrk2
nicotinamide riboside kinase 2
chr22_-_23668356 5.11 ENSDART00000167106
ENSDART00000159622
ENSDART00000163228
cfh
complement factor H
chr6_+_60055168 4.73 ENSDART00000008752
pck1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr15_+_28202170 4.70 ENSDART00000077736
vtna
vitronectin a
chr20_+_10538025 4.67 ENSDART00000129762
serpina1l
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
chr1_+_10051763 4.43 ENSDART00000011701
fgb
fibrinogen beta chain
chr19_+_19772765 4.37 ENSDART00000182028
ENSDART00000161019
hoxa3a
homeobox A3a
chr24_-_39610585 4.29 ENSDART00000066506
cox6b1
cytochrome c oxidase subunit VIb polypeptide 1
chr16_-_42894628 4.26 ENSDART00000045600
hfe2
hemochromatosis type 2
chr7_-_25895189 4.22 ENSDART00000173599
ENSDART00000079235
ENSDART00000173786
ENSDART00000173602
ENSDART00000079245
ENSDART00000187568
ENSDART00000173505
cd99l2
CD99 molecule-like 2
chr22_-_23748284 4.21 ENSDART00000162005
cfhl2
complement factor H like 2
chr20_+_10544100 3.80 ENSDART00000113927
serpina1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr5_+_37854685 3.72 ENSDART00000051222
ENSDART00000185283
ins
preproinsulin
chr5_-_19394440 3.69 ENSDART00000163771
foxn4
forkhead box N4
chr2_+_1487118 3.57 ENSDART00000147283
c8a
complement component 8, alpha polypeptide
chr1_-_12126535 3.55 ENSDART00000164817
ENSDART00000015251
mttp
microsomal triglyceride transfer protein
chr8_+_15254564 3.52 ENSDART00000024433
slc5a9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr16_+_26777473 3.37 ENSDART00000188870
cdh17
cadherin 17, LI cadherin (liver-intestine)
chr23_-_20345473 3.35 ENSDART00000140935
si:rp71-17i16.6
si:rp71-17i16.6
chr8_-_1051438 3.33 ENSDART00000067093
ENSDART00000170737
smyd1b
SET and MYND domain containing 1b
chr18_-_48530221 3.19 ENSDART00000188134
ENSDART00000142107
kcnj1a.2
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 2
chr2_+_1486822 3.09 ENSDART00000132500
c8a
complement component 8, alpha polypeptide
chr24_+_14713776 2.87 ENSDART00000134475
gdap1
ganglioside induced differentiation associated protein 1
chr5_-_41307550 2.83 ENSDART00000143446
npr3
natriuretic peptide receptor 3
chr25_-_27541621 2.72 ENSDART00000130678
spam1
sperm adhesion molecule 1
chr4_+_7827261 2.72 ENSDART00000129568
phyh
phytanoyl-CoA 2-hydroxylase
chr23_+_32335871 2.66 ENSDART00000149698
slc39a5
solute carrier family 39 (zinc transporter), member 5
chr3_+_40170216 2.61 ENSDART00000011568
syngr3a
synaptogyrin 3a
chr13_-_40726865 2.56 ENSDART00000099847
st3gal7
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr9_+_21151138 2.53 ENSDART00000133903
hao2
hydroxyacid oxidase 2 (long chain)
chr2_-_17828279 2.50 ENSDART00000083314
ptprfb
protein tyrosine phosphatase, receptor type, f, b
chr21_-_20328375 2.44 ENSDART00000079593
slc26a1
solute carrier family 26 (anion exchanger), member 1
chr15_+_35043007 2.41 ENSDART00000086954
sesn3
sestrin 3
chr10_+_25369254 2.39 ENSDART00000164375
bach1b
BTB and CNC homology 1, basic leucine zipper transcription factor 1 b
chr6_+_7977611 2.39 ENSDART00000112290
palm3
paralemmin 3
chr21_+_43669943 2.33 ENSDART00000136025
tmlhe
trimethyllysine hydroxylase, epsilon
chr22_-_23706771 2.33 ENSDART00000159771
cfhl1
complement factor H like 1
chr12_-_3940768 2.30 ENSDART00000134292
zgc:92040
zgc:92040
chr18_-_48500545 2.28 ENSDART00000058989
ENSDART00000098450
kcnj1a.6
kcnj1a.5
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 5
chr23_+_28770225 2.28 ENSDART00000132179
ENSDART00000142273
masp2
mannan-binding lectin serine peptidase 2
chr3_+_26734162 2.22 ENSDART00000114552
si:dkey-202l16.5
si:dkey-202l16.5
chr16_-_9675982 2.21 ENSDART00000113724
mal2
mal, T cell differentiation protein 2 (gene/pseudogene)
chr8_-_47800754 2.17 ENSDART00000115050
ENSDART00000133669
kank3
KN motif and ankyrin repeat domains 3
chr2_+_26647472 2.16 ENSDART00000145415
ENSDART00000157409
ttpa
tocopherol (alpha) transfer protein
chr24_-_17039638 2.14 ENSDART00000048823
c8g
complement component 8, gamma polypeptide
chr21_-_23308286 2.14 ENSDART00000184419
zbtb16a
zinc finger and BTB domain containing 16a
chr9_-_14108896 2.11 ENSDART00000135209
prkag3b
protein kinase, AMP-activated, gamma 3b non-catalytic subunit
chr24_-_6078222 2.08 ENSDART00000146830
apbb1ip
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr22_-_26100282 2.01 ENSDART00000166075
pdgfaa
platelet-derived growth factor alpha polypeptide a
chr5_-_37886063 1.97 ENSDART00000131378
ENSDART00000132152
si:ch211-139a5.9
si:ch211-139a5.9
chr18_-_48550426 1.96 ENSDART00000145189
kcnj1a.1
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr2_-_43635777 1.96 ENSDART00000148633
itgb1b.1
integrin, beta 1b.1
chr14_+_38654300 1.93 ENSDART00000148938
ENSDART00000150107
rnasel3
ribonuclease like 3
chr22_-_26005894 1.88 ENSDART00000105088
pdgfaa
platelet-derived growth factor alpha polypeptide a
chr12_-_6177894 1.87 ENSDART00000152292
a1cf
apobec1 complementation factor
chr13_+_23988442 1.86 ENSDART00000010918
agt
angiotensinogen
chr2_-_5466708 1.82 ENSDART00000136682
proca
protein C (inactivator of coagulation factors Va and VIIIa), a
chr8_-_18535822 1.81 ENSDART00000100558
nexn
nexilin (F actin binding protein)
chr7_-_4296771 1.81 ENSDART00000128855
cbln11
cerebellin 11
chr6_+_54221654 1.77 ENSDART00000128456
pacsin1b
protein kinase C and casein kinase substrate in neurons 1b
chr17_+_15033822 1.68 ENSDART00000154987
samd4a
sterile alpha motif domain containing 4A
chr24_+_23791758 1.66 ENSDART00000066655
ENSDART00000146580
mybl1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr25_+_3347461 1.63 ENSDART00000104888
slc35b4
solute carrier family 35, member B4
chr8_+_26522013 1.62 ENSDART00000046863
sema3bl
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl
chr13_-_36534380 1.60 ENSDART00000177857
ENSDART00000181046
ENSDART00000187243
srsf5a
serine/arginine-rich splicing factor 5a
chr10_-_41664427 1.59 ENSDART00000150213
ggt1b
gamma-glutamyltransferase 1b
chr17_-_17948587 1.59 ENSDART00000090447
hhipl1
HHIP-like 1
chr18_-_48492951 1.58 ENSDART00000146346
kcnj1a.6
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6
chr10_+_35439952 1.58 ENSDART00000006284
hhla2a.2
HERV-H LTR-associating 2a, tandem duplicate 2
chr24_-_4765740 1.58 ENSDART00000121576
cpb1
carboxypeptidase B1 (tissue)
chr1_+_45085194 1.57 ENSDART00000193863
si:ch211-151p13.8
si:ch211-151p13.8
chr9_+_29994439 1.56 ENSDART00000012447
tmem30c
transmembrane protein 30C
chr2_-_5475910 1.50 ENSDART00000100954
ENSDART00000172143
ENSDART00000132496
proca
proca
protein C (inactivator of coagulation factors Va and VIIIa), a
protein C (inactivator of coagulation factors Va and VIIIa), a
chr6_+_30456788 1.50 ENSDART00000121492
FP236735.1

chr1_-_22851481 1.45 ENSDART00000054386
qdprb1
quinoid dihydropteridine reductase b1
chr13_-_18835254 1.43 ENSDART00000147579
ENSDART00000146795
lzts2a
leucine zipper, putative tumor suppressor 2a
chr8_-_53490376 1.42 ENSDART00000158789
chdh
choline dehydrogenase
chr10_-_17159761 1.42 ENSDART00000080449
slc5a1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr25_+_13406069 1.41 ENSDART00000010495
znrf1
zinc and ring finger 1
chr7_+_19817306 1.32 ENSDART00000044425
BX957278.1

chr5_+_45322734 1.29 ENSDART00000084411
adamts3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr21_+_39100289 1.28 ENSDART00000075958
slc13a2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr18_+_13182528 1.27 ENSDART00000166298
zgc:56622
zgc:56622
chr1_+_26667872 1.27 ENSDART00000152803
ENSDART00000152144
ENSDART00000152785
ENSDART00000152393
hemgn
hemogen
chr23_+_27740788 1.24 ENSDART00000053871
dhh
desert hedgehog
chr18_-_48508585 1.23 ENSDART00000133364
kcnj1a.4
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 4
chr10_+_25369859 1.22 ENSDART00000047541
bach1b
BTB and CNC homology 1, basic leucine zipper transcription factor 1 b
chr3_-_16250527 1.21 ENSDART00000146699
ENSDART00000141181
bckdhbl
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr20_-_25481306 1.19 ENSDART00000182495
si:dkey-183n20.15
si:dkey-183n20.15
chr9_+_30720048 1.17 ENSDART00000146115
klf12b
Kruppel-like factor 12b
chr5_+_21225017 1.16 ENSDART00000141573
si:dkey-13n15.11
si:dkey-13n15.11
chr21_+_39941184 1.16 ENSDART00000133604
slc47a1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr7_-_29534001 1.13 ENSDART00000124028
anxa2b
annexin A2b
chr3_-_16760923 1.12 ENSDART00000055855
aspdh
aspartate dehydrogenase domain containing
chr6_+_28141135 1.11 ENSDART00000113405
ENSDART00000179795
inpp5d
inositol polyphosphate-5-phosphatase D
chr19_+_8144556 1.09 ENSDART00000027274
ENSDART00000147218
efna3a
ephrin-A3a
chr21_+_39941559 1.07 ENSDART00000189718
ENSDART00000160875
ENSDART00000135235
slc47a1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr7_-_59564011 1.06 ENSDART00000186053
zgc:112271
zgc:112271
chr11_+_575665 1.05 ENSDART00000122133
mkrn2os.1
MKRN2 opposite strand, tandem duplicate 1
chr18_-_48517040 1.03 ENSDART00000143645
kcnj1a.3
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 3
chr23_+_25856541 1.03 ENSDART00000145426
ENSDART00000028236
hnf4a
hepatocyte nuclear factor 4, alpha
chr10_+_25726694 0.99 ENSDART00000140308
ugt5d1
UDP glucuronosyltransferase 5 family, polypeptide D1
chr21_+_38002879 0.95 ENSDART00000065183
cldn2
claudin 2
chr22_+_16555939 0.95 ENSDART00000012604
pdzk1ip1
PDZK1 interacting protein 1
chr6_-_56103718 0.95 ENSDART00000191002
gcnt7
glucosaminyl (N-acetyl) transferase family member 7
chr8_+_46418996 0.90 ENSDART00000144285
si:ch211-196g2.4
si:ch211-196g2.4
chr24_+_35787629 0.88 ENSDART00000136721
si:dkeyp-7a3.1
si:dkeyp-7a3.1
chr6_+_38381957 0.87 ENSDART00000087300
gabrb3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr8_+_26293673 0.86 ENSDART00000144977
mgll
monoglyceride lipase
chr20_+_23440632 0.86 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
si:dkey-90m5.4
chr4_+_76416268 0.82 ENSDART00000174351
ENSDART00000191591
zgc:113209
FP074874.1
zgc:113209

chr5_-_42904329 0.82 ENSDART00000112807
cxcl20
chemokine (C-X-C motif) ligand 20
chr23_+_27740592 0.75 ENSDART00000137875
dhh
desert hedgehog
chr19_-_22568203 0.74 ENSDART00000182888
pleca
plectin a
chr4_+_45484774 0.74 ENSDART00000150573
si:dkey-256i11.6
si:dkey-256i11.6
chr24_+_25913162 0.74 ENSDART00000143099
ENSDART00000184814
map3k15
mitogen-activated protein kinase kinase kinase 15
chr4_-_9533345 0.71 ENSDART00000128501
si:ch73-139j3.4
si:ch73-139j3.4
chr5_-_65158203 0.67 ENSDART00000171656
sh2d3cb
SH2 domain containing 3Cb
chr4_-_73136420 0.66 ENSDART00000160907
si:ch73-170d6.3
si:ch73-170d6.3
chr1_-_19502322 0.65 ENSDART00000181888
ENSDART00000044030
kitb
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b
chr10_+_21867307 0.64 ENSDART00000126629
cbln17
cerebellin 17
chr4_+_58016732 0.63 ENSDART00000165777
CT027609.1

chr5_-_63302944 0.62 ENSDART00000047110
gsnb
gelsolin b
chr24_-_21913426 0.60 ENSDART00000081178
c1qtnf9
C1q and TNF related 9
chr14_+_740032 0.58 ENSDART00000165014
klb
klotho beta
chr4_+_54798291 0.58 ENSDART00000165113
ENSDART00000109624
si:dkeyp-82b4.6
si:dkeyp-82b4.6
chr8_+_30699429 0.54 ENSDART00000005345
upb1
ureidopropionase, beta
chr16_-_22294265 0.53 ENSDART00000124718
aqp10a
aquaporin 10a
chr16_+_11623956 0.51 ENSDART00000137788
cxcr3.1
chemokine (C-X-C motif) receptor 3, tandem duplicate 1
chr15_+_25156382 0.51 ENSDART00000171092
slc35f2l
info solute carrier family 35, member F2, like
chr25_+_23280220 0.49 ENSDART00000153940
ptprjb.1
protein tyrosine phosphatase, receptor type, Jb, tandem duplicate 1
chr15_+_29283981 0.49 ENSDART00000099895
rap1gap2a
RAP1 GTPase activating protein 2a
chr3_+_28576173 0.49 ENSDART00000151189
sept12
septin 12
chr3_-_34084387 0.48 ENSDART00000155365
ighv4-3
immunoglobulin heavy variable 4-3
chr2_-_41942666 0.46 ENSDART00000075673
ebi3
Epstein-Barr virus induced 3
chr19_-_18418763 0.44 ENSDART00000167271
zgc:112966
zgc:112966
chr4_+_34119824 0.44 ENSDART00000165637
si:ch211-223g7.6
si:ch211-223g7.6
chr4_-_56954002 0.44 ENSDART00000160934
si:dkey-269o24.1
si:dkey-269o24.1
chr5_-_30715225 0.44 ENSDART00000016758
ftr82
finTRIM family, member 82
chr20_-_31075972 0.43 ENSDART00000122927
si:ch211-198b3.4
si:ch211-198b3.4
chr7_-_27696958 0.42 ENSDART00000173470
calca
calcitonin/calcitonin-related polypeptide, alpha
chr6_+_28140816 0.42 ENSDART00000137907
inpp5d
inositol polyphosphate-5-phosphatase D
chr4_-_67980261 0.41 ENSDART00000182305
si:ch211-223k15.1
si:ch211-223k15.1
chr7_-_35066457 0.41 ENSDART00000058067
zgc:112160
zgc:112160
chr4_-_32642681 0.40 ENSDART00000188695
ENSDART00000193974
si:dkey-265e7.1
si:dkey-265e7.1
chr12_+_5209822 0.40 ENSDART00000152610
SLC35G1
si:ch211-197g18.2
chr4_+_18804317 0.38 ENSDART00000101043
slc26a3.2
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr16_+_11603096 0.37 ENSDART00000146286
si:dkey-11o1.3
si:dkey-11o1.3
chr20_-_40755614 0.35 ENSDART00000061247
cx32.3
connexin 32.3
chr21_-_38853737 0.34 ENSDART00000184100
tlr22
toll-like receptor 22
chr11_-_37997419 0.34 ENSDART00000102870
slc41a1
solute carrier family 41 (magnesium transporter), member 1
chr15_-_41744509 0.34 ENSDART00000176952
ENSDART00000156690
ftr88
finTRIM family, member 88
chr3_+_19446997 0.32 ENSDART00000079352
zgc:123297
zgc:123297
chr18_+_3530769 0.30 ENSDART00000163469
si:ch73-338a16.3
si:ch73-338a16.3
chr17_-_47305034 0.29 ENSDART00000150116
alk
ALK receptor tyrosine kinase
chr7_+_27059330 0.28 ENSDART00000173919
plekha7b
pleckstrin homology domain containing, family A member 7b
chr4_-_32179699 0.28 ENSDART00000124106
ENSDART00000158835
si:dkey-72l17.6
si:dkey-72l17.6
chr25_+_17920361 0.27 ENSDART00000185644
borcs5
BLOC-1 related complex subunit 5
chr5_+_13385837 0.25 ENSDART00000191190
ccl19a.1
chemokine (C-C motif) ligand 19a, tandem duplicate 1
chr21_-_23307653 0.25 ENSDART00000140284
ENSDART00000134103
zbtb16a
zinc finger and BTB domain containing 16a
chr17_+_5895500 0.24 ENSDART00000019905
fndc4b
fibronectin type III domain containing 4b
chr4_-_5317006 0.24 ENSDART00000150867
si:ch211-214j24.15
si:ch211-214j24.15
chr2_-_7845110 0.23 ENSDART00000091987
si:ch211-38m6.7
si:ch211-38m6.7
chr15_+_25156121 0.23 ENSDART00000189709
slc35f2l
info solute carrier family 35, member F2, like
chr18_+_2554666 0.22 ENSDART00000167218
p2ry2.1
purinergic receptor P2Y2, tandem duplicate 1
chr20_-_40750953 0.20 ENSDART00000061256
cx28.9
connexin 28.9
chr23_+_26491931 0.20 ENSDART00000190124
ENSDART00000132905
si:ch73-206d17.1
si:ch73-206d17.1
chr15_+_35139457 0.18 ENSDART00000059204
slc19a3a
solute carrier family 19 (thiamine transporter), member 3a
chr25_-_3759322 0.13 ENSDART00000088077
zgc:158398
zgc:158398
chr2_-_27609189 0.12 ENSDART00000040555
lyn
LYN proto-oncogene, Src family tyrosine kinase
chr7_+_27317174 0.11 ENSDART00000193058
sox6
SRY (sex determining region Y)-box 6
chr7_-_17412559 0.11 ENSDART00000163020
nitr3a
novel immune-type receptor 3a
chr4_-_34480599 0.11 ENSDART00000159602
ENSDART00000182248
si:dkeyp-51g9.4
si:ch211-64i20.3
si:dkeyp-51g9.4
si:ch211-64i20.3
chr22_+_21317597 0.09 ENSDART00000132605
shc2
SHC (Src homology 2 domain containing) transforming protein 2
chr8_+_23391263 0.05 ENSDART00000149687
si:dkey-16n15.6
si:dkey-16n15.6
chr5_+_1877464 0.04 ENSDART00000050658
zgc:101699
zgc:101699
chr9_+_28688574 0.04 ENSDART00000101319
zgc:162396
zgc:162396
chr19_+_28256076 0.03 ENSDART00000133354
irx4b
iroquois homeobox 4b
chr10_-_42131408 0.02 ENSDART00000076693
stambpa
STAM binding protein a
chr18_+_33353271 0.02 ENSDART00000099142
v2rh13
vomeronasal 2 receptor, h13

Network of associatons between targets according to the STRING database.

First level regulatory network of hnf1ba+hnf1bb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.2 4.7 GO:0071548 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548)
0.9 3.7 GO:2000252 positive regulation of epithelial cell differentiation(GO:0030858) negative regulation of behavior(GO:0048521) negative regulation of feeding behavior(GO:2000252)
0.8 3.9 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.6 4.4 GO:0060017 parathyroid gland development(GO:0060017)
0.6 3.7 GO:0035881 amacrine cell differentiation(GO:0035881)
0.6 2.4 GO:0019532 oxalate transport(GO:0019532)
0.5 1.4 GO:0019695 choline metabolic process(GO:0019695)
0.5 2.3 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.4 3.5 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.4 2.2 GO:0045056 transcytosis(GO:0045056)
0.4 2.7 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.4 1.8 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.3 2.4 GO:1901031 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.3 2.3 GO:0045329 amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.3 1.6 GO:0031179 peptide modification(GO:0031179)
0.3 4.4 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.3 3.3 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.3 2.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.3 2.0 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.3 2.5 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.3 6.7 GO:0019835 cytolysis(GO:0019835)
0.2 1.1 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.2 1.5 GO:0071623 negative regulation of leukocyte chemotaxis(GO:0002689) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.2 2.7 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.2 2.4 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.2 2.9 GO:0008053 mitochondrial fusion(GO:0008053)
0.2 1.4 GO:0051013 microtubule severing(GO:0051013)
0.2 0.6 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.2 0.5 GO:0033210 leptin-mediated signaling pathway(GO:0033210) cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.1 2.8 GO:0060038 cardiac muscle cell proliferation(GO:0060038)
0.1 1.6 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.1 2.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 11.3 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 1.9 GO:0016556 mRNA modification(GO:0016556)
0.1 2.2 GO:0006775 fat-soluble vitamin metabolic process(GO:0006775)
0.1 0.5 GO:0019483 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
0.1 1.9 GO:0001990 regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.1 1.8 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 1.9 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 0.4 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 1.0 GO:0070365 hepatocyte differentiation(GO:0070365)
0.1 5.8 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 2.0 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.1 0.8 GO:0036230 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.1 2.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.2 GO:0070255 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.1 2.7 GO:0007596 blood coagulation(GO:0007596)
0.1 1.4 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.7 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 1.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:0005513 detection of calcium ion(GO:0005513)
0.0 1.1 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 1.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 1.6 GO:0008643 carbohydrate transport(GO:0008643)
0.0 0.3 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.3 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.7 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.1 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 4.7 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.5 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.5 GO:0002455 humoral immune response mediated by circulating immunoglobulin(GO:0002455) complement activation, classical pathway(GO:0006958)
0.0 0.6 GO:0051014 actin filament severing(GO:0051014)
0.0 0.4 GO:0015701 bicarbonate transport(GO:0015701)
0.0 3.4 GO:0048793 pronephros development(GO:0048793)
0.0 0.9 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 1.6 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.1 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.5 GO:0002685 regulation of leukocyte migration(GO:0002685)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
1.5 4.4 GO:0005577 fibrinogen complex(GO:0005577)
0.4 6.7 GO:0005579 membrane attack complex(GO:0005579)
0.3 2.4 GO:0061700 GATOR2 complex(GO:0061700)
0.3 2.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 2.9 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.2 2.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 3.3 GO:0031430 M band(GO:0031430)
0.1 2.6 GO:0031594 neuromuscular junction(GO:0031594)
0.1 0.3 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.1 2.5 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.7 GO:0030056 hemidesmosome(GO:0030056)
0.0 1.4 GO:0030496 midbody(GO:0030496)
0.0 0.9 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 2.2 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.3 GO:0016342 catenin complex(GO:0016342)
0.0 1.6 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 1.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.8 GO:0030018 Z disc(GO:0030018)
0.0 1.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 34.5 GO:0005576 extracellular region(GO:0005576)
0.0 0.5 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 2.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.2 GO:0005770 late endosome(GO:0005770)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:1904121 phosphatidylethanolamine transporter activity(GO:1904121)
0.9 2.6 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.8 4.9 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.8 11.3 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.8 5.3 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.6 2.3 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.4 3.9 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.4 2.0 GO:0098639 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.3 2.4 GO:0070728 leucine binding(GO:0070728)
0.3 1.6 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.3 1.6 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.3 1.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 2.0 GO:0005113 patched binding(GO:0005113)
0.2 2.7 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.2 0.8 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.2 4.7 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 2.8 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 2.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 3.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 2.2 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.1 0.4 GO:0031716 calcitonin receptor binding(GO:0031716)
0.1 0.5 GO:0015105 arsenite transmembrane transporter activity(GO:0015105)
0.1 0.5 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 4.7 GO:0030145 manganese ion binding(GO:0030145)
0.1 2.5 GO:0010181 FMN binding(GO:0010181)
0.1 1.6 GO:0038191 neuropilin binding(GO:0038191)
0.1 2.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.1 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.1 2.1 GO:0016208 AMP binding(GO:0016208)
0.1 5.1 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 1.2 GO:0033691 sialic acid binding(GO:0033691)
0.1 1.7 GO:0030371 translation repressor activity(GO:0030371)
0.1 0.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 7.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.8 GO:0098631 protein binding involved in cell adhesion(GO:0098631)
0.1 0.7 GO:0030506 ankyrin binding(GO:0030506)
0.1 1.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.6 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 1.1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.0 2.0 GO:0019842 vitamin binding(GO:0019842)
0.0 1.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.4 GO:0008013 beta-catenin binding(GO:0008013)
0.0 5.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.9 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 2.5 GO:0008201 heparin binding(GO:0008201)
0.0 0.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 3.6 GO:0005179 hormone activity(GO:0005179)
0.0 0.2 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.0 1.9 GO:0004540 ribonuclease activity(GO:0004540)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 1.1 GO:0051540 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.0 0.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.5 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.9 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 7.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 5.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 4.3 PID BMP PATHWAY BMP receptor signaling
0.1 3.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 7.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.6 PID FGF PATHWAY FGF signaling pathway
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
1.3 5.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.8 17.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.4 2.1 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.4 4.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.4 3.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 3.7 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.2 3.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 2.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 0.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 4.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 0.5 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 3.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 0.9 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 1.0 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.3 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.0 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.4 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.0 2.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.6 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 1.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 1.9 REACTOME MRNA PROCESSING Genes involved in mRNA Processing