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PRJNA195909:zebrafish embryo and larva development
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Results for hnf1a
Z-value: 1.76
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Transcription factors associated with hnf1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hnf1a | dr11_v1_chr8_+_39802506_39802506 | -0.62 | 7.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_-_45920 Show fit | 4.54 |
ENSDART00000040422
|
betaine-homocysteine methyltransferase |
|
| chr5_+_32345187 Show fit | 3.90 |
ENSDART00000147132
|
complement component 9 |
|
| chr8_+_999421 Show fit | 3.72 |
ENSDART00000149528
|
fatty acid binding protein 1b, tandem duplicate 1 |
|
| chr22_-_23625351 Show fit | 3.66 |
ENSDART00000192588
ENSDART00000163423 |
complement factor H like 4 |
|
| chr24_-_39610585 Show fit | 3.30 |
ENSDART00000066506
|
cytochrome c oxidase subunit VIb polypeptide 1 |
|
| chr17_+_4030493 Show fit | 3.19 |
ENSDART00000151849
|
hydroxyacid oxidase (glycolate oxidase) 1 |
|
| chr22_-_23668356 Show fit | 3.11 |
ENSDART00000167106
ENSDART00000159622 ENSDART00000163228 |
complement factor H |
|
| chr16_-_42894628 Show fit | 2.85 |
ENSDART00000045600
|
hemochromatosis type 2 |
|
| chr1_+_10051763 Show fit | 2.83 |
ENSDART00000011701
|
fibrinogen beta chain |
|
| chr22_-_17595310 Show fit | 2.77 |
ENSDART00000099056
|
glutathione peroxidase 4a |
Network of associatons between targets according to the STRING database.
First level regulatory network of hnf1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 4.9 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.0 | 4.8 | GO:0006979 | response to oxidative stress(GO:0006979) |
| 0.3 | 4.5 | GO:0009086 | methionine biosynthetic process(GO:0009086) |
| 1.3 | 3.9 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 1.1 | 3.3 | GO:0072068 | distal convoluted tubule development(GO:0072025) late distal convoluted tubule development(GO:0072068) |
| 0.2 | 3.1 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.2 | 2.8 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 0.5 | 2.6 | GO:0003261 | cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261) |
| 0.2 | 2.6 | GO:0016556 | mRNA modification(GO:0016556) |
| 0.2 | 2.5 | GO:0051452 | vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.9 | GO:0044218 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
| 0.3 | 3.1 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.9 | 2.8 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.2 | 2.5 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.0 | 2.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 2.0 | GO:0008305 | integrin complex(GO:0008305) |
| 0.2 | 1.8 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 1.8 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 1.4 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.1 | 1.3 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 4.8 | GO:0047066 | phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066) |
| 0.5 | 4.5 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.2 | 4.5 | GO:0010181 | FMN binding(GO:0010181) |
| 0.2 | 3.7 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.2 | 3.1 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.9 | 2.7 | GO:0047291 | lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291) |
| 0.5 | 2.6 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.3 | 2.6 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.0 | 2.6 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 2.6 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 2.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 2.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 2.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 1.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.3 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 5.2 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 4.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 4.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.8 | 3.1 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 2.9 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.3 | 2.8 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 2.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 1.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 1.9 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |