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PRJNA195909:zebrafish embryo and larva development

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Results for hmx1+hmx3b

Z-value: 0.74

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Transcription factors associated with hmx1+hmx3b

Gene Symbol Gene ID Gene Info
hmx1
ENSDARG00000095651 H6 family homeobox 1
hmx3b
ENSDARG00000096716 H6 family homeobox 3b
hmx1
ENSDARG00000109725 H6 family homeobox 1
hmx1
ENSDARG00000111765 H6 family homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hmx1dr11_v1_chr1_-_40914752_409147520.916.5e-04Click!
hmx3bdr11_v1_chr12_-_49154934_491549340.646.2e-02Click!

Activity profile of hmx1+hmx3b motif

Sorted Z-values of hmx1+hmx3b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_26657404 1.67 ENSDART00000129035
ENSDART00000186550
prdx5
peroxiredoxin 5
chr11_+_30244356 1.51 ENSDART00000036050
ENSDART00000150080
rs1a
retinoschisin 1a
chr14_-_3381303 1.44 ENSDART00000171601
im:7150988
im:7150988
chr11_-_7261717 1.29 ENSDART00000128959
zgc:113223
zgc:113223
chr3_+_60721342 1.28 ENSDART00000157772
foxj1a
forkhead box J1a
chr12_+_2446837 1.27 ENSDART00000112032
ARHGAP22
si:dkey-191m6.4
chr5_-_42272517 1.14 ENSDART00000137692
ENSDART00000164363
si:ch211-207c6.2
si:ch211-207c6.2
chr20_+_28861435 1.06 ENSDART00000142678
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr8_-_23194408 1.05 ENSDART00000141090
si:ch211-196c10.15
si:ch211-196c10.15
chr18_+_9171778 1.04 ENSDART00000101192
sema3d
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr25_+_18965430 1.01 ENSDART00000169742
tdg.1
thymine DNA glycosylase, tandem duplicate 1
chr7_+_71683853 0.99 ENSDART00000163002
emilin2b
elastin microfibril interfacer 2b
chr18_-_5595546 0.96 ENSDART00000191825
cyp1a
cytochrome P450, family 1, subfamily A
chr15_-_1822548 0.91 ENSDART00000082026
ENSDART00000180230
mmp28
matrix metallopeptidase 28
chr7_+_32722227 0.90 ENSDART00000126565
si:ch211-150g13.3
si:ch211-150g13.3
chr20_+_28861629 0.80 ENSDART00000187274
ENSDART00000047826
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr14_+_14568437 0.78 ENSDART00000164749
pcdh20
protocadherin 20
chr1_+_34696503 0.77 ENSDART00000186106
CR339054.2

chr1_+_52929185 0.75 ENSDART00000147683
inpp4b
inositol polyphosphate-4-phosphatase type II B
chr12_+_24342303 0.67 ENSDART00000111239
nrxn1a
neurexin 1a
chr5_+_11290851 0.67 ENSDART00000180408
CABZ01077124.1

chr13_-_50108337 0.65 ENSDART00000133308
nid1a
nidogen 1a
chr24_+_38301080 0.63 ENSDART00000105672
mybpc2b
myosin binding protein C, fast type b
chr5_-_14326959 0.62 ENSDART00000137355
tet3
tet methylcytosine dioxygenase 3
chr23_-_18913032 0.60 ENSDART00000136678
si:ch211-209j10.6
si:ch211-209j10.6
chr15_-_14884332 0.58 ENSDART00000165237
si:ch211-24o8.4
si:ch211-24o8.4
chr22_-_6988102 0.58 ENSDART00000185618
fgfr1bl
fibroblast growth factor receptor 1b, like
chr14_-_33454595 0.58 ENSDART00000109615
ENSDART00000173267
ENSDART00000185737
ENSDART00000190989
tmem255a
transmembrane protein 255A
chr9_-_31108285 0.54 ENSDART00000003193
gpr183a
G protein-coupled receptor 183a
chr25_-_10503043 0.54 ENSDART00000155404
cox8b
cytochrome c oxidase subunit 8b
chr6_-_37422841 0.54 ENSDART00000138351
cth
cystathionase (cystathionine gamma-lyase)
chrM_+_8130 0.53 ENSDART00000093609
mt-co2
cytochrome c oxidase II, mitochondrial
chr22_-_4649238 0.53 ENSDART00000125302
fbn2b
fibrillin 2b
chr7_+_66565930 0.51 ENSDART00000154597
tmem176l.3b
transmembrane protein 176l.3b
chr21_+_21906671 0.50 ENSDART00000016916
gria4b
glutamate receptor, ionotropic, AMPA 4b
chr16_-_6391275 0.50 ENSDART00000060550
ndufb9
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9
chr10_-_39153959 0.47 ENSDART00000150193
ENSDART00000111362
slc37a4b
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr8_-_13013123 0.47 ENSDART00000147802
dennd2da
DENN/MADD domain containing 2Da
chr10_-_39154594 0.45 ENSDART00000148825
slc37a4b
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr13_+_30874153 0.41 ENSDART00000112380
ENSDART00000189016
ENSDART00000134809
ercc6
excision repair cross-complementation group 6
chr10_+_35439952 0.41 ENSDART00000006284
hhla2a.2
HERV-H LTR-associating 2a, tandem duplicate 2
chr18_+_11970987 0.40 ENSDART00000144111
si:dkeyp-2c8.3
si:dkeyp-2c8.3
chr13_-_37109987 0.40 ENSDART00000136750
syne2b
spectrin repeat containing, nuclear envelope 2b
chr8_-_19649617 0.39 ENSDART00000189033
fam78bb
family with sequence similarity 78, member B b
chr15_+_1134870 0.39 ENSDART00000155392
p2ry13
purinergic receptor P2Y13
chr21_-_37973819 0.38 ENSDART00000133405
ripply1
ripply transcriptional repressor 1
chr23_+_9353552 0.38 ENSDART00000163298
BX511246.1

chr14_-_7137808 0.36 ENSDART00000054803
trpt1
tRNA phosphotransferase 1
chr20_+_37295006 0.33 ENSDART00000153137
cx23
connexin 23
chr1_-_22512063 0.33 ENSDART00000031546
ENSDART00000190987
chrna6
cholinergic receptor, nicotinic, alpha 6
chr5_+_37032038 0.31 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr13_+_23176330 0.31 ENSDART00000168351
sorbs1
sorbin and SH3 domain containing 1
chr4_-_18741942 0.28 ENSDART00000145747
ENSDART00000066980
ENSDART00000186518
atxn10
ataxin 10
chr10_+_16069987 0.27 ENSDART00000043936
megf10
multiple EGF-like-domains 10
chr24_-_27400017 0.26 ENSDART00000145829
ccl34b.1
chemokine (C-C motif) ligand 34b, duplicate 1
chr6_-_6448519 0.26 ENSDART00000180157
ENSDART00000191112
si:ch211-194e18.2
si:ch211-194e18.2
chr20_-_34164278 0.25 ENSDART00000153128
hmcn1
hemicentin 1
chr4_+_14727018 0.25 ENSDART00000124189
cmasa
cytidine monophosphate N-acetylneuraminic acid synthetase a
chr6_-_40697585 0.24 ENSDART00000113196
si:ch211-157b11.14
si:ch211-157b11.14
chr25_+_3327071 0.24 ENSDART00000136131
ENSDART00000133243
ldhbb
lactate dehydrogenase Bb
chr25_+_3326885 0.23 ENSDART00000104866
ldhbb
lactate dehydrogenase Bb
chr4_-_76154252 0.19 ENSDART00000161269
BX957252.1

chr4_+_13931733 0.18 ENSDART00000141742
ENSDART00000067175
pphln1
periphilin 1
chr9_+_43799829 0.18 ENSDART00000186240
ube2e3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr5_+_32835219 0.18 ENSDART00000140832
ENSDART00000186055
si:ch211-208h16.4
si:ch211-208h16.4
chr8_+_22472584 0.17 ENSDART00000138303
si:dkey-23c22.9
si:dkey-23c22.9
chr2_-_16380283 0.15 ENSDART00000149992
si:dkey-231j24.3
si:dkey-231j24.3
chr4_+_13931578 0.15 ENSDART00000142466
pphln1
periphilin 1
chr19_+_43604256 0.15 ENSDART00000151080
ENSDART00000110305
si:ch211-199g17.9
si:ch211-199g17.9
chr10_+_43039947 0.15 ENSDART00000193434
atg10
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr4_-_72609735 0.14 ENSDART00000174299
ENSDART00000159227
si:cabz01054394.6
si:cabz01054394.6
chr4_-_43388943 0.14 ENSDART00000150796
si:dkey-29j8.2
si:dkey-29j8.2
chr17_+_6563307 0.13 ENSDART00000156454
adgrf3a
adhesion G protein-coupled receptor F3a
chr8_+_23194212 0.12 ENSDART00000028946
ENSDART00000186842
ENSDART00000137815
ENSDART00000136914
ENSDART00000144855
ENSDART00000182689
tpd52l2a
tumor protein D52-like 2a
chr22_+_1911269 0.11 ENSDART00000164158
ENSDART00000168205
znf1156
zinc finger protein 1156
chr18_+_44080948 0.10 ENSDART00000191036
BX908388.2

chr18_-_25568994 0.09 ENSDART00000133029
si:ch211-13k12.2
si:ch211-13k12.2
chr13_+_30169681 0.09 ENSDART00000138326
pald1b
phosphatase domain containing, paladin 1b
chr14_-_9128919 0.07 ENSDART00000108641
sh2d1ab
SH2 domain containing 1A duplicate b
chr11_-_37691449 0.07 ENSDART00000185340
zgc:158258
zgc:158258
chr19_-_6239248 0.07 ENSDART00000014127
pou2f2a
POU class 2 homeobox 2a
chr21_+_21702623 0.06 ENSDART00000136840
or125-2
odorant receptor, family E, subfamily 125, member 2
chr4_+_20576857 0.06 ENSDART00000125340
BX248410.2

chr1_-_23596391 0.05 ENSDART00000155184
lcorl
ligand dependent nuclear receptor corepressor-like
chr3_+_22327738 0.05 ENSDART00000055675
gh1
growth hormone 1
chr21_-_14803366 0.05 ENSDART00000190872
si:dkey-11o18.5
si:dkey-11o18.5
chr21_-_14966718 0.05 ENSDART00000151200
mmp17a
matrix metallopeptidase 17a
chr6_-_40352215 0.05 ENSDART00000103992
ttll3
tubulin tyrosine ligase-like family, member 3
chr8_-_46486009 0.04 ENSDART00000140431
sult1st9
sulfotransferase family 1, cytosolic sulfotransferase 9
chr2_+_16652238 0.03 ENSDART00000091351
gk5
glycerol kinase 5 (putative)
chr22_+_724639 0.03 ENSDART00000105323
zgc:162255
zgc:162255
chr1_-_56032619 0.02 ENSDART00000143793
c3a.4
complement component c3a, duplicate 4
chr10_+_40690411 0.00 ENSDART00000146865
taar19m
trace amine associated receptor 19m

Network of associatons between targets according to the STRING database.

First level regulatory network of hmx1+hmx3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0060295 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.2 1.0 GO:0002164 larval development(GO:0002164) larval heart development(GO:0007508)
0.2 0.5 GO:0002407 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.2 0.5 GO:0060958 cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) endocardial cell development(GO:0060958) cell proliferation involved in heart valve development(GO:2000793)
0.1 1.9 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.6 GO:0032616 interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.1 1.0 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 0.5 GO:0019344 homoserine metabolic process(GO:0009092) cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344) transsulfuration(GO:0019346)
0.1 0.3 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.1 1.7 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 0.4 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.4 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.4 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 1.0 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.4 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 2.4 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 1.1 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.2 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:0014823 response to activity(GO:0014823)
0.0 0.1 GO:0050996 positive regulation of lipid catabolic process(GO:0050996)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.1 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 1.7 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 1.0 GO:0070330 aromatase activity(GO:0070330)
0.1 1.0 GO:0008263 mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.1 0.7 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 0.5 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.6 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 1.0 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.1 GO:0019777 Atg12 transferase activity(GO:0019777)
0.0 1.1 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.4 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131) growth hormone activity(GO:0070186)
0.0 0.0 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.0 0.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.4 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases