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PRJNA195909:zebrafish embryo and larva development

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Results for hey2_hey1+heyl

Z-value: 0.73

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Transcription factors associated with hey2_hey1+heyl

Gene Symbol Gene ID Gene Info
ENSDARG00000013441 hes-related family bHLH transcription factor with YRPW motif 2
ENSDARG00000055798 hes related family bHLH transcription factor with YRPW motif like
ENSDARG00000070538 hes-related family bHLH transcription factor with YRPW motif 1
ENSDARG00000112770 hes related family bHLH transcription factor with YRPW motif like

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
heyldr11_v1_chr19_+_32553874_325538740.665.3e-02Click!
hey2dr11_v1_chr20_-_39596338_39596338-0.412.8e-01Click!
hey1dr11_v1_chr19_-_31802296_318022960.402.9e-01Click!

Activity profile of hey2_hey1+heyl motif

Sorted Z-values of hey2_hey1+heyl motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_7607114 1.20 ENSDART00000158095
solute carrier family 16, member 9b
chr19_-_24555935 1.18 ENSDART00000132660
ENSDART00000162801
polymerase (RNA) III (DNA directed) polypeptide G like a
chr4_-_13580348 1.10 ENSDART00000067160
opsin 1 (cone pigments), short-wave-sensitive 1
chr19_-_24555623 1.10 ENSDART00000176022
polymerase (RNA) III (DNA directed) polypeptide G like a
chr1_-_39943596 0.98 ENSDART00000149730
storkhead box 2a
chr9_-_56272465 0.91 ENSDART00000039235
lymphocyte cytosolic protein 1 (L-plastin)
chr6_+_12968101 0.89 ENSDART00000013781
minichromosome maintenance complex component 6
chr24_-_12938922 0.85 ENSDART00000024084
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr17_+_25414033 0.84 ENSDART00000001691
L-threonine dehydrogenase 2
chr11_-_3552067 0.79 ENSDART00000163656
si:dkey-33m11.6
chr16_-_45069882 0.78 ENSDART00000058384
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr25_+_18964782 0.76 ENSDART00000017299
thymine DNA glycosylase, tandem duplicate 1
chr13_+_32148338 0.75 ENSDART00000188591
odd-skipped related transciption factor 1
chr14_+_14836468 0.74 ENSDART00000166728
si:dkey-102m7.3
chr19_+_42470396 0.71 ENSDART00000191679
si:dkey-166k12.1
chr8_+_17184602 0.71 ENSDART00000050228
ENSDART00000140531
DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
chr21_-_20765338 0.68 ENSDART00000135940
growth hormone receptor b
chr24_-_8732519 0.68 ENSDART00000082351
transcription factor AP-2 alpha
chr3_+_23488652 0.66 ENSDART00000126282
nuclear receptor subfamily 1, group d, member 1
chr14_-_498979 0.64 ENSDART00000171976
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr18_+_14693682 0.63 ENSDART00000132249
URI1, prefoldin-like chaperone
chr7_+_38750871 0.62 ENSDART00000114238
ENSDART00000052325
ENSDART00000137001
coagulation factor II (thrombin)
chr12_-_6159545 0.62 ENSDART00000152487
RAMP-like triterpene glycoside receptor
chr16_+_23960744 0.59 ENSDART00000058965
apolipoprotein Eb
chr16_+_23960933 0.57 ENSDART00000146077
apolipoprotein Eb
chr7_-_30082931 0.56 ENSDART00000075600
tetraspanin 3b
chr20_-_48485354 0.56 ENSDART00000124040
ENSDART00000148437
insulinoma-associated 1a
chr23_+_36063599 0.55 ENSDART00000103147
homeobox C12a
chr14_+_46313135 0.53 ENSDART00000172902
crystallin, beta A1, like 1
chr22_+_16497670 0.53 ENSDART00000014330
immediate early response 5
chr20_+_45893173 0.52 ENSDART00000131169
bone morphogenetic protein 2b
chr6_-_60147517 0.52 ENSDART00000083453
solute carrier family 32 (GABA vesicular transporter), member 1
chr22_-_12160283 0.51 ENSDART00000146785
ENSDART00000128176
transmembrane protein 163b
chr18_-_21218851 0.51 ENSDART00000060160
calbindin 2a
chr14_+_24215046 0.51 ENSDART00000079215
stanniocalcin 2a
chr10_-_7988396 0.50 ENSDART00000141445
ENSDART00000024282
EWS RNA-binding protein 1a
chr23_-_21463788 0.49 ENSDART00000079265
hairy-related 4, tandem duplicate 4
chr7_+_49715750 0.49 ENSDART00000019446
achaete-scute family bHLH transcription factor 1b
chr20_+_34915945 0.48 ENSDART00000153064
synaptosomal-associated protein, 25a
chr7_-_73752955 0.48 ENSDART00000171254
ENSDART00000009888
calsequestrin 1b
chr21_-_42100471 0.47 ENSDART00000166148
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr19_+_42469058 0.47 ENSDART00000076915
si:dkey-166k12.1
chr6_-_24301324 0.46 ENSDART00000171401

chr16_+_20915319 0.46 ENSDART00000079383
homeobox A9b
chr21_+_6780340 0.45 ENSDART00000139493
ENSDART00000140478
olfactomedin 1b
chr14_+_35748385 0.44 ENSDART00000064617
ENSDART00000074671
ENSDART00000172803
glutamate receptor, ionotropic, AMPA 2b
chr6_+_42819337 0.44 ENSDART00000046498
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
chr4_+_8569199 0.44 ENSDART00000165181
wingless-type MMTV integration site family, member 5b
chr2_+_25019387 0.43 ENSDART00000142601
stromal antigen 1a
chr8_-_18239494 0.43 ENSDART00000079989
ENSDART00000022959
guanylate kinase 1b
chr11_+_3959495 0.43 ENSDART00000122953
guanine nucleotide binding protein-like 3 (nucleolar)
chr15_+_1148074 0.42 ENSDART00000152638
ENSDART00000152466
ENSDART00000188011
myeloid leukemia factor 1
chr18_+_17428506 0.41 ENSDART00000100223
zgc:91860
chr20_-_35246150 0.41 ENSDART00000090549
frizzled class receptor 3a
chr18_-_17020231 0.40 ENSDART00000129146
TBC1 domain family, member 15
chr2_-_42375275 0.39 ENSDART00000026339
GTP binding protein 4
chr5_+_4366431 0.39 ENSDART00000168560
ENSDART00000149185
spermidine/spermine N1-acetyltransferase 1a, duplicate 2
chr18_+_17428258 0.39 ENSDART00000010452
zgc:91860
chr3_+_32526263 0.39 ENSDART00000150897
si:ch73-367p23.2
chr8_-_25247284 0.39 ENSDART00000132697
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr20_-_147574 0.38 ENSDART00000104762
ENSDART00000131635
solute carrier family 16 (aromatic amino acid transporter), member 10
chr9_-_22281854 0.38 ENSDART00000146319
crystallin, gamma M2d3
chr7_-_40993456 0.37 ENSDART00000031700
engrailed homeobox 2a
chr1_-_22834824 0.37 ENSDART00000043556
LIM domain binding 2b
chr23_-_29824146 0.36 ENSDART00000020616
zgc:194189
chr14_-_32016615 0.36 ENSDART00000105761
zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)
chr3_+_28939759 0.36 ENSDART00000141904
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1
chr16_+_7154266 0.35 ENSDART00000168830
BMP binding endothelial regulator
chr14_+_36223097 0.35 ENSDART00000186872
paired-like homeodomain 2
chr6_-_10591607 0.35 ENSDART00000151376
dynein, axonemal, heavy polypeptide 9 like
chr25_+_37268900 0.35 ENSDART00000156737
si:dkey-234i14.6
chr1_-_50859053 0.35 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
chr3_+_54887782 0.35 ENSDART00000018205
arylalkylamine N-acetyltransferase 2
chr6_+_42818963 0.34 ENSDART00000184833
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
chr19_-_791016 0.34 ENSDART00000037515
misato 1, mitochondrial distribution and morphology regulator
chr8_-_23081511 0.34 ENSDART00000142015
ENSDART00000135764
ENSDART00000147021
si:dkey-70p6.1
chr12_+_47663419 0.34 ENSDART00000171932
hematopoietically expressed homeobox
chr1_+_7956030 0.33 ENSDART00000159655

chr7_-_30174882 0.33 ENSDART00000110409
FERM domain containing 5
chr1_-_35916247 0.33 ENSDART00000181541
SMAD family member 1
chr19_+_43119698 0.33 ENSDART00000167847
ENSDART00000186962
ENSDART00000187305
eukaryotic translation elongation factor 1 alpha 1, like 1
chr24_-_33756003 0.33 ENSDART00000079283
transmembrane protein with EGF-like and two follistatin-like domains 1b
chr23_+_21459263 0.32 ENSDART00000104209
hairy-related 4, tandem duplicate 3
chr10_+_17026870 0.32 ENSDART00000184529
ENSDART00000157480

chr3_+_20156956 0.32 ENSDART00000125281
nerve growth factor receptor a (TNFR superfamily, member 16)
chr25_-_6223567 0.32 ENSDART00000067512
proteasome subunit alpha 4
chr22_+_28446365 0.32 ENSDART00000189359
ABI family, member 3 (NESH) binding protein b
chr12_+_24342303 0.31 ENSDART00000111239
neurexin 1a
chr19_+_43563179 0.30 ENSDART00000151478
CD164 sialomucin-like 2
chr15_-_2652640 0.30 ENSDART00000146094
claudin f
chr1_+_45783886 0.30 ENSDART00000132555
protein kinase N1a
chr14_+_35748206 0.29 ENSDART00000177391
glutamate receptor, ionotropic, AMPA 2b
chr1_+_17376922 0.29 ENSDART00000145068
FAT atypical cadherin 1a
chr16_+_20895904 0.29 ENSDART00000052662
homeobox A13b
chr10_+_158590 0.29 ENSDART00000081982
potassium voltage-gated channel subfamily J member 15
chr14_-_30387894 0.28 ENSDART00000176136
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr6_+_22597362 0.28 ENSDART00000131242
cytoglobin 2
chr6_-_44711942 0.28 ENSDART00000055035
contactin 3b
chr17_-_17948587 0.28 ENSDART00000090447
HHIP-like 1
chr11_-_16975190 0.28 ENSDART00000122222
succinate-CoA ligase, GDP-forming, beta subunit
chr3_-_62380146 0.28 ENSDART00000155853
G protein-coupled receptor, class C, group 5, member Ba
chr18_-_44129151 0.28 ENSDART00000087339
cell adhesion associated, oncogene regulated
chr4_+_17417111 0.28 ENSDART00000056005
achaete-scute family bHLH transcription factor 1a
chr4_-_21652643 0.27 ENSDART00000066898
ribosomal protein S16
chr13_+_24662238 0.27 ENSDART00000014176
muscle segment homeobox 3
chr18_-_39583601 0.27 ENSDART00000125116
tumor necrosis factor, alpha-induced protein 8-like 3
chr4_-_211714 0.26 ENSDART00000172566
protein tyrosine phosphatase, receptor type, O
chr19_-_22346582 0.26 ENSDART00000045675
ENSDART00000169065
solute carrier family 52 (riboflavin transporter), member 2
zgc:109744
chr25_-_21092222 0.26 ENSDART00000154765
proline rich 5a (renal)
chr24_-_42090635 0.26 ENSDART00000166413
signal sequence receptor, alpha
chr2_+_29976419 0.26 ENSDART00000056748
engrailed homeobox 2b
chr9_-_22232902 0.26 ENSDART00000101845
crystallin, gamma M2d5
chr14_-_42231293 0.25 ENSDART00000185486

chr11_+_24900123 0.25 ENSDART00000044987
ENSDART00000148023
translocase of inner mitochondrial membrane 17 homolog A (yeast)
chr14_-_46675850 0.25 ENSDART00000113285
transmembrane anterior posterior transformation 1a
chr9_-_44295071 0.25 ENSDART00000011837
neuronal differentiation 1
chr22_-_94352 0.24 ENSDART00000184883
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr9_-_22240052 0.24 ENSDART00000111109
crystallin, gamma M2d9
chr9_+_41821613 0.24 ENSDART00000097295
collagen type XVIII alpha 1 chain a
chr19_+_31183495 0.24 ENSDART00000088618
mesenchyme homeobox 2b
chr13_+_281214 0.24 ENSDART00000137572
mitochondrial pyruvate carrier 1
chr22_-_17489040 0.24 ENSDART00000141286
si:ch211-197g15.6
chr20_+_32406011 0.23 ENSDART00000018640
ENSDART00000137910
sorting nexin 3
chr6_-_47953829 0.23 ENSDART00000157264
si:dkey-166d12.2
chr2_+_301898 0.23 ENSDART00000157246
zinc finger protein 1008
chr11_+_40032790 0.23 ENSDART00000158809
si:dkey-264d12.1
chr10_-_11012000 0.23 ENSDART00000132995
adenylate kinase 3
chr12_+_30200652 0.23 ENSDART00000193405
ENSDART00000132335
actin binding LIM protein 1b
chr5_-_61349059 0.22 ENSDART00000136553
si:ch211-209a2.2
chr21_-_30408775 0.22 ENSDART00000101037
NHP2 ribonucleoprotein homolog (yeast)
chr20_-_2949028 0.22 ENSDART00000104667
ENSDART00000193151
ENSDART00000131946
cyclin-dependent kinase 19
chr13_-_18637244 0.21 ENSDART00000057869
methionine adenosyltransferase I, alpha
chr4_+_36489448 0.21 ENSDART00000143181
zinc finger protein 1149
chr2_+_16160906 0.21 ENSDART00000135783
selenoprotein J
chr2_-_5505094 0.21 ENSDART00000145035
S-antigen; retina and pineal gland (arrestin) a
chr18_-_19103929 0.21 ENSDART00000188370
ENSDART00000177621
DENN/MADD domain containing 4A
chr20_-_54259780 0.20 ENSDART00000172631
FK506 binding protein 3
chr21_-_20711739 0.20 ENSDART00000190918

chr19_+_24882845 0.20 ENSDART00000010580
si:ch211-195b13.1
chr24_-_22702017 0.20 ENSDART00000179403
catenin (cadherin-associated protein), delta 2a
chr19_+_22850657 0.20 ENSDART00000130472
polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
chr18_+_40993369 0.20 ENSDART00000141162
si:dkey-283j8.1
chr5_+_36932718 0.20 ENSDART00000037879
cone-rod homeobox
chr13_-_37519774 0.20 ENSDART00000141420
ENSDART00000185478
sphingosine-1-phosphate phosphatase 1
chr19_+_19750101 0.20 ENSDART00000168041
ENSDART00000170697
homeobox A9a

chr14_-_8795081 0.20 ENSDART00000106671
transforming growth factor, beta 2, like
chr8_+_23213320 0.20 ENSDART00000032996
ENSDART00000137536
pancreatic progenitor cell differentiation and proliferation factor a
chr18_-_12052132 0.19 ENSDART00000074361
zgc:110789
chr3_+_1223824 0.19 ENSDART00000065922
WBP2 N-terminal like
chr24_+_2519761 0.19 ENSDART00000106619
neuritin 1a
chr19_-_35361556 0.19 ENSDART00000012167
NADH dehydrogenase (ubiquinone) Fe-S protein 5
chr11_+_25638172 0.19 ENSDART00000114226
ENSDART00000143677
glutamate receptor, metabotropic 6b
chr9_-_785444 0.19 ENSDART00000012506
engrailed homeobox 1a
chr7_+_54605640 0.19 ENSDART00000168474
fibroblast growth factor 3
chr6_-_38818582 0.19 ENSDART00000149833
cyclic nucleotide gated channel alpha 3a
chr25_+_3328487 0.19 ENSDART00000181143
lactate dehydrogenase Bb
chr19_+_6938289 0.19 ENSDART00000139122
ENSDART00000178832
flotillin 1b
chr4_-_31064584 0.18 ENSDART00000187247
ENSDART00000134357
ENSDART00000166459
si:dkey-11n14.1
chr12_+_30586599 0.18 ENSDART00000124920
ENSDART00000126984
nebulin-related anchoring protein
chr20_-_25486384 0.18 ENSDART00000141340
si:dkey-183n20.15
chr24_-_17023392 0.18 ENSDART00000106058
prostaglandin D2 synthase b, tandem duplicate 2
chr5_+_22677786 0.18 ENSDART00000142112
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr2_-_47904043 0.18 ENSDART00000185328
ENSDART00000126740
finTRIM family, member 22
chr2_-_9489611 0.18 ENSDART00000146715
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr19_+_7152966 0.18 ENSDART00000080348
bromodomain containing 2a
chr13_+_29771463 0.18 ENSDART00000134424
ENSDART00000138332
ENSDART00000134330
ENSDART00000160944
ENSDART00000076992
ENSDART00000160921
paired box 2a
chr7_+_67467702 0.18 ENSDART00000168460
ENSDART00000170322
ribosomal protein L13
chr17_-_23674495 0.18 ENSDART00000122209
phosphatase and tensin homolog A
chr10_-_41450367 0.18 ENSDART00000122682
ENSDART00000189549
calcium binding protein 1b
chr17_+_19499157 0.17 ENSDART00000077804
solute carrier family 22, member 15
chr12_+_42574148 0.17 ENSDART00000157855
early B cell factor 3a
chr2_-_10188598 0.17 ENSDART00000189122
diencephalon/mesencephalon homeobox 1a
chr15_-_36533322 0.17 ENSDART00000156466
ENSDART00000121755
si:dkey-262k9.4
chr2_+_6181383 0.17 ENSDART00000153307
si:ch73-344o19.1
chr13_+_4205724 0.17 ENSDART00000134105
delta-like 2 homolog (Drosophila)
chr4_-_5913338 0.17 ENSDART00000183590
ADP-ribosylation factor-like 1
chr8_+_40628926 0.17 ENSDART00000163598
dual specificity phosphatase 2
chr8_+_46536893 0.17 ENSDART00000124023
Pim proto-oncogene, serine/threonine kinase, related 187
chr2_-_31614277 0.17 ENSDART00000137054
ENSDART00000131507
ENSDART00000137674
ENSDART00000147041
si:ch211-106h4.5
chr16_-_560574 0.17 ENSDART00000148452
iroquois homeobox 2a
chr12_-_7655322 0.16 ENSDART00000181162
ankyrin 3b
chr1_-_54765262 0.16 ENSDART00000150362
si:ch211-197k17.3
chr24_-_38787457 0.16 ENSDART00000112318
ENSDART00000154461
netrin 2
chr4_+_5180650 0.16 ENSDART00000067390
fibroblast growth factor 6b
chr1_+_54766943 0.16 ENSDART00000144759
NLR family CARD domain containing 6
chr4_-_5912951 0.16 ENSDART00000169439
ADP-ribosylation factor-like 1
chr1_-_41192059 0.16 ENSDART00000084665
ENSDART00000135369
docking protein 7
chr25_+_37443194 0.16 ENSDART00000163178
ENSDART00000190262
solute carrier family 10, member 3
chr18_+_40993196 0.16 ENSDART00000115111
si:dkey-283j8.1
chr20_-_27733683 0.16 ENSDART00000103317
ENSDART00000138139
zgc:153157
chr9_+_32872690 0.16 ENSDART00000020798
si:dkey-145p14.5
chr10_-_6775271 0.16 ENSDART00000110735
zgc:194281
chr4_-_44611273 0.16 ENSDART00000156793
zinc finger protein 1115
chr1_-_30457062 0.15 ENSDART00000185318
ENSDART00000157924
ENSDART00000161380
insulin-like growth factor 2 mRNA binding protein 2b
chr11_-_15090564 0.15 ENSDART00000162079
solute carrier family 1 (glutamate transporter), member 8a
chr22_-_20105969 0.15 ENSDART00000088687
relaxin/insulin-like family peptide receptor 3.2b
chr19_+_19756425 0.15 ENSDART00000167606
homeobox A3a
chr12_+_19384615 0.15 ENSDART00000078266
ribosomal L1 domain containing 1
chr4_-_13921185 0.15 ENSDART00000143202
ENSDART00000080334
YY1 associated factor 2
chr4_-_68913650 0.15 ENSDART00000184297
si:dkey-264f17.5

Network of associatons between targets according to the STRING database.

First level regulatory network of hey2_hey1+heyl

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0071830 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.3 0.8 GO:0048389 intermediate mesoderm development(GO:0048389)
0.2 0.7 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.2 0.9 GO:0019626 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548)
0.2 0.6 GO:0003156 regulation of organ formation(GO:0003156)
0.2 0.5 GO:0090008 hypoblast development(GO:0090008)
0.2 0.5 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.5 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.1 0.5 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.1 0.6 GO:0006953 acute-phase response(GO:0006953)
0.1 0.4 GO:0006598 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.1 0.5 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.8 GO:0006567 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.1 0.4 GO:0008591 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591) positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.1 0.3 GO:0045938 positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 0.3 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.1 0.3 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 0.9 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.2 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.1 0.6 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.1 0.4 GO:0061072 iris morphogenesis(GO:0061072)
0.1 2.2 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 0.3 GO:0061549 sympathetic ganglion development(GO:0061549)
0.1 0.7 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.5 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 0.2 GO:0021985 neurohypophysis development(GO:0021985)
0.1 0.8 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 0.2 GO:1901890 positive regulation of cell junction assembly(GO:1901890)
0.1 0.2 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.7 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.1 0.7 GO:0014034 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.0 0.6 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.3 GO:0090467 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.0 0.6 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.0 0.3 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.6 GO:0021754 facial nucleus development(GO:0021754)
0.0 0.4 GO:0000467 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.0 0.2 GO:0007343 egg activation(GO:0007343)
0.0 0.4 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0019878 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.2 GO:0009136 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.0 0.2 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.0 0.8 GO:0043049 otic placode formation(GO:0043049)
0.0 0.7 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 0.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.1 GO:0002407 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0 0.1 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.0 0.1 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.0 0.0 GO:0009188 ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0 0.1 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.3 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.5 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.1 GO:0042245 RNA repair(GO:0042245)
0.0 0.1 GO:0071435 potassium ion export(GO:0071435) potassium ion export across plasma membrane(GO:0097623)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121) respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.2 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:0060017 parathyroid gland development(GO:0060017)
0.0 1.1 GO:0007602 phototransduction(GO:0007602)
0.0 0.2 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 0.1 GO:0034650 cortisol metabolic process(GO:0034650)
0.0 0.3 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.6 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.1 GO:0045124 regulation of bone resorption(GO:0045124)
0.0 0.1 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.3 GO:0048311 mitochondrion distribution(GO:0048311)
0.0 0.5 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.2 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.0 0.1 GO:0045905 positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.4 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.1 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.0 0.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.2 GO:0035778 pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014)
0.0 0.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.0 0.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.0 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471)
0.0 0.1 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.0 0.1 GO:0061015 RNA import into nucleus(GO:0006404) snRNA import into nucleus(GO:0061015)
0.0 0.0 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.1 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.1 GO:0052651 phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.1 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.1 GO:0001964 startle response(GO:0001964)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 1.9 GO:0007601 visual perception(GO:0007601)
0.0 0.5 GO:0021575 hindbrain morphogenesis(GO:0021575)
0.0 0.1 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 0.7 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 2.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.3 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.1 0.5 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 1.0 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.5 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.1 0.3 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 0.2 GO:0016600 flotillin complex(GO:0016600)
0.0 0.3 GO:0070062 extracellular exosome(GO:0070062)
0.0 0.8 GO:0042555 MCM complex(GO:0042555)
0.0 1.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.2 GO:0030904 retromer complex(GO:0030904)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.5 GO:0043195 terminal bouton(GO:0043195)
0.0 0.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.1 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.1 GO:0016586 RSC complex(GO:0016586)
0.0 0.5 GO:0032589 neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.6 GO:0005902 microvillus(GO:0005902)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.1 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.3 GO:0008278 cohesin complex(GO:0008278)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 0.8 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 0.7 GO:0004903 growth hormone receptor activity(GO:0004903)
0.2 0.9 GO:1990518 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.2 0.8 GO:0008743 L-threonine 3-dehydrogenase activity(GO:0008743)
0.1 0.6 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.4 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.1 0.4 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 0.3 GO:0004774 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.1 0.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.8 GO:0008263 mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.1 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 0.4 GO:0005035 death receptor activity(GO:0005035)
0.1 0.4 GO:0019809 spermidine binding(GO:0019809)
0.1 0.4 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.5 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.2 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.3 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.3 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.3 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.3 GO:0098809 nitrite reductase activity(GO:0098809)
0.0 0.5 GO:0015295 solute:proton symporter activity(GO:0015295)
0.0 0.2 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.0 0.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.4 GO:0016936 galactoside binding(GO:0016936)
0.0 0.5 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.1 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.2 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 0.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 0.2 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 1.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.9 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.1 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.1 GO:0034618 arginine binding(GO:0034618)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0035516 oxidative DNA demethylase activity(GO:0035516) DNA-N1-methyladenine dioxygenase activity(GO:0043734) RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.4 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.2 GO:0005222 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.6 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 1.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.0 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.0 0.1 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.0 0.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.0 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.0 0.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0008327 methyl-CpG binding(GO:0008327)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.4 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.3 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.2 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.5 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.5 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.1 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.6 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.4 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.1 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.1 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells