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PRJNA195909:zebrafish embryo and larva development

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Results for her6+her9

Z-value: 0.59

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Transcription factors associated with her6+her9

Gene Symbol Gene ID Gene Info
her6
ENSDARG00000006514 hairy-related 6
her9
ENSDARG00000056438 hairy-related 9
her6
ENSDARG00000111099 hairy-related 6
her9
ENSDARG00000115775 hairy-related 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
her9dr11_v1_chr23_-_23401305_23401305-0.963.4e-05Click!
her6dr11_v1_chr6_-_36552844_36552844-0.862.9e-03Click!

Activity profile of her6+her9 motif

Sorted Z-values of her6+her9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_77551860 2.07 ENSDART00000188176
AL935186.6

chr4_-_77563411 2.04 ENSDART00000186841
AL935186.8

chr20_-_16498991 1.58 ENSDART00000104137
ches1
checkpoint suppressor 1
chr12_+_48340133 1.48 ENSDART00000152899
ENSDART00000153335
ENSDART00000054788
ddit4
DNA-damage-inducible transcript 4
chr1_+_49955869 0.94 ENSDART00000150517
gstcd
glutathione S-transferase, C-terminal domain containing
chr16_+_48729947 0.94 ENSDART00000049051
brd2b
bromodomain containing 2b
chr7_-_6438544 0.91 ENSDART00000173180
zgc:165555
zgc:165555
chr13_-_24826607 0.90 ENSDART00000087786
ENSDART00000186951
slka
STE20-like kinase a
chr14_-_32520295 0.90 ENSDART00000165463
atp11c
ATPase phospholipid transporting 11C
chr7_+_24528430 0.85 ENSDART00000133022
si:dkeyp-75h12.2
si:dkeyp-75h12.2
chr9_+_500052 0.78 ENSDART00000166707
CU984600.1

chr19_-_35450661 0.78 ENSDART00000113574
ENSDART00000136895
anln
anillin, actin binding protein
chr4_+_68562464 0.75 ENSDART00000192954
BX548011.4

chr18_+_41772474 0.69 ENSDART00000097547
trpc6b
transient receptor potential cation channel, subfamily C, member 6b
chr8_+_36509885 0.67 ENSDART00000109530
slc7a4
solute carrier family 7, member 4
chr18_+_3169579 0.61 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr10_-_2942900 0.60 ENSDART00000002622
oclna
occludin a
chr5_-_12560569 0.59 ENSDART00000133587
wsb2
WD repeat and SOCS box containing 2
chr21_+_1647990 0.54 ENSDART00000148540
fech
ferrochelatase
chr5_-_29122834 0.54 ENSDART00000087197
whrnb
whirlin b
chr22_-_193234 0.52 ENSDART00000131067
fbxo42
F-box protein 42
chr18_-_14274803 0.51 ENSDART00000166643
mlycd
malonyl-CoA decarboxylase
chr11_-_12800945 0.50 ENSDART00000191178
txlng
taxilin gamma
chr5_-_54395488 0.49 ENSDART00000160781
zmynd19
zinc finger, MYND-type containing 19
chr11_-_12801157 0.48 ENSDART00000103449
txlng
taxilin gamma
chr13_+_35925490 0.48 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr20_-_6196989 0.48 ENSDART00000013343
b4galt6
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
chr23_+_36616717 0.44 ENSDART00000042701
ENSDART00000192980
pip4k2ca
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma a
chr24_+_39537565 0.44 ENSDART00000140868
ENSDART00000145358
si:dkey-161j23.5
si:dkey-161j23.5
chr5_+_1965296 0.39 ENSDART00000156224
dhx33
DEAH (Asp-Glu-Ala-His) box polypeptide 33
chr25_+_27744293 0.38 ENSDART00000103519
ENSDART00000149456
wasla
Wiskott-Aldrich syndrome-like a
chr8_+_12925385 0.38 ENSDART00000085377
KIF2A
zgc:103670
chr1_-_54107321 0.37 ENSDART00000148382
ENSDART00000150357
rfx1b
regulatory factor X, 1b (influences HLA class II expression)
chr5_-_29122615 0.35 ENSDART00000144802
whrnb
whirlin b
chr3_+_14641962 0.32 ENSDART00000091070
zgc:158403
zgc:158403
chr3_-_11828206 0.30 ENSDART00000018159
si:ch211-262e15.1
si:ch211-262e15.1
chr5_-_36916790 0.30 ENSDART00000143827
kptn
kaptin (actin binding protein)
chr25_-_21280584 0.29 ENSDART00000143644
tmem60
transmembrane protein 60
chr21_-_44731865 0.29 ENSDART00000013814
ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 homolog (human)
chr7_+_31374383 0.29 ENSDART00000085505
ctdspl2b
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2b
chr17_-_3986236 0.26 ENSDART00000188794
ENSDART00000160830
PLCB1
si:ch1073-140o9.2
chr3_-_8765165 0.25 ENSDART00000191131
CABZ01058333.1

chr7_+_17938128 0.25 ENSDART00000141044
mta2
metastasis associated 1 family, member 2
chr14_-_41075262 0.24 ENSDART00000180518
drp2
dystrophin related protein 2
chr20_-_40766387 0.23 ENSDART00000061173
hsdl1
hydroxysteroid dehydrogenase like 1
chr10_+_29138021 0.23 ENSDART00000025227
ENSDART00000123033
ENSDART00000034242
picalma
phosphatidylinositol binding clathrin assembly protein a
chr9_-_43538328 0.23 ENSDART00000140526
znf385b
zinc finger protein 385B
chr8_-_912821 0.15 ENSDART00000082296
ptger4a
prostaglandin E receptor 4 (subtype EP4) a
chr1_-_52461322 0.13 ENSDART00000083836
si:ch211-217k17.7
si:ch211-217k17.7
chr25_+_388258 0.10 ENSDART00000166834
rfx7b
regulatory factor X7b
chr23_-_6765653 0.10 ENSDART00000192310
FP102169.1

chr9_+_30213144 0.10 ENSDART00000139920
senp7a
SUMO1/sentrin specific peptidase 7a
chr12_+_19362335 0.09 ENSDART00000041711
gspt1
G1 to S phase transition 1
chr3_+_431208 0.07 ENSDART00000154296
ENSDART00000048733
si:ch73-308m11.1
si:dkey-167k11.5
si:ch73-308m11.1
si:dkey-167k11.5
chr13_-_45022527 0.07 ENSDART00000159021
khdrbs1a
KH domain containing, RNA binding, signal transduction associated 1a
chr12_+_36390422 0.07 ENSDART00000193826
galr2a
galanin receptor 2a
chr12_+_19362547 0.06 ENSDART00000180148
gspt1
G1 to S phase transition 1
chr3_-_58823762 0.04 ENSDART00000101253
luc7l3
LUC7-like 3 pre-mRNA splicing factor
chr4_+_332709 0.04 ENSDART00000067486
tulp4a
tubby like protein 4a
chr22_+_19311411 0.03 ENSDART00000133234
ENSDART00000138284
si:dkey-21e2.16
si:dkey-21e2.16
chr25_+_19954576 0.01 ENSDART00000149335
kcna1a
potassium voltage-gated channel, shaker-related subfamily, member 1a
chr14_+_12109535 0.01 ENSDART00000054620
ENSDART00000121913
kctd12b
potassium channel tetramerisation domain containing 12b

Network of associatons between targets according to the STRING database.

First level regulatory network of her6+her9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0008356 asymmetric cell division(GO:0008356)
0.1 0.5 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.5 GO:2001293 malonyl-CoA metabolic process(GO:2001293)
0.1 0.6 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 1.3 GO:0002574 thrombocyte differentiation(GO:0002574)
0.1 0.4 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.9 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 1.8 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.2 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.9 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.7 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.5 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.5 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.2 GO:1990402 embryonic liver development(GO:1990402)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.9 GO:0002142 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142) stereocilium tip(GO:0032426)
0.1 0.5 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0018444 translation release factor complex(GO:0018444)
0.0 0.2 GO:0098888 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.0 0.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 0.5 GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489)
0.1 0.4 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.2 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0004966 galanin receptor activity(GO:0004966)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 1.0 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 0.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases