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PRJNA195909:zebrafish embryo and larva development
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Results for her1+her11+her5_her12+her15.1+her15.2+her2+her4.1+her4.2+her4.3+her4.4
Z-value: 1.28
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Transcription factors associated with her1+her11+her5_her12+her15.1+her15.2+her2+her4.1+her4.2+her4.3+her4.4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
her11
|
ENSDARG00000002707 | hairy-related 11 |
|
her5
|
ENSDARG00000008796 | hairy-related 5 |
|
her1
|
ENSDARG00000014722 | hairy-related 1 |
|
her4.4
|
ENSDARG00000009822 | hairy-related 4, tandem duplicate 4 |
|
her12
|
ENSDARG00000032963 | hairy-related 12 |
|
her2
|
ENSDARG00000038205 | hairy-related 2 |
|
her15.2
|
ENSDARG00000054560 | hairy and enhancer of split-related 15, tandem duplicate 2 |
|
her15.1
|
ENSDARG00000054562 | hairy and enhancer of split-related 15, tandem duplicate 1 |
|
her4.2
|
ENSDARG00000056729 | hairy-related 4, tandem duplicate 2 |
|
her4.1
|
ENSDARG00000056732 | hairy-related 4, tandem duplicate 1 |
|
her4.3
|
ENSDARG00000070770 | hairy-related 4, tandem duplicate 3 |
|
her4.2
|
ENSDARG00000094426 | hairy-related 4, tandem duplicate 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| her4.1 | dr11_v1_chr23_-_21453614_21453614 | 0.95 | 1.1e-04 | Click! |
| her4.2 | dr11_v1_chr23_-_21471022_21471022 | 0.94 | 1.5e-04 | Click! |
| her4.3 | dr11_v1_chr23_+_21459263_21459263 | 0.93 | 2.2e-04 | Click! |
| her4.4 | dr11_v1_chr23_-_21463788_21463788 | 0.93 | 3.5e-04 | Click! |
| her2 | dr11_v1_chr11_-_41966854_41966854 | 0.86 | 3.1e-03 | Click! |
| her15.1 | dr11_v1_chr11_+_41981959_41981959 | 0.85 | 3.3e-03 | Click! |
| her15.2 | dr11_v1_chr11_-_41996957_41996957 | 0.85 | 3.5e-03 | Click! |
| her12 | dr11_v1_chr23_-_21446985_21446985 | 0.83 | 5.2e-03 | Click! |
| her11 | dr11_v1_chr14_-_30540967_30540967 | -0.72 | 3.0e-02 | Click! |
| her5 | dr11_v1_chr14_+_30543008_30543008 | -0.68 | 4.2e-02 | Click! |
| her1 | dr11_v1_chr5_-_68795063_68795063 | -0.46 | 2.2e-01 | Click! |
Activity profile of her1+her11+her5_her12+her15.1+her15.2+her2+her4.1+her4.2+her4.3+her4.4 motif
Sorted Z-values of her1+her11+her5_her12+her15.1+her15.2+her2+her4.1+her4.2+her4.3+her4.4 motif
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_-_45069882 | 5.35 |
ENSDART00000058384
|
gapdhs
|
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic |
| chr23_+_21459263 | 4.48 |
ENSDART00000104209
|
her4.3
|
hairy-related 4, tandem duplicate 3 |
| chr14_+_46313135 | 4.44 |
ENSDART00000172902
|
cryba1l1
|
crystallin, beta A1, like 1 |
| chr9_-_44295071 | 4.10 |
ENSDART00000011837
|
neurod1
|
neuronal differentiation 1 |
| chr23_-_21463788 | 3.85 |
ENSDART00000079265
|
her4.4
|
hairy-related 4, tandem duplicate 4 |
| chr6_-_60147517 | 3.80 |
ENSDART00000083453
|
slc32a1
|
solute carrier family 32 (GABA vesicular transporter), member 1 |
| chr7_-_40993456 | 3.05 |
ENSDART00000031700
|
en2a
|
engrailed homeobox 2a |
| chr2_+_29976419 | 2.68 |
ENSDART00000056748
|
en2b
|
engrailed homeobox 2b |
| chr19_+_31183495 | 2.19 |
ENSDART00000088618
|
meox2b
|
mesenchyme homeobox 2b |
| chr10_+_158590 | 2.12 |
ENSDART00000081982
|
KCNJ15
|
potassium voltage-gated channel subfamily J member 15 |
| chr8_+_29593986 | 2.12 |
ENSDART00000077642
|
atoh1a
|
atonal bHLH transcription factor 1a |
| chr14_+_46313396 | 1.83 |
ENSDART00000047525
|
cryba1l1
|
crystallin, beta A1, like 1 |
| chr14_-_30387894 | 1.39 |
ENSDART00000176136
|
slc7a2
|
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 |
| chr6_+_39184236 | 1.35 |
ENSDART00000156187
|
tac3b
|
tachykinin 3b |
| chr10_-_27566481 | 1.03 |
ENSDART00000078920
|
auts2a
|
autism susceptibility candidate 2a |
| chr5_-_46329880 | 0.93 |
ENSDART00000156577
|
si:ch211-130m23.5
|
si:ch211-130m23.5 |
| chr15_-_14469704 | 0.91 |
ENSDART00000185077
|
numbl
|
numb homolog (Drosophila)-like |
| chr19_+_42470396 | 0.72 |
ENSDART00000191679
|
si:dkey-166k12.1
|
si:dkey-166k12.1 |
| chr5_-_45894802 | 0.59 |
ENSDART00000097648
|
crfb6
|
cytokine receptor family member b6 |
| chr8_+_21146262 | 0.55 |
ENSDART00000045684
|
porcn
|
porcupine O-acyltransferase |
| chr8_+_39760258 | 0.55 |
ENSDART00000037914
|
cox6a1
|
cytochrome c oxidase subunit VIa polypeptide 1 |
| chr14_+_14836468 | 0.48 |
ENSDART00000166728
|
si:dkey-102m7.3
|
si:dkey-102m7.3 |
| chr19_-_35596207 | 0.42 |
ENSDART00000136811
|
col8a2
|
collagen, type VIII, alpha 2 |
| chr19_+_42469058 | 0.39 |
ENSDART00000076915
|
si:dkey-166k12.1
|
si:dkey-166k12.1 |
| chr12_+_30046320 | 0.37 |
ENSDART00000179904
ENSDART00000153394 |
ablim1b
|
actin binding LIM protein 1b |
| chr3_-_6441619 | 0.32 |
ENSDART00000157771
ENSDART00000166758 |
sumo2b
|
small ubiquitin-like modifier 2b |
| chr10_+_17026870 | 0.29 |
ENSDART00000184529
ENSDART00000157480 |
CR855996.2
|
|
| chr20_-_27733683 | 0.28 |
ENSDART00000103317
ENSDART00000138139 |
zgc:153157
|
zgc:153157 |
| chr24_-_42090635 | 0.27 |
ENSDART00000166413
|
ssr1
|
signal sequence receptor, alpha |
| chr3_+_23029934 | 0.26 |
ENSDART00000110343
|
nags
|
N-acetylglutamate synthase |
| chr1_+_5576151 | 0.22 |
ENSDART00000109756
|
cpo
|
carboxypeptidase O |
| chr11_-_3959889 | 0.21 |
ENSDART00000159683
|
pbrm1
|
polybromo 1 |
| chr23_-_31969786 | 0.20 |
ENSDART00000134550
|
ormdl2
|
ORMDL sphingolipid biosynthesis regulator 2 |
| chr20_-_39344116 | 0.16 |
ENSDART00000037282
|
ccdc25
|
coiled-coil domain containing 25 |
| chr11_+_3959495 | 0.13 |
ENSDART00000122953
|
gnl3
|
guanine nucleotide binding protein-like 3 (nucleolar) |
| chr12_+_33038757 | 0.12 |
ENSDART00000153146
|
rbfox3a
|
RNA binding fox-1 homolog 3a |
| chr11_-_3959477 | 0.09 |
ENSDART00000045971
|
pbrm1
|
polybromo 1 |
| chr9_+_3283608 | 0.08 |
ENSDART00000192275
|
hat1
|
histone acetyltransferase 1 |
| chr18_+_30370339 | 0.06 |
ENSDART00000158871
|
gse1
|
Gse1 coiled-coil protein |
| chr9_+_45789887 | 0.06 |
ENSDART00000135202
|
si:dkey-34f9.3
|
si:dkey-34f9.3 |
| chr18_+_30370559 | 0.04 |
ENSDART00000165450
|
gse1
|
Gse1 coiled-coil protein |
| chr16_-_4026265 | 0.04 |
ENSDART00000149339
|
si:ch211-175f12.2
|
si:ch211-175f12.2 |
| chr5_+_62723233 | 0.02 |
ENSDART00000183718
|
nanos2
|
nanos homolog 2 |
| chr8_-_39760427 | 0.01 |
ENSDART00000184336
ENSDART00000186500 |
si:ch211-170d8.8
|
si:ch211-170d8.8 |
Network of associatons between targets according to the STRING database.
First level regulatory network of her1+her11+her5_her12+her15.1+her15.2+her2+her4.1+her4.2+her4.3+her4.4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.1 | GO:0009912 | auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120) |
| 0.5 | 3.8 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.4 | 8.3 | GO:0048936 | peripheral nervous system neuron axonogenesis(GO:0048936) |
| 0.3 | 1.4 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.3 | 4.1 | GO:0048923 | posterior lateral line neuromast hair cell differentiation(GO:0048923) |
| 0.3 | 3.1 | GO:0060385 | axonogenesis involved in innervation(GO:0060385) |
| 0.2 | 1.4 | GO:1903400 | L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826) |
| 0.2 | 0.6 | GO:0061355 | Wnt protein secretion(GO:0061355) |
| 0.1 | 5.3 | GO:0006096 | glycolytic process(GO:0006096) |
| 0.1 | 0.3 | GO:0006526 | arginine biosynthetic process(GO:0006526) |
| 0.1 | 0.2 | GO:1905038 | regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303) |
| 0.0 | 6.3 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.0 | 2.7 | GO:0030901 | midbrain development(GO:0030901) |
| 0.0 | 0.6 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 1.0 | GO:0021884 | forebrain neuron development(GO:0021884) |
| 0.0 | 0.9 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.0 | 0.4 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.0 | 0.1 | GO:0000459 | exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467) |
| 0.0 | 0.3 | GO:0016925 | protein sumoylation(GO:0016925) |
| 0.0 | 2.2 | GO:0061053 | somite development(GO:0061053) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.8 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 0.2 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.0 | 0.6 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 0.3 | GO:0016586 | RSC complex(GO:0016586) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 5.3 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.3 | 3.8 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.2 | 1.4 | GO:0015189 | L-lysine transmembrane transporter activity(GO:0015189) |
| 0.1 | 0.3 | GO:0034618 | arginine binding(GO:0034618) |
| 0.1 | 6.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 13.9 | GO:0046983 | protein dimerization activity(GO:0046983) |
| 0.0 | 0.3 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 0.6 | GO:0016675 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.6 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.0 | 0.3 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.4 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.8 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.3 | 5.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 4.1 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 2.1 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 1.4 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |