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PRJNA195909:zebrafish embryo and larva development
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Results for gsx2+pnx
Z-value: 1.92
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Transcription factors associated with gsx2+pnx
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| gsx2 | dr11_v1_chr20_-_22484621_22484621 | 0.85 | 3.9e-03 | Click! |
| pnx | dr11_v1_chr10_+_2799285_2799285 | 0.05 | 8.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_22310919 Show fit | 7.17 |
ENSDART00000108719
|
crystallin, gamma M2d10 |
|
| chr25_+_31277415 Show fit | 5.41 |
ENSDART00000036275
|
troponin I type 2a (skeletal, fast), tandem duplicate 4 |
|
| chr21_+_26390549 Show fit | 4.22 |
ENSDART00000185643
|
thymosin, beta |
|
| chr20_+_26966725 Show fit | 3.77 |
ENSDART00000029781
|
AHA1, activator of heat shock protein ATPase homolog 1a |
|
| chr25_+_31276842 Show fit | 3.40 |
ENSDART00000187238
|
troponin I type 2a (skeletal, fast), tandem duplicate 4 |
|
| chr14_-_4145594 Show fit | 3.16 |
ENSDART00000077348
|
caspase 3, apoptosis-related cysteine peptidase b |
|
| chr25_+_29160102 Show fit | 2.99 |
ENSDART00000162854
|
pyruvate kinase M1/2b |
|
| chr15_-_12011390 Show fit | 2.87 |
ENSDART00000187403
|
si:dkey-202l22.6 |
|
| chr16_+_31804590 Show fit | 2.72 |
ENSDART00000167321
|
wingless-type MMTV integration site family, member 4b |
|
| chr11_+_38280454 Show fit | 2.69 |
ENSDART00000171496
|
si:dkey-166c18.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of gsx2+pnx
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.3 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 7.7 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.1 | 4.5 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 1.1 | 4.2 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.1 | 3.9 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 0.3 | 3.8 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
| 0.2 | 3.2 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
| 0.0 | 3.0 | GO:0032869 | cellular response to insulin stimulus(GO:0032869) |
| 0.0 | 3.0 | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742) |
| 0.1 | 2.7 | GO:0045839 | negative regulation of mitotic nuclear division(GO:0045839) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 13.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 4.5 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 3.3 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.1 | 3.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 2.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 2.5 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.1 | 2.3 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.1 | 2.3 | GO:1902711 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.1 | 2.2 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 9.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 4.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 4.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 4.2 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 4.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 4.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 3.2 | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153) |
| 0.2 | 3.1 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.5 | 3.0 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 1.9 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 1.9 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 1.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.4 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 1.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.1 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.9 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 0.8 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 3.5 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.3 | 3.3 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 2.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 1.7 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.7 | REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
| 0.0 | 1.7 | REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.1 | 1.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 1.2 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 0.9 | REACTOME EARLY PHASE OF HIV LIFE CYCLE | Genes involved in Early Phase of HIV Life Cycle |