ISMARA results: gata1b+gata2a

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PRJNA195909:zebrafish embryo and larva development

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Results for gata1b+gata2a

Z-value: 3.40

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Transcription factors associated with gata1b+gata2a

Gene Symbol	Gene ID	Gene Info
gata1b NCBI UniProt	ENSDARG00000059130	GATA binding protein 1b
gata2a NCBI UniProt	ENSDARG00000059327	GATA binding protein 2a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
gata1b	dr11_v1_chr8_-_7474997_7474997	0.76	1.6e-02	Click!
gata2a	dr11_v1_chr11_-_3865472_3865472	0.51	1.6e-01	Click!

Activity profile of gata1b+gata2a motif

Sorted Z-values of gata1b+gata2a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_20350629 Show fit	7.96	ENSDART00000066384	hbbe2 NCBI UniProt Show fit	hemoglobin beta embryonic-2
chr14_-_25949713 Show fit	7.83	ENSDART00000181455	sparc NCBI UniProt Show fit	secreted protein, acidic, cysteine-rich (osteonectin)
chr23_-_23401305 Show fit	7.62	ENSDART00000078936	her9 NCBI UniProt Show fit	hairy-related 9
chr25_+_21829777 Show fit	7.44	ENSDART00000027393	ckmt1 NCBI UniProt Show fit	creatine kinase, mitochondrial 1
chr14_-_25949951 Show fit	6.70	ENSDART00000141304	sparc NCBI UniProt Show fit	secreted protein, acidic, cysteine-rich (osteonectin)
chr19_+_7567763 Show fit	6.21	ENSDART00000140411	s100a11 NCBI UniProt Show fit	S100 calcium binding protein A11
chr1_+_25848231 Show fit	5.88	ENSDART00000027973	fabp2 NCBI UniProt Show fit	fatty acid binding protein 2, intestinal
chr1_-_45636362 Show fit	5.87	ENSDART00000181757	sept3 NCBI UniProt Show fit	septin 3
chr7_-_51102479 Show fit	5.85	ENSDART00000174023	col4a6 NCBI UniProt Show fit	collagen, type IV, alpha 6
chr20_+_15552657 Show fit	5.75	ENSDART00000063912	jun NCBI UniProt Show fit	Jun proto-oncogene, AP-1 transcription factor subunit

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of gata1b+gata2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	16.5	GO:0032474	otolith morphogenesis(GO:0032474)
2.0	11.8	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
0.0	11.6	GO:0006397	mRNA processing(GO:0006397)
0.2	10.8	GO:0018298	protein-chromophore linkage(GO:0018298)
1.4	8.4	GO:0038065	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.4	8.2	GO:0015671	oxygen transport(GO:0015671)
0.1	7.7	GO:0050768	negative regulation of neurogenesis(GO:0050768)
0.6	7.4	GO:0006603	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
1.4	7.2	GO:0001773	myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
0.0	5.8	GO:0007626	locomotory behavior(GO:0007626)

Showing 1 to 10 of 102 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	48.7	GO:0005576	extracellular region(GO:0005576)
0.2	9.9	GO:0043204	perikaryon(GO:0043204)
1.4	8.4	GO:0098645	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.7	8.2	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	8.1	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.0	6.6	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.2	6.3	GO:0005861	troponin complex(GO:0005861)
0.2	5.9	GO:0099569	presynaptic cytoskeleton(GO:0099569)
0.1	5.1	GO:0031941	filamentous actin(GO:0031941)
0.7	5.0	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)

Showing 1 to 10 of 38 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	14.5	GO:0005518	collagen binding(GO:0005518)
0.0	13.7	GO:0046983	protein dimerization activity(GO:0046983)
0.1	10.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	9.1	GO:0008013	beta-catenin binding(GO:0008013)
0.1	8.6	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.7	8.2	GO:0031720	haptoglobin binding(GO:0031720)
0.3	7.7	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.6	7.4	GO:0004111	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.0	6.7	GO:0042803	protein homodimerization activity(GO:0042803)
0.4	6.0	GO:0008266	poly(U) RNA binding(GO:0008266)

Showing 1 to 10 of 89 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	13.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	8.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	8.4	NABA COLLAGENS	Genes encoding collagen proteins
0.7	5.9	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	5.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	3.9	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	3.8	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	3.7	PID ENDOTHELIN PATHWAY	Endothelins
0.2	3.3	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.1	2.8	PID CDC42 PATHWAY	CDC42 signaling events

Showing 1 to 10 of 17 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	16.4	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.2	8.4	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	7.2	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.4	6.6	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.6	5.7	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	4.4	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2	4.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.4	3.8	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2	3.8	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	3.7	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors

Showing 1 to 10 of 28 entries

Results for gata1b+gata2a

Z-value: 3.40

Motif logo

Transcription factors associated with gata1b+gata2a

Activity-expression correlation:

Activity profile of gata1b+gata2a motif

Sorted Z-values of gata1b+gata2a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of gata1b+gata2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: