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PRJNA195909:zebrafish embryo and larva development
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Results for foxo4
Z-value: 1.91
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Transcription factors associated with foxo4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxo4 | dr11_v1_chr14_+_30910114_30910114 | 0.47 | 2.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_33207367 Show fit | 4.03 |
ENSDART00000146138
ENSDART00000109667 ENSDART00000182741 |
thyroid hormone receptor interactor 11 |
|
| chr14_+_15155684 Show fit | 3.97 |
ENSDART00000167966
|
zgc:158852 |
|
| chr15_+_19990068 Show fit | 3.71 |
ENSDART00000154033
ENSDART00000054428 |
zgc:112083 |
|
| chr5_-_33236637 Show fit | 3.68 |
ENSDART00000085512
ENSDART00000144694 |
KN motif and ankyrin repeat domains 1b |
|
| chr22_-_28777557 Show fit | 3.04 |
ENSDART00000135214
ENSDART00000131761 ENSDART00000005112 |
si:dkeyp-34c12.1 |
|
| chr10_+_33744098 Show fit | 2.87 |
ENSDART00000147775
|
relaxin/insulin-like family peptide receptor 2a |
|
| chr16_+_31511739 Show fit | 2.80 |
ENSDART00000049420
|
N-myc downstream regulated 1b |
|
| chr22_+_38276024 Show fit | 2.79 |
ENSDART00000143792
|
REST corepressor 3 |
|
| chr6_+_38626926 Show fit | 2.72 |
ENSDART00000190339
|
ATPase phospholipid transporting 10A |
|
| chr8_+_37749263 Show fit | 2.61 |
ENSDART00000108556
ENSDART00000147942 |
nucleophosmin/nucleoplasmin, 2a |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxo4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.4 | GO:0032272 | negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272) |
| 0.1 | 4.8 | GO:0044744 | protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593) |
| 0.1 | 4.4 | GO:0045332 | phospholipid translocation(GO:0045332) |
| 0.3 | 4.2 | GO:0045762 | activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762) |
| 0.0 | 4.0 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.1 | 3.5 | GO:0016575 | histone deacetylation(GO:0016575) |
| 0.1 | 3.3 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
| 0.5 | 3.2 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
| 0.0 | 3.1 | GO:0009953 | dorsal/ventral pattern formation(GO:0009953) |
| 0.1 | 3.0 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 5.9 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 3.6 | GO:0005819 | spindle(GO:0005819) |
| 0.0 | 3.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 3.2 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 3.2 | GO:0036464 | cytoplasmic ribonucleoprotein granule(GO:0036464) |
| 0.0 | 3.2 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 2.8 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.1 | 2.6 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.6 | 2.5 | GO:0097134 | cyclin E1-CDK2 complex(GO:0097134) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.9 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 5.9 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 4.6 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 4.2 | GO:0008528 | G-protein coupled peptide receptor activity(GO:0008528) |
| 0.0 | 3.9 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 3.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 3.1 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 3.1 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 3.0 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 3.0 | GO:0004386 | helicase activity(GO:0004386) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.2 | 2.7 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.2 | 2.5 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 2.2 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 1.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 1.6 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 1.3 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.2 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 1.1 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 1.1 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 3.3 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 2.6 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 0.2 | 2.5 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 2.5 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 2.3 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.1 | 2.3 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.1 | 2.2 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 2.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 2.0 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |