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PRJNA195909:zebrafish embryo and larva development
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Results for foxo3b+foxo6a+foxo6b
Z-value: 1.37
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Transcription factors associated with foxo3b+foxo6a+foxo6b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxo6b | dr11_v1_chr19_+_15571290_15571290 | -0.84 | 4.7e-03 | Click! |
| foxo3b | dr11_v1_chr20_-_32332736_32332736 | -0.76 | 1.7e-02 | Click! |
| foxo6a | dr11_v1_chr16_-_7362806_7362806 | -0.44 | 2.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_25753972 Show fit | 2.20 |
ENSDART00000188417
|
|
|
| chr23_+_28322986 Show fit | 2.14 |
ENSDART00000134710
|
baculoviral IAP repeat containing 5b |
|
| chr15_+_38299385 Show fit | 2.01 |
ENSDART00000142403
|
si:dkey-24p1.6 |
|
| chr15_+_38299563 Show fit | 1.87 |
ENSDART00000099375
|
si:dkey-24p1.6 |
|
| chr5_-_17876709 Show fit | 1.78 |
ENSDART00000141978
|
si:dkey-112e17.1 |
|
| chr4_-_12781182 Show fit | 1.76 |
ENSDART00000058020
|
helicase (DNA) B |
|
| chr6_-_41138854 Show fit | 1.52 |
ENSDART00000128723
ENSDART00000151055 ENSDART00000132484 |
solute carrier family 6 member 22, tandem duplicate 1 |
|
| chr10_-_25570647 Show fit | 1.46 |
ENSDART00000134215
|
glutamate receptor, ionotropic, kainate 1a |
|
| chr7_+_69449814 Show fit | 1.46 |
ENSDART00000109644
|
CTD nuclear envelope phosphatase 1b |
|
| chr21_-_17037907 Show fit | 1.35 |
ENSDART00000101263
|
ubiquitin-conjugating enzyme E2G 1b (UBC7 homolog, yeast) |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxo3b+foxo6a+foxo6b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.9 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077) |
| 0.7 | 2.1 | GO:0000212 | meiotic spindle organization(GO:0000212) |
| 0.2 | 2.1 | GO:0090308 | methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.0 | 2.0 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 0.4 | 1.8 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.3 | 1.5 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867) |
| 0.0 | 1.5 | GO:0035249 | synaptic transmission, glutamatergic(GO:0035249) |
| 0.1 | 1.3 | GO:0070475 | rRNA base methylation(GO:0070475) |
| 0.1 | 1.2 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.0 | 1.2 | GO:0001757 | somite specification(GO:0001757) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | GO:0005730 | nucleolus(GO:0005730) |
| 0.6 | 2.9 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.0 | 2.1 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 2.0 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.3 | 1.5 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.1 | 1.1 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.1 | 1.1 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.2 | 0.9 | GO:0061673 | mitotic spindle astral microtubule(GO:0061673) |
| 0.2 | 0.9 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.0 | 0.9 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | GO:0043028 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028) |
| 0.2 | 1.8 | GO:0043142 | single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142) |
| 0.0 | 1.8 | GO:0008173 | RNA methyltransferase activity(GO:0008173) |
| 0.1 | 1.7 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.1 | 1.5 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 0.0 | 1.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 1.4 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.4 | 1.3 | GO:0016434 | rRNA (cytosine) methyltransferase activity(GO:0016434) |
| 0.4 | 1.1 | GO:0034618 | arginine binding(GO:0034618) |
| 0.2 | 1.1 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 0.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.6 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 0.6 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.4 | PID NECTIN PATHWAY | Nectin adhesion pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 1.0 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.1 | 0.9 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.9 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.7 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.7 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.1 | 0.6 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 0.6 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |