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PRJNA195909:zebrafish embryo and larva development
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Results for foxd2_foxd5
Z-value: 1.30
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Transcription factors associated with foxd2_foxd5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxd2 | dr11_v1_chr8_+_19674369_19674369 | 0.84 | 5.0e-03 | Click! |
| foxd5 | dr11_v1_chr8_+_30452945_30452945 | 0.28 | 4.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_12013043 Show fit | 3.54 |
ENSDART00000130692
|
cryptochrome circadian clock 1aa |
|
| chr14_+_21107032 Show fit | 2.91 |
ENSDART00000138319
ENSDART00000139103 ENSDART00000184735 |
aldolase b, fructose-bisphosphate |
|
| chr22_-_17595310 Show fit | 2.76 |
ENSDART00000099056
|
glutathione peroxidase 4a |
|
| chr14_+_11458044 Show fit | 2.66 |
ENSDART00000186425
|
si:ch211-153b23.5 |
|
| chr14_+_11457500 Show fit | 2.58 |
ENSDART00000169202
|
si:ch211-153b23.5 |
|
| chr8_-_16697615 Show fit | 2.58 |
ENSDART00000187929
|
retinal pigment epithelium-specific protein 65b |
|
| chr3_+_36424055 Show fit | 2.46 |
ENSDART00000170318
|
si:ch1073-443f11.2 |
|
| chr6_+_2097690 Show fit | 2.44 |
ENSDART00000193770
|
transglutaminase 2b |
|
| chr16_+_11724230 Show fit | 2.41 |
ENSDART00000060266
|
carcinoembryonic antigen-related cell adhesion molecule 1 |
|
| chr8_+_16004551 Show fit | 2.26 |
ENSDART00000165141
|
ELAV like neuron-specific RNA binding protein 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxd2_foxd5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | GO:0006914 | autophagy(GO:0006914) |
| 0.1 | 3.3 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.0 | 2.9 | GO:0006979 | response to oxidative stress(GO:0006979) |
| 0.6 | 2.6 | GO:1901827 | tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827) |
| 0.0 | 2.6 | GO:0072175 | epithelial tube formation(GO:0072175) |
| 0.1 | 2.4 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.7 | 2.0 | GO:0048785 | hatching gland development(GO:0048785) |
| 0.1 | 1.9 | GO:0014823 | response to activity(GO:0014823) |
| 0.0 | 1.9 | GO:0007599 | hemostasis(GO:0007599) |
| 0.4 | 1.8 | GO:0032616 | interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 1.9 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.8 | GO:0005901 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.0 | 1.7 | GO:0016459 | myosin complex(GO:0016459) |
| 0.2 | 1.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 1.5 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 1.4 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.1 | 1.4 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.1 | 1.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 1.2 | GO:0000118 | histone deacetylase complex(GO:0000118) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.2 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.6 | 2.8 | GO:0047066 | phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066) |
| 0.6 | 2.6 | GO:0052885 | retinol isomerase activity(GO:0050251) all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity(GO:0052885) |
| 0.0 | 2.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 2.4 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 2.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.1 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.5 | 1.8 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.3 | 1.8 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.3 | 1.8 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 1.7 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 1.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 1.4 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 1.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.1 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 0.9 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 0.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 2.9 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 2.2 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 2.0 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 1.8 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 1.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.2 | 1.7 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 1.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 1.4 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 1.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |