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PRJNA195909:zebrafish embryo and larva development
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Results for foxb1b+foxb2
Z-value: 2.44
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Transcription factors associated with foxb1b+foxb2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxb1b | dr11_v1_chr7_+_29461060_29461060 | -0.61 | 8.3e-02 | Click! |
| foxb2 | dr11_v1_chr8_-_38506339_38506339 | -0.32 | 4.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_37749263 Show fit | 4.88 |
ENSDART00000108556
ENSDART00000147942 |
nucleophosmin/nucleoplasmin, 2a |
|
| chr11_-_6452444 Show fit | 4.59 |
ENSDART00000137879
ENSDART00000134957 ENSDART00000004483 |
La ribonucleoprotein domain family, member 6b |
|
| chr9_-_8314028 Show fit | 4.58 |
ENSDART00000102739
|
si:ch211-145c1.1 |
|
| chr5_-_33236637 Show fit | 4.46 |
ENSDART00000085512
ENSDART00000144694 |
KN motif and ankyrin repeat domains 1b |
|
| chr23_+_44236281 Show fit | 3.72 |
ENSDART00000149842
|
si:ch1073-157b13.1 |
|
| chr14_+_15155684 Show fit | 3.63 |
ENSDART00000167966
|
zgc:158852 |
|
| chr5_-_17876709 Show fit | 3.43 |
ENSDART00000141978
|
si:dkey-112e17.1 |
|
| chr16_-_47381519 Show fit | 3.36 |
ENSDART00000032188
ENSDART00000150136 |
si:dkey-256h2.1 |
|
| chr12_+_2648043 Show fit | 3.19 |
ENSDART00000082220
|
growth differentiation factor 2 |
|
| chr8_-_25771474 Show fit | 3.12 |
ENSDART00000193883
|
suppressor of variegation 3-9 homolog 1b |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxb1b+foxb2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.1 | 5.3 | GO:0000281 | mitotic cytokinesis(GO:0000281) |
| 0.1 | 4.8 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
| 0.1 | 4.2 | GO:0034968 | histone lysine methylation(GO:0034968) |
| 0.2 | 3.9 | GO:0035268 | protein mannosylation(GO:0035268) mannosylation(GO:0097502) |
| 0.2 | 3.9 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 0.0 | 3.8 | GO:0032272 | negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272) |
| 0.6 | 3.5 | GO:0035092 | spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 0.2 | 3.5 | GO:0008078 | mesodermal cell migration(GO:0008078) |
| 0.1 | 3.5 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.0 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 6.8 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 5.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 4.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 3.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 3.9 | GO:1990904 | ribonucleoprotein complex(GO:1990904) |
| 0.0 | 3.6 | GO:0036464 | cytoplasmic ribonucleoprotein granule(GO:0036464) |
| 0.9 | 3.5 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 3.5 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 3.4 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 6.6 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 6.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 5.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 5.6 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 5.3 | GO:0016887 | ATPase activity(GO:0016887) |
| 0.0 | 4.8 | GO:0101005 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 4.5 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 4.4 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 0.2 | 3.9 | GO:0015377 | cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.2 | 3.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.2 | 2.8 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 2.8 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 2.6 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.1 | 2.4 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 2.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 2.2 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 2.2 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 2.2 | PID RHOA PATHWAY | RhoA signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 4.8 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 3.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.1 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 2.8 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 2.7 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 2.5 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 2.4 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 2.3 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 2.2 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |