ISMARA results: foxa_foxa1

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PRJNA195909:zebrafish embryo and larva development

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Results for foxa_foxa1_foxa2

Z-value: 1.55

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Transcription factors associated with foxa_foxa1_foxa2

Gene Symbol	Gene ID	Gene Info
foxa NCBI UniProt	ENSDARG00000087094	forkhead box A sequence
foxa NCBI UniProt	ENSDARG00000110743	forkhead box A sequence
foxa NCBI UniProt	ENSDARG00000115019	forkhead box A sequence
foxa1 NCBI UniProt	ENSDARG00000102138	forkhead box A1
foxa2 NCBI UniProt	ENSDARG00000003411	forkhead box A2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
foxa1	dr11_v1_chr17_+_10318071_10318071	0.93	3.2e-04	Click!
foxa	dr11_v1_chr14_-_33981544_33981544	-0.88	1.8e-03	Click!
foxa2	dr11_v1_chr17_-_42568498_42568498	0.60	9.0e-02	Click!

Activity profile of foxa_foxa1_foxa2 motif

Sorted Z-values of foxa_foxa1_foxa2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_31616412 Show fit	4.84	ENSDART00000124439	cpn1 NCBI UniProt Show fit	carboxypeptidase N, polypeptide 1
chr9_+_53725294 Show fit	3.66	ENSDART00000165991	cnmd NCBI UniProt Show fit	chondromodulin
chr5_+_49744713 Show fit	3.64	ENSDART00000133384	nr2f1a NCBI UniProt Show fit	nuclear receptor subfamily 2, group F, member 1a
chr9_+_53725128 Show fit	3.55	ENSDART00000169062	cnmd NCBI UniProt Show fit	chondromodulin
chr16_-_21785261 Show fit	3.20	ENSDART00000078858	si:ch73-86n18.1 NCBI UniProt Show fit	si:ch73-86n18.1
chr3_-_50863370 Show fit	3.00	ENSDART00000169771 ENSDART00000165083	pmp22a NCBI UniProt Show fit	peripheral myelin protein 22a
chr16_+_23978978 Show fit	2.91	ENSDART00000058964 ENSDART00000135084	apoa2 NCBI UniProt Show fit	apolipoprotein A-II
chr15_-_18138607 Show fit	2.85	ENSDART00000176690	CR385077.1 NCBI UniProt Show fit
chr4_+_17417111 Show fit	2.80	ENSDART00000056005	ascl1a NCBI UniProt Show fit	achaete-scute family bHLH transcription factor 1a
chr6_+_24817852 Show fit	2.57	ENSDART00000165609	barhl2 NCBI UniProt Show fit	BarH-like homeobox 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of foxa_foxa1_foxa2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	7.2	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.1	4.6	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.4	3.6	GO:0055011	atrial cardiac muscle cell differentiation(GO:0055011)
0.9	3.5	GO:0010226	response to lithium ion(GO:0010226)
1.0	3.0	GO:0021530	spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.3	2.9	GO:0019731	antibacterial humoral response(GO:0019731)
0.7	2.8	GO:0061549	sympathetic ganglion development(GO:0061549)
0.1	2.3	GO:0097320	membrane tubulation(GO:0097320)
0.0	2.2	GO:0055113	epiboly involved in gastrulation with mouth forming second(GO:0055113)
0.4	2.1	GO:0071800	podosome assembly(GO:0071800)

Showing 1 to 10 of 155 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	29.1	GO:0005576	extracellular region(GO:0005576)
0.0	6.0	GO:0005667	transcription factor complex(GO:0005667)
0.9	3.5	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	2.6	GO:0055037	recycling endosome(GO:0055037)
0.0	2.4	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1	2.3	GO:0031012	extracellular matrix(GO:0031012)
0.1	2.2	GO:0031672	A band(GO:0031672)
0.3	2.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	1.8	GO:0044853	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0	1.7	GO:0030141	secretory granule(GO:0030141)

Showing 1 to 10 of 61 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	20.2	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0	6.5	GO:0046983	protein dimerization activity(GO:0046983)
0.0	4.9	GO:0051015	actin filament binding(GO:0051015)
0.2	4.8	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.1	3.9	GO:0008013	beta-catenin binding(GO:0008013)
0.0	3.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	3.2	GO:0030246	carbohydrate binding(GO:0030246)
0.0	2.7	GO:0004879	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0	2.3	GO:0030414	peptidase inhibitor activity(GO:0030414)
0.0	2.1	GO:0005179	hormone activity(GO:0005179)

Showing 1 to 10 of 105 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.5	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	2.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	1.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	1.2	PID NOTCH PATHWAY	Notch signaling pathway
0.1	1.1	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	1.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	1.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.8	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions

Showing 1 to 10 of 22 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.9	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.2	2.9	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.1	1.6	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	1.5	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	1.5	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	1.4	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.1	1.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	1.2	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.1	1.1	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.2	1.0	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules

Showing 1 to 10 of 37 entries

Results for foxa_foxa1_foxa2

Z-value: 1.55

Motif logo

Transcription factors associated with foxa_foxa1_foxa2

Activity-expression correlation:

Activity profile of foxa_foxa1_foxa2 motif

Sorted Z-values of foxa_foxa1_foxa2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of foxa_foxa1_foxa2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: