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PRJNA195909:zebrafish embryo and larva development
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Results for ets2
Z-value: 1.23
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Transcription factors associated with ets2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ets2 | dr11_v1_chr10_+_187760_187764 | 0.51 | 1.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_50135492 Show fit | 2.00 |
ENSDART00000149398
|
si:ch73-132k15.2 |
|
| chr12_-_4301234 Show fit | 1.99 |
ENSDART00000152377
ENSDART00000152521 |
carbonic anhydrase XVb |
|
| chr12_-_42368296 Show fit | 1.77 |
ENSDART00000171075
|
zgc:111868 |
|
| chr11_+_18037729 Show fit | 1.68 |
ENSDART00000111624
|
zgc:175135 |
|
| chr7_+_24153070 Show fit | 1.64 |
ENSDART00000076735
|
low density lipoprotein receptor-related protein 10 |
|
| chr20_-_164300 Show fit | 1.62 |
ENSDART00000183354
|
si:ch211-241j12.3 |
|
| chr20_+_54312970 Show fit | 1.60 |
ENSDART00000024598
ENSDART00000193172 |
zona pellucida glycoprotein 2, tandem duplicate 5 |
|
| chr20_+_27087539 Show fit | 1.59 |
ENSDART00000062094
|
transmembrane protein 251 |
|
| chr20_+_54304800 Show fit | 1.59 |
ENSDART00000121661
|
zona pellucida glycoprotein 2, tandem duplicate 6 |
|
| chr14_-_897874 Show fit | 1.52 |
ENSDART00000167395
|
regulator of G protein signaling 14a |
Network of associatons between targets according to the STRING database.
First level regulatory network of ets2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.4 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.1 | 4.0 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 3.1 | GO:0048545 | response to steroid hormone(GO:0048545) |
| 0.1 | 2.9 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 0.4 | 2.0 | GO:0051792 | medium-chain fatty acid biosynthetic process(GO:0051792) |
| 0.3 | 1.9 | GO:1990511 | piRNA biosynthetic process(GO:1990511) |
| 0.1 | 1.9 | GO:0006301 | postreplication repair(GO:0006301) |
| 0.1 | 1.9 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.0 | 1.9 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.0 | 1.7 | GO:0030178 | negative regulation of Wnt signaling pathway(GO:0030178) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 3.9 | GO:0005769 | early endosome(GO:0005769) |
| 0.5 | 2.0 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.1 | 1.8 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 1.6 | GO:0048179 | activin receptor complex(GO:0048179) |
| 0.1 | 1.6 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 1.6 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.1 | 1.4 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.0 | 1.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 1.3 | GO:0031228 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.6 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.2 | 2.9 | GO:0031729 | CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729) |
| 0.1 | 2.7 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.2 | 2.6 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 2.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.2 | 2.2 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.3 | 2.0 | GO:0008126 | acetylesterase activity(GO:0008126) |
| 0.1 | 2.0 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 2.0 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 2.0 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 1.5 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 1.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 1.4 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 1.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 1.2 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.0 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 0.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.9 | PID BARD1 PATHWAY | BARD1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 1.9 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.2 | 1.8 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.4 | 1.5 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 1.4 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 0.0 | 1.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 1.2 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 1.2 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 1.0 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 1.0 | REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |