ISMARA results: esrrd+esrrga_esrrb

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PRJNA195909:zebrafish embryo and larva development

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Results for esrrd+esrrga_esrrb_esrra+esrrgb

Z-value: 1.78

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Transcription factors associated with esrrd+esrrga_esrrb_esrra+esrrgb

Gene Symbol	Gene ID	Gene Info
esrrga NCBI UniProt	ENSDARG00000004861	estrogen-related receptor gamma a
esrrd NCBI UniProt	ENSDARG00000015064	estrogen-related receptor delta
esrrb NCBI UniProt	ENSDARG00000100847	estrogen-related receptor beta
esrrgb NCBI UniProt	ENSDARG00000011696	estrogen-related receptor gamma b
esrra NCBI UniProt	ENSDARG00000069266	estrogen-related receptor alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
esrrgb	dr11_v1_chr20_-_46817223_46817223	0.91	7.8e-04	Click!
esrrb	dr11_v1_chr17_+_52300018_52300018	0.90	9.5e-04	Click!
esrra	dr11_v1_chr21_+_26612777_26612777	-0.29	4.6e-01	Click!
esrrd	dr11_v1_chr18_-_48992363_48992363	-0.23	5.6e-01	Click!

Activity profile of esrrd+esrrga_esrrb_esrra+esrrgb motif

Sorted Z-values of esrrd+esrrga_esrrb_esrra+esrrgb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_45338073 Show fit	3.42	ENSDART00000185024	pabpc1l NCBI UniProt Show fit	poly(A) binding protein, cytoplasmic 1-like
chr14_-_35892767 Show fit	3.19	ENSDART00000052648	tmem144b NCBI UniProt Show fit	transmembrane protein 144b
chr22_+_25720725 Show fit	2.47	ENSDART00000150778	si:dkeyp-98a7.8 NCBI UniProt Show fit	si:dkeyp-98a7.8
chr5_-_37103487 Show fit	2.44	ENSDART00000149211	il13ra2 NCBI UniProt Show fit	interleukin 13 receptor, alpha 2
chr3_-_45250924 Show fit	2.33	ENSDART00000109017	usp31 NCBI UniProt Show fit	ubiquitin specific peptidase 31
chr2_+_30032303 Show fit	2.19	ENSDART00000151841	rbm33b NCBI UniProt Show fit	RNA binding motif protein 33b
chr1_-_55262763 Show fit	2.18	ENSDART00000152769	si:ch211-286b5.4 NCBI UniProt Show fit	si:ch211-286b5.4
chr22_+_34784075 Show fit	2.12	ENSDART00000167538	lcor NCBI UniProt Show fit	ligand dependent nuclear receptor corepressor
chr16_+_50741154 Show fit	2.08	ENSDART00000101627	IGLON5 NCBI UniProt Show fit	zgc:110372
chr6_-_4214297 Show fit	1.95	ENSDART00000191433	trak2 NCBI UniProt Show fit	trafficking protein, kinesin binding 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of esrrd+esrrga_esrrb_esrra+esrrgb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.2	GO:0048545	response to steroid hormone(GO:0048545)
0.8	3.2	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.7	2.8	GO:0019242	methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1	2.6	GO:1902287	semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0	2.4	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
0.0	2.4	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.1	2.3	GO:0009250	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2	2.2	GO:0006382	adenosine to inosine editing(GO:0006382)
0.1	2.1	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.3	2.0	GO:0098957	anterograde axonal transport of mitochondrion(GO:0098957)

Showing 1 to 10 of 203 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.5	GO:0031901	early endosome membrane(GO:0031901)
0.0	3.5	GO:0005730	nucleolus(GO:0005730)
0.0	3.4	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1	3.1	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	2.6	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	2.6	GO:0030424	axon(GO:0030424)
0.0	2.5	GO:0005769	early endosome(GO:0005769)
0.0	2.4	GO:0009897	external side of plasma membrane(GO:0009897)
0.1	1.8	GO:0048179	activin receptor complex(GO:0048179)
0.2	1.6	GO:0030877	beta-catenin destruction complex(GO:0030877)

Showing 1 to 10 of 78 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.4	GO:0008266	poly(U) RNA binding(GO:0008266)
0.1	3.1	GO:0015144	carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0	3.0	GO:0008081	phosphoric diester hydrolase activity(GO:0008081)
0.0	2.9	GO:0019955	cytokine binding(GO:0019955)
0.7	2.8	GO:0004807	triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.0	2.8	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1	2.6	GO:0017154	semaphorin receptor activity(GO:0017154)
0.2	2.5	GO:0031726	CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.1	2.5	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.5	2.2	GO:0003844	1,4-alpha-glucan branching enzyme activity(GO:0003844)

Showing 1 to 10 of 146 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.4	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	2.3	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.1	2.1	PID AURORA B PATHWAY	Aurora B signaling
0.0	1.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	1.4	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	1.3	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.1	1.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	1.0	PID FOXO PATHWAY	FoxO family signaling
0.0	1.0	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.1	0.9	ST STAT3 PATHWAY	STAT3 Pathway

Showing 1 to 10 of 26 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.1	REACTOME G PROTEIN BETA GAMMA SIGNALLING	Genes involved in G-protein beta:gamma signalling
0.0	2.1	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	1.8	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	1.7	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	1.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	1.2	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.1	1.0	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	1.0	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.1	0.9	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	0.9	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis

Showing 1 to 10 of 50 entries

Results for esrrd+esrrga_esrrb_esrra+esrrgb

Z-value: 1.78

Motif logo

Transcription factors associated with esrrd+esrrga_esrrb_esrra+esrrgb

Activity-expression correlation:

Activity profile of esrrd+esrrga_esrrb_esrra+esrrgb motif

Sorted Z-values of esrrd+esrrga_esrrb_esrra+esrrgb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of esrrd+esrrga_esrrb_esrra+esrrgb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: