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PRJNA195909:zebrafish embryo and larva development
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Results for esr1+esr2a+esr2b
Z-value: 2.50
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Transcription factors associated with esr1+esr2a+esr2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| esr1 | dr11_v1_chr20_-_26383368_26383375 | 0.89 | 1.4e-03 | Click! |
| esr2b | dr11_v1_chr13_+_37022601_37022632 | 0.83 | 5.5e-03 | Click! |
| esr2a | dr11_v1_chr20_+_21583639_21583639 | -0.72 | 2.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_44027391 Show fit | 9.55 |
ENSDART00000145404
|
crystallin, beta B1 |
|
| chr12_-_43685802 Show fit | 5.06 |
ENSDART00000170723
|
zgc:112964 |
|
| chr9_-_22310919 Show fit | 4.60 |
ENSDART00000108719
|
crystallin, gamma M2d10 |
|
| chr5_-_71722257 Show fit | 4.07 |
ENSDART00000013404
|
adenylate kinase 1 |
|
| chr19_-_5332784 Show fit | 3.82 |
ENSDART00000010373
|
keratin, type 1, gene 19d |
|
| chr10_+_9561066 Show fit | 3.66 |
ENSDART00000136281
|
si:ch211-243g18.2 |
|
| chr7_+_20017211 Show fit | 3.64 |
ENSDART00000100808
|
B-cell CLL/lymphoma 6, member B |
|
| chr23_+_44741500 Show fit | 3.53 |
ENSDART00000166421
|
ATPase Na+/K+ transporting subunit beta 2a |
|
| chr9_-_22240052 Show fit | 3.44 |
ENSDART00000111109
|
crystallin, gamma M2d9 |
|
| chr10_-_29900546 Show fit | 3.44 |
ENSDART00000147441
|
lens intrinsic membrane protein 2.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of esr1+esr2a+esr2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 46.4 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.1 | 7.5 | GO:0002040 | sprouting angiogenesis(GO:0002040) |
| 0.1 | 6.1 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 0.0 | 5.9 | GO:0043062 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.1 | 5.2 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.1 | 5.0 | GO:0030865 | cortical cytoskeleton organization(GO:0030865) |
| 0.3 | 4.4 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.6 | 4.1 | GO:0009180 | ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) |
| 0.4 | 4.1 | GO:0006797 | polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798) |
| 0.1 | 3.6 | GO:0060840 | artery development(GO:0060840) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 49.3 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 20.4 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 10.6 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 8.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 7.9 | GO:0030017 | sarcomere(GO:0030017) |
| 0.1 | 5.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 4.2 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 4.1 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.3 | 3.9 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.4 | 3.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 47.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 15.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 9.7 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 9.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.6 | 5.9 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.1 | 5.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 5.0 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 4.4 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.3 | 4.3 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.3 | 4.2 | GO:0031682 | G-protein gamma-subunit binding(GO:0031682) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.1 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.0 | 6.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 3.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.8 | NABA MATRISOME | Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins |
| 0.1 | 2.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.0 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 1.6 | ST G ALPHA S PATHWAY | G alpha s Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 6.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 4.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 3.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 2.8 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.2 | 2.7 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.0 | 2.2 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 2.1 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 2.0 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 1.8 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |