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PRJNA195909:zebrafish embryo and larva development

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Results for eomesa

Z-value: 2.00

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Transcription factors associated with eomesa

Gene Symbol Gene ID Gene Info
eomesa
ENSDARG00000006640 eomesodermin homolog a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
eomesadr11_v1_chr19_-_868187_8681870.941.7e-04Click!

Activity profile of eomesa motif

Sorted Z-values of eomesa motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_19596214 6.26 ENSDART00000183110
CABZ01059626.1

chr10_-_25217347 4.63 ENSDART00000036906
kpna7
karyopherin alpha 7 (importin alpha 8)
chr15_-_35112937 4.28 ENSDART00000154565
ENSDART00000099642
zgc:77118
zgc:77118
chr19_-_867071 4.20 ENSDART00000122257
eomesa
eomesodermin homolog a
chr19_-_27564458 4.20 ENSDART00000123155
si:dkeyp-46h3.6
si:dkeyp-46h3.6
chr10_+_19595009 3.92 ENSDART00000112276
zgc:173837
zgc:173837
chr22_+_25693295 3.81 ENSDART00000123888
ENSDART00000150783
si:dkeyp-98a7.4
si:dkeyp-98a7.3
si:dkeyp-98a7.4
si:dkeyp-98a7.3
chr22_+_25715925 3.79 ENSDART00000150650
si:dkeyp-98a7.7
si:dkeyp-98a7.7
chr22_+_25687525 3.76 ENSDART00000135717
si:dkeyp-98a7.3
si:dkeyp-98a7.3
chr22_+_25681911 3.75 ENSDART00000113381
si:dkeyp-98a7.3
si:dkeyp-98a7.3
chr22_+_25704430 3.73 ENSDART00000143776
si:dkeyp-98a7.3
si:dkeyp-98a7.3
chr22_+_25753972 3.44 ENSDART00000188417
AL929192.2

chr11_-_1550709 3.25 ENSDART00000110097
si:ch73-303b9.1
si:ch73-303b9.1
chr22_+_25774750 3.20 ENSDART00000174421
AL929192.1

chr2_-_57469115 3.14 ENSDART00000192201
pias4b
protein inhibitor of activated STAT, 4b
chr22_+_25274712 2.86 ENSDART00000137341
BX950205.1

chr5_+_62319217 2.75 ENSDART00000050879
pho
phoenix
chr22_+_25352530 2.69 ENSDART00000176742
ENSDART00000113186
si:dkey-240e12.6
si:dkey-240e12.6
chr5_+_37749503 2.66 ENSDART00000148586
dpf2
D4, zinc and double PHD fingers family 2
chr18_-_20444296 2.61 ENSDART00000132993
kif23
kinesin family member 23
chr15_-_35126632 2.49 ENSDART00000187324
ENSDART00000037389
zgc:77118
zgc:55413
zgc:77118
zgc:55413
chr1_+_29741843 2.40 ENSDART00000136066
raph1b
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b
chr23_+_37579107 2.28 ENSDART00000169376
plekhg5b
pleckstrin homology domain containing, family G (with RhoGef domain) member 5b
chr15_-_45538773 2.25 ENSDART00000113494
MB21D2
Mab-21 domain containing 2
chr11_-_13341051 2.23 ENSDART00000121872
mast3b
microtubule associated serine/threonine kinase 3b
chr17_-_27048537 2.08 ENSDART00000050018
ENSDART00000193861
cnksr1
connector enhancer of kinase suppressor of Ras 1
chr12_-_628024 1.86 ENSDART00000158563
ENSDART00000152612
wu:fj29h11
si:ch73-301j1.1
wu:fj29h11
si:ch73-301j1.1
chr18_+_6641542 1.85 ENSDART00000160379
c2cd5
C2 calcium-dependent domain containing 5
chr5_-_16475374 1.84 ENSDART00000134274
ENSDART00000136004
piwil2
piwi-like RNA-mediated gene silencing 2
chr17_-_29312506 1.82 ENSDART00000133668
tecpr2
tectonin beta-propeller repeat containing 2
chr17_+_23554932 1.78 ENSDART00000135814
pank1a
pantothenate kinase 1a
chr14_+_49231776 1.66 ENSDART00000169096
rmnd5b
required for meiotic nuclear division 5 homolog B
chr7_-_1101694 1.62 ENSDART00000183017
ENSDART00000182681
dctn1a
dynactin 1a
chr1_-_55750208 1.57 ENSDART00000142244
dnajb1b
DnaJ (Hsp40) homolog, subfamily B, member 1b
chr10_+_16225553 1.55 ENSDART00000129844
slc12a2
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
chr1_-_56951369 1.54 ENSDART00000152294
si:ch211-1f22.2
si:ch211-1f22.2
chr22_-_6066867 1.53 ENSDART00000142383
si:dkey-19a16.1
si:dkey-19a16.1
chr10_+_16225870 1.49 ENSDART00000164647
slc12a2
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
chr1_-_45042210 1.48 ENSDART00000073694
smu1b
SMU1, DNA replication regulator and spliceosomal factor b
chr20_-_32007209 1.45 ENSDART00000021575
adgb
androglobin
chr1_-_40015782 1.44 ENSDART00000157425
ENSDART00000159238
cdk2ap2
cyclin-dependent kinase 2 associated protein 2
chr22_-_3564563 1.39 ENSDART00000145114
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr5_+_37379825 1.36 ENSDART00000171826
klhl13
kelch-like family member 13
chr15_+_22448456 1.35 ENSDART00000040542
ENSDART00000190270
ENSDART00000185897
arhgef12a
Rho guanine nucleotide exchange factor (GEF) 12a
chr5_+_31036911 1.31 ENSDART00000141463
ENSDART00000162121
zzef1
zinc finger, ZZ-type with EF hand domain 1
chr3_+_37083765 1.30 ENSDART00000125611
retreg3
reticulophagy regulator family member 3
chr4_+_77948517 1.29 ENSDART00000149305
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr11_-_40504170 1.26 ENSDART00000165394
si:dkeyp-61b2.1
si:dkeyp-61b2.1
chr14_-_470505 1.23 ENSDART00000067147
ANKRD50
ankyrin repeat domain 50
chr2_-_42393590 1.15 ENSDART00000135529
slco5a1b
solute carrier organic anion transporter family member 5A1b
chr1_-_40016058 1.10 ENSDART00000165373
cdk2ap2
cyclin-dependent kinase 2 associated protein 2
chr18_+_5618368 1.09 ENSDART00000159945
ulk3
unc-51 like kinase 3
chr10_-_9115383 1.08 ENSDART00000139324
si:dkeyp-41f9.3
si:dkeyp-41f9.3
chr15_-_3940671 1.00 ENSDART00000189741
mindy4b
MINDY family member 4B
chr16_+_25107344 0.98 ENSDART00000033211
zgc:66448
zgc:66448
chr22_-_9896180 0.96 ENSDART00000138343
znf990
zinc finger protein 990
chr4_+_77948970 0.93 ENSDART00000149636
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr22_-_14475927 0.93 ENSDART00000135768
lrp1ba
low density lipoprotein receptor-related protein 1Ba
chr21_-_14815952 0.92 ENSDART00000134278
ENSDART00000067004
phpt1
phosphohistidine phosphatase 1
chr13_+_33703784 0.90 ENSDART00000173361
macrod2
MACRO domain containing 2
chr12_-_17424162 0.87 ENSDART00000079144
ENSDART00000079138
ptenb
phosphatase and tensin homolog B
chr13_-_51952020 0.84 ENSDART00000181079
LT631676.1

chr7_+_9981757 0.82 ENSDART00000113429
ENSDART00000173233
adamts17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr24_-_36196077 0.77 ENSDART00000154395
esco1
establishment of sister chromatid cohesion N-acetyltransferase 1
chr6_-_15641686 0.77 ENSDART00000135583
mlpha
melanophilin a
chr19_-_81851 0.76 ENSDART00000172319
hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr15_-_1584137 0.75 ENSDART00000056772
trim59
tripartite motif containing 59
chr22_+_39096911 0.75 ENSDART00000157127
ENSDART00000153841
lmcd1
LIM and cysteine-rich domains 1
chr1_-_57129179 0.74 ENSDART00000157226
ENSDART00000152469
si:ch73-94k4.2
si:ch73-94k4.2
chr7_-_5396154 0.70 ENSDART00000172980
arhgef11
Rho guanine nucleotide exchange factor (GEF) 11
chr18_-_50921002 0.69 ENSDART00000017053
ENSDART00000008696
cttn
cortactin
chr9_-_12885201 0.68 ENSDART00000124957
ankzf1
ankyrin repeat and zinc finger domain containing 1
chr23_+_24957008 0.61 ENSDART00000181069
nol9
nucleolar protein 9
chr2_+_35240485 0.58 ENSDART00000179804
tnr
tenascin R (restrictin, janusin)
chr5_+_32007627 0.57 ENSDART00000183061
scai
suppressor of cancer cell invasion
chr7_+_30493684 0.52 ENSDART00000027466
mindy2
MINDY lysine 48 deubiquitinase 2
chr23_+_4362463 0.49 ENSDART00000039829
zgc:112175
zgc:112175
chr6_+_22025806 0.44 ENSDART00000151240
ZXDC
si:dkey-156n14.3
chr25_+_32071558 0.44 ENSDART00000155992
tjp1b
tight junction protein 1b
chr5_+_13647288 0.44 ENSDART00000099660
ENSDART00000139199
h2afva
H2A histone family, member Va
chr22_-_5252005 0.43 ENSDART00000132942
ENSDART00000081801
ncln
nicalin
chr23_-_31648026 0.42 ENSDART00000133569
sgk1
serum/glucocorticoid regulated kinase 1
chr7_+_21887787 0.41 ENSDART00000162252
pop7
POP7 homolog, ribonuclease P/MRP subunit
chr11_+_14312260 0.40 ENSDART00000102518
si:ch211-262i1.5
si:ch211-262i1.5
chr23_-_31647793 0.38 ENSDART00000145621
sgk1
serum/glucocorticoid regulated kinase 1
chr24_-_24060460 0.36 ENSDART00000142813
abcc13
ATP-binding cassette, sub-family C (CFTR/MRP), member 13
chr22_-_36690742 0.35 ENSDART00000017188
ENSDART00000124698
ncl
nucleolin
chr20_-_14665002 0.34 ENSDART00000152816
scrn2
secernin 2
chr13_-_280827 0.30 ENSDART00000144819
slc30a6
solute carrier family 30 (zinc transporter), member 6
chr9_+_56449505 0.29 ENSDART00000187725
CABZ01079480.1

chr7_+_27691647 0.28 ENSDART00000079091
cyp2r1
cytochrome P450, family 2, subfamily R, polypeptide 1
chr10_-_28193642 0.27 ENSDART00000019050
rps6kb1a
ribosomal protein S6 kinase b, polypeptide 1a
chr2_+_22592139 0.26 ENSDART00000130603
ENSDART00000126891
sept2
septin 2
chr8_-_43158486 0.26 ENSDART00000134801
ccdc92
coiled-coil domain containing 92
chr9_+_44721808 0.24 ENSDART00000190578
nckap1
NCK-associated protein 1
chr13_-_49586255 0.23 ENSDART00000190813
tomm20a
translocase of outer mitochondrial membrane 20
chr2_+_37838259 0.19 ENSDART00000136796
parp2
poly (ADP-ribose) polymerase 2
chr4_-_77624155 0.16 ENSDART00000099761
si:ch211-250m6.7
si:ch211-250m6.7
chr15_+_28940352 0.15 ENSDART00000154085
gipr
gastric inhibitory polypeptide receptor
chr20_-_35052464 0.15 ENSDART00000037195
kif26bb
kinesin family member 26Bb
chr22_+_26263290 0.14 ENSDART00000184840
BX649315.1

chr12_-_10421955 0.11 ENSDART00000052004
zgc:153595
zgc:153595
chr25_-_17852944 0.11 ENSDART00000155169
si:ch211-176l24.4
si:ch211-176l24.4
chr22_+_17531214 0.10 ENSDART00000161174
ENSDART00000088356
hnrnpm
heterogeneous nuclear ribonucleoprotein M
chr22_+_17531020 0.10 ENSDART00000137689
hnrnpm
heterogeneous nuclear ribonucleoprotein M
chr4_+_10721795 0.06 ENSDART00000136000
ENSDART00000067253
stab2
stabilin 2
chr12_-_25380028 0.05 ENSDART00000142674
zfp36l2
zinc finger protein 36, C3H type-like 2
chr17_-_33416020 0.05 ENSDART00000140149
ccdc28a
coiled-coil domain containing 28A
chr5_-_67762434 0.04 ENSDART00000167301
b4galt4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
chr10_+_26612321 0.02 ENSDART00000134322
fhl1b
four and a half LIM domains 1b
chr1_-_8966046 0.00 ENSDART00000136198
socs1b
suppressor of cytokine signaling 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of eomesa

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0060571 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.5 1.8 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.4 4.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.4 2.6 GO:0040016 embryonic cleavage(GO:0040016)
0.4 1.8 GO:0010828 positive regulation of glucose transport(GO:0010828)
0.3 0.9 GO:0035971 peptidyl-histidine dephosphorylation(GO:0035971)
0.3 0.8 GO:0034421 post-translational protein acetylation(GO:0034421)
0.2 3.0 GO:0048798 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.2 2.2 GO:0001765 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.2 0.8 GO:0051876 pigment granule dispersal(GO:0051876)
0.2 0.9 GO:0031174 lifelong otolith mineralization(GO:0031174)
0.2 0.6 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.1 0.4 GO:0016264 gap junction assembly(GO:0016264)
0.1 2.7 GO:0070654 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.1 1.3 GO:0061709 reticulophagy(GO:0061709)
0.1 1.8 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 1.6 GO:0008105 asymmetric protein localization(GO:0008105) apical protein localization(GO:0045176)
0.1 3.1 GO:0016925 protein sumoylation(GO:0016925)
0.1 1.4 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.1 0.4 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.1 1.5 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 0.2 GO:0010610 regulation of mRNA stability involved in response to stress(GO:0010610) regulation of mRNA stability involved in response to oxidative stress(GO:2000815)
0.0 1.6 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.3 GO:0070640 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.0 2.3 GO:0043534 blood vessel endothelial cell migration(GO:0043534)
0.0 0.4 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.4 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.7 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 1.8 GO:0030865 cortical cytoskeleton organization(GO:0030865)
0.0 0.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 3.3 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.1 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:1990923 PET complex(GO:1990923)
0.3 1.7 GO:0034657 GID complex(GO:0034657)
0.2 2.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 2.7 GO:0071565 nBAF complex(GO:0071565)
0.1 2.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 1.6 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.5 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 2.0 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.9 GO:0016605 PML body(GO:0016605)
0.0 2.6 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.2 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.0 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.3 1.8 GO:0004594 pantothenate kinase activity(GO:0004594)
0.3 4.6 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.3 1.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.2 3.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.2 1.8 GO:0034584 piRNA binding(GO:0034584)
0.2 0.9 GO:0101006 protein histidine phosphatase activity(GO:0101006)
0.2 0.9 GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.1 1.6 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 25.7 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.6 GO:0051731 polynucleotide 5'-hydroxyl-kinase activity(GO:0051731)
0.1 0.3 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.1 0.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.2 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.0 2.8 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.3 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.8 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.8 GO:0017022 myosin binding(GO:0017022)
0.0 0.2 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 2.2 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.6 GO:0042393 histone binding(GO:0042393)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 PID AURORA B PATHWAY Aurora B signaling
0.1 2.1 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.7 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.6 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.7 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.8 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME KINESINS Genes involved in Kinesins
0.0 0.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 3.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type