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PRJNA195909:zebrafish embryo and larva development

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Results for emx2+emx3

Z-value: 2.36

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Transcription factors associated with emx2+emx3

Gene Symbol Gene ID Gene Info
ENSDARG00000020417 empty spiracles homeobox 3
ENSDARG00000039701 empty spiracles homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
emx2dr11_v1_chr13_+_19322686_19322686-0.872.1e-03Click!
emx3dr11_v1_chr14_-_26377044_26377044-0.674.8e-02Click!

Activity profile of emx2+emx3 motif

Sorted Z-values of emx2+emx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_10330778 5.68 ENSDART00000081465
ENSDART00000136653
ENSDART00000171232
coiled-coil domain containing 106b
chr25_+_22320738 5.28 ENSDART00000073566
cytochrome P450, family 11, subfamily A, polypeptide 1
chr11_-_6452444 5.25 ENSDART00000137879
ENSDART00000134957
ENSDART00000004483
La ribonucleoprotein domain family, member 6b
chr17_-_4245902 5.17 ENSDART00000151851
growth differentiation factor 3
chr10_-_34916208 4.91 ENSDART00000187371
cyclin A1
chr1_-_18811517 4.40 ENSDART00000142026
si:dkey-167i21.2
chr2_+_41926707 4.38 ENSDART00000023208
zgc:110183
chr19_-_20403507 4.15 ENSDART00000052603
ENSDART00000137590
deleted in azoospermia-like
chr19_-_20403845 4.12 ENSDART00000151265
ENSDART00000147911
ENSDART00000151356
deleted in azoospermia-like
chr8_-_23780334 4.00 ENSDART00000145179
ENSDART00000145894
zgc:195245
chr18_-_40708537 3.42 ENSDART00000077577
si:ch211-132b12.8
chr22_+_17261801 3.36 ENSDART00000192978
ENSDART00000193187
ENSDART00000179953
ENSDART00000134798
tudor domain containing 5
chr9_+_29548195 3.34 ENSDART00000176057
ring finger protein 17
chr8_+_42917515 3.31 ENSDART00000021715
solute carrier family 23 (ascorbic acid transporter), member 2
chr17_-_11357851 3.21 ENSDART00000153915
si:ch211-185a18.2
chr20_+_54299419 3.13 ENSDART00000056089
ENSDART00000193107
si:zfos-1505d6.3
chr20_+_54309148 3.10 ENSDART00000099360
zona pellucida glycoprotein 2, tandem duplicate 1
chr23_+_32101202 2.98 ENSDART00000000992
zgc:56699
chr10_-_44560165 2.94 ENSDART00000181217
ENSDART00000076084
nucleophosmin/nucleoplasmin, 2b
chr4_+_9467049 2.92 ENSDART00000012659
zgc:55888
chr21_-_44081540 2.91 ENSDART00000130833

chr14_-_48765262 2.69 ENSDART00000166463
CCR4-NOT transcription complex, subunit 6b
chr19_-_20403318 2.69 ENSDART00000136826
deleted in azoospermia-like
chr8_-_39884359 2.64 ENSDART00000131372
malectin
chr20_+_54304800 2.60 ENSDART00000121661
zona pellucida glycoprotein 2, tandem duplicate 6
chr17_-_1703259 2.46 ENSDART00000156489
x globin
chr2_+_42871831 2.45 ENSDART00000171393
EFR3 homolog A (S. cerevisiae)
chr11_-_44979281 2.40 ENSDART00000190972
LIM-domain binding 1b
chr3_+_7808459 2.39 ENSDART00000162374
hook microtubule-tethering protein 2
chr7_+_23515966 2.37 ENSDART00000186893
ENSDART00000186189
zgc:109889
chr7_+_69459759 2.37 ENSDART00000160500
CTD nuclear envelope phosphatase 1b
chr16_-_41646164 2.30 ENSDART00000184257
ATPase secretory pathway Ca2+ transporting 1
chr15_+_45544589 2.23 ENSDART00000055978

chr16_+_25068576 2.18 ENSDART00000125838
im:7147486
chr7_+_22313533 2.13 ENSDART00000123457
si:dkey-11f12.2
chr8_-_53044300 2.08 ENSDART00000191653
nuclear receptor subfamily 6, group A, member 1a
chr15_+_34934568 2.08 ENSDART00000165210
zgc:66024
chr22_-_22337382 2.07 ENSDART00000144684
si:ch211-129c21.1
chr21_+_13387965 2.06 ENSDART00000134347
zgc:113162
chr7_+_24573721 2.05 ENSDART00000173938
ENSDART00000173681
si:dkeyp-75h12.7
chr13_-_15082024 2.05 ENSDART00000157482
sideroflexin 5a
chr16_-_10223741 2.03 ENSDART00000188099
si:rp71-15i12.1
chr19_-_42045372 1.98 ENSDART00000144275
trio Rho guanine nucleotide exchange factor a
chr23_+_42254960 1.97 ENSDART00000102980
zinc finger, CCHC domain containing 11
chr16_-_36064143 1.96 ENSDART00000158358
ENSDART00000182584
serine/threonine kinase 40
chr13_+_7665890 1.95 ENSDART00000046792
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr5_+_6954162 1.95 ENSDART00000086666
sperm-tail PG-rich repeat containing 2
chr13_+_30035253 1.92 ENSDART00000181303
ENSDART00000057525
ENSDART00000136622
DnaJ (Hsp40) homolog, subfamily B, member 12a
chr19_+_14351560 1.87 ENSDART00000182732
AT rich interactive domain 1Ab (SWI-like)
chr11_-_8126223 1.84 ENSDART00000091617
ENSDART00000192391
ENSDART00000101561
tubulin tyrosine ligase-like family, member 7
chr5_+_44944778 1.78 ENSDART00000130428
ENSDART00000044361
ENSDART00000128825
ENSDART00000124637
ENSDART00000126066
ENSDART00000177635
doublesex and mab-3 related transcription factor 1
chr2_+_15100742 1.74 ENSDART00000027171
coagulation factor IIIb
chr23_+_38251864 1.74 ENSDART00000183498
ENSDART00000129593
zinc finger protein 217
chr2_+_1988036 1.73 ENSDART00000155956
synovial sarcoma, X breakpoint 2 interacting protein a
chr9_+_54039006 1.73 ENSDART00000112441
toll-like receptor 7
chr25_-_21031007 1.71 ENSDART00000138985
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a
chr16_+_1100559 1.70 ENSDART00000092657
ADAM metallopeptidase with thrombospondin type 1 motif, 16
chr22_-_20812822 1.69 ENSDART00000193778
DOT1-like histone H3K79 methyltransferase
chr9_+_24065855 1.69 ENSDART00000161468
ENSDART00000171577
ENSDART00000172743
ENSDART00000159324
ENSDART00000079689
ENSDART00000023196
ENSDART00000101577
leucine rich repeat (in FLII) interacting protein 1a
chr19_-_2822372 1.66 ENSDART00000109130
ENSDART00000122385
RecQ helicase-like 4
chr9_+_48761455 1.65 ENSDART00000139631
ATP-binding cassette, sub-family B (MDR/TAP), member 11a
chr23_-_18024543 1.64 ENSDART00000139695
peptidase M20 domain containing 1, tandem duplicate 1
chr5_+_45140914 1.64 ENSDART00000172702
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_-_25144439 1.64 ENSDART00000132355
F-box and WD repeat domain containing 7
chr21_-_2185600 1.64 ENSDART00000169897
zgc:171220
chr21_+_31253048 1.61 ENSDART00000178521
ENSDART00000132317
ENSDART00000040190
argininosuccinate lyase
chr19_+_15485287 1.58 ENSDART00000182797
PDLIM1 interacting kinase 1 like
chr5_+_37903790 1.58 ENSDART00000162470
transmembrane protease, serine 4b
chr24_+_18714212 1.57 ENSDART00000171181
centrosome and spindle pole associated protein 1a
chr20_+_474288 1.56 ENSDART00000026794
5'-nucleotidase domain containing 1
chr17_+_6469419 1.56 ENSDART00000191729
si:dkey-36g24.3
chr23_-_19686791 1.55 ENSDART00000161973
zgc:193598
chr2_-_42871286 1.54 ENSDART00000087823
adenylate cyclase 8 (brain)
chr23_+_12160900 1.54 ENSDART00000136046
protein phosphatase 1, regulatory subunit 3Da
chr8_+_17009199 1.52 ENSDART00000139452
phosphodiesterase 4D, cAMP-specific
chr5_-_11809710 1.51 ENSDART00000186998
ENSDART00000181363
ENSDART00000180681
neurofibromin 2a (merlin)
chr21_-_32060993 1.51 ENSDART00000131651
si:ch211-160j14.2
chr23_+_26026383 1.51 ENSDART00000141553
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr4_-_3353595 1.51 ENSDART00000009076
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr23_-_40536017 1.50 ENSDART00000153751
ENSDART00000140623
ENSDART00000133356
ring finger protein 146
chr19_-_25149034 1.50 ENSDART00000148432
ENSDART00000175266
protein tyrosine phosphatase type IVA, member 3
chr21_+_21195487 1.49 ENSDART00000181746
ENSDART00000184832
RPTOR independent companion of MTOR, complex 2b
chr18_+_16750080 1.48 ENSDART00000136320
ring finger protein 141
chr21_-_2814709 1.47 ENSDART00000097664
semaphorin 4D
chr1_-_9195629 1.47 ENSDART00000143587
ENSDART00000192174
endoplasmic reticulum to nucleus signaling 2
chr4_+_2482046 1.46 ENSDART00000103371
zinc finger, DHHC-type containing 17
chr9_-_5318873 1.46 ENSDART00000129308
activin A receptor type 1C
chr10_+_16225117 1.46 ENSDART00000169885
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
chr21_+_11883336 1.45 ENSDART00000151757
DDB1 and CUL4 associated factor 12
chr10_-_28380919 1.44 ENSDART00000183409
ENSDART00000183105
ENSDART00000100207
ENSDART00000185392
ENSDART00000131220
B-cell translocation gene 3
chr13_-_31008275 1.44 ENSDART00000139394
WDFY family member 4
chr25_+_20694177 1.44 ENSDART00000073648
KxDL motif containing 1
chr3_+_32416948 1.43 ENSDART00000157324
ENSDART00000154267
ENSDART00000186094
ENSDART00000155860
ENSDART00000156986
proline rich Gla (G-carboxyglutamic acid) 2
chr1_+_18811679 1.43 ENSDART00000078610
solute carrier family 25, member 51a
chr16_+_32736588 1.42 ENSDART00000075191
ENSDART00000168358
zgc:172323
chr23_-_306796 1.42 ENSDART00000143125
ankyrin repeat and sterile alpha motif domain containing 1Aa
chr13_+_35528607 1.41 ENSDART00000075414
ENSDART00000112947
WD repeat domain 27
chr5_+_19933356 1.41 ENSDART00000088819
ankyrin repeat domain 13A
chr21_-_4849029 1.39 ENSDART00000168930
ENSDART00000151019
notch 1a
chr15_+_34946779 1.38 ENSDART00000192661
ENSDART00000188800
ENSDART00000156515
si:ch73-95l15.5
zgc:55621
chr12_+_47698356 1.38 ENSDART00000112010
leucine zipper, putative tumor suppressor 2b
chr8_-_51930826 1.37 ENSDART00000109785
calcineurin binding protein 1
chr1_+_27977297 1.36 ENSDART00000180692
ENSDART00000166819
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr20_-_19511700 1.35 ENSDART00000040191
sorting nexin 17
chr13_+_15656042 1.35 ENSDART00000134240
MAP/microtubule affinity-regulating kinase 3a
chr6_-_39005133 1.35 ENSDART00000104116
ENSDART00000151750
vitamin D receptor b
chr6_+_30533504 1.34 ENSDART00000155842
WWC family member 3
chr6_-_7686594 1.34 ENSDART00000091836
ENSDART00000151697
ubinuclein 2a
chr12_-_48188928 1.33 ENSDART00000184384
phosphatase domain containing, paladin 1a
chr4_-_72296520 1.32 ENSDART00000182638
si:cabz01071911.3
chr11_+_30091155 1.32 ENSDART00000158691
si:ch211-161f7.2
chr22_+_35275468 1.32 ENSDART00000189516
ENSDART00000181572
ENSDART00000165353
ENSDART00000185352
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
chr11_-_13341483 1.31 ENSDART00000164978
microtubule associated serine/threonine kinase 3b
chr10_-_17550239 1.30 ENSDART00000057513
spindle and kinetochore associated complex subunit 1
chr4_-_42015883 1.30 ENSDART00000163399
zinc finger protein 1145
chr10_+_5268054 1.29 ENSDART00000114491
receptor tyrosine kinase-like orphan receptor 2
chr5_-_25733745 1.29 ENSDART00000051566
zgc:101016
chr25_+_2263857 1.27 ENSDART00000076439
tyrosyl-tRNA synthetase 2, mitochondrial
chr8_-_2616326 1.27 ENSDART00000027214
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a
chr2_-_37743834 1.27 ENSDART00000088040
ENSDART00000191057
myosin IXb
chr11_-_34478225 1.26 ENSDART00000189604
xyloside xylosyltransferase 1
chr23_+_36460239 1.26 ENSDART00000172441
LIM domain and actin binding 1a
chr4_-_5019113 1.26 ENSDART00000189321
ENSDART00000081990
striatin interacting protein 2
chr17_-_29311835 1.25 ENSDART00000104224
tectonin beta-propeller repeat containing 2
chr21_-_36571804 1.25 ENSDART00000138129
WW and C2 domain containing 1
chr22_+_35275206 1.25 ENSDART00000112234
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
chr1_+_31658011 1.24 ENSDART00000192203
polymerase (DNA directed), lambda
chr23_-_900795 1.24 ENSDART00000190517
ENSDART00000182849
ENSDART00000111456
ENSDART00000185430
RNA binding motif protein 10
chr19_-_29853402 1.23 ENSDART00000024292
ENSDART00000188508
taxilin alpha
chr23_-_14766902 1.23 ENSDART00000168113
glutathione synthetase
chr21_-_38618540 1.21 ENSDART00000036600
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr25_-_35101673 1.21 ENSDART00000140864
zgc:162611
chr17_+_24109012 1.20 ENSDART00000156251
EH domain binding protein 1
chr21_-_45363871 1.20 ENSDART00000075443
ENSDART00000182078
ENSDART00000151106
zgc:56064
chr6_+_13787855 1.20 ENSDART00000182899
transmembrane protein 198b
chr2_+_9990491 1.20 ENSDART00000011906
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr7_+_66884291 1.19 ENSDART00000187499
SET binding factor 2
chr16_-_7793457 1.18 ENSDART00000113483
tripartite motif containing 71, E3 ubiquitin protein ligase
chr2_-_37632896 1.17 ENSDART00000008302
insulin receptor a
chr9_+_29643036 1.17 ENSDART00000023210
ENSDART00000175160
tripartite motif containing 13
chr16_-_31622777 1.17 ENSDART00000137311
ENSDART00000002930
PHD finger protein 20 like 1
chr18_+_14684115 1.16 ENSDART00000108469
spermatogenesis associated 2-like
chr20_+_32552912 1.15 ENSDART00000009691
Scm polycomb group protein like 4
chr14_-_26425416 1.14 ENSDART00000088690
lectin, mannose-binding 2
chr12_-_35386910 1.14 ENSDART00000153453
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr10_-_35257458 1.14 ENSDART00000143890
ENSDART00000139107
ENSDART00000082445
proline rich 11
chr12_+_1492641 1.13 ENSDART00000152411
ubiquitin specific peptidase 22
chr25_-_27621268 1.13 ENSDART00000146205
ENSDART00000073511
hyaluronoglucosaminidase 6
chr7_-_2285499 1.13 ENSDART00000182211
si:dkey-187j14.6
chr1_+_54124209 1.13 ENSDART00000187730

chr1_-_29139141 1.13 ENSDART00000075546
ENSDART00000133246
heat shock transcription factor 2 binding protein
chr13_-_38730267 1.13 ENSDART00000157524
LMBR1 domain containing 1
chr2_-_17392799 1.12 ENSDART00000136470
ENSDART00000141188
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr9_-_3934963 1.11 ENSDART00000062336
ubiquitin protein ligase E3 component n-recognin 3
chr12_-_3978306 1.10 ENSDART00000149473
ENSDART00000114857
protein phosphatase 4, catalytic subunit b
chr4_+_20063279 1.10 ENSDART00000024925
GRIP and coiled-coil domain containing 1
chr11_+_42726712 1.09 ENSDART00000028955
tudor domain containing 3
chr18_-_18874921 1.09 ENSDART00000193332
ADP-ribosylation factor-like 2 binding protein
chr7_-_2285314 1.08 ENSDART00000153614
si:dkey-187j14.6
chr24_+_36204028 1.08 ENSDART00000063832
ENSDART00000155260
retinoblastoma binding protein 8
chr11_+_3005536 1.07 ENSDART00000174539
copine Vb
chr8_+_44722140 1.07 ENSDART00000163381
ELMO/CED-12 domain containing 3
chr1_+_45002971 1.07 ENSDART00000021336
DnaJ (Hsp40) homolog, subfamily A, member 1
chr18_+_22416051 1.07 ENSDART00000115388
craniofacial development protein 1
chr2_-_17393216 1.06 ENSDART00000123137
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr25_+_18025414 1.05 ENSDART00000154488
transmembrane and tetratricopeptide repeat containing 3
chr9_+_55379283 1.05 ENSDART00000192728
neuroligin 4b
chr9_+_38314466 1.05 ENSDART00000048753
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr18_+_26829362 1.05 ENSDART00000132728
solute carrier family 28 (concentrative nucleoside transporter), member 1
chr16_-_15988320 1.03 ENSDART00000160883

chr19_-_25149598 1.03 ENSDART00000162917
protein tyrosine phosphatase type IVA, member 3
chr2_-_9989919 1.03 ENSDART00000180213
ENSDART00000184369
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr25_-_25058508 1.02 ENSDART00000087570
ENSDART00000178891

chr8_+_36560019 1.01 ENSDART00000136418
ENSDART00000061378
ENSDART00000185237
splicing factor 3a, subunit 1
chr4_-_5018705 1.00 ENSDART00000154025
striatin interacting protein 2
chr13_-_46687097 1.00 ENSDART00000169106
ENSDART00000158202

chr10_+_26990095 1.00 ENSDART00000064111
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed b
chr14_-_470505 0.99 ENSDART00000067147
ankyrin repeat domain 50
chr3_-_27061637 0.98 ENSDART00000157126
activating transcription factor 7 interacting protein 2
chr21_+_6394929 0.98 ENSDART00000138600
si:ch211-225g23.1
chr2_+_30182431 0.98 ENSDART00000004903
retinol dehydrogenase 10b
chr23_+_45200481 0.97 ENSDART00000004357
ENSDART00000111126
ENSDART00000193560
ENSDART00000190476
PC4 and SFRS1 interacting protein 1b
chr12_-_6818676 0.97 ENSDART00000106391
protocadherin-related 15b
chr1_-_47071979 0.96 ENSDART00000160817
intersectin 1 (SH3 domain protein)
chr7_+_66884570 0.95 ENSDART00000082664
SET binding factor 2
chr15_-_16177603 0.94 ENSDART00000156352
si:ch211-259g3.4
chr12_+_5977777 0.93 ENSDART00000152302
si:ch211-131k2.2
chr4_-_5108844 0.93 ENSDART00000132666
ENSDART00000136096
transmembrane protein 209
chr9_-_41040492 0.93 ENSDART00000163164
adenosine deaminase, tRNA-specific 3
chr24_+_26329018 0.93 ENSDART00000145752
myoneurin
chr18_+_26829086 0.92 ENSDART00000098356
solute carrier family 28 (concentrative nucleoside transporter), member 1
chr11_+_31323746 0.91 ENSDART00000180220
ENSDART00000189937
signal-induced proliferation-associated 1 like 2
chr10_-_1636452 0.91 ENSDART00000010626
nucleoporin 155
chr17_-_16422654 0.90 ENSDART00000150149
tyrosyl-DNA phosphodiesterase 1
chr20_-_43663494 0.90 ENSDART00000144564

chr22_+_10606573 0.89 ENSDART00000192638
RAD54 like 2
chr7_-_11596450 0.89 ENSDART00000173863
StAR-related lipid transfer (START) domain containing 5
chr25_+_25085349 0.89 ENSDART00000192166
si:ch73-182e20.4
chr24_-_18876877 0.89 ENSDART00000186269
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr19_+_31873308 0.88 ENSDART00000146560
ENSDART00000133045
si:dkeyp-34f6.4

Network of associatons between targets according to the STRING database.

First level regulatory network of emx2+emx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 11.0 GO:0060965 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
1.1 3.3 GO:0019852 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
1.1 5.5 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
1.1 5.3 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.9 2.6 GO:0090219 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.6 1.8 GO:0030238 male sex determination(GO:0030238)
0.6 1.7 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.5 1.6 GO:0031645 negative regulation of myelination(GO:0031642) negative regulation of neurological system process(GO:0031645)
0.5 2.4 GO:0010867 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.5 1.4 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.5 1.4 GO:0021531 spinal cord radial glial cell differentiation(GO:0021531)
0.5 2.3 GO:0055071 manganese ion homeostasis(GO:0055071)
0.4 1.7 GO:0034729 histone H3-K79 methylation(GO:0034729) regulation of transcription regulatory region DNA binding(GO:2000677)
0.4 2.1 GO:0010693 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
0.4 1.6 GO:0032782 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.4 1.6 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.4 1.2 GO:0010586 miRNA metabolic process(GO:0010586)
0.4 1.1 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.3 3.4 GO:0043046 DNA methylation involved in gamete generation(GO:0043046)
0.3 1.2 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.3 0.9 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
0.3 1.2 GO:0032755 positive regulation of interleukin-6 production(GO:0032755) protein import into mitochondrial intermembrane space(GO:0045041)
0.3 1.5 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.3 1.5 GO:0000012 single strand break repair(GO:0000012)
0.3 1.6 GO:0031507 heterochromatin assembly(GO:0031507)
0.3 1.1 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.2 1.0 GO:0006526 arginine biosynthetic process(GO:0006526)
0.2 0.7 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.2 1.5 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.2 1.2 GO:0015729 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.2 1.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.2 0.9 GO:0071926 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.2 0.6 GO:0021563 glossopharyngeal nerve development(GO:0021563)
0.2 2.0 GO:0006842 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.2 2.9 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.2 0.8 GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902165)
0.2 0.9 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.2 1.2 GO:0032475 otolith formation(GO:0032475)
0.2 0.7 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2 3.0 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 0.9 GO:0031650 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.2 1.4 GO:0051013 microtubule severing(GO:0051013)
0.2 0.9 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.2 0.8 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.2 2.4 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 2.7 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.2 0.6 GO:0018343 protein farnesylation(GO:0018343)
0.2 0.6 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.2 2.3 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.2 3.5 GO:0071218 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.1 0.7 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.6 GO:0071869 response to monoamine(GO:0071867) response to catecholamine(GO:0071869) response to epinephrine(GO:0071871)
0.1 0.5 GO:0010758 regulation of macrophage chemotaxis(GO:0010758) positive regulation of macrophage chemotaxis(GO:0010759) mononuclear cell migration(GO:0071674) regulation of mononuclear cell migration(GO:0071675) positive regulation of lamellipodium organization(GO:1902745)
0.1 2.0 GO:0015858 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.1 0.4 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 1.0 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.1 0.6 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 0.7 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.1 2.5 GO:0015671 oxygen transport(GO:0015671)
0.1 1.4 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.1 1.5 GO:0048796 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.1 1.5 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 0.3 GO:0044650 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.1 0.9 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 1.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.5 GO:0006309 apoptotic DNA fragmentation(GO:0006309) cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.1 0.4 GO:0070084 protein initiator methionine removal(GO:0070084)
0.1 1.5 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 1.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.1 GO:0072595 maintenance of protein localization in organelle(GO:0072595)
0.1 0.8 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 0.8 GO:0098789 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 1.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.3 GO:1990575 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.1 1.1 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 0.8 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 1.0 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 2.5 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 1.2 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 1.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 0.5 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.1 1.8 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.1 0.2 GO:0097053 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.1 1.5 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 0.4 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1 1.0 GO:0042572 retinol metabolic process(GO:0042572)
0.1 2.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 3.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 1.4 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.9 GO:0048264 determination of ventral identity(GO:0048264)
0.1 0.7 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.1 1.5 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.1 0.3 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.1 1.3 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.1 0.7 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.1 0.4 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.7 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.1 0.6 GO:0035065 regulation of histone acetylation(GO:0035065)
0.1 3.0 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 1.0 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 0.3 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.1 0.2 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.1 0.5 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.1 0.6 GO:0070309 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.1 1.3 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 0.2 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 0.2 GO:0090387 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.1 0.6 GO:0002551 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1 0.4 GO:0015809 arginine transport(GO:0015809)
0.0 0.5 GO:0090329 regulation of DNA-dependent DNA replication(GO:0090329)
0.0 0.6 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.5 GO:0030878 thyroid gland development(GO:0030878)
0.0 0.2 GO:0070983 dendrite guidance(GO:0070983) regulation of homophilic cell adhesion(GO:1903385)
0.0 1.1 GO:0009408 response to heat(GO:0009408)
0.0 0.4 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.3 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.5 GO:0019372 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 1.2 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.3 GO:2001286 optomotor response(GO:0071632) caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 1.7 GO:0061386 closure of optic fissure(GO:0061386)
0.0 2.4 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.7 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.5 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 1.1 GO:0072114 pronephros morphogenesis(GO:0072114)
0.0 1.9 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 0.6 GO:0031297 replication fork processing(GO:0031297)
0.0 0.5 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.5 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 1.8 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 1.1 GO:0061462 protein localization to lysosome(GO:0061462)
0.0 0.8 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.8 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.9 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.2 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.6 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.3 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 1.3 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 2.0 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 1.3 GO:0071599 otic vesicle development(GO:0071599)
0.0 0.5 GO:0098781 ncRNA transcription(GO:0098781)
0.0 0.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.7 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 1.1 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.8 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.8 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.5 GO:0032526 response to retinoic acid(GO:0032526)
0.0 0.7 GO:0010212 response to ionizing radiation(GO:0010212)
0.0 2.0 GO:0007283 spermatogenesis(GO:0007283)
0.0 0.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.0 GO:0016573 histone acetylation(GO:0016573)
0.0 1.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 1.2 GO:0007596 blood coagulation(GO:0007596)
0.0 0.8 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 1.1 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 0.4 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 10.0 GO:0006396 RNA processing(GO:0006396)
0.0 0.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.6 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.9 GO:0030048 actin filament-based movement(GO:0030048)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 1.3 GO:0051321 meiotic cell cycle(GO:0051321)
0.0 0.4 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)
0.0 0.7 GO:0006096 glycolytic process(GO:0006096)
0.0 0.1 GO:0032264 IMP salvage(GO:0032264)
0.0 0.3 GO:0050821 protein stabilization(GO:0050821)
0.0 0.2 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.8 GO:0007098 centrosome cycle(GO:0007098)
0.0 1.1 GO:0016579 protein deubiquitination(GO:0016579)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
1.1 3.4 GO:0033391 chromatoid body(GO:0033391)
0.5 1.5 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.5 2.4 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.4 1.5 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.3 1.0 GO:0034457 Mpp10 complex(GO:0034457)
0.2 1.2 GO:0005899 insulin receptor complex(GO:0005899)
0.2 1.9 GO:0035060 brahma complex(GO:0035060)
0.2 0.9 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 1.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 0.6 GO:0030689 Noc complex(GO:0030689)
0.2 0.6 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.2 1.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 2.4 GO:0031209 SCAR complex(GO:0031209)
0.1 1.6 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 2.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.7 GO:0070876 SOSS complex(GO:0070876)
0.1 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 1.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.8 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.8 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 1.2 GO:0044545 NSL complex(GO:0044545)
0.1 0.6 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 1.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 1.5 GO:0031932 TORC2 complex(GO:0031932)
0.1 5.9 GO:0036064 ciliary basal body(GO:0036064)
0.1 1.6 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 1.3 GO:0005686 U2 snRNP(GO:0005686)
0.1 0.4 GO:0005682 U5 snRNP(GO:0005682)
0.1 0.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.8 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 1.0 GO:0032420 stereocilium(GO:0032420)
0.0 1.1 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 1.1 GO:0035861 site of double-strand break(GO:0035861)
0.0 5.5 GO:0005769 early endosome(GO:0005769)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.4 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 2.0 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 1.6 GO:0000922 spindle pole(GO:0000922)
0.0 0.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.2 GO:0031941 filamentous actin(GO:0031941)
0.0 0.9 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.6 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.4 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)
0.0 1.1 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.7 GO:0030496 midbody(GO:0030496)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 2.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 4.9 GO:0005730 nucleolus(GO:0005730)
0.0 5.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.4 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 0.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.4 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0016713 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
1.2 11.0 GO:0008494 translation activator activity(GO:0008494)
0.4 1.7 GO:0031151 histone methyltransferase activity (H3-K79 specific)(GO:0031151)
0.4 1.6 GO:0015126 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.4 1.6 GO:0016842 amidine-lyase activity(GO:0016842)
0.4 2.3 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.4 1.1 GO:0070336 flap-structured DNA binding(GO:0070336)
0.4 2.5 GO:0098809 nitrite reductase activity(GO:0098809)
0.3 2.4 GO:0030274 LIM domain binding(GO:0030274)
0.3 2.0 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.3 2.2 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.3 0.9 GO:0031834 neurokinin receptor binding(GO:0031834) substance P receptor binding(GO:0031835)
0.3 0.9 GO:0052717 tRNA-specific adenosine-34 deaminase activity(GO:0052717)
0.3 1.5 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.3 0.9 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.3 1.3 GO:0070644 vitamin D response element binding(GO:0070644)
0.3 2.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.2 0.7 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.2 1.2 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140) succinate transmembrane transporter activity(GO:0015141)
0.2 1.2 GO:0005009 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.2 0.6 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.2 1.7 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 1.3 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.2 2.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 0.9 GO:0032052 bile acid binding(GO:0032052)
0.2 0.5 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.2 0.7 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.2 0.9 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.2 0.5 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.2 1.5 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.2 0.6 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 1.6 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.6 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.1 1.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.7 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 1.1 GO:0031419 cobalamin binding(GO:0031419)
0.1 1.5 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 1.7 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 1.8 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.1 1.9 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 0.6 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.1 0.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.2 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 0.8 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 1.2 GO:0035198 miRNA binding(GO:0035198)
0.1 0.3 GO:0004061 arylformamidase activity(GO:0004061)
0.1 0.7 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.5 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.1 1.5 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 0.5 GO:0043295 glutathione binding(GO:0043295)
0.1 0.5 GO:0050218 propionate-CoA ligase activity(GO:0050218)
0.1 1.5 GO:2001069 glycogen binding(GO:2001069)
0.1 2.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.5 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.1 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 1.1 GO:0005537 mannose binding(GO:0005537)
0.1 1.1 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 1.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.9 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.4 GO:0050699 WW domain binding(GO:0050699)
0.1 1.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 1.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 1.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.3 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.1 1.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.4 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.8 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 3.2 GO:0031491 nucleosome binding(GO:0031491)
0.1 1.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 0.9 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.8 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 0.4 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.1 0.2 GO:0052726 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726)
0.1 1.5 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 1.4 GO:0005112 Notch binding(GO:0005112)
0.1 0.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.3 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.1 0.5 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 1.9 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.0 GO:0030515 snoRNA binding(GO:0030515)
0.1 0.6 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 3.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 1.3 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 3.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.4 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0 7.6 GO:0042393 histone binding(GO:0042393)
0.0 0.8 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.8 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.6 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595)
0.0 1.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.8 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 2.5 GO:0003724 RNA helicase activity(GO:0003724)
0.0 2.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.3 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 9.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 2.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 3.2 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 2.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.2 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.4 GO:0051087 chaperone binding(GO:0051087)
0.0 2.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 1.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.5 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 3.1 GO:0008083 growth factor activity(GO:0008083)
0.0 0.6 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.9 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.1 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 1.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.7 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 2.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 1.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 6.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.8 PID ARF 3PATHWAY Arf1 pathway
0.1 1.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.5 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 2.6 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 2.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 1.2 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 1.8 PID BARD1 PATHWAY BARD1 signaling events
0.1 2.7 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 3.1 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.1 0.8 PID ALK2 PATHWAY ALK2 signaling events
0.1 1.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 0.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 2.0 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.0 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.3 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 2.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.3 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.3 5.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 4.2 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.2 2.0 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.2 1.5 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 2.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 1.5 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.7 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 0.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 1.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.1 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 0.8 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 2.0 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 0.5 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 0.8 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.1 0.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 3.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.3 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 2.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 2.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.9 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 1.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.6 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.8 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 0.8 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.9 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 0.9 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 2.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.6 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.5 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.8 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.9 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 1.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.0 REACTOME MRNA SPLICING Genes involved in mRNA Splicing