ISMARA results: ebf3a-2+ebf3b

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PRJNA195909:zebrafish embryo and larva development

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Results for ebf3a-2+ebf3b

Z-value: 1.19

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Transcription factors associated with ebf3a-2+ebf3b

Gene Symbol	Gene ID	Gene Info
ebf3b NCBI UniProt	ENSDARG00000091287	EBF transcription factor 3b
ebf3a-2 NCBI UniProt	ENSDARG00000100244	EBF transcription factor 3a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ebf3a	dr11_v1_chr12_+_42436328_42436328	0.92	4.0e-04	Click!
ebf3b	dr11_v1_chr17_-_20229812_20229812	0.26	5.0e-01	Click!

Activity profile of ebf3a-2+ebf3b motif

Sorted Z-values of ebf3a-2+ebf3b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr23_-_21471022 Show fit	5.51	ENSDART00000104206	her4.2 NCBI UniProt Show fit	hairy-related 4, tandem duplicate 2
chr23_+_21455152 Show fit	2.82	ENSDART00000158511 ENSDART00000161321 ENSDART00000160731 ENSDART00000137573	her4.2 NCBI UniProt Show fit	hairy-related 4, tandem duplicate 2
chr25_+_31323978 Show fit	2.81	ENSDART00000067030	lsp1 NCBI UniProt Show fit	lymphocyte-specific protein 1
chr9_-_7673856 Show fit	2.40	ENSDART00000102715	tuba8l3 NCBI UniProt Show fit	tubulin, alpha 8 like 3
chr11_+_41981959 Show fit	2.33	ENSDART00000055707	her15.1 NCBI UniProt Show fit	hairy and enhancer of split-related 15, tandem duplicate 1
chr7_-_52558495 Show fit	2.27	ENSDART00000138263 ENSDART00000009938 ENSDART00000174292 ENSDART00000174218 ENSDART00000174335	tcf12 NCBI UniProt Show fit	transcription factor 12
chr21_+_5129513 Show fit	2.13	ENSDART00000102572	thbs4b NCBI UniProt Show fit	thrombospondin 4b
chr22_+_11775269 Show fit	2.08	ENSDART00000140272	krt96 NCBI UniProt Show fit	keratin 96
chr22_+_11756040 Show fit	1.92	ENSDART00000105808	krt97 NCBI UniProt Show fit	keratin 97
chr22_-_23253481 Show fit	1.89	ENSDART00000054807	lhx9 NCBI UniProt Show fit	LIM homeobox 9

Showing 1 to 10 of 160 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ebf3a-2+ebf3b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	9.2	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
0.0	3.4	GO:0021782	glial cell development(GO:0021782)
1.0	3.0	GO:0097377	interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.9	2.7	GO:1904251	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0	2.3	GO:0007219	Notch signaling pathway(GO:0007219)
0.4	2.1	GO:0021534	cell proliferation in hindbrain(GO:0021534)
0.4	2.1	GO:0035989	tendon development(GO:0035989)
0.1	1.7	GO:0016082	synaptic vesicle priming(GO:0016082)
0.4	1.6	GO:0003322	pancreatic A cell development(GO:0003322)
0.3	1.6	GO:0035332	positive regulation of hippo signaling(GO:0035332)

Showing 1 to 10 of 52 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.2	GO:0005882	intermediate filament(GO:0005882)
0.3	1.7	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1	1.5	GO:0031430	M band(GO:0031430)
0.0	1.5	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.1	1.4	GO:0030057	desmosome(GO:0030057)
0.1	1.3	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
0.2	1.1	GO:0008091	spectrin(GO:0008091)
0.0	1.1	GO:0005861	troponin complex(GO:0005861)
0.0	1.1	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.1	1.0	GO:0031209	SCAR complex(GO:0031209)

Showing 1 to 10 of 19 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	12.2	GO:0046983	protein dimerization activity(GO:0046983)
0.1	3.5	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.2	2.7	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.1	2.2	GO:0005109	frizzled binding(GO:0005109)
0.0	1.7	GO:0017075	syntaxin-1 binding(GO:0017075)
0.1	1.5	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	1.5	GO:0008083	growth factor activity(GO:0008083)
0.2	1.3	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.1	1.3	GO:0070411	I-SMAD binding(GO:0070411)
0.0	1.2	GO:0017147	Wnt-protein binding(GO:0017147)

Showing 1 to 10 of 30 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.5	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	3.4	PID FGF PATHWAY	FGF signaling pathway
0.1	1.1	PID ALK2 PATHWAY	ALK2 signaling events
0.0	1.0	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	0.9	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.9	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	0.9	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.3	PID NETRIN PATHWAY	Netrin-mediated signaling events

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	3.4	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.1	2.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	1.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	1.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.1	1.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	0.9	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.9	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.8	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1	0.6	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	0.4	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels

Showing 1 to 10 of 13 entries

Results for ebf3a-2+ebf3b

Z-value: 1.19

Motif logo

Transcription factors associated with ebf3a-2+ebf3b

Activity-expression correlation:

Activity profile of ebf3a-2+ebf3b motif

Sorted Z-values of ebf3a-2+ebf3b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ebf3a-2+ebf3b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: