ISMARA results: e2f8

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PRJNA195909:zebrafish embryo and larva development

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Results for e2f8

Z-value: 1.28

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Transcription factors associated with e2f8

Gene Symbol	Gene ID	Gene Info
e2f8 NCBI UniProt	ENSDARG00000057323	E2F transcription factor 8

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
e2f8	dr11_v1_chr7_-_16596938_16596938	0.93	2.5e-04	Click!

Activity profile of e2f8 motif

Sorted Z-values of e2f8 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_33220342 Show fit	2.46	ENSDART00000100893 ENSDART00000113451	si:ch211-125e6.13 NCBI UniProt Show fit	si:ch211-125e6.13
chr7_-_55648336 Show fit	2.08	ENSDART00000147792 ENSDART00000135304 ENSDART00000131923	pabpn1l NCBI UniProt Show fit	poly(A) binding protein, nuclear 1-like (cytoplasmic)
chr7_+_24814866 Show fit	1.87	ENSDART00000173581	si:ch211-226l4.6 NCBI UniProt Show fit	si:ch211-226l4.6
chr8_-_44238526 Show fit	1.50	ENSDART00000061115 ENSDART00000132473 ENSDART00000138019 ENSDART00000133021	piwil1 NCBI UniProt Show fit	piwi-like RNA-mediated gene silencing 1
chr13_+_31402067 Show fit	1.44	ENSDART00000019202	tdrd9 NCBI UniProt Show fit	tudor domain containing 9
chr23_-_29357764 Show fit	1.42	ENSDART00000156512	si:ch211-129o18.4 NCBI UniProt Show fit	si:ch211-129o18.4
chr1_-_18811517 Show fit	1.38	ENSDART00000142026	si:dkey-167i21.2 NCBI UniProt Show fit	si:dkey-167i21.2
chr10_+_6884123 Show fit	1.35	ENSDART00000149095 ENSDART00000148772 ENSDART00000149334	ddx4 NCBI UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr13_+_46941930 Show fit	1.22	ENSDART00000056962	fbxo5 NCBI UniProt Show fit	F-box protein 5
chr7_+_41812636 Show fit	1.21	ENSDART00000174333	orc6 NCBI UniProt Show fit	origin recognition complex, subunit 6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.1	GO:0006270	DNA replication initiation(GO:0006270)
0.3	2.9	GO:0010529	regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.2	1.9	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.1	1.4	GO:0051445	regulation of meiotic cell cycle(GO:0051445)
0.1	1.3	GO:0008156	negative regulation of DNA replication(GO:0008156)
0.0	1.3	GO:0006342	chromatin silencing(GO:0006342)
0.4	1.2	GO:0016446	somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.3	1.2	GO:0051444	negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.3	1.2	GO:1990511	piRNA biosynthetic process(GO:1990511)
0.0	1.2	GO:0043039	amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039)

Showing 1 to 10 of 58 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.3	GO:0043186	P granule(GO:0043186)
0.0	4.0	GO:0000786	nucleosome(GO:0000786)
0.3	3.3	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	1.7	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1	1.3	GO:0000782	telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.4	1.2	GO:0032301	MutSalpha complex(GO:0032301)
0.2	1.1	GO:0031298	replication fork protection complex(GO:0031298)
0.0	1.1	GO:0046540	U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.1	1.0	GO:0035060	brahma complex(GO:0035060)
0.0	1.0	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)

Showing 1 to 10 of 34 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.2	GO:0046982	protein heterodimerization activity(GO:0046982)
0.0	2.8	GO:0003724	RNA helicase activity(GO:0003724)
0.0	2.5	GO:0042393	histone binding(GO:0042393)
0.1	1.9	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	1.6	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	1.6	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2	1.5	GO:0034584	piRNA binding(GO:0034584)
0.4	1.3	GO:0071532	ankyrin repeat binding(GO:0071532)
0.1	1.3	GO:0030515	snoRNA binding(GO:0030515)
0.4	1.2	GO:0032356	guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)

Showing 1 to 10 of 41 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.3	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	1.2	PID PLK1 PATHWAY	PLK1 signaling events
0.0	1.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	0.8	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.8	PID ATR PATHWAY	ATR signaling pathway
0.0	0.7	PID IL23 PATHWAY	IL23-mediated signaling events
0.1	0.6	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.3	PID BARD1 PATHWAY	BARD1 signaling events
0.0	0.3	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway

Showing 1 to 10 of 10 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.2	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.1	1.8	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	1.3	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.1	1.2	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.1	0.8	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1	0.7	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.7	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	0.6	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.6	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions

Showing 1 to 10 of 20 entries

Results for e2f8

Z-value: 1.28

Motif logo

Transcription factors associated with e2f8

Activity-expression correlation:

Activity profile of e2f8 motif

Sorted Z-values of e2f8 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: