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PRJNA195909:zebrafish embryo and larva development
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Results for e2f4
Z-value: 1.43
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Transcription factors associated with e2f4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| e2f4 | dr11_v1_chr25_+_17405201_17405201 | 0.75 | 2.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_6884123 Show fit | 3.09 |
ENSDART00000149095
ENSDART00000148772 ENSDART00000149334 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 |
|
| chr7_+_24814866 Show fit | 2.88 |
ENSDART00000173581
|
si:ch211-226l4.6 |
|
| chr20_+_35445462 Show fit | 2.72 |
ENSDART00000124497
|
tudor domain containing 6 |
|
| chr25_+_35155676 Show fit | 2.09 |
ENSDART00000114598
|
zgc:112234 |
|
| chr3_-_7897563 Show fit | 1.99 |
ENSDART00000185232
|
ubinuclein 2b |
|
| chr3_-_7897305 Show fit | 1.99 |
ENSDART00000169757
|
ubinuclein 2b |
|
| chr5_+_20453874 Show fit | 1.90 |
ENSDART00000124545
ENSDART00000008402 |
squamous cell carcinoma antigen recognized by T cells 3 |
|
| chr25_-_36370292 Show fit | 1.84 |
ENSDART00000152766
|
Histone H2B 1/2 |
|
| chr7_+_5960491 Show fit | 1.82 |
ENSDART00000145370
|
zgc:112234 |
|
| chr23_-_19831739 Show fit | 1.73 |
ENSDART00000125066
|
HAUS augmin-like complex, subunit 7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of e2f4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.1 | GO:0051445 | regulation of meiotic cell cycle(GO:0051445) |
| 0.2 | 2.7 | GO:0030719 | P granule organization(GO:0030719) |
| 0.0 | 2.7 | GO:0006119 | oxidative phosphorylation(GO:0006119) |
| 0.2 | 2.4 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.6 | 1.9 | GO:1903003 | positive regulation of protein deubiquitination(GO:1903003) |
| 0.0 | 1.7 | GO:0007098 | centrosome cycle(GO:0007098) |
| 0.2 | 1.5 | GO:0008207 | C21-steroid hormone metabolic process(GO:0008207) |
| 0.5 | 1.4 | GO:1902767 | farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767) |
| 0.2 | 1.4 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 0.0 | 1.2 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | GO:0043186 | P granule(GO:0043186) |
| 0.0 | 3.0 | GO:0000786 | nucleosome(GO:0000786) |
| 0.9 | 2.7 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.1 | 1.9 | GO:0015030 | Cajal body(GO:0015030) |
| 0.2 | 1.7 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 1.2 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 1.1 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 1.0 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.9 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.0 | 0.9 | GO:0031228 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.0 | 3.0 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.1 | 2.9 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.3 | 2.4 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.2 | 1.9 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.1 | 1.7 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.1 | 1.5 | GO:0016832 | aldehyde-lyase activity(GO:0016832) |
| 0.5 | 1.4 | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity(GO:0004421) |
| 0.2 | 1.4 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 1.0 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.5 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.5 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 1.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.4 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 1.4 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 1.0 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 1.0 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 0.9 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.3 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |