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PRJNA195909:zebrafish embryo and larva development

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Results for e2f3

Z-value: 0.78

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Transcription factors associated with e2f3

Gene Symbol Gene ID Gene Info
ENSDARG00000070463 E2F transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f3dr11_v1_chr19_-_29294457_292944570.147.2e-01Click!

Activity profile of e2f3 motif

Sorted Z-values of e2f3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_21140097 1.61 ENSDART00000145837
ENSDART00000146500
si:dkey-271j15.3
chr1_-_42289704 1.54 ENSDART00000150124
si:ch211-71k14.1
chr17_-_29224908 1.51 ENSDART00000156288
si:dkey-28g23.6
chr16_+_28728347 1.47 ENSDART00000149240
si:dkey-24i24.3
chr7_+_26534131 1.40 ENSDART00000173980
si:dkey-62k3.5
chr4_-_9909371 1.38 ENSDART00000102656
si:dkey-22l11.6
chr15_-_14884332 1.36 ENSDART00000165237
si:ch211-24o8.4
chr16_+_40575742 1.32 ENSDART00000161503
cyclin E2
chr3_+_38540411 1.31 ENSDART00000154943
si:dkey-7f16.3
chr24_-_38657683 1.28 ENSDART00000154843
si:ch1073-164k15.3
chr23_-_18913032 1.22 ENSDART00000136678
si:ch211-209j10.6
chr1_-_9980765 1.19 ENSDART00000142906
si:dkeyp-75b4.7
chr6_+_54142311 0.72 ENSDART00000154115
high mobility group AT-hook 1b
chr18_-_48983690 0.63 ENSDART00000182359

chr19_+_43604643 0.56 ENSDART00000151168
si:ch211-199g17.9
chr15_+_33991928 0.52 ENSDART00000170177
von Willebrand factor D and EGF domains
chr24_+_39108243 0.49 ENSDART00000156353
MSS51 mitochondrial translational activator
chr15_-_2954443 0.45 ENSDART00000161053
zgc:153184
chr19_+_43604256 0.43 ENSDART00000151080
ENSDART00000110305
si:ch211-199g17.9
chr5_-_10946232 0.40 ENSDART00000163139
ENSDART00000031265
reticulon 4 receptor
chr19_+_636886 0.39 ENSDART00000149192
telomerase reverse transcriptase
chr15_-_34056733 0.39 ENSDART00000170130
ENSDART00000188272
si:dkey-30e9.7
chr6_+_7533601 0.38 ENSDART00000057823
proliferation-associated 2G4, a
chr11_+_41936435 0.38 ENSDART00000173103
aldehyde dehydrogenase 4 family, member A1
chr16_-_25085327 0.38 ENSDART00000077661
protease, serine 1
chr3_-_61592417 0.36 ENSDART00000155082
neuronal pentraxin 2a
chr7_+_67434677 0.32 ENSDART00000165971
ENSDART00000166702
lysyl-tRNA synthetase
chr21_-_26490186 0.29 ENSDART00000009889
zgc:110540
chr19_-_6988837 0.29 ENSDART00000145741
ENSDART00000167640
zinc finger protein 384 like
chr7_-_43857938 0.28 ENSDART00000183602
cadherin 11, type 2, OB-cadherin (osteoblast)
chr3_-_53486169 0.25 ENSDART00000115243
heme-binding protein soul5
chr25_-_4482449 0.25 ENSDART00000056278
ENSDART00000149425
solute carrier family 25 member 22a
chr5_+_64732270 0.25 ENSDART00000134241
olfactomedin 1a
chr23_+_43950674 0.24 ENSDART00000167813
corin, serine peptidase
chr18_+_54354 0.20 ENSDART00000097163
zgc:158482
chr8_+_23355484 0.19 ENSDART00000085361
ENSDART00000125729
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
chr22_+_1028724 0.19 ENSDART00000149625
si:ch73-352p18.4
chr25_+_36339867 0.15 ENSDART00000152195
si:ch211-113a14.18
chr17_-_465285 0.15 ENSDART00000168718
cholinergic receptor, muscarinic 5a
chr23_-_44219902 0.12 ENSDART00000185874
zgc:158659
chr14_+_14841685 0.08 ENSDART00000158291
ENSDART00000162039
stem-loop binding protein
chr14_+_904850 0.07 ENSDART00000161847
si:ch73-208h1.1
chr4_-_72100774 0.06 ENSDART00000170099
solute carrier organic anion transporter family, member 1F1
chr1_+_36722122 0.05 ENSDART00000111566
transmembrane protein 184C
chr3_-_5664123 0.05 ENSDART00000145866
si:ch211-106h11.1
chr22_-_20259309 0.03 ENSDART00000139160
si:dkey-110c1.10
chr15_-_37425468 0.01 ENSDART00000059630
si:ch211-113j13.2
chr14_+_22076596 0.01 ENSDART00000106147
ENSDART00000100278
ENSDART00000131489
solute carrier family 43 (amino acid system L transporter), member 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0007571 age-dependent general metabolic decline(GO:0007571)
0.1 0.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 1.0 GO:0007130 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.0 0.2 GO:1902868 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.0 1.3 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.2 GO:0015813 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.0 0.4 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 0.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.1 0.4 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 1.0 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
0.0 0.3 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.4 GO:0048495 Roundabout binding(GO:0048495)
0.0 1.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.4 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.4 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.3 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres