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PRJNA195909:zebrafish embryo and larva development
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Results for e2f2_e2f5
Z-value: 3.30
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Transcription factors associated with e2f2_e2f5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| e2f5 | dr11_v1_chr2_-_31686353_31686403 | 0.88 | 2.0e-03 | Click! |
| E2F2 | dr11_v1_chr17_-_27266053_27266053 | 0.37 | 3.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of e2f2_e2f5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 10.5 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.2 | 10.5 | GO:0000723 | telomere maintenance(GO:0000723) telomere organization(GO:0032200) |
| 0.0 | 9.7 | GO:0006281 | DNA repair(GO:0006281) |
| 0.2 | 8.5 | GO:0048538 | thymus development(GO:0048538) |
| 0.7 | 7.4 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 1.3 | 6.4 | GO:0032776 | DNA methylation on cytosine(GO:0032776) |
| 0.8 | 5.9 | GO:0000076 | DNA replication checkpoint(GO:0000076) |
| 0.6 | 5.3 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
| 0.2 | 4.9 | GO:0097178 | ruffle assembly(GO:0097178) |
| 0.4 | 4.8 | GO:0030719 | P granule organization(GO:0030719) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 12.3 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 10.4 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 7.9 | GO:0044815 | DNA packaging complex(GO:0044815) |
| 0.0 | 5.2 | GO:0005694 | chromosome(GO:0005694) |
| 1.6 | 4.8 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.1 | 4.7 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.1 | 4.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.6 | 4.3 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 4.1 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.3 | 3.7 | GO:0000792 | heterochromatin(GO:0000792) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.5 | GO:0042393 | histone binding(GO:0042393) |
| 0.4 | 10.1 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 9.5 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.5 | 6.4 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.9 | 6.2 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.0 | 5.5 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.3 | 4.9 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.0 | 4.5 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 4.5 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.9 | 4.4 | GO:0009374 | biotin binding(GO:0009374) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.3 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 6.2 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 5.5 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.4 | 4.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 3.2 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 3.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 2.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 2.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 2.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 1.9 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 23.6 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.7 | 15.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.3 | 2.8 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 2.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 2.2 | REACTOME EARLY PHASE OF HIV LIFE CYCLE | Genes involved in Early Phase of HIV Life Cycle |
| 0.1 | 1.9 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.3 | 1.8 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.2 | 1.6 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 1.6 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.6 | REACTOME SPHINGOLIPID METABOLISM | Genes involved in Sphingolipid metabolism |