ISMARA results: e2f1

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PRJNA195909:zebrafish embryo and larva development

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Results for e2f1_e2f7

Z-value: 3.54

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Transcription factors associated with e2f1_e2f7

Gene Symbol	Gene ID	Gene Info
e2f1 NCBI UniProt	ENSDARG00000103868	E2F transcription factor 1
e2f7 NCBI UniProt	ENSDARG00000008986	E2F transcription factor 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
e2f7	dr11_v1_chr4_-_2545310_2545345	-0.57	1.1e-01	Click!
e2f1	dr11_v1_chr23_-_43486714_43486714	-0.06	8.8e-01	Click!

Activity profile of e2f1_e2f7 motif

Sorted Z-values of e2f1_e2f7 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr18_+_14277003 Show fit	8.90	ENSDART00000006628	zgc:173742 NCBI UniProt Show fit	zgc:173742
chr2_-_52550135 Show fit	6.35	ENSDART00000044411	gna11b NCBI UniProt Show fit	guanine nucleotide binding protein (G protein), alpha 11b (Gq class)
chr7_+_24814866 Show fit	5.95	ENSDART00000173581	si:ch211-226l4.6 NCBI UniProt Show fit	si:ch211-226l4.6
chr22_-_38274188 Show fit	5.47	ENSDART00000139420 ENSDART00000015117	elavl2 NCBI UniProt Show fit	ELAV like neuron-specific RNA binding protein 2
chr10_+_6884123 Show fit	5.31	ENSDART00000149095 ENSDART00000148772 ENSDART00000149334	ddx4 NCBI UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr23_-_29357764 Show fit	5.26	ENSDART00000156512	si:ch211-129o18.4 NCBI UniProt Show fit	si:ch211-129o18.4
chr13_+_31402067 Show fit	4.82	ENSDART00000019202	tdrd9 NCBI UniProt Show fit	tudor domain containing 9
chr21_+_34992550 Show fit	4.73	ENSDART00000109041 ENSDART00000135400	tmprss15 NCBI UniProt Show fit	transmembrane protease, serine 15
chr20_+_35438300 Show fit	4.48	ENSDART00000102504 ENSDART00000153249	tdrd6 NCBI UniProt Show fit	tudor domain containing 6
chr1_+_12196688 Show fit	4.40	ENSDART00000143839	tdrd7a NCBI UniProt Show fit	tudor domain containing 7 a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f1_e2f7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	11.4	GO:0030719	P granule organization(GO:0030719)
0.2	10.7	GO:1902593	protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.5	8.9	GO:0006265	DNA topological change(GO:0006265)
0.0	7.9	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
1.4	7.0	GO:0043570	maintenance of DNA repeat elements(GO:0043570)
0.1	6.9	GO:0006334	nucleosome assembly(GO:0006334)
0.6	6.8	GO:0000729	DNA double-strand break processing(GO:0000729)
0.7	6.7	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.2	6.6	GO:0071427	mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.2	5.5	GO:0006278	RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004)

Showing 1 to 10 of 141 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	14.5	GO:0043186	P granule(GO:0043186)
0.0	13.6	GO:0005654	nucleoplasm(GO:0005654)
0.0	10.4	GO:0005730	nucleolus(GO:0005730)
0.1	8.2	GO:0000786	nucleosome(GO:0000786)
0.3	7.1	GO:0000783	telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.3	7.1	GO:0035861	site of double-strand break(GO:0035861)
2.3	7.0	GO:0033391	chromatoid body(GO:0033391)
0.6	7.0	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1	6.5	GO:0001750	photoreceptor outer segment(GO:0001750)
0.1	5.9	GO:0031228	integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)

Showing 1 to 10 of 71 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.5	GO:0003724	RNA helicase activity(GO:0003724)
0.0	9.0	GO:0046982	protein heterodimerization activity(GO:0046982)
0.0	9.0	GO:0004721	phosphoprotein phosphatase activity(GO:0004721)
0.7	8.9	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.1	8.7	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	7.2	GO:0042393	histone binding(GO:0042393)
1.7	7.0	GO:0032135	DNA insertion or deletion binding(GO:0032135)
0.0	6.9	GO:0030246	carbohydrate binding(GO:0030246)
0.1	6.6	GO:0101005	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.8	6.3	GO:0031826	type 2A serotonin receptor binding(GO:0031826)

Showing 1 to 10 of 109 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.5	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.2	5.4	PID BARD1 PATHWAY	BARD1 signaling events
0.1	5.4	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	2.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	2.6	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.1	2.2	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.1	1.9	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	1.9	PID P53 REGULATION PATHWAY	p53 pathway
0.1	1.8	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	1.6	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Showing 1 to 10 of 18 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	9.4	REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION	Genes involved in E2F mediated regulation of DNA replication
0.4	7.0	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.3	4.6	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.3	4.5	REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1	3.4	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.3	3.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2	3.2	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.2	2.8	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2	2.6	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.3	2.3	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling

Showing 1 to 10 of 37 entries

Results for e2f1_e2f7

Z-value: 3.54

Motif logo

Transcription factors associated with e2f1_e2f7

Activity-expression correlation:

Activity profile of e2f1_e2f7 motif

Sorted Z-values of e2f1_e2f7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f1_e2f7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: