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PRJNA195909:zebrafish embryo and larva development
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Results for drgx_arxb
Z-value: 1.26
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Transcription factors associated with drgx_arxb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| drgx | dr11_v1_chr13_+_30912385_30912385 | 0.88 | 2.0e-03 | Click! |
| arxb | dr11_v1_chr21_-_40676224_40676224 | 0.61 | 8.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_+_31276842 Show fit | 11.01 |
ENSDART00000187238
|
troponin I type 2a (skeletal, fast), tandem duplicate 4 |
|
| chr21_+_7582036 Show fit | 3.23 |
ENSDART00000135485
ENSDART00000027268 |
orthopedia homeobox a |
|
| chr4_+_9669717 Show fit | 3.00 |
ENSDART00000004604
|
si:dkey-153k10.9 |
|
| chr7_+_26629084 Show fit | 2.26 |
ENSDART00000101044
ENSDART00000173765 |
heat shock factor binding protein 1a |
|
| chr9_+_34641237 Show fit | 2.23 |
ENSDART00000133996
|
short stature homeobox |
|
| chr10_-_26744131 Show fit | 2.06 |
ENSDART00000020096
ENSDART00000162710 ENSDART00000179853 |
fibroblast growth factor 13b |
|
| chr16_-_31717851 Show fit | 2.04 |
ENSDART00000169109
|
retinol binding protein 1a, cellular |
|
| chr6_+_23887314 Show fit | 1.94 |
ENSDART00000163188
|
zinc finger protein 648 |
|
| chr12_+_42436920 Show fit | 1.85 |
ENSDART00000177303
|
early B cell factor 3a |
|
| chr16_-_31718013 Show fit | 1.73 |
ENSDART00000190716
|
retinol binding protein 1a, cellular |
Network of associatons between targets according to the STRING database.
First level regulatory network of drgx_arxb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.0 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.5 | 3.2 | GO:0021767 | mammillary body development(GO:0021767) social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703) |
| 0.2 | 2.3 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 2.2 | GO:0033339 | pectoral fin development(GO:0033339) |
| 0.1 | 2.1 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.5 | 2.0 | GO:0061549 | sympathetic ganglion development(GO:0061549) |
| 0.1 | 1.7 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.0 | 1.6 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
| 0.3 | 1.5 | GO:0048025 | negative regulation of RNA splicing(GO:0033119) negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.1 | 1.4 | GO:1900052 | regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.0 | GO:0005861 | troponin complex(GO:0005861) |
| 0.2 | 2.7 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
| 0.0 | 2.3 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 1.6 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 1.4 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 1.0 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 0.9 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.0 | 0.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
| 0.1 | 0.7 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 0.7 | GO:0031045 | dense core granule(GO:0031045) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.8 | GO:0016918 | retinal binding(GO:0016918) |
| 0.1 | 2.7 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.0 | 2.4 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 2.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 2.1 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 1.3 | GO:0008263 | mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263) |
| 0.0 | 1.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 1.1 | GO:0016413 | O-acetyltransferase activity(GO:0016413) |
| 0.1 | 1.0 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 1.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 1.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 1.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.4 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 0.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.2 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 1.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 0.9 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 0.7 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.4 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |