ISMARA results: ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

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PRJNA195909:zebrafish embryo and larva development

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Results for ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

Z-value: 2.28

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Transcription factors associated with ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

Gene Symbol	Gene ID	Gene Info
nfatc1 NCBI UniProt	ENSDARG00000036168	nuclear factor of activated T cells 1
nfatc3b NCBI UniProt	ENSDARG00000051729	nuclear factor of activated T cells 3b
nfatc4 NCBI UniProt	ENSDARG00000054162	nuclear factor of activated T cells 4
nfatc3a NCBI UniProt	ENSDARG00000076297	nuclear factor of activated T cells 3a
nfatc2b NCBI UniProt	ENSDARG00000079972	nuclear factor of activated T cells 2b
ddx28 NCBI UniProt	ENSDARG00000112133	nuclear factor of activated T cells 3a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nfatc1	dr11_v1_chr19_+_22216778_22216778	0.91	5.6e-04	Click!
nfatc3b	dr11_v1_chr25_-_36248053_36248053	0.76	1.7e-02	Click!
nfatc3a	dr11_v1_chr7_-_34927961_34927961	-0.63	7.0e-02	Click!
nfatc2b	dr11_v1_chr6_-_55254786_55254786	-0.56	1.2e-01	Click!
nfatc4	dr11_v1_chr2_-_37797577_37797577	0.34	3.7e-01	Click!

Activity profile of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4 motif

Sorted Z-values of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_42191592 Show fit	4.90	ENSDART00000144716	cavin4a NCBI UniProt Show fit	caveolae associated protein 4a
chr3_-_32817274 Show fit	4.62	ENSDART00000142582	mylpfa NCBI UniProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle a
chr6_-_39313027 Show fit	4.36	ENSDART00000012644	krt4 NCBI UniProt Show fit	keratin 4
chr11_-_24191928 Show fit	4.13	ENSDART00000136827	sox12 NCBI UniProt Show fit	SRY (sex determining region Y)-box 12
chr3_-_20091964 Show fit	4.04	ENSDART00000029386 ENSDART00000020253 ENSDART00000124326	slc4a1a NCBI UniProt Show fit	solute carrier family 4 (anion exchanger), member 1a (Diego blood group)
chr12_-_16636627 Show fit	3.89	ENSDART00000128811	si:dkey-239j18.3 NCBI UniProt Show fit	si:dkey-239j18.3
chr1_+_19332837 Show fit	3.85	ENSDART00000078594	tyrp1b NCBI UniProt Show fit	tyrosinase-related protein 1b
chr16_+_23397785 Show fit	3.71	ENSDART00000148961	s100a10b NCBI UniProt Show fit	S100 calcium binding protein A10b
chr16_+_23398369 Show fit	3.70	ENSDART00000037694	s100a10b NCBI UniProt Show fit	S100 calcium binding protein A10b
chr25_-_15045338 Show fit	3.42	ENSDART00000161165 ENSDART00000165774 ENSDART00000172538	pax6a NCBI UniProt Show fit	paired box 6a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	16.9	GO:0006955	immune response(GO:0006955)
0.0	7.8	GO:0048704	embryonic skeletal system morphogenesis(GO:0048704)
0.1	5.9	GO:0035023	regulation of Rho protein signal transduction(GO:0035023)
0.2	4.0	GO:0015701	bicarbonate transport(GO:0015701)
1.3	3.9	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.8	3.9	GO:0097066	response to thyroid hormone(GO:0097066)
0.5	3.4	GO:0060221	retinal rod cell differentiation(GO:0060221)
0.3	3.3	GO:0060561	apoptotic process involved in morphogenesis(GO:0060561)
0.1	3.0	GO:0007634	optokinetic behavior(GO:0007634)
0.0	3.0	GO:0010842	retina layer formation(GO:0010842)

Showing 1 to 10 of 147 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	16.4	GO:0005764	lysosome(GO:0005764)
0.0	12.3	GO:0005615	extracellular space(GO:0005615)
0.1	4.9	GO:0005901	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.4	4.4	GO:0045095	keratin filament(GO:0045095)
0.1	4.3	GO:0005884	actin filament(GO:0005884)
0.0	4.1	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	4.0	GO:0043235	receptor complex(GO:0043235)
0.3	3.9	GO:0033162	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	3.6	GO:0031012	extracellular matrix(GO:0031012)
0.1	3.3	GO:0031941	filamentous actin(GO:0031941)

Showing 1 to 10 of 53 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	22.1	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1	21.7	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	20.9	GO:0005509	calcium ion binding(GO:0005509)
0.3	9.1	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.1	8.5	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	8.2	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2	4.0	GO:0005452	inorganic anion exchanger activity(GO:0005452)
0.1	3.9	GO:0017075	syntaxin-1 binding(GO:0017075)
0.1	3.9	GO:0008013	beta-catenin binding(GO:0008013)
0.2	3.4	GO:0051371	muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)

Showing 1 to 10 of 99 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	2.7	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.1	2.5	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.1	2.5	NABA COLLAGENS	Genes encoding collagen proteins
0.1	2.4	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	2.0	PID FGF PATHWAY	FGF signaling pathway
0.0	1.9	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	1.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	1.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Showing 1 to 10 of 28 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.7	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.2	5.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	3.9	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.1	2.5	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	2.4	REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	Genes involved in 3' -UTR-mediated translational regulation
0.3	1.8	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.3	1.8	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.0	1.3	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	1.3	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	1.2	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors

Showing 1 to 10 of 27 entries

Results for ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

Z-value: 2.28

Motif logo

Transcription factors associated with ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

Activity-expression correlation:

Activity profile of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4 motif

Sorted Z-values of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: