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PRJNA195909:zebrafish embryo and larva development

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Results for ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

Z-value: 2.28

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Transcription factors associated with ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

Gene Symbol Gene ID Gene Info
ENSDARG00000036168 nuclear factor of activated T cells 1
ENSDARG00000051729 nuclear factor of activated T cells 3b
ENSDARG00000054162 nuclear factor of activated T cells 4
ENSDARG00000076297 nuclear factor of activated T cells 3a
ENSDARG00000079972 nuclear factor of activated T cells 2b
ENSDARG00000112133 nuclear factor of activated T cells 3a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nfatc1dr11_v1_chr19_+_22216778_222167780.915.6e-04Click!
nfatc3bdr11_v1_chr25_-_36248053_362480530.761.7e-02Click!
nfatc3adr11_v1_chr7_-_34927961_34927961-0.637.0e-02Click!
nfatc2bdr11_v1_chr6_-_55254786_55254786-0.561.2e-01Click!
nfatc4dr11_v1_chr2_-_37797577_377975770.343.7e-01Click!

Activity profile of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4 motif

Sorted Z-values of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_42191592 4.90 ENSDART00000144716
caveolae associated protein 4a
chr3_-_32817274 4.62 ENSDART00000142582
myosin light chain, phosphorylatable, fast skeletal muscle a
chr6_-_39313027 4.36 ENSDART00000012644
keratin 4
chr11_-_24191928 4.13 ENSDART00000136827
SRY (sex determining region Y)-box 12
chr3_-_20091964 4.04 ENSDART00000029386
ENSDART00000020253
ENSDART00000124326
solute carrier family 4 (anion exchanger), member 1a (Diego blood group)
chr12_-_16636627 3.89 ENSDART00000128811
si:dkey-239j18.3
chr1_+_19332837 3.85 ENSDART00000078594
tyrosinase-related protein 1b
chr16_+_23397785 3.71 ENSDART00000148961
S100 calcium binding protein A10b
chr16_+_23398369 3.70 ENSDART00000037694
S100 calcium binding protein A10b
chr25_-_15045338 3.42 ENSDART00000161165
ENSDART00000165774
ENSDART00000172538
paired box 6a
chr12_-_26064480 3.41 ENSDART00000158215
ENSDART00000171206
ENSDART00000171212
ENSDART00000182956
ENSDART00000186779
LIM domain binding 3b
chr7_-_52558495 3.29 ENSDART00000138263
ENSDART00000009938
ENSDART00000174292
ENSDART00000174218
ENSDART00000174335
transcription factor 12
chr12_-_16595406 3.23 ENSDART00000166798
si:dkey-239j18.2
chr23_+_36130883 3.23 ENSDART00000103132
homeobox C4a
chr3_-_61181018 3.23 ENSDART00000187970
parvalbumin 4
chr12_-_16595177 3.03 ENSDART00000133962
si:dkey-239j18.2
chr2_-_41518340 2.83 ENSDART00000130830
otolith matrix protein
chr4_+_17417111 2.81 ENSDART00000056005
achaete-scute family bHLH transcription factor 1a
chr12_-_31103187 2.72 ENSDART00000005562
ENSDART00000031408
ENSDART00000125046
ENSDART00000009237
ENSDART00000122972
ENSDART00000153068
transcription factor 7 like 2
chr13_+_23157053 2.72 ENSDART00000162359
sorbin and SH3 domain containing 1
chr9_+_3388099 2.72 ENSDART00000019910
distal-less homeobox 1a
chr20_-_10120442 2.71 ENSDART00000144970
Meis homeobox 2b
chr9_+_53276356 2.69 ENSDART00000003310
SRY (sex determining region Y)-box 21b
chr6_-_49063085 2.64 ENSDART00000156124
si:ch211-105j21.9
chr4_+_7677318 2.58 ENSDART00000149218
ELK3, ETS-domain protein
chr19_-_41069573 2.55 ENSDART00000111982
ENSDART00000193142
sarcoglycan, epsilon
chr12_+_42436920 2.53 ENSDART00000177303
early B cell factor 3a
chr1_-_12278522 2.51 ENSDART00000142122
ENSDART00000003825
complexin 2, like
chr3_-_41791178 2.46 ENSDART00000049687
galectin-related inter-fiber protein
chr22_-_37349967 2.41 ENSDART00000104493
SRY (sex determining region Y)-box 2
chr5_+_32345187 2.39 ENSDART00000147132
complement component 9
chr12_-_16898140 2.30 ENSDART00000152656
Cathepsin L1-like
chr22_-_26353916 2.29 ENSDART00000077958
calpain 2, (m/II) large subunit b
chr12_-_16923162 2.24 ENSDART00000106072
si:dkey-26g8.5
chr7_-_38658411 2.23 ENSDART00000109463
ENSDART00000017155
nephrosin
chr12_-_16694092 2.22 ENSDART00000047916
cathepsin Lb
chr12_-_16558106 2.20 ENSDART00000109033
si:dkey-269i1.4
chr8_-_40464935 2.19 ENSDART00000040013
myosin, light chain 7, regulatory
chr13_+_25449681 2.19 ENSDART00000101328
atonal bHLH transcription factor 7
chr12_-_16877136 2.19 ENSDART00000152593
si:dkey-269i1.4
chr22_-_15587360 2.17 ENSDART00000142717
ENSDART00000138978
tropomyosin 4a
chr6_+_6491013 2.16 ENSDART00000140827
B cell CLL/lymphoma 11Ab
chr6_+_49095646 2.14 ENSDART00000103385
solute carrier family 25, member 55a
chr12_-_16720196 2.13 ENSDART00000187639
si:dkey-26g8.4
chr4_-_15420452 2.09 ENSDART00000016230
plexin A4
chr10_-_29903165 2.07 ENSDART00000078800
lens intrinsic membrane protein 2.1
chr1_-_38195012 2.07 ENSDART00000020409
heart and neural crest derivatives expressed 2
chr16_+_20910186 2.02 ENSDART00000046766
homeobox A10b
chr12_-_16941319 2.01 ENSDART00000109968
zgc:174855
chr2_+_38161318 2.01 ENSDART00000044264
matrix metallopeptidase 14b (membrane-inserted)
chr22_-_17606575 1.99 ENSDART00000183951
glutathione peroxidase 4a
chr7_-_52531252 1.98 ENSDART00000174369
transcription factor 12
chr2_-_30182353 1.97 ENSDART00000019149
ribosomal protein L7
chr23_+_23119008 1.96 ENSDART00000132418
sterile alpha motif domain containing 11
chr12_+_16949391 1.95 ENSDART00000152635
zgc:174153
chr13_+_17672527 1.92 ENSDART00000148269
ENSDART00000137776
catechol-O-methyltransferase domain containing 1
chr24_+_11334733 1.90 ENSDART00000147552
ENSDART00000143171
si:dkey-12l12.1
chr9_+_26103814 1.89 ENSDART00000026011
ephrin-B2a
chr20_+_31287356 1.85 ENSDART00000007688
solute carrier family 22 (organic cation/carnitine transporter), member 16
chr7_-_40993456 1.84 ENSDART00000031700
engrailed homeobox 2a
chr3_+_23721808 1.83 ENSDART00000012470
homeobox B4a
chr2_-_48196092 1.82 ENSDART00000139944
secondary ossification center associated regulator of chondrocyte maturation
chr20_+_26690036 1.82 ENSDART00000103232
forkhead box F2b
chr2_-_20923864 1.81 ENSDART00000006870
prostaglandin-endoperoxide synthase 2a
chr9_+_31752628 1.80 ENSDART00000060054
integrin, beta-like 1
chr25_+_4837915 1.80 ENSDART00000168016
guanine nucleotide binding protein (G protein), beta 5a
chr13_-_46429220 1.80 ENSDART00000149125
ENSDART00000098269
ENSDART00000150061
ENSDART00000080916
fibroblast growth factor receptor 2
chr7_-_30367650 1.76 ENSDART00000075519
aldehyde dehydrogenase 1 family, member A2
chr9_-_1949915 1.76 ENSDART00000190712
homeobox D3a
chr16_-_22713152 1.73 ENSDART00000140953
ENSDART00000143836
si:ch211-105c13.3
chr2_-_39017838 1.72 ENSDART00000048838
retinol binding protein 2b, cellular
chr11_+_13630107 1.72 ENSDART00000172220
si:ch211-1a19.3
chr9_-_1959917 1.72 ENSDART00000082359
homeobox D3a
chr7_-_24022340 1.72 ENSDART00000149133
cell death-inducing DFFA-like effector b
chr8_+_17078692 1.72 ENSDART00000023206
polo-like kinase 2b (Drosophila)
chr4_+_19534833 1.71 ENSDART00000140028
leucine rich repeat containing 4.1
chr23_-_27633730 1.67 ENSDART00000103639
ADP-ribosylation factor 3a
chr23_+_36101185 1.66 ENSDART00000103139
homeobox C8a
chr7_-_13882988 1.64 ENSDART00000169828
retinaldehyde binding protein 1a
chr14_+_24277556 1.63 ENSDART00000122660
heterogeneous nuclear ribonucleoprotein A0a
chr2_-_37956768 1.61 ENSDART00000034595
cerebellin 10
chr20_-_49681850 1.59 ENSDART00000025926
collagen, type XII, alpha 1b
chr1_-_58664854 1.55 ENSDART00000109528
adhesion G protein-coupled receptor E5b, duplicate 3
chr12_-_16720432 1.55 ENSDART00000152261
ENSDART00000152154
si:dkey-26g8.4
chr1_-_56223913 1.55 ENSDART00000019573
zgc:65894
chr8_+_25616946 1.53 ENSDART00000133983
solute carrier family 38, member 5a
chr8_+_37489495 1.51 ENSDART00000141516
fibromodulin b
chr13_+_13681681 1.51 ENSDART00000057825
complement factor D (adipsin)
chr14_-_32744464 1.50 ENSDART00000075617
SRY (sex determining region Y)-box 3
chr7_+_15871156 1.47 ENSDART00000145946
paired box 6b
chr11_-_32723851 1.47 ENSDART00000155592
protocadherin 17
chr4_+_19535946 1.46 ENSDART00000192342
ENSDART00000183740
ENSDART00000180812
ENSDART00000180017
leucine rich repeat containing 4.1
chr1_-_38816685 1.46 ENSDART00000075230
ankyrin repeat and SOCS box containing 5b
chr4_+_12013642 1.45 ENSDART00000067281
cryptochrome circadian clock 1aa
chr10_-_28761454 1.44 ENSDART00000129400
activated leukocyte cell adhesion molecule a
chr9_+_33145522 1.43 ENSDART00000005879
ATP synthase peripheral stalk subunit OSCP
chr13_-_31470439 1.42 ENSDART00000076574
reticulon 1a
chr13_+_1155536 1.41 ENSDART00000148356
PERP, TP53 apoptosis effector
chr5_+_30179010 1.41 ENSDART00000134624
ADAM metallopeptidase with thrombospondin type 1 motif, 15a
chr4_+_61995745 1.38 ENSDART00000171539

chr8_+_22931427 1.37 ENSDART00000063096
synaptophysin a
chr18_-_39583601 1.37 ENSDART00000125116
tumor necrosis factor, alpha-induced protein 8-like 3
chr14_-_448182 1.37 ENSDART00000180018
FAT atypical cadherin 4
chr23_-_20309505 1.36 ENSDART00000130856
laminin, beta 2-like
chr10_-_43771447 1.35 ENSDART00000052307
arrestin domain containing 3b
chr14_+_49296052 1.34 ENSDART00000006073
ENSDART00000105346
annexin A6
chr23_-_24682244 1.34 ENSDART00000104035
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr16_-_35975254 1.32 ENSDART00000167537
eva-1 homolog Ba (C. elegans)
chr4_-_22311610 1.31 ENSDART00000137814
hematopoietic cell-specific Lyn substrate 1
chr5_+_37091626 1.31 ENSDART00000161054
transgelin 2
chr6_-_8311044 1.29 ENSDART00000129674
solute carrier family 44 (choline transporter), member 2
chr1_-_28629471 1.28 ENSDART00000121758
endothelin receptor Ba
chr12_+_18234557 1.28 ENSDART00000130741
family with sequence similarity 20, member Cb
chr11_-_18705303 1.28 ENSDART00000059732
inhibitor of DNA binding 1
chr22_+_28446557 1.27 ENSDART00000089546
ABI family, member 3 (NESH) binding protein b
chr1_-_22834824 1.25 ENSDART00000043556
LIM domain binding 2b
chr14_-_33454595 1.22 ENSDART00000109615
ENSDART00000173267
ENSDART00000185737
ENSDART00000190989
transmembrane protein 255A
chr22_+_28446365 1.22 ENSDART00000189359
ABI family, member 3 (NESH) binding protein b
chr20_+_15552657 1.22 ENSDART00000063912
Jun proto-oncogene, AP-1 transcription factor subunit
chr3_-_39152478 1.22 ENSDART00000154550
si:dkeyp-57f11.2
chr25_+_27493444 1.22 ENSDART00000112299
G protein-coupled receptor 37a
chr1_-_21599219 1.22 ENSDART00000148327
ADAMTS-like 7
chr11_-_26666501 1.22 ENSDART00000188067
ENSDART00000111539
EF-hand and coiled-coil domain containing 1
chr7_-_68373495 1.22 ENSDART00000167440
zinc finger homeobox 3
chr19_-_31522625 1.20 ENSDART00000158438
ENSDART00000035049
N-terminal EF-hand calcium binding protein 1
chr19_+_5674907 1.20 ENSDART00000042189
pyruvate dehydrogenase kinase, isozyme 2b
chr1_+_44911405 1.19 ENSDART00000182465
wu:fc21g02
chr9_-_12424791 1.18 ENSDART00000135447
ENSDART00000088199
zgc:162707
chr13_-_39947335 1.18 ENSDART00000056996
secreted frizzled-related protein 5
chr6_-_50204262 1.16 ENSDART00000163648
RALY heterogeneous nuclear ribonucleoprotein
chr11_+_24290130 1.16 ENSDART00000029695
purine nucleoside phosphorylase 4a
chr4_-_22310956 1.16 ENSDART00000162585
hematopoietic cell-specific Lyn substrate 1
chr9_-_18716 1.15 ENSDART00000164763

chr2_-_32558795 1.14 ENSDART00000140026
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr21_+_2091895 1.14 ENSDART00000161828
si:rp71-1h20.9
chr7_-_52417777 1.12 ENSDART00000110265
myocardial zonula adherens protein
chr10_+_8767541 1.10 ENSDART00000170272
integrin, alpha 1
chr10_-_42685512 1.09 ENSDART00000081347
stanniocalcin 1, like
chr15_-_20933574 1.09 ENSDART00000152648
ENSDART00000152448
ENSDART00000152244
ubiquitin specific peptidase 2a
chr4_-_9722568 1.09 ENSDART00000067190
tetraspanin 9b
chr13_-_50139916 1.07 ENSDART00000099475
nidogen 1a
chr18_-_44610992 1.07 ENSDART00000125968
ENSDART00000185836
sprouty-related, EVH1 domain containing 3
chr19_+_18797623 1.07 ENSDART00000166172
dimethylarginine dimethylaminohydrolase 2
chr6_-_48094342 1.06 ENSDART00000137458
solute carrier family 2 (facilitated glucose transporter), member 1b
chr6_-_19023468 1.06 ENSDART00000184729
septin 9b
chr1_+_37391141 1.04 ENSDART00000083593
ENSDART00000168647
SPARC-like 1
chr25_+_8955530 1.03 ENSDART00000156444
si:ch211-256a21.4
chr12_+_31713239 1.03 ENSDART00000122379
hyaluronan binding protein 2
chr1_+_19303241 1.03 ENSDART00000129970
si:dkeyp-118a3.2
chr3_-_28209001 1.03 ENSDART00000151178
RNA binding fox-1 homolog 1
chr11_-_36350421 1.03 ENSDART00000141477
proteasome subunit alpha 5
chr8_-_34051548 1.02 ENSDART00000105204
pre-B-cell leukemia homeobox 3b
chr13_+_1575276 1.02 ENSDART00000165987
dystonin
chr1_-_41192059 1.02 ENSDART00000084665
ENSDART00000135369
docking protein 7
chr3_+_45687266 1.02 ENSDART00000131652
G protein-coupled receptor 146
chr11_-_11471857 1.01 ENSDART00000030103
keratin 94
chr9_-_8454060 1.01 ENSDART00000110158
insulin receptor substrate 2b
chr13_-_42749916 1.01 ENSDART00000140019
calpain 2, (m/II) large subunit a
chr21_+_29077509 1.00 ENSDART00000128561
endothelial cell surface expressed chemotaxis and apoptosis regulator
chr13_+_42544009 1.00 ENSDART00000145409
si:dkey-221j11.3
chr8_-_19904124 0.99 ENSDART00000129193
TraB domain containing 2B
chr21_-_43131752 0.99 ENSDART00000024137
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2
chr9_-_42989297 0.99 ENSDART00000126871
titin, tandem duplicate 2
chr2_+_4207209 0.98 ENSDART00000157903
ENSDART00000166476
GATA binding protein 6
chr13_+_32740509 0.97 ENSDART00000076423
ENSDART00000160138
sine oculis binding protein homolog (Drosophila) a
chr17_+_51499789 0.96 ENSDART00000187701

chr11_+_10541258 0.96 ENSDART00000132365
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5a
chr24_-_17029374 0.96 ENSDART00000039267
prostaglandin D2 synthase b, tandem duplicate 1
chr1_-_51474974 0.96 ENSDART00000152719
sprouty-related, EVH1 domain containing 2a
chr7_-_33961551 0.95 ENSDART00000100104
SKI family transcriptional corepressor 1a
chr6_+_53349966 0.94 ENSDART00000167079
si:ch211-161c3.5
chr5_-_34997630 0.94 ENSDART00000170684
basic transcription factor 3
chr14_+_790166 0.94 ENSDART00000123912
adrenergic, alpha-2D-, receptor a
chr7_+_30787903 0.94 ENSDART00000174000
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr6_-_49673476 0.94 ENSDART00000112226
adenomatosis polyposis coli down-regulated 1-like
chr11_-_31039533 0.93 ENSDART00000127355
immediate early response 2b
chr12_+_17106117 0.93 ENSDART00000149990
actin, alpha 2, smooth muscle, aorta
chr8_+_7144066 0.93 ENSDART00000146306
solute carrier family 6 (neurotransmitter transporter), member 6a
chr20_+_1996202 0.92 ENSDART00000184143

chr17_+_33340675 0.92 ENSDART00000184396
ENSDART00000077553
xanthine dehydrogenase
chr8_+_40628926 0.92 ENSDART00000163598
dual specificity phosphatase 2
chr17_+_24848976 0.91 ENSDART00000062917
connexin 35.4
chr13_+_4205724 0.91 ENSDART00000134105
delta-like 2 homolog (Drosophila)
chr8_-_21268303 0.91 ENSDART00000067211
G protein-coupled receptor 37 like 1b
chr13_-_40401870 0.90 ENSDART00000128951
NK3 homeobox 3
chr5_-_48307804 0.88 ENSDART00000182831
ENSDART00000186920
ENSDART00000183585
myocyte enhancer factor 2cb
chr24_+_15670013 0.88 ENSDART00000185826

chr19_-_46775562 0.88 ENSDART00000187144
actin binding Rho activating protein b
chr15_-_1066269 0.88 ENSDART00000093133
arylacetamide deacetylase
chr19_-_38611814 0.87 ENSDART00000151958
collagen, type XVI, alpha 1
chr16_+_40301056 0.87 ENSDART00000058578
R-spondin 3
chr9_+_6587056 0.86 ENSDART00000193421
four and a half LIM domains 2a
chr13_-_27038407 0.85 ENSDART00000146712
coiled-coil domain containing 85A
chr9_+_4429593 0.83 ENSDART00000184855

chr2_-_13216269 0.83 ENSDART00000149947
BCL2, apoptosis regulator b
chr19_-_10243148 0.83 ENSDART00000148073
shisa family member 7
chr13_+_49175947 0.83 ENSDART00000056927
egl-9 family hypoxia-inducible factor 1a
chr10_-_35236949 0.82 ENSDART00000145804
yippee-like 2a
chr25_-_2081371 0.82 ENSDART00000104915
ENSDART00000156925
wingless-type MMTV integration site family, member 7Bb
chr22_+_13886821 0.81 ENSDART00000130585
ENSDART00000105711
SH3-domain binding protein 4a

Network of associatons between targets according to the STRING database.

First level regulatory network of ddx28+nfatc1+nfatc2b+nfatc3a+nfatc3b+nfatc4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.8 3.9 GO:0097066 response to thyroid hormone(GO:0097066)
0.7 2.8 GO:0061549 sympathetic ganglion development(GO:0061549)
0.7 2.1 GO:0007414 axonal defasciculation(GO:0007414)
0.7 2.7 GO:0010226 response to lithium ion(GO:0010226)
0.6 1.8 GO:0015695 organic cation transport(GO:0015695)
0.6 1.2 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031)
0.5 2.2 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.5 2.1 GO:0048485 sympathetic nervous system development(GO:0048485)
0.5 3.4 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.5 2.7 GO:0035881 amacrine cell differentiation(GO:0035881)
0.5 1.8 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.4 1.8 GO:0061113 pancreas morphogenesis(GO:0061113)
0.4 2.6 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.4 2.4 GO:0021982 pineal gland development(GO:0021982)
0.4 2.3 GO:0055014 atrial cardiac muscle cell development(GO:0055014)
0.4 1.5 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.4 1.9 GO:0007412 axon target recognition(GO:0007412)
0.4 1.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.3 1.3 GO:0001778 plasma membrane repair(GO:0001778) chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)
0.3 1.3 GO:0015871 choline transport(GO:0015871)
0.3 1.3 GO:0070166 enamel mineralization(GO:0070166)
0.3 1.6 GO:0051145 smooth muscle cell differentiation(GO:0051145)
0.3 0.9 GO:0090131 mesenchyme migration(GO:0090131)
0.3 0.9 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.3 1.1 GO:1903428 regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
0.3 0.8 GO:0070914 UV-damage excision repair(GO:0070914)
0.3 1.8 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.3 0.8 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
0.3 3.3 GO:0060561 apoptotic process involved in morphogenesis(GO:0060561)
0.2 2.7 GO:0003209 cardiac atrium morphogenesis(GO:0003209)
0.2 2.0 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.2 0.9 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.2 2.1 GO:0043490 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.2 1.5 GO:0090104 pancreatic D cell differentiation(GO:0003311) pancreatic epsilon cell differentiation(GO:0090104)
0.2 0.8 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.2 0.6 GO:1904088 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.2 1.0 GO:0001773 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
0.2 0.8 GO:0009826 unidimensional cell growth(GO:0009826)
0.2 0.4 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.2 0.8 GO:0071675 regulation of macrophage chemotaxis(GO:0010758) positive regulation of macrophage chemotaxis(GO:0010759) regulation of odontogenesis(GO:0042481) mononuclear cell migration(GO:0071674) regulation of mononuclear cell migration(GO:0071675)
0.2 0.8 GO:0061010 gall bladder development(GO:0061010)
0.2 0.9 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.2 0.7 GO:0060406 copulation(GO:0007620) regulation of epinephrine secretion(GO:0014060) positive regulation of epinephrine secretion(GO:0032812) positive regulation of catecholamine secretion(GO:0033605) penile erection(GO:0043084) epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242) regulation of penile erection(GO:0060405) positive regulation of penile erection(GO:0060406) prolactin secretion(GO:0070459)
0.2 0.5 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.2 4.0 GO:0015701 bicarbonate transport(GO:0015701)
0.2 1.2 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.2 1.1 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.1 0.6 GO:0014909 smooth muscle cell migration(GO:0014909)
0.1 0.4 GO:0035142 hindbrain structural organization(GO:0021577) dorsal fin morphogenesis(GO:0035142) axial mesoderm structural organization(GO:0048331) mesoderm structural organization(GO:0048338) cell motility involved in somitogenic axis elongation(GO:0090247) cell migration involved in somitogenic axis elongation(GO:0090248)
0.1 2.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.1 1.1 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 3.0 GO:0007634 optokinetic behavior(GO:0007634)
0.1 1.0 GO:0035479 angioblast cell migration from lateral mesoderm to midline(GO:0035479)
0.1 1.2 GO:0051597 response to methylmercury(GO:0051597)
0.1 0.5 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.1 0.4 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.1 0.7 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.1 0.8 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 0.4 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 1.0 GO:0048769 sarcomerogenesis(GO:0048769)
0.1 0.6 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 0.4 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.1 1.8 GO:0007622 rhythmic behavior(GO:0007622) circadian behavior(GO:0048512)
0.1 1.6 GO:0048679 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.1 2.4 GO:0006826 iron ion transport(GO:0006826)
0.1 0.2 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.1 0.6 GO:0030240 skeletal muscle thin filament assembly(GO:0030240) pointed-end actin filament capping(GO:0051694)
0.1 0.6 GO:0051013 microtubule severing(GO:0051013)
0.1 1.3 GO:0048070 regulation of developmental pigmentation(GO:0048070)
0.1 0.3 GO:0072337 modified amino acid transport(GO:0072337)
0.1 0.8 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.1 0.7 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 0.9 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.8 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 0.5 GO:0048790 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.1 0.5 GO:0021794 thalamus development(GO:0021794)
0.1 5.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 1.5 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.1 1.3 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 2.5 GO:0010675 regulation of cellular carbohydrate metabolic process(GO:0010675) regulation of glucose metabolic process(GO:0010906)
0.1 1.4 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 1.7 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.1 1.6 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.1 0.2 GO:0036363 transforming growth factor beta activation(GO:0036363) regulation of transforming growth factor beta production(GO:0071634) negative regulation of transforming growth factor beta production(GO:0071635)
0.1 1.4 GO:0070831 basement membrane assembly(GO:0070831)
0.0 3.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.9 GO:0043049 otic placode formation(GO:0043049)
0.0 2.5 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 0.3 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.0 0.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.4 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.6 GO:0016556 mRNA modification(GO:0016556)
0.0 0.7 GO:0050921 positive regulation of chemotaxis(GO:0050921) regulation of positive chemotaxis(GO:0050926) positive regulation of positive chemotaxis(GO:0050927) induction of positive chemotaxis(GO:0050930)
0.0 1.7 GO:0042742 defense response to bacterium(GO:0042742)
0.0 7.8 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 0.3 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 0.8 GO:0097192 signal transduction in absence of ligand(GO:0038034) extrinsic apoptotic signaling pathway in absence of ligand(GO:0097192)
0.0 1.0 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.2 GO:0070293 renal absorption(GO:0070293)
0.0 0.9 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.5 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 1.0 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.1 GO:0019323 pentose catabolic process(GO:0019323)
0.0 0.5 GO:0071594 B cell differentiation(GO:0030183) T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 0.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 1.1 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.3 GO:0036230 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0 16.9 GO:0006955 immune response(GO:0006955)
0.0 0.7 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.6 GO:0071910 determination of liver left/right asymmetry(GO:0071910)
0.0 1.6 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.9 GO:0060914 heart formation(GO:0060914)
0.0 0.1 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.1 GO:0006699 bile acid biosynthetic process(GO:0006699) bile acid metabolic process(GO:0008206)
0.0 0.2 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.1 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.0 0.4 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 1.2 GO:0030835 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.2 GO:0030816 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 1.3 GO:0051592 response to calcium ion(GO:0051592)
0.0 0.6 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043280) positive regulation of cysteine-type endopeptidase activity(GO:2001056)
0.0 0.7 GO:0007548 sex differentiation(GO:0007548)
0.0 1.1 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.2 GO:0030042 actin filament depolymerization(GO:0030042)
0.0 0.3 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 2.0 GO:0006979 response to oxidative stress(GO:0006979)
0.0 1.0 GO:0007596 blood coagulation(GO:0007596)
0.0 0.4 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.2 GO:0030217 T cell differentiation(GO:0030217)
0.0 0.5 GO:0051923 sulfation(GO:0051923)
0.0 0.3 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.0 2.3 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 0.4 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 0.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:0035912 establishment of cell polarity involved in ameboidal cell migration(GO:0003365) aorta morphogenesis(GO:0035909) dorsal aorta morphogenesis(GO:0035912)
0.0 0.2 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 0.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.0 1.0 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.7 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.2 GO:0045116 protein neddylation(GO:0045116) positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 0.5 GO:0043113 receptor clustering(GO:0043113)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0044279 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.7 2.7 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.4 4.4 GO:0045095 keratin filament(GO:0045095)
0.4 2.5 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 3.9 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2 1.4 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 0.8 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.2 1.4 GO:0071914 prominosome(GO:0071914)
0.2 0.9 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 4.9 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 2.5 GO:0043195 terminal bouton(GO:0043195)
0.1 1.8 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.4 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.9 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 3.3 GO:0031941 filamentous actin(GO:0031941)
0.1 1.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 2.9 GO:0008305 integrin complex(GO:0008305)
0.1 1.4 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.1 4.3 GO:0005884 actin filament(GO:0005884)
0.1 0.9 GO:0005869 dynactin complex(GO:0005869)
0.1 16.4 GO:0005764 lysosome(GO:0005764)
0.1 1.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.7 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.7 GO:0071564 npBAF complex(GO:0071564)
0.0 4.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.8 GO:0031430 M band(GO:0031430)
0.0 0.4 GO:0014704 intercalated disc(GO:0014704)
0.0 0.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 2.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 2.7 GO:0005581 collagen trimer(GO:0005581)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.7 GO:0030018 Z disc(GO:0030018)
0.0 1.1 GO:0005604 basement membrane(GO:0005604)
0.0 0.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.2 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.7 GO:0043204 perikaryon(GO:0043204)
0.0 0.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.2 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.7 GO:0000922 spindle pole(GO:0000922)
0.0 0.3 GO:0043209 myelin sheath(GO:0043209)
0.0 0.5 GO:0098831 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.2 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.8 GO:0016342 catenin complex(GO:0016342)
0.0 0.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.0 GO:0005814 centriole(GO:0005814)
0.0 3.6 GO:0031012 extracellular matrix(GO:0031012)
0.0 4.0 GO:0043235 receptor complex(GO:0043235)
0.0 0.9 GO:0030017 sarcomere(GO:0030017)
0.0 12.3 GO:0005615 extracellular space(GO:0005615)
0.0 1.1 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0048030 disaccharide binding(GO:0048030)
0.5 1.8 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 2.0 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.3 9.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.3 1.3 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.3 1.0 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.2 4.0 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.2 1.3 GO:0004962 endothelin receptor activity(GO:0004962)
0.2 1.3 GO:0030274 LIM domain binding(GO:0030274)
0.2 2.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.2 3.4 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.2 2.4 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.2 0.9 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.2 0.8 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.2 1.5 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.2 1.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 1.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 1.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.7 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 0.6 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.1 21.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 1.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 1.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.4 GO:0005183 gonadotropin hormone-releasing hormone activity(GO:0005183) gonadotropin-releasing hormone receptor binding(GO:0031530)
0.1 1.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 1.8 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 2.5 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 0.4 GO:0038046 enkephalin receptor activity(GO:0038046)
0.1 1.0 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.1 GO:0005113 patched binding(GO:0005113)
0.1 1.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.5 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697) type II activin receptor binding(GO:0070699)
0.1 2.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.7 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.5 GO:0046592 polyamine oxidase activity(GO:0046592)
0.1 0.9 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups(GO:0016725)
0.1 3.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.9 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 0.7 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 1.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.8 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.3 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.1 1.0 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.5 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.7 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.7 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 3.9 GO:0008013 beta-catenin binding(GO:0008013)
0.1 1.5 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 0.4 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 0.4 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.1 0.7 GO:0005042 netrin receptor activity(GO:0005042)
0.1 1.8 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 1.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.3 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 0.4 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 0.7 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.1 8.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.3 GO:0004960 thromboxane receptor activity(GO:0004960)
0.1 1.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 8.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.8 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 2.4 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.2 GO:0043914 NADPH:sulfur oxidoreductase activity(GO:0043914)
0.0 2.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.6 GO:2001069 glycogen binding(GO:2001069)
0.0 1.8 GO:0005178 integrin binding(GO:0005178)
0.0 0.5 GO:0005165 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.0 0.9 GO:0005112 Notch binding(GO:0005112)
0.0 1.0 GO:0005518 collagen binding(GO:0005518)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785) tropomyosin binding(GO:0005523)
0.0 0.5 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:1903924 estradiol binding(GO:1903924)
0.0 0.5 GO:0098882 structural constituent of presynaptic active zone(GO:0098882) structural constituent of synapse(GO:0098918)
0.0 0.9 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.0 0.3 GO:0030507 spectrin binding(GO:0030507)
0.0 1.9 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 20.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.5 GO:0008201 heparin binding(GO:0008201)
0.0 0.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.8 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 1.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.9 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.3 GO:0030546 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.0 0.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 22.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 1.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 1.1 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 1.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 0.8 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 1.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.3 PID IL3 PATHWAY IL3-mediated signaling events
0.1 2.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 0.6 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 2.5 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.7 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 4.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 0.5 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.1 2.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.0 PID FGF PATHWAY FGF signaling pathway
0.1 0.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.9 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.5 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.2 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.2 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.0 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.2 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.3 1.8 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.2 5.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 0.9 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 5.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 3.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 1.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 0.7 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 0.6 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 1.1 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 2.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.0 1.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.8 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.9 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 2.4 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.0 0.2 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 1.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.3 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.1 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12