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PRJNA195909:zebrafish embryo and larva development

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Results for crx+otx1

Z-value: 2.57

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Transcription factors associated with crx+otx1

Gene Symbol Gene ID Gene Info
ENSDARG00000011989 cone-rod homeobox
ENSDARG00000094992 orthodenticle homeobox 1
ENSDARG00000113850 cone-rod homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
otx1dr11_v1_chr17_+_24318753_243187530.932.7e-04Click!
crxdr11_v1_chr5_+_36932718_36932718-0.491.8e-01Click!

Activity profile of crx+otx1 motif

Sorted Z-values of crx+otx1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_45125537 5.83 ENSDART00000113552
zgc:163014
chr16_-_46579936 5.53 ENSDART00000166143
ENSDART00000127212
si:dkey-152b24.6
chr10_-_42898220 5.26 ENSDART00000099270

chr11_-_1550709 5.08 ENSDART00000110097
si:ch73-303b9.1
chr2_-_31686353 4.66 ENSDART00000126177
ENSDART00000056679
E2F transcription factor 5
chr9_-_8314028 4.58 ENSDART00000102739
si:ch211-145c1.1
chr19_+_42898239 3.38 ENSDART00000051724
cAMP-regulated phosphoprotein, 21
chr13_+_15581270 3.13 ENSDART00000189880
ENSDART00000190067
ENSDART00000041293
MAP/microtubule affinity-regulating kinase 3a
chr20_-_54014539 3.07 ENSDART00000060466
si:dkey-241l7.6
chr16_-_25741225 2.98 ENSDART00000130641
B cell CLL/lymphoma 3
chr22_+_1170294 2.92 ENSDART00000159761
ENSDART00000169809
interferon regulatory factor 6
chr20_-_54014373 2.84 ENSDART00000152934
si:dkey-241l7.6
chr22_+_25453334 2.83 ENSDART00000123962
si:ch211-12h2.6
chr20_+_1272526 2.81 ENSDART00000008115
ENSDART00000133825
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr23_+_2560005 2.70 ENSDART00000186906
gamma-glutamyltransferase 7
chr3_-_3366590 2.67 ENSDART00000109428
ENSDART00000175329
si:dkey-46g23.1
chr13_+_1015749 2.67 ENSDART00000190982
prokineticin receptor 1b
chr14_+_30340251 2.65 ENSDART00000148448
microtubule associated tumor suppressor 1a
chr16_-_16225260 2.57 ENSDART00000165790
granulito
chr20_+_18260358 2.57 ENSDART00000187734
ENSDART00000191947
ENSDART00000057039
TAF4B RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr20_+_42537768 2.55 ENSDART00000134066
ENSDART00000153434
si:dkeyp-93d12.1
chr23_+_7710721 2.48 ENSDART00000186852
ENSDART00000161193
kinesin family member 3B
chr24_+_10039165 2.47 ENSDART00000144186
POU class 6 homeobox 2
chr5_-_69180587 2.45 ENSDART00000156681
ENSDART00000160753
zgc:171967
chr2_-_39036604 2.44 ENSDART00000129963
retinol binding protein 1b, cellular
chr1_+_52633367 2.36 ENSDART00000134658
solute carrier family 44 (choline transporter), member 1a
chr10_+_6013076 2.36 ENSDART00000167613
ENSDART00000159216
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr8_+_25091407 2.35 ENSDART00000143922
ataxin 7-like 2b
chr7_+_39011852 2.23 ENSDART00000093009
diacylglycerol kinase, zeta a
chr15_+_25683069 2.22 ENSDART00000148190
hypermethylated in cancer 1
chr8_+_2656681 2.21 ENSDART00000185067
ENSDART00000165943
family with sequence similarity 102, member Aa
chr5_-_23715027 2.18 ENSDART00000139020
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 1
chr3_-_15679107 2.15 ENSDART00000080441
zgc:66443
chr5_-_69180227 2.14 ENSDART00000154816
zgc:171967
chr15_-_5580093 2.11 ENSDART00000143726
WD repeat domain 62
chr1_-_24349759 2.09 ENSDART00000142740
ENSDART00000177989
LPS-responsive vesicle trafficking, beach and anchor containing
chr4_+_68562464 2.06 ENSDART00000192954

chr17_+_50701748 2.06 ENSDART00000191938
ENSDART00000183220
ENSDART00000049464
fermitin family member 2
chr4_-_17353100 2.04 ENSDART00000134467
ENSDART00000189019
PARP1 binding protein
chr8_+_28724692 2.02 ENSDART00000140115
coiled-coil serine-rich protein 1
chr7_-_39378903 2.02 ENSDART00000173659
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr23_+_39963599 2.00 ENSDART00000166539
FYVE and coiled-coil domain containing 1a
chr10_+_42898103 2.00 ENSDART00000015872
zinc finger, CCHC domain containing 9
chr8_+_2656231 1.97 ENSDART00000160833
family with sequence similarity 102, member Aa
chr20_+_2134816 1.96 ENSDART00000039249
l(3)mbt-like 3 (Drosophila)
chr5_-_27994679 1.94 ENSDART00000132740
protein phosphatase 3, catalytic subunit, gamma isozyme, a
chr18_+_27439680 1.92 ENSDART00000014726
tumor protein p53 inducible protein 11b
chr14_-_6402769 1.90 ENSDART00000121552
solute carrier family 44 (choline transporter), member 1b
chr5_-_27993972 1.88 ENSDART00000175819
protein phosphatase 3, catalytic subunit, gamma isozyme, a
chr5_-_23715861 1.86 ENSDART00000019992
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 1
chr12_+_23850661 1.85 ENSDART00000152921
supervillin a
chr5_-_52216170 1.82 ENSDART00000158542
ENSDART00000192981
leucyl/cystinyl aminopeptidase
chr13_+_8840772 1.80 ENSDART00000059321
epithelial cell adhesion molecule
chr2_+_44972720 1.77 ENSDART00000075146
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr16_+_53519048 1.72 ENSDART00000124691
sphingomyelin phosphodiesterase 5
chr21_-_18262287 1.70 ENSDART00000176716
vav 2 guanine nucleotide exchange factor
chr18_+_3634652 1.68 ENSDART00000159913
leucine-rich repeats and calponin homology (CH) domain containing 3
chr7_+_39011355 1.67 ENSDART00000173855
diacylglycerol kinase, zeta a
chr25_-_10610961 1.66 ENSDART00000153474
protein phosphatase 6, regulatory subunit 3
chr24_-_31140356 1.66 ENSDART00000167837
transmembrane protein 56a
chr25_+_35891342 1.65 ENSDART00000147093
LSM14A mRNA processing body assembly factor a
chr6_+_37655078 1.64 ENSDART00000122199
ENSDART00000065127
cytoplasmic FMR1 interacting protein 1
chr10_+_39476600 1.58 ENSDART00000135756
kirre like nephrin family adhesion molecule 3a
chr9_-_2945008 1.57 ENSDART00000183452
sterile alpha motif and leucine zipper containing kinase AZK
chr7_+_20030888 1.53 ENSDART00000192808
solute carrier family 16, member 13 (monocarboxylic acid transporter 13)
chr1_+_44523516 1.52 ENSDART00000147702
zinc finger, DHHC-type containing 5a
chr9_-_5318873 1.52 ENSDART00000129308
activin A receptor type 1C
chr11_+_6295370 1.51 ENSDART00000139882
RAN binding protein 3a
chr9_-_135774 1.50 ENSDART00000160435

chr18_+_173603 1.49 ENSDART00000185918
La ribonucleoprotein domain family, member 6a
chr9_+_17982737 1.48 ENSDART00000192569
A kinase (PRKA) anchor protein 11
chr17_-_1705013 1.47 ENSDART00000182864

chr9_-_46276626 1.45 ENSDART00000165238
histone deacetylase 4
chr20_-_36617313 1.45 ENSDART00000172395
ENSDART00000152856
enabled homolog (Drosophila)
chr16_+_9726038 1.43 ENSDART00000192988
ENSDART00000020859
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b
chr17_+_18031304 1.41 ENSDART00000127259
SET domain containing 3
chr1_-_43712120 1.40 ENSDART00000074600
si:dkey-162b23.4
chr2_-_32387441 1.38 ENSDART00000148202
upstream binding transcription factor, like
chr10_-_35108683 1.38 ENSDART00000049633
zgc:110006
chr14_+_21754521 1.37 ENSDART00000111839
lysine (K)-specific demethylase 2Ab
chr2_-_42864472 1.37 ENSDART00000134139
adenylate cyclase 8 (brain)
chr20_-_2134620 1.36 ENSDART00000064375
transmembrane protein 244
chr11_-_27821 1.35 ENSDART00000158769
ENSDART00000172970
ENSDART00000173118
ENSDART00000168674
ENSDART00000163545
ENSDART00000173411
ENSDART00000172132
sp1 transcription factor
chr18_-_8030073 1.34 ENSDART00000151490
SH3 and multiple ankyrin repeat domains 3a
chr23_+_25893020 1.31 ENSDART00000144769
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr23_-_42810664 1.28 ENSDART00000102328
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2a
chr18_-_19006634 1.27 ENSDART00000060731
integrator complex subunit 14
chr4_-_73562122 1.27 ENSDART00000174096

chr4_-_28353538 1.26 ENSDART00000064219
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
chr15_-_26930999 1.26 ENSDART00000181674
ENSDART00000126046
coiled-coil domain containing 9
chr18_-_19005919 1.26 ENSDART00000129776
integrator complex subunit 14
chr2_-_37537887 1.25 ENSDART00000143496
ENSDART00000025841
rho/rac guanine nucleotide exchange factor (GEF) 18a
chr22_-_16154771 1.25 ENSDART00000009464
solute carrier family 30 (zinc transporter), member 7
chr4_-_11053543 1.24 ENSDART00000067262
methyltransferase like 25
chr22_-_12304591 1.23 ENSDART00000136408
zinc finger, RAN-binding domain containing 3
chr19_-_12078583 1.20 ENSDART00000024193
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr16_+_38337783 1.19 ENSDART00000135008
GA binding protein transcription factor, beta subunit 2b
chr11_-_25257595 1.18 ENSDART00000123567
snail family zinc finger 1a
chr25_-_32363341 1.18 ENSDART00000153892
ENSDART00000114385
centrosomal protein 152
chr4_+_72797711 1.15 ENSDART00000190934
ENSDART00000163236
myelin regulatory factor-like
chr20_+_54666222 1.15 ENSDART00000166592

chr7_+_22330466 1.14 ENSDART00000187347
ENSDART00000174483
fibroblast growth factor 11a
chr23_+_21492151 1.13 ENSDART00000025487
isoprenylcysteine carboxyl methyltransferase
chr12_-_33659328 1.12 ENSDART00000153457
transmembrane protein 94
chr1_-_45580787 1.11 ENSDART00000135089
activating transcription factor 7 interacting protein
chr2_+_15069011 1.11 ENSDART00000145893
calponin 3, acidic b
chr2_+_24080694 1.10 ENSDART00000024058
potassium voltage-gated channel, subfamily H (eag-related), member 2a
chr21_-_40562705 1.08 ENSDART00000158289
ENSDART00000171997
TAO kinase 1b
chr6_+_37623693 1.08 ENSDART00000144812
ENSDART00000182709
tubulin, gamma complex associated protein 5
chr4_+_5196469 1.07 ENSDART00000067386
RAD51 associated protein 1
chr16_+_19637384 1.06 ENSDART00000184773
ENSDART00000191895
ENSDART00000182020
ENSDART00000135359
metastasis associated in colon cancer 1
chr23_+_12361899 1.00 ENSDART00000143728
phosphatidylinositol glycan anchor biosynthesis, class T
chr5_+_11407504 0.99 ENSDART00000186723
ENSDART00000018047
zgc:112294
chr15_+_20355465 0.98 ENSDART00000143092
ENSDART00000062666
interleukin 15, like
chr8_-_51806584 0.98 ENSDART00000146976
si:ch73-313l22.2
chr21_-_2209012 0.97 ENSDART00000158345
zgc:162971
chr3_-_26183699 0.96 ENSDART00000147517
ENSDART00000140731
si:ch211-11k18.4
chr23_-_42876596 0.95 ENSDART00000086156
discs, large (Drosophila) homolog-associated protein 4a
chr25_-_10630496 0.94 ENSDART00000153639
ENSDART00000181722
ENSDART00000177834
protein phosphatase 6, regulatory subunit 3
chr3_-_15210491 0.93 ENSDART00000037906
HIRA interacting protein 3
chr3_-_13068189 0.93 ENSDART00000167180
protein kinase, cAMP-dependent, regulatory, type I, beta
chr18_+_5618368 0.92 ENSDART00000159945
unc-51 like kinase 3
chr9_+_3519191 0.91 ENSDART00000008606
methyltransferase like 8
chr22_+_30047245 0.91 ENSDART00000142857
ENSDART00000141247
ENSDART00000140015
ENSDART00000040538
adducin 3 (gamma) a
chr11_+_19080400 0.89 ENSDART00000044423
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr18_-_10713414 0.88 ENSDART00000034817
RNA binding motif protein 28
chr2_+_36112273 0.88 ENSDART00000191315
T-cell receptor alpha joining 35
chr5_-_32489796 0.87 ENSDART00000168870
G protein-coupled receptor 107
chr4_-_73561848 0.87 ENSDART00000174210

chr8_+_18545933 0.84 ENSDART00000148806
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr5_-_22868650 0.84 ENSDART00000057541
apolipoprotein O-like
chr15_-_26931541 0.83 ENSDART00000027563
coiled-coil domain containing 9
chr3_+_62000822 0.79 ENSDART00000106680
retinoic acid induced 1
chr25_+_7532627 0.78 ENSDART00000187660
phosphatidylserine synthase 2
chr18_+_10784730 0.78 ENSDART00000028938
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr4_+_43408004 0.77 ENSDART00000150476
si:dkeyp-53e4.2
chr17_+_10593398 0.76 ENSDART00000168897
ENSDART00000193989
ENSDART00000191664
ENSDART00000167188
mitogen-activated protein kinase binding protein 1
chr25_-_19090479 0.76 ENSDART00000027465
ENSDART00000177670
calcium channel, voltage-dependent, alpha 2/delta subunit 4b
chr14_+_11289851 0.75 ENSDART00000113567
ring finger protein, LIM domain interacting
chr6_-_15641686 0.75 ENSDART00000135583
melanophilin a
chr3_-_26184018 0.73 ENSDART00000191604
si:ch211-11k18.4
chr25_+_29694158 0.72 ENSDART00000174568
bromodomain containing 1b
chr22_+_2431585 0.69 ENSDART00000167758
zgc:171435
chr1_+_59328030 0.68 ENSDART00000172464

chr17_+_18031899 0.67 ENSDART00000022758
SET domain containing 3
chr13_+_2442841 0.66 ENSDART00000114456
ENSDART00000137124
ENSDART00000193737
ENSDART00000189722
ENSDART00000187485
ARFGEF family member 3
chr7_-_30492261 0.64 ENSDART00000173954
ADAM metallopeptidase domain 10a
chr3_-_20058417 0.62 ENSDART00000165695
upstream binding transcription factor, RNA polymerase I
chr13_-_9101236 0.62 ENSDART00000163266
si:dkey-19p15.4
chr22_-_7457247 0.62 ENSDART00000106081

chr15_+_20364595 0.60 ENSDART00000062676
SPT5 homolog, DSIF elongation factor subunit
chr2_-_15349382 0.59 ENSDART00000057238
olfactomedin 3b
chr9_+_1313418 0.59 ENSDART00000191361
caspase 8, apoptosis-related cysteine peptidase, like 2
chr16_+_38159758 0.58 ENSDART00000058666
ENSDART00000112165
phosphatidylinositol 4-kinase, catalytic, beta
chr3_+_1209006 0.58 ENSDART00000158633
polymerase (DNA-directed), delta interacting protein 3
chr1_-_45215343 0.57 ENSDART00000014727
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Aa
chr4_+_31450683 0.56 ENSDART00000169303
zinc finger protein 996
chr17_+_2130018 0.56 ENSDART00000193675
ENSDART00000110529
BUB1 mitotic checkpoint serine/threonine kinase Bb
chr10_+_39476432 0.55 ENSDART00000190375
ENSDART00000183954
kirre like nephrin family adhesion molecule 3a
chr25_+_32031536 0.55 ENSDART00000173656
tight junction protein 1b
chr3_+_22327738 0.54 ENSDART00000055675
growth hormone 1
chr25_-_13549577 0.53 ENSDART00000166772
anoctamin 10b
chr21_+_33503835 0.52 ENSDART00000125658
clathrin interactor 1b
chr8_+_53120278 0.52 ENSDART00000125232
nuclear receptor subfamily 2, group C, member 2
chr16_+_33987892 0.50 ENSDART00000166302
phosphatidylinositol glycan anchor biosynthesis, class V
chr15_+_20363859 0.49 ENSDART00000166846
SPT5 homolog, DSIF elongation factor subunit
chr22_-_38934989 0.49 ENSDART00000008365
nuclear cap binding protein subunit 2
chr15_-_18213515 0.48 ENSDART00000101635
bloodthirsty-related gene family, member 21
chr11_-_15090118 0.45 ENSDART00000171118
solute carrier family 1 (glutamate transporter), member 8a
chr7_-_30492018 0.45 ENSDART00000099639
ENSDART00000162705
ENSDART00000173663
ADAM metallopeptidase domain 10a
chr9_+_1365747 0.44 ENSDART00000140917
ENSDART00000036605
protein kinase, interferon-inducible double stranded RNA dependent activator
chr14_+_2487672 0.44 ENSDART00000170629
ENSDART00000123063
fibroblast growth factor 18a
chr8_-_46572298 0.41 ENSDART00000030470
sulfotransferase family 1, cytosolic sulfotransferase 3
chr3_+_32842825 0.41 ENSDART00000122228
proline rich 14
chr4_-_20485508 0.40 ENSDART00000183276
ENSDART00000023337
N-acyl phosphatidylethanolamine phospholipase D
chr17_+_30448452 0.40 ENSDART00000153939
lipin 1
chr4_+_36906436 0.39 ENSDART00000136773

chr3_+_50602866 0.38 ENSDART00000190069
ENSDART00000153921
gsg1-like 2a
chr11_+_29770966 0.37 ENSDART00000088624
ENSDART00000124471
retinitis pigmentosa GTPase regulator b
chr12_-_35883814 0.37 ENSDART00000177986
ENSDART00000129888
centrosomal protein 131
chr10_+_26652859 0.36 ENSDART00000079174
HIV-1 Tat specific factor 1
chr14_+_52413846 0.35 ENSDART00000160952
nitric oxide associated 1
chr5_-_65082107 0.35 ENSDART00000162511
inositol polyphosphate-5-phosphatase E
chr25_-_10629940 0.33 ENSDART00000154483
ENSDART00000155231
protein phosphatase 6, regulatory subunit 3
chr25_+_35913614 0.33 ENSDART00000022437
glucose-6-phosphate isomerase a
chr13_+_41917606 0.33 ENSDART00000114741
polymerase (RNA) I polypeptide B
chr19_-_2876321 0.33 ENSDART00000159253
exosome component 7
chr23_-_35064785 0.33 ENSDART00000172240

chr20_-_54924593 0.31 ENSDART00000151522
si:dkey-15f23.1
chr14_-_8816933 0.30 ENSDART00000163383
si:dkeyp-115e12.7
chr5_+_26847190 0.30 ENSDART00000076742
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr14_-_36412473 0.29 ENSDART00000128244
ENSDART00000138376
ankyrin repeat and SOCS box containing 5a
chr2_+_24722771 0.28 ENSDART00000147207
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
chr19_+_34169055 0.27 ENSDART00000135592
ENSDART00000186043
POC1 centriolar protein homolog B (Chlamydomonas), like
chr23_+_30827959 0.27 ENSDART00000033429
neuropeptides B/W receptor 2a
chr4_+_65281752 0.27 ENSDART00000183934
zinc finger protein 1027
chr13_-_40499296 0.26 ENSDART00000158338
Danio rerio cyclin and CBS domain divalent metal cation transport mediator 1 (cnnm1), mRNA.
chr6_-_39218609 0.26 ENSDART00000133305
osteosarcoma amplified 9, endoplasmic reticulum lectin
chr17_-_7371564 0.25 ENSDART00000060336
RAB32b, member RAS oncogene family
chr23_+_1181248 0.24 ENSDART00000170942
utrophin

Network of associatons between targets according to the STRING database.

First level regulatory network of crx+otx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.5 1.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.4 1.6 GO:0099563 modification of synaptic structure(GO:0099563)
0.4 2.0 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.4 1.5 GO:0090299 regulation of neural crest formation(GO:0090299)
0.3 2.0 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.3 1.3 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.3 2.5 GO:0043584 nose development(GO:0043584)
0.3 2.1 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.3 2.6 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.2 4.0 GO:0030259 lipid glycosylation(GO:0030259)
0.2 1.2 GO:0098535 de novo centriole assembly(GO:0098535)
0.2 2.7 GO:0030431 sleep(GO:0030431)
0.2 1.1 GO:0060760 positive regulation of cytokine-mediated signaling pathway(GO:0001961) positive regulation of response to cytokine stimulus(GO:0060760)
0.2 1.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 1.6 GO:0034063 stress granule assembly(GO:0034063)
0.2 1.3 GO:2000463 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.2 0.7 GO:0051876 pigment granule dispersal(GO:0051876)
0.2 0.5 GO:0016264 gap junction assembly(GO:0016264)
0.2 2.7 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.2 1.2 GO:0048478 replication fork protection(GO:0048478)
0.2 1.7 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.2 3.9 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2 1.0 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 0.5 GO:0046831 regulation of nucleobase-containing compound transport(GO:0032239) positive regulation of nucleobase-containing compound transport(GO:0032241) positive regulation of nucleocytoplasmic transport(GO:0046824) regulation of RNA export from nucleus(GO:0046831) positive regulation of RNA export from nucleus(GO:0046833)
0.2 1.4 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 1.5 GO:0006611 protein export from nucleus(GO:0006611)
0.1 4.9 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.1 0.3 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.1 1.5 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1 2.5 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 1.1 GO:0018410 C-terminal protein amino acid modification(GO:0018410)
0.1 0.4 GO:0070291 N-acylethanolamine metabolic process(GO:0070291)
0.1 1.4 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 2.9 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.1 1.1 GO:0090308 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 1.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 1.0 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.1 1.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.6 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.1 0.8 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 1.8 GO:0043171 peptide catabolic process(GO:0043171)
0.1 1.2 GO:0008078 mesodermal cell migration(GO:0008078)
0.1 2.8 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.1 0.4 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.1 2.1 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.1 0.9 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 1.3 GO:0007020 microtubule nucleation(GO:0007020)
0.1 1.0 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 0.2 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 2.6 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 1.8 GO:0048920 posterior lateral line neuromast primordium migration(GO:0048920)
0.1 0.4 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.3 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 0.7 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.8 GO:0046549 retinal cone cell development(GO:0046549)
0.0 1.2 GO:0006829 zinc II ion transport(GO:0006829)
0.0 2.2 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0 0.1 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 1.1 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.4 GO:0046548 retinal rod cell development(GO:0046548)
0.0 1.1 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 1.1 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.1 GO:0060292 long term synaptic depression(GO:0060292)
0.0 2.8 GO:0006694 steroid biosynthetic process(GO:0006694)
0.0 0.1 GO:1901004 ubiquinone-6 metabolic process(GO:1901004) ubiquinone-6 biosynthetic process(GO:1901006)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.7 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.5 GO:0040019 positive regulation of embryonic development(GO:0040019)
0.0 2.1 GO:0007416 synapse assembly(GO:0007416)
0.0 1.5 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.4 GO:0006584 catecholamine metabolic process(GO:0006584) catechol-containing compound metabolic process(GO:0009712)
0.0 2.4 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.8 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 0.3 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.1 GO:0070255 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.0 1.0 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.2 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.6 GO:0060872 semicircular canal development(GO:0060872)
0.0 0.8 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.7 GO:1903844 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) regulation of cellular response to transforming growth factor beta stimulus(GO:1903844)
0.0 0.3 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.8 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.7 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.6 GO:0030042 actin filament depolymerization(GO:0030042)
0.0 1.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.0 GO:0045649 regulation of macrophage differentiation(GO:0045649)
0.0 0.2 GO:0032438 melanosome organization(GO:0032438)
0.0 1.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.4 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 1.0 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 1.6 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.0 1.5 GO:0001756 somitogenesis(GO:0001756)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.8 GO:0005955 calcineurin complex(GO:0005955)
0.4 1.2 GO:0098536 deuterosome(GO:0098536)
0.4 1.1 GO:0032044 DSIF complex(GO:0032044)
0.3 2.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.3 1.1 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.2 1.0 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 2.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 2.5 GO:0032039 integrator complex(GO:0032039)
0.1 1.6 GO:0031209 SCAR complex(GO:0031209)
0.1 1.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.5 GO:0031501 mannosyltransferase complex(GO:0031501)
0.1 0.3 GO:0034457 Mpp10 complex(GO:0034457)
0.1 2.6 GO:0043186 P granule(GO:0043186)
0.1 0.5 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 1.0 GO:0036038 MKS complex(GO:0036038)
0.0 4.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.7 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.2 GO:0043596 nuclear replication fork(GO:0043596)
0.0 2.0 GO:0005776 autophagosome(GO:0005776)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 2.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.6 GO:0000780 condensed nuclear chromosome kinetochore(GO:0000778) condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.6 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 1.0 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 2.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.2 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.4 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.2 GO:0005871 kinesin complex(GO:0005871)
0.0 3.1 GO:0030425 dendrite(GO:0030425)
0.0 2.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.5 GO:0005911 cell-cell junction(GO:0005911)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.6 3.8 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.4 1.8 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.4 2.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.4 1.1 GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945)
0.3 2.8 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.3 1.2 GO:0051059 NF-kappaB binding(GO:0051059)
0.2 0.9 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.2 1.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 1.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.2 0.5 GO:0005131 growth hormone receptor binding(GO:0005131) growth hormone activity(GO:0070186)
0.2 3.9 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 2.0 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 2.7 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.1 1.4 GO:0005522 profilin binding(GO:0005522)
0.1 3.1 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 2.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.9 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 2.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 2.6 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.1 1.1 GO:0051998 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.1 1.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.7 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 1.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.3 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 1.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 0.6 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 1.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 1.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.4 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.7 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.1 1.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 1.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.4 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 1.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 1.5 GO:0051018 protein kinase A binding(GO:0051018)
0.0 1.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 2.9 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.4 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 5.5 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 1.4 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 2.1 GO:0005178 integrin binding(GO:0005178)
0.0 1.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 8.0 GO:0030246 carbohydrate binding(GO:0030246)
0.0 1.5 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.2 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 1.0 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.2 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0 2.6 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.7 GO:0017022 myosin binding(GO:0017022)
0.0 0.8 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.3 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.2 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.8 GO:0071949 FAD binding(GO:0071949)
0.0 0.3 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 1.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 3.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.0 GO:0042393 histone binding(GO:0042393)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 1.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.0 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 1.5 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 2.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 7.1 PID E2F PATHWAY E2F transcription factor network
0.1 1.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 2.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 0.9 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 1.4 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 3.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.5 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.3 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.6 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.6 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.3 PID CERAMIDE PATHWAY Ceramide signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 2.8 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.3 1.5 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.2 6.0 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 2.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 2.3 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 2.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 2.5 REACTOME KINESINS Genes involved in Kinesins
0.1 3.0 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 2.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.0 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 1.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.6 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.1 2.6 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 0.8 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 1.7 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 1.8 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter