Project
PRJNA195909:zebrafish embryo and larva development
Navigation
Downloads
Results for crx+otx1
Z-value: 2.57
Motif logo
Transcription factors associated with crx+otx1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| otx1 | dr11_v1_chr17_+_24318753_24318753 | 0.93 | 2.7e-04 | Click! |
| crx | dr11_v1_chr5_+_36932718_36932718 | -0.49 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_45125537 Show fit | 5.83 |
ENSDART00000113552
|
zgc:163014 |
|
| chr16_-_46579936 Show fit | 5.53 |
ENSDART00000166143
ENSDART00000127212 |
si:dkey-152b24.6 |
|
| chr10_-_42898220 Show fit | 5.26 |
ENSDART00000099270
|
|
|
| chr11_-_1550709 Show fit | 5.08 |
ENSDART00000110097
|
si:ch73-303b9.1 |
|
| chr2_-_31686353 Show fit | 4.66 |
ENSDART00000126177
ENSDART00000056679 |
E2F transcription factor 5 |
|
| chr9_-_8314028 Show fit | 4.58 |
ENSDART00000102739
|
si:ch211-145c1.1 |
|
| chr19_+_42898239 Show fit | 3.38 |
ENSDART00000051724
|
cAMP-regulated phosphoprotein, 21 |
|
| chr13_+_15581270 Show fit | 3.13 |
ENSDART00000189880
ENSDART00000190067 ENSDART00000041293 |
MAP/microtubule affinity-regulating kinase 3a |
|
| chr20_-_54014539 Show fit | 3.07 |
ENSDART00000060466
|
si:dkey-241l7.6 |
|
| chr16_-_25741225 Show fit | 2.98 |
ENSDART00000130641
|
B cell CLL/lymphoma 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of crx+otx1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | GO:0010921 | regulation of phosphatase activity(GO:0010921) |
| 0.2 | 4.0 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 0.2 | 3.9 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.1 | 2.9 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) |
| 0.1 | 2.8 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.0 | 2.8 | GO:0006694 | steroid biosynthetic process(GO:0006694) |
| 0.2 | 2.7 | GO:0030431 | sleep(GO:0030431) |
| 0.2 | 2.7 | GO:0035278 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.3 | 2.6 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.1 | 2.6 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.6 | 3.8 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 3.1 | GO:0030425 | dendrite(GO:0030425) |
| 0.1 | 2.6 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.1 | 2.6 | GO:0043186 | P granule(GO:0043186) |
| 0.1 | 2.5 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 2.5 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.0 | 2.2 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.3 | 2.1 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 2.1 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 5.5 | GO:0008081 | phosphoric diester hydrolase activity(GO:0008081) |
| 0.2 | 3.9 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.6 | 3.8 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 3.6 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.1 | 3.1 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 2.9 | GO:0019903 | protein phosphatase binding(GO:0019903) |
| 0.3 | 2.8 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
| 0.1 | 2.7 | GO:0004983 | neuropeptide Y receptor activity(GO:0004983) |
| 0.4 | 2.6 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 3.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.0 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 2.4 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 2.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 1.8 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 1.7 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.1 | 1.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 1.5 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 1.4 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.0 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 3.0 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.3 | 2.8 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.2 | 2.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 2.6 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 2.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 2.4 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 2.3 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 2.1 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.4 | 1.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |