ISMARA results: creb1a+creb1b+crema+cremb

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PRJNA195909:zebrafish embryo and larva development

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Results for creb1a+creb1b+crema+cremb

Z-value: 8.89

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Transcription factors associated with creb1a+creb1b+crema+cremb

Gene Symbol	Gene ID	Gene Info
crema NCBI UniProt	ENSDARG00000023217	cAMP responsive element modulator a
creb1a NCBI UniProt	ENSDARG00000053586	cAMP responsive element binding protein 1a
creb1b NCBI UniProt	ENSDARG00000093420	cAMP responsive element binding protein 1b
cremb NCBI UniProt	ENSDARG00000102899	cAMP responsive element modulator b
cremb NCBI UniProt	ENSDARG00000109505	cAMP responsive element modulator b
cremb NCBI UniProt	ENSDARG00000116064	cAMP responsive element modulator b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
creb1b	dr11_v1_chr9_-_28275600_28275600	-0.60	8.9e-02	Click!
crema	dr11_v1_chr2_-_43168292_43168292	-0.56	1.2e-01	Click!
cremb	dr11_v1_chr24_+_31348595_31348735	0.47	2.0e-01	Click!
creb1a	dr11_v1_chr1_-_33556428_33556428	0.39	3.0e-01	Click!

Activity profile of creb1a+creb1b+crema+cremb motif

Sorted Z-values of creb1a+creb1b+crema+cremb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_55459037 Show fit	8.25	ENSDART00000172184	znf569l NCBI UniProt Show fit	zinc finger protein 569, like
chr4_-_65037243 Show fit	7.51	ENSDART00000170059	si:ch211-283l16.1 NCBI UniProt Show fit	si:ch211-283l16.1
chr4_-_63769147 Show fit	6.79	ENSDART00000189919	znf1098 NCBI UniProt Show fit	zinc finger protein 1098
chr4_+_42556555 Show fit	6.02	ENSDART00000168536	znf1053 NCBI UniProt Show fit	zinc finger protein 1053
chr4_+_58016732 Show fit	5.92	ENSDART00000165777	CT027609.1 NCBI UniProt Show fit
chr4_+_63769987 Show fit	5.70	ENSDART00000168878	znf1048 NCBI UniProt Show fit	zinc finger protein 1048
chr4_+_62184754 Show fit	5.44	ENSDART00000168844	si:dkeyp-35e5.9 NCBI UniProt Show fit	si:dkeyp-35e5.9
chr4_-_61650771 Show fit	5.33	ENSDART00000168593	si:dkey-26i24.1 NCBI UniProt Show fit	si:dkey-26i24.1
chr4_-_65036768 Show fit	5.20	ENSDART00000184455	si:ch211-283l16.1 NCBI UniProt Show fit	si:ch211-283l16.1
chr4_-_44872722 Show fit	5.18	ENSDART00000150621	BX649307.1 NCBI UniProt Show fit

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of creb1a+creb1b+crema+cremb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	752.4	GO:0006355	regulation of transcription, DNA-templated(GO:0006355)
0.1	19.3	GO:0006364	rRNA processing(GO:0006364)
0.7	12.9	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0	12.5	GO:0008380	RNA splicing(GO:0008380)
0.0	4.8	GO:0016070	RNA metabolic process(GO:0016070)
0.2	4.5	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.1	4.4	GO:0000187	activation of MAPK activity(GO:0000187)
1.4	4.3	GO:0071431	tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.6	4.3	GO:0000479	endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
1.0	3.8	GO:0036265	RNA (guanine-N7)-methylation(GO:0036265)

Showing 1 to 10 of 63 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	386.3	GO:0005634	nucleus(GO:0005634)
0.1	35.3	GO:0005730	nucleolus(GO:0005730)
1.2	13.7	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.1	9.5	GO:0016604	nuclear body(GO:0016604)
0.2	8.6	GO:0032040	small-subunit processome(GO:0032040)
1.7	5.0	GO:0070545	PeBoW complex(GO:0070545)
1.4	4.3	GO:0032545	CURI complex(GO:0032545) UTP-C complex(GO:0034456)
0.1	3.3	GO:0071011	precatalytic spliceosome(GO:0071011)
0.0	3.3	GO:0031201	SNARE complex(GO:0031201)
0.2	3.1	GO:0030687	preribosome, large subunit precursor(GO:0030687)

Showing 1 to 10 of 34 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	741.9	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	27.5	GO:0003723	RNA binding(GO:0003723)
1.9	7.6	GO:0034511	U3 snoRNA binding(GO:0034511)
0.3	6.7	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.1	5.8	GO:0003724	RNA helicase activity(GO:0003724)
0.3	5.0	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.1	4.7	GO:0043021	ribonucleoprotein complex binding(GO:0043021)
1.5	4.6	GO:0016436	rRNA (uridine) methyltransferase activity(GO:0016436)
0.0	4.3	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.1	3.7	GO:0004521	endoribonuclease activity(GO:0004521)

Showing 1 to 10 of 47 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	4.4	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	3.3	PID P73PATHWAY	p73 transcription factor network
0.0	3.1	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.2	3.0	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	1.9	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	1.3	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	1.1	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	0.6	PID ILK PATHWAY	Integrin-linked kinase signaling

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.4	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2	4.4	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.2	3.4	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.1	3.1	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	2.8	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.1	2.6	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.1	2.4	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	1.8	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.1	1.6	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.1	1.5	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease

Showing 1 to 10 of 18 entries

Results for creb1a+creb1b+crema+cremb

Z-value: 8.89

Motif logo

Transcription factors associated with creb1a+creb1b+crema+cremb

Activity-expression correlation:

Activity profile of creb1a+creb1b+crema+cremb motif

Sorted Z-values of creb1a+creb1b+crema+cremb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of creb1a+creb1b+crema+cremb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: