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PRJNA195909:zebrafish embryo and larva development

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Results for bhlhe40

Z-value: 0.69

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Transcription factors associated with bhlhe40

Gene Symbol Gene ID Gene Info
ENSDARG00000004060 basic helix-loop-helix family, member e40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
bhlhe40dr11_v1_chr11_-_35763323_35763323-0.941.9e-04Click!

Activity profile of bhlhe40 motif

Sorted Z-values of bhlhe40 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_10804796 1.58 ENSDART00000134911
si:ch1073-416j23.1
chr10_+_32050906 1.29 ENSDART00000137373
si:ch211-266i6.3
chr9_-_34269066 1.11 ENSDART00000059955
immunoglobulin-like domain containing receptor 1b
chr17_-_25331439 1.04 ENSDART00000155422
ENSDART00000082324
zona pellucida protein C
chr21_+_43178831 1.02 ENSDART00000151512
AF4/FMR2 family, member 4
chr25_-_1323623 0.99 ENSDART00000156532
ENSDART00000157163
ENSDART00000156062
ENSDART00000082447
ENSDART00000189175
calmodulin-like 4b
chr14_-_36345175 0.93 ENSDART00000077823
info leucine-rich repeat, immunoglobulin-like and transmembrane domains 3a
chr8_+_13700605 0.91 ENSDART00000144516
LON peptidase N-terminal domain and ring finger 1, like
chr9_-_10805231 0.91 ENSDART00000193913
ENSDART00000078348
si:ch1073-416j23.1
chr1_-_47114310 0.88 ENSDART00000144899
ENSDART00000053157
SET domain containing 4
chr19_+_15441022 0.85 ENSDART00000098970
ENSDART00000140276
lin-28 homolog A (C. elegans)
chr5_+_57210237 0.84 ENSDART00000167660
praja ring finger ubiquitin ligase 2
chr16_+_25296389 0.79 ENSDART00000114528
TBC1 domain family, member 31
chr6_-_49547680 0.78 ENSDART00000169678
protein phosphatase 4, regulatory subunit 1-like
chr15_+_34939906 0.78 ENSDART00000131182
si:ch73-95l15.3
chr22_-_16759151 0.77 ENSDART00000191880
PATJ, crumbs cell polarity complex component
chr12_+_19958845 0.76 ENSDART00000193248
excision repair cross-complementation group 4
chr8_-_47329755 0.75 ENSDART00000060853
peroxisomal biogenesis factor 10
chr15_-_44077937 0.73 ENSDART00000110112
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr19_+_791538 0.73 ENSDART00000146554
ENSDART00000138406
transmembrane protein 79a
chr15_-_26570948 0.73 ENSDART00000156621
WD repeat domain 81
chr9_-_1200187 0.72 ENSDART00000158760
INO80 complex subunit Da
chr16_+_19029297 0.70 ENSDART00000115263
ENSDART00000114954
Rap guanine nucleotide exchange factor (GEF) 5b
chr4_-_9196291 0.69 ENSDART00000153963
host cell factor C2
chr17_+_32622933 0.68 ENSDART00000077418
cathepsin Ba
chr9_-_27868267 0.66 ENSDART00000079502
debranching RNA lariats 1
chr19_-_5103313 0.64 ENSDART00000037007
triosephosphate isomerase 1a
chr22_-_16758973 0.63 ENSDART00000145208
PATJ, crumbs cell polarity complex component
chr14_-_16810401 0.63 ENSDART00000158396
ENSDART00000170758
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b
chr3_+_13929860 0.61 ENSDART00000164179
synaptonemal complex central element protein 2
chr10_+_5268054 0.59 ENSDART00000114491
receptor tyrosine kinase-like orphan receptor 2
chr9_+_16854121 0.59 ENSDART00000110866
CLN5, intracellular trafficking protein
chr12_-_7280551 0.56 ENSDART00000061633
zgc:171971
chr20_-_45040916 0.55 ENSDART00000190001
kelch-like family member 29
chr1_+_50639416 0.54 ENSDART00000141977
HECT and RLD domain containing E3 ubiquitin protein ligase 3
chr15_-_41807371 0.52 ENSDART00000156819
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36b
chr13_+_7164345 0.52 ENSDART00000022051
GINS complex subunit 1 (Psf1 homolog)
chr4_-_17353972 0.52 ENSDART00000041529
PARP1 binding protein
chr23_+_42131509 0.52 ENSDART00000184544
shisa like 2A
chr5_+_41476443 0.52 ENSDART00000145228
ENSDART00000137981
ENSDART00000142538
protein inhibitor of activated STAT, 2
chr15_+_1534644 0.52 ENSDART00000130413
structural maintenance of chromosomes 4
chr19_+_40379771 0.52 ENSDART00000017917
ENSDART00000110699
VPS50 EARP/GARPII complex subunit
VPS50 EARP/GARPII complex subunit
chr11_+_5499661 0.51 ENSDART00000027850
solute carrier family 35, member E1
chr5_+_32009956 0.50 ENSDART00000188482
suppressor of cancer cell invasion
chr19_+_9111550 0.50 ENSDART00000088336
SET domain, bifurcated 1a
chr12_+_34891529 0.50 ENSDART00000015643
tubulin folding cofactor C
chr3_-_25420931 0.49 ENSDART00000109601
ENSDART00000182184
bromodomain PHD finger transcription factor
chr20_-_211920 0.49 ENSDART00000104790
zinc finger protein 292b
chr5_-_22130937 0.48 ENSDART00000138606
LAS1-like, ribosome biogenesis factor
chr18_-_7677208 0.48 ENSDART00000092456
SH3 and multiple ankyrin repeat domains 3a
chr24_+_33462800 0.46 ENSDART00000166666
ENSDART00000050826
regulator of MON1-CCZ1
chr23_-_31913231 0.43 ENSDART00000146852
ENSDART00000085054
mitochondrial fission regulator 2
chr7_+_51795667 0.42 ENSDART00000174201
ENSDART00000073839
solute carrier family 38, member 7
chr17_+_30843881 0.41 ENSDART00000149600
ENSDART00000148547
tripeptidyl peptidase I
chr7_-_14446512 0.41 ENSDART00000041577
kinesin family member 7
chr12_+_17933775 0.40 ENSDART00000186047
ENSDART00000160586
transformation/transcription domain-associated protein
chr25_-_19608382 0.39 ENSDART00000022279
ENSDART00000135201
ENSDART00000147223
ENSDART00000190220
ENSDART00000184242
ENSDART00000166824
G-2 and S-phase expressed 1
chr24_-_42072886 0.39 ENSDART00000171389

chr23_-_10786400 0.38 ENSDART00000055038
RING1 and YY1 binding protein a
chr23_-_22130778 0.38 ENSDART00000079212
polyhomeotic homolog 2a (Drosophila)
chr9_+_54686686 0.38 ENSDART00000066198
RAB9A, member RAS oncogene family
chr23_-_2901167 0.37 ENSDART00000165955
ENSDART00000190616
zinc fingers and homeoboxes 3
chr4_+_13640903 0.37 ENSDART00000155349
patatin-like phospholipase domain containing 8
chr14_-_45595711 0.36 ENSDART00000074038
SCY1-like, kinase-like 1
chr10_-_24724388 0.36 ENSDART00000148582
sphingomyelin phosphodiesterase 1, acid lysosomal
chr14_+_44804326 0.35 ENSDART00000079866
ENSDART00000172974
solute carrier family 30 (zinc transporter), member 9
chr5_-_9540641 0.35 ENSDART00000124384
ENSDART00000160079
cyclin G associated kinase
chr3_-_25421504 0.35 ENSDART00000154200
bromodomain PHD finger transcription factor
chr17_-_44440832 0.34 ENSDART00000148786
exocyst complex component 5
chr10_-_35108683 0.33 ENSDART00000049633
zgc:110006
chr23_+_32028574 0.32 ENSDART00000145501
ENSDART00000143121
ENSDART00000111877
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr17_-_15229787 0.32 ENSDART00000039165
serine/threonine/tyrosine interacting protein
chr4_-_5831522 0.31 ENSDART00000008898
forkhead box M1
chr11_-_2478374 0.31 ENSDART00000173205
si:ch73-267c23.10
chr5_+_26204561 0.30 ENSDART00000137178
MARVEL domain containing 2b
chr15_-_34418525 0.30 ENSDART00000147582
alkylglycerol monooxygenase
chr8_-_25817106 0.29 ENSDART00000099364
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr12_+_47044707 0.28 ENSDART00000186506
zinc finger, RAN-binding domain containing 1a
chr10_+_22891126 0.28 ENSDART00000057291
arrestin, beta 2a
chr19_-_38830582 0.27 ENSDART00000189966
ENSDART00000183055
adhesion G protein-coupled receptor B2
chr20_-_40766387 0.27 ENSDART00000061173
hydroxysteroid dehydrogenase like 1
chr21_+_4540127 0.27 ENSDART00000043431
nucleoporin 188
chr20_-_51386511 0.26 ENSDART00000151429
ENSDART00000066072
ring finger protein 8, E3 ubiquitin protein ligase
chr18_+_6479963 0.26 ENSDART00000092752
ENSDART00000136333
WAS protein family homolog 1
chr6_+_149405 0.26 ENSDART00000161154
ferredoxin 1-like
chr13_+_40692804 0.25 ENSDART00000109822
Hermansky-Pudlak syndrome 1
chr7_+_1442059 0.25 ENSDART00000173391
si:cabz01090193.1
chr16_+_7985886 0.25 ENSDART00000126041
anoctamin 10a
chr10_-_15644904 0.24 ENSDART00000138389
ENSDART00000101191
ENSDART00000186559
ENSDART00000122170
structural maintenance of chromosomes 5
chr4_+_17655872 0.23 ENSDART00000066999
WASH complex subunit 3
chr21_+_11916788 0.23 ENSDART00000136103
ubiquitin associated protein 2a
chr10_+_22890791 0.22 ENSDART00000176011
arrestin, beta 2a
chr20_-_13140309 0.22 ENSDART00000020703
ENSDART00000188594
integrator complex subunit 7
chr14_-_36437249 0.22 ENSDART00000016728
aspartylglucosaminidase
chr7_+_22293894 0.21 ENSDART00000056790
transmembrane protein 256
chr19_+_15440841 0.20 ENSDART00000182329
lin-28 homolog A (C. elegans)
chr22_+_8800432 0.20 ENSDART00000139940
si:dkey-182g1.6
chr12_+_18529228 0.19 ENSDART00000193931
ENSDART00000146260
meiosis specific with OB domains
methionine sulfoxide reductase B1b
chr5_+_61839707 0.19 ENSDART00000163051
Danio rerio interferon-induced protein with tetratricopeptide repeats 5 (LOC572297), mRNA.
chr15_-_1534232 0.19 ENSDART00000056763
ENSDART00000133943
intraflagellar transport 80 homolog (Chlamydomonas)
chr3_+_16922226 0.17 ENSDART00000017646
ATPase H+ transporting V0 subunit a1a
chr20_+_40766645 0.15 ENSDART00000144401
TBC1 domain family, member 32
chr21_-_14251306 0.14 ENSDART00000114715
ENSDART00000181380
mannosidase, alpha, class 1B, member 1a
chr24_+_32472155 0.09 ENSDART00000098859
neuronal differentiation 6a
chr10_+_26515946 0.08 ENSDART00000134276
synaptojanin 1
chr22_+_30184039 0.08 ENSDART00000049075
adducin 3 (gamma) a
chr3_-_4501026 0.08 ENSDART00000163052
zgc:162198
chr25_+_3788074 0.08 ENSDART00000154008
chitinase domain containing 1
chr17_-_37299394 0.08 ENSDART00000154414
prostaglandin reductase 2
chr1_-_54765262 0.07 ENSDART00000150362
si:ch211-197k17.3
chr17_+_10501647 0.07 ENSDART00000140391
TYRO3 protein tyrosine kinase
chr2_-_32486080 0.05 ENSDART00000110821
tetratricopeptide repeat domain 19
chr25_+_3788443 0.05 ENSDART00000189747
chitinase domain containing 1
chr14_-_3071564 0.04 ENSDART00000166136
ENSDART00000167138
solute carrier family 35, member A4
chr12_+_18445604 0.03 ENSDART00000078860
NADPH oxidase organizer 1b
chr12_-_3778848 0.02 ENSDART00000152128
si:ch211-166g5.4
chr17_-_2126517 0.02 ENSDART00000013093
zinc finger, FYVE domain containing 19
chr17_+_25331576 0.02 ENSDART00000157309
transmembrane protein 54a
chr24_-_6024466 0.01 ENSDART00000040865
prenyl (decaprenyl) diphosphate synthase, subunit 1
chr11_-_44945636 0.01 ENSDART00000157658
origin recognition complex, subunit 2

Network of associatons between targets according to the STRING database.

First level regulatory network of bhlhe40

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.3 GO:0043393 regulation of protein binding(GO:0043393)
0.3 0.8 GO:1901255 nucleotide-excision repair involved in interstrand cross-link repair(GO:1901255)
0.2 0.7 GO:0035973 aggrephagy(GO:0035973)
0.2 1.2 GO:0001919 regulation of receptor recycling(GO:0001919)
0.2 0.5 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.2 0.8 GO:0042766 nucleosome mobilization(GO:0042766)
0.2 0.6 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.9 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 0.5 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 0.2 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.1 0.5 GO:2000463 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.1 0.3 GO:1903232 melanosome assembly(GO:1903232)
0.1 1.1 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.1 1.0 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.3 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.4 GO:0072319 clathrin coat disassembly(GO:0072318) vesicle uncoating(GO:0072319)
0.1 0.8 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.3 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1 0.8 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.5 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.3 GO:0045190 B cell activation involved in immune response(GO:0002312) isotype switching(GO:0045190)
0.0 0.8 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.5 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.5 GO:0031937 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.3 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.4 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.6 GO:0070193 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.0 0.8 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.3 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.6 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 0.3 GO:0071156 regulation of cell cycle arrest(GO:0071156)
0.0 0.2 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.4 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.4 GO:0035675 neuromast hair cell development(GO:0035675)
0.0 1.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.6 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.5 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.6 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.4 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.3 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.5 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.2 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 0.4 GO:0000266 mitochondrial fission(GO:0000266)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.2 0.5 GO:1990745 EARP complex(GO:1990745)
0.1 0.8 GO:0016589 NURF complex(GO:0016589)
0.1 1.0 GO:0032783 ELL-EAF complex(GO:0032783)
0.1 0.7 GO:0071986 Ragulator complex(GO:0071986)
0.1 0.7 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.5 GO:0000811 GINS complex(GO:0000811)
0.1 0.4 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.1 0.6 GO:0000801 central element(GO:0000801)
0.1 0.5 GO:0071203 WASH complex(GO:0071203)
0.1 0.3 GO:0005880 nuclear microtubule(GO:0005880)
0.1 0.8 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.3 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.3 GO:0031085 BLOC-3 complex(GO:0031085)
0.0 0.4 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.7 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 0.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.7 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 0.8 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.2 0.5 GO:0031701 angiotensin receptor binding(GO:0031701)
0.2 0.6 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.1 0.4 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.8 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.3 GO:0043621 protein self-association(GO:0043621)
0.1 1.0 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 0.5 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 0.5 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.8 GO:0051117 ATPase binding(GO:0051117)
0.0 0.2 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) L-methionine-(R)-S-oxide reductase activity(GO:0033745)
0.0 0.5 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.3 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.6 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.7 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 0.7 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.6 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.4 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.1 GO:0015924 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.9 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.5 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.5 PID AURORA B PATHWAY Aurora B signaling
0.0 0.4 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.3 PID AURORA A PATHWAY Aurora A signaling
0.0 0.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.7 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing