ISMARA results: bhlha15_bhlhe23+si:ch211-196c10.13

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PRJNA195909:zebrafish embryo and larva development

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Results for bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

Z-value: 1.91

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Transcription factors associated with bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

Gene Symbol	Gene ID	Gene Info
bhlha15 NCBI UniProt	ENSDARG00000045166	basic helix-loop-helix family, member a15
bhlhe23 NCBI UniProt	ENSDARG00000037588	basic helix-loop-helix family, member e23
si_ch211-196c10.13 NCBI UniProt	ENSDARG00000096756	si_ch211-196c10.13
bhlhe22 NCBI UniProt	ENSDARG00000058039	basic helix-loop-helix family, member e22

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
bhlhe22	dr11_v1_chr24_+_24461341_24461341	0.97	9.2e-06	Click!
bhlhe23	dr11_v1_chr23_-_17657348_17657348	0.86	3.1e-03	Click!
si:ch211-196c10.13	dr11_v1_chr8_+_23142946_23142946	0.51	1.6e-01	Click!
bhlha15	dr11_v1_chr12_+_17754859_17754859	-0.19	6.2e-01	Click!

Activity profile of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22 motif

Sorted Z-values of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_36693859 Show fit	5.68	ENSDART00000019259	dlb NCBI UniProt Show fit	deltaB
chr3_+_40809011 Show fit	4.97	ENSDART00000033713	arpc1b NCBI UniProt Show fit	actin related protein 2/3 complex, subunit 1B
chr17_+_33453689 Show fit	4.91	ENSDART00000156894	rin3 NCBI UniProt Show fit	Ras and Rab interactor 3
chr19_-_21766461 Show fit	4.59	ENSDART00000104279	znf516 NCBI UniProt Show fit	zinc finger protein 516
chr3_+_28953274 Show fit	4.53	ENSDART00000133528 ENSDART00000103602	lgals2a NCBI UniProt Show fit	lectin, galactoside-binding, soluble, 2a
chr20_+_34326874 Show fit	4.37	ENSDART00000061659	ivns1abpa NCBI UniProt Show fit	influenza virus NS1A binding protein a
chr17_-_42218652 Show fit	3.98	ENSDART00000081396 ENSDART00000190007	nkx2.2a NCBI UniProt Show fit	NK2 homeobox 2a
chr19_-_15855427 Show fit	3.79	ENSDART00000133059	cited4a NCBI UniProt Show fit	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4a
chr10_+_22012389 Show fit	3.66	ENSDART00000035188	kcnip1b NCBI UniProt Show fit	Kv channel interacting protein 1 b
chr23_-_21453614 Show fit	3.65	ENSDART00000079274	her4.1 NCBI UniProt Show fit	hairy-related 4, tandem duplicate 1

Showing 1 to 10 of 142 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.2	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.2	5.1	GO:0043171	peptide catabolic process(GO:0043171)
0.2	5.0	GO:0002574	thrombocyte differentiation(GO:0002574)
0.3	4.5	GO:0090303	positive regulation of wound healing(GO:0090303)
1.3	4.0	GO:0021530	spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0	3.8	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.2	3.6	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
1.2	3.5	GO:1902571	regulation of serine-type peptidase activity(GO:1902571)
0.1	3.4	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.2	3.1	GO:0071501	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)

Showing 1 to 10 of 55 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.0	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.2	2.5	GO:0032593	insulin-responsive compartment(GO:0032593)
0.2	2.4	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.2	1.2	GO:0033263	CORVET complex(GO:0033263)
0.0	0.9	GO:0005814	centriole(GO:0005814)
0.1	0.8	GO:0001772	immunological synapse(GO:0001772)
0.0	0.7	GO:0043204	perikaryon(GO:0043204)
0.0	0.4	GO:0031526	brush border membrane(GO:0031526)
0.0	0.3	GO:0071564	npBAF complex(GO:0071564)
0.0	0.2	GO:1902636	kinociliary basal body(GO:1902636)

Showing 1 to 10 of 11 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.7	GO:0005112	Notch binding(GO:0005112)
0.5	5.3	GO:0016936	galactoside binding(GO:0016936)
0.2	5.1	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.0	5.0	GO:0005096	GTPase activator activity(GO:0005096)
0.2	3.5	GO:0043236	laminin binding(GO:0043236)
0.0	3.4	GO:0005125	cytokine activity(GO:0005125)
0.0	3.1	GO:0003713	transcription coactivator activity(GO:0003713)
0.1	2.6	GO:0042577	lipid phosphatase activity(GO:0042577)
0.1	2.4	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.5	2.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.0	PID RAC1 PATHWAY	RAC1 signaling pathway
0.1	3.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	2.1	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.1	2.0	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	1.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	1.0	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.9	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.0	0.7	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	0.5	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.3	PID PTP1B PATHWAY	Signaling events mediated by PTP1B

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.5	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	2.0	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.1	1.6	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.1	1.0	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.9	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.0	0.9	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.1	0.7	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.6	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	0.5	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.5	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters

Showing 1 to 10 of 12 entries

Results for bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

Z-value: 1.91

Motif logo

Transcription factors associated with bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

Activity-expression correlation:

Activity profile of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22 motif

Sorted Z-values of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: