ISMARA results: barhl1a+barhl1b

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PRJNA195909:zebrafish embryo and larva development

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Results for barhl1a+barhl1b

Z-value: 2.87

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Transcription factors associated with barhl1a+barhl1b

Gene Symbol	Gene ID	Gene Info
barhl1b NCBI UniProt	ENSDARG00000019013	BarH-like homeobox 1b
barhl1a NCBI UniProt	ENSDARG00000035508	BarH-like homeobox 1a
barhl1a NCBI UniProt	ENSDARG00000110061	BarH-like homeobox 1a
barhl1a NCBI UniProt	ENSDARG00000112355	BarH-like homeobox 1a
barhl1b NCBI UniProt	ENSDARG00000113145	BarH-like homeobox 1b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
barhl1b	dr11_v1_chr21_-_17482465_17482465	-0.96	4.1e-05	Click!
barhl1a	dr11_v1_chr5_-_29750377_29750377	-0.83	5.3e-03	Click!

Activity profile of barhl1a+barhl1b motif

Sorted Z-values of barhl1a+barhl1b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_45320126 Show fit	4.47	ENSDART00000133572	si:ch73-90k17.1 NCBI UniProt Show fit	si:ch73-90k17.1
chr18_-_20674121 Show fit	3.71	ENSDART00000005145	asz1 NCBI UniProt Show fit	ankyrin repeat, SAM and basic leucine zipper domain containing 1
chr14_+_32918172 Show fit	3.59	ENSDART00000182867	lnx2b NCBI UniProt Show fit	ligand of numb-protein X 2b
chr6_-_8362419 Show fit	3.49	ENSDART00000142752 ENSDART00000135810	acp5a NCBI UniProt Show fit	acid phosphatase 5a, tartrate resistant
chr7_+_25126629 Show fit	3.35	ENSDART00000077217	zgc:101765 NCBI UniProt Show fit	zgc:101765
chr10_+_6884123 Show fit	3.19	ENSDART00000149095 ENSDART00000148772 ENSDART00000149334	ddx4 NCBI UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr23_-_44577885 Show fit	3.09	ENSDART00000166654	si:ch73-160p18.4 NCBI UniProt Show fit	si:ch73-160p18.4
chr14_-_46198373 Show fit	3.08	ENSDART00000031640 ENSDART00000132966	zgc:113425 NCBI UniProt Show fit	zgc:113425
chr1_+_10129099 Show fit	3.08	ENSDART00000187740	rbm46 NCBI UniProt Show fit	RNA binding motif protein 46
chr14_+_32918484 Show fit	2.98	ENSDART00000105721	lnx2b NCBI UniProt Show fit	ligand of numb-protein X 2b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of barhl1a+barhl1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.2	GO:0000209	protein polyubiquitination(GO:0000209)
0.2	6.6	GO:0070936	protein K48-linked ubiquitination(GO:0070936)
0.4	4.9	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	4.2	GO:0090630	activation of GTPase activity(GO:0090630)
0.0	4.0	GO:0016579	protein deubiquitination(GO:0016579)
0.4	3.9	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.3	3.9	GO:0045842	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.3	3.7	GO:0034587	piRNA metabolic process(GO:0034587)
0.2	3.7	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.2	3.7	GO:0016926	protein desumoylation(GO:0016926)

Showing 1 to 10 of 158 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.6	GO:0005680	anaphase-promoting complex(GO:0005680)
0.2	4.0	GO:0043186	P granule(GO:0043186)
0.0	3.9	GO:0005871	kinesin complex(GO:0005871)
0.0	3.8	GO:0000775	chromosome, centromeric region(GO:0000775)
0.5	3.7	GO:0071546	pi-body(GO:0071546)
0.1	3.3	GO:0016514	SWI/SNF complex(GO:0016514)
0.1	3.0	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	2.6	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.1	2.5	GO:0005657	replication fork(GO:0005657)
0.5	2.4	GO:1990513	CLOCK-BMAL transcription complex(GO:1990513)

Showing 1 to 10 of 68 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	19.5	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.0	6.9	GO:0005096	GTPase activator activity(GO:0005096)
0.1	5.8	GO:0003724	RNA helicase activity(GO:0003724)
0.2	4.9	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.1	4.8	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.0	4.7	GO:0003777	microtubule motor activity(GO:0003777)
0.0	4.5	GO:0101005	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2	3.7	GO:0016929	SUMO-specific protease activity(GO:0016929)
0.0	3.6	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.4	3.5	GO:0003993	acid phosphatase activity(GO:0003993)

Showing 1 to 10 of 105 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.5	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	4.7	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	3.5	PID BARD1 PATHWAY	BARD1 signaling events
0.1	3.5	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	3.3	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.1	2.4	PID EPHA FWDPATHWAY	EPHA forward signaling
0.1	1.9	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.1	1.9	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.1	1.6	PID ATR PATHWAY	ATR signaling pathway
0.0	1.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors

Showing 1 to 10 of 22 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.4	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	3.8	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.2	3.4	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	2.6	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3	2.2	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.1	2.1	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
0.0	2.1	REACTOME HOST INTERACTIONS OF HIV FACTORS	Genes involved in Host Interactions of HIV factors
0.2	1.9	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.1	1.9	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.1	1.8	REACTOME FGFR LIGAND BINDING AND ACTIVATION	Genes involved in FGFR ligand binding and activation

Showing 1 to 10 of 40 entries

Results for barhl1a+barhl1b

Z-value: 2.87

Motif logo

Transcription factors associated with barhl1a+barhl1b

Activity-expression correlation:

Activity profile of barhl1a+barhl1b motif

Sorted Z-values of barhl1a+barhl1b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of barhl1a+barhl1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: