ISMARA results: atf5a+atf5b

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PRJNA195909:zebrafish embryo and larva development

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Results for atf5a+atf5b

Z-value: 1.88

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Transcription factors associated with atf5a+atf5b

Gene Symbol	Gene ID	Gene Info
atf5a NCBI UniProt	ENSDARG00000068096	activating transcription factor 5a
atf5b NCBI UniProt	ENSDARG00000077785	activating transcription factor 5b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
atf5b	dr11_v1_chr15_-_17868870_17868870	0.89	1.2e-03	Click!
atf5a	dr11_v1_chr5_-_30418636_30418636	-0.41	2.7e-01	Click!

Activity profile of atf5a+atf5b motif

Sorted Z-values of atf5a+atf5b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_24518027 Show fit	3.47	ENSDART00000134120 ENSDART00000143761	cadm4 NCBI UniProt Show fit	cell adhesion molecule 4
chr14_-_25949951 Show fit	3.35	ENSDART00000141304	sparc NCBI UniProt Show fit	secreted protein, acidic, cysteine-rich (osteonectin)
chr25_+_20216159 Show fit	3.06	ENSDART00000048642	tnnt2d NCBI UniProt Show fit	troponin T2d, cardiac
chr1_-_5746030 Show fit	2.96	ENSDART00000150863	nrp2a NCBI UniProt Show fit	neuropilin 2a
chr18_-_23875370 Show fit	2.77	ENSDART00000130163	nr2f2 NCBI UniProt Show fit	nuclear receptor subfamily 2, group F, member 2
chr3_+_36275633 Show fit	2.68	ENSDART00000185027 ENSDART00000149532 ENSDART00000102883 ENSDART00000148444	zgc:86896 NCBI UniProt Show fit	zgc:86896
chr22_+_15624371 Show fit	2.62	ENSDART00000124868	lpl NCBI UniProt Show fit	lipoprotein lipase
chr3_+_23703704 Show fit	2.62	ENSDART00000024256	hoxb6a NCBI UniProt Show fit	homeobox B6a
chr25_-_32751982 Show fit	2.59	ENSDART00000012862	isl2a NCBI UniProt Show fit	ISL LIM homeobox 2a
chr5_-_28679135 Show fit	2.58	ENSDART00000193585	tnc NCBI UniProt Show fit	tenascin C

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of atf5a+atf5b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.7	GO:0050767	regulation of neurogenesis(GO:0050767)
1.5	4.4	GO:0060843	lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845)
0.2	4.4	GO:0038084	vascular endothelial growth factor signaling pathway(GO:0038084)
0.6	3.5	GO:0003232	bulbus arteriosus development(GO:0003232)
0.1	3.4	GO:0032474	otolith morphogenesis(GO:0032474) semicircular canal morphogenesis(GO:0048752)
0.1	3.1	GO:0006937	regulation of muscle contraction(GO:0006937)
0.9	2.6	GO:0014814	regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.3	2.6	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.3	2.6	GO:0060612	adipose tissue development(GO:0060612)
0.2	2.6	GO:0019433	triglyceride catabolic process(GO:0019433)

Showing 1 to 10 of 92 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.5	GO:0031012	extracellular matrix(GO:0031012)
0.1	3.8	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	3.1	GO:0005861	troponin complex(GO:0005861)
0.1	2.7	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	2.7	GO:0005840	ribosome(GO:0005840)
0.2	2.6	GO:0042627	chylomicron(GO:0042627)
0.6	2.3	GO:0031673	H zone(GO:0031673)
0.0	2.2	GO:0030141	secretory granule(GO:0030141)
0.0	2.2	GO:0005871	kinesin complex(GO:0005871)
0.1	2.0	GO:0031430	M band(GO:0031430)

Showing 1 to 10 of 32 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	5.7	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	5.5	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	5.0	GO:0051015	actin filament binding(GO:0051015)
0.5	4.4	GO:0001972	retinoic acid binding(GO:0001972)
0.0	3.6	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	3.4	GO:0005518	collagen binding(GO:0005518)
0.3	3.1	GO:0030172	troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.2	2.7	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.9	2.6	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	2.6	GO:0003713	transcription coactivator activity(GO:0003713)

Showing 1 to 10 of 61 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	3.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	3.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	3.2	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	2.9	NABA COLLAGENS	Genes encoding collagen proteins
0.2	2.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	2.1	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	1.5	PID NOTCH PATHWAY	Notch signaling pathway
0.0	1.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.8	PID INSULIN PATHWAY	Insulin Pathway

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.9	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	3.8	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	3.7	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	3.4	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	2.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.3	2.6	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.1	2.6	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	2.1	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.1	2.1	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	1.0	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides

Showing 1 to 10 of 19 entries

Results for atf5a+atf5b

Z-value: 1.88

Motif logo

Transcription factors associated with atf5a+atf5b

Activity-expression correlation:

Activity profile of atf5a+atf5b motif

Sorted Z-values of atf5a+atf5b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of atf5a+atf5b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: