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PRJNA195909:zebrafish embryo and larva development

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Results for atf5a+atf5b

Z-value: 1.88

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Transcription factors associated with atf5a+atf5b

Gene Symbol Gene ID Gene Info
ENSDARG00000068096 activating transcription factor 5a
ENSDARG00000077785 activating transcription factor 5b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
atf5bdr11_v1_chr15_-_17868870_178688700.891.2e-03Click!
atf5adr11_v1_chr5_-_30418636_30418636-0.412.7e-01Click!

Activity profile of atf5a+atf5b motif

Sorted Z-values of atf5a+atf5b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_24518027 3.47 ENSDART00000134120
ENSDART00000143761
cell adhesion molecule 4
chr14_-_25949951 3.35 ENSDART00000141304
secreted protein, acidic, cysteine-rich (osteonectin)
chr25_+_20216159 3.06 ENSDART00000048642
troponin T2d, cardiac
chr1_-_5746030 2.96 ENSDART00000150863
neuropilin 2a
chr18_-_23875370 2.77 ENSDART00000130163
nuclear receptor subfamily 2, group F, member 2
chr3_+_36275633 2.68 ENSDART00000185027
ENSDART00000149532
ENSDART00000102883
ENSDART00000148444
zgc:86896
chr22_+_15624371 2.62 ENSDART00000124868
lipoprotein lipase
chr3_+_23703704 2.62 ENSDART00000024256
homeobox B6a
chr25_-_32751982 2.59 ENSDART00000012862
ISL LIM homeobox 2a
chr5_-_28679135 2.58 ENSDART00000193585
tenascin C
chr3_-_46818001 2.56 ENSDART00000166505
ELAV like neuron-specific RNA binding protein 3
chr12_+_8373525 2.55 ENSDART00000152180
AT-rich interaction domain 5B
chr3_-_46817838 2.47 ENSDART00000028610
ELAV like neuron-specific RNA binding protein 3
chr5_-_67911111 2.38 ENSDART00000051833
GS homeobox 1
chr3_+_26081343 2.28 ENSDART00000134647
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr10_-_7785930 2.24 ENSDART00000043961
ENSDART00000111058
myeloid-specific peroxidase
chr21_+_13908858 2.22 ENSDART00000148199
syntaxin binding protein 1a
chr5_+_39087364 2.15 ENSDART00000004286
annexin A3a
chr7_+_25323742 2.12 ENSDART00000110347
cytochrome P450, family 26, subfamily b, polypeptide 1
chr19_+_30662529 2.10 ENSDART00000175662
family with sequence similarity 49, member A-like
chr13_-_23007813 2.08 ENSDART00000057638
hexokinase 1
chr4_-_16333944 1.98 ENSDART00000079523
epiphycan
chr5_-_64213253 1.94 ENSDART00000171711
G protein signaling modulator 1a
chr7_-_28147838 1.89 ENSDART00000158921
LIM domain only 1
chr18_-_50152689 1.87 ENSDART00000006078
lysyl oxidase-like 1
chr12_+_47663419 1.86 ENSDART00000171932
hematopoietically expressed homeobox
chr15_+_36977208 1.78 ENSDART00000183625
kirre like nephrin family adhesion molecule 3, like
chr2_+_30916188 1.75 ENSDART00000137012
myomesin 1a (skelemin)
chr19_-_3931917 1.74 ENSDART00000162532
MAP7 domain containing 1b
chr7_+_60359347 1.70 ENSDART00000145201
ENSDART00000039827
protein phosphatase 1, regulatory (inhibitor) subunit 14Bb
chr21_-_22115136 1.70 ENSDART00000134715
ENSDART00000089246
ENSDART00000139789
ELMO/CED-12 domain containing 1
chr17_+_42027969 1.65 ENSDART00000147563
kizuna centrosomal protein
chr11_-_29657947 1.63 ENSDART00000125753
ribosomal protein L22
chr24_+_25069609 1.62 ENSDART00000115165
APC membrane recruitment protein 2
chr18_-_23875219 1.61 ENSDART00000059976
nuclear receptor subfamily 2, group F, member 2
chr11_+_5926850 1.61 ENSDART00000104364
ribosomal protein S15
chr24_+_9372292 1.60 ENSDART00000082422
ENSDART00000191127
ENSDART00000180510
si:ch211-285f17.1
chr24_+_34606966 1.59 ENSDART00000105477
leucine rich repeat transmembrane neuronal 2
chr5_-_1963498 1.58 ENSDART00000073462
ribosomal protein, large, P0
chr9_+_25775816 1.57 ENSDART00000127834
ENSDART00000189994
zinc finger E-box binding homeobox 2a
chr7_+_31879649 1.57 ENSDART00000099789
myosin binding protein C, cardiac
chr23_-_31506854 1.57 ENSDART00000131352
ENSDART00000138625
ENSDART00000133002
EYA transcriptional coactivator and phosphatase 4
chr16_+_10422836 1.56 ENSDART00000161568
INO80 complex subunit E
chr17_-_21793113 1.49 ENSDART00000104612
H6 family homeobox 3a
chr3_-_53533128 1.49 ENSDART00000183591
notch 3
chr9_-_23944470 1.48 ENSDART00000138754
collagen, type VI, alpha 3
chr17_-_37214196 1.48 ENSDART00000128715
kinesin family member 3Cb
chr11_+_26476153 1.47 ENSDART00000103507
un-named sa1614
chr16_-_24135508 1.47 ENSDART00000171819
ENSDART00000103176
basal cell adhesion molecule (Lutheran blood group)
chr7_+_36041509 1.45 ENSDART00000162850
iroquois homeobox 3a
chr1_-_5745420 1.45 ENSDART00000166779
neuropilin 2a
chr10_-_43568239 1.45 ENSDART00000131731
ENSDART00000097433
ENSDART00000131309
myocyte enhancer factor 2ca
chr9_-_6372535 1.44 ENSDART00000149189
esophageal cancer related gene 4a
chr9_+_31282161 1.42 ENSDART00000010774
zic family member 2 (odd-paired homolog, Drosophila), a
chr13_+_28854438 1.41 ENSDART00000193407
ENSDART00000189554

chr16_+_10918252 1.41 ENSDART00000172949
POU class 2 homeobox 2a
chr4_-_16334362 1.41 ENSDART00000101461
epiphycan
chr11_-_18253111 1.40 ENSDART00000125984
musculoskeletal, embryonic nuclear protein 1b
chr25_-_27541288 1.39 ENSDART00000187245
sperm adhesion molecule 1
chr18_-_19456269 1.38 ENSDART00000060363
ribosomal protein L4
chr7_-_38087865 1.38 ENSDART00000052366
CCAAT/enhancer binding protein (C/EBP), alpha
chr19_-_35596207 1.37 ENSDART00000136811
collagen, type VIII, alpha 2
chr21_-_17482465 1.37 ENSDART00000004548
BarH-like homeobox 1b
chr15_-_39963009 1.36 ENSDART00000157388
ly6 domain containing, pigment cell
chr8_+_25767610 1.36 ENSDART00000062406
calcium channel, voltage-dependent, L type, alpha 1S subunit, b
chr13_-_35051897 1.34 ENSDART00000129559
BTB (POZ) domain containing 3b
chr8_+_22289320 1.33 ENSDART00000075126
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7, like
chr19_+_32553874 1.32 ENSDART00000078197
hes-related family bHLH transcription factor with YRPW motif-like
chr16_-_9802998 1.30 ENSDART00000154217
TAP binding protein (tapasin)-like
chr14_+_14225048 1.29 ENSDART00000168749
neuroligin 3a
chr7_-_26924903 1.28 ENSDART00000124363
ALX homeobox 4a
chr22_-_30935510 1.26 ENSDART00000133335
si:dkey-49n23.1
chr24_-_1341543 1.25 ENSDART00000169341
neuropilin 1a
chr5_-_48307804 1.24 ENSDART00000182831
ENSDART00000186920
ENSDART00000183585
myocyte enhancer factor 2cb
chr14_+_8127893 1.23 ENSDART00000169091
pleckstrin and Sec7 domain containing 2
chr6_-_39765546 1.20 ENSDART00000185767
phosphofructokinase, muscle b
chr17_-_37052622 1.19 ENSDART00000186408
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr17_+_38262408 1.14 ENSDART00000017493
NK2 homeobox 1
chr2_-_5399437 1.12 ENSDART00000132411
si:ch1073-184j22.2
chr9_-_27648683 1.11 ENSDART00000017292
syntaxin binding protein 5-like
chr17_-_37054959 1.09 ENSDART00000151921
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr22_-_4644484 1.09 ENSDART00000167748
fibrillin 2b
chr18_-_38087875 1.08 ENSDART00000111301
leucine zipper protein 2
chr16_+_42018367 1.07 ENSDART00000058613
Fli-1 proto-oncogene, ETS transcription factor b
chr15_+_7054754 1.06 ENSDART00000149800
forkhead box L2a
chr18_+_28988373 1.06 ENSDART00000018685
synaptotagmin IXa
chr20_+_15982482 1.06 ENSDART00000020999
angiopoietin-like 1a
chr18_-_38088099 1.04 ENSDART00000146120
leucine zipper protein 2
chr18_+_5213338 1.02 ENSDART00000033574
solute carrier family 24 (sodium/potassium/calcium exchanger), member 5
chr23_+_42346799 1.00 ENSDART00000159985
ENSDART00000172144
cytochrome P450, family 2, subfamily AA, polypeptide 11
chr16_+_42018041 0.99 ENSDART00000134010
ENSDART00000102789
Fli-1 proto-oncogene, ETS transcription factor b
chr3_-_30123113 0.96 ENSDART00000153562
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr14_+_5385855 0.95 ENSDART00000031508
ladybird homeobox 2
chr9_+_38962017 0.95 ENSDART00000140436
microtubule-associated protein 2
chr3_+_37707432 0.92 ENSDART00000151236
mitogen-activated protein kinase kinase kinase 14a
chr7_+_25036188 0.91 ENSDART00000163957
ENSDART00000169749
sb:cb1058
chr7_+_26138240 0.90 ENSDART00000193750
ENSDART00000184942
N-acetyltransferase 16
chr17_-_20711735 0.90 ENSDART00000150056
ankyrin 3b
chr3_+_18389363 0.90 ENSDART00000146114
si:ch211-139g16.8
chr8_+_26125218 0.88 ENSDART00000145095
cadherin, EGF LAG seven-pass G-type receptor 3
chr12_+_25945560 0.88 ENSDART00000109799
multimerin 2b
chr1_+_23784905 0.87 ENSDART00000171951
ENSDART00000188521
ENSDART00000183029
ENSDART00000187183
slit homolog 2 (Drosophila)
chr5_-_26187097 0.86 ENSDART00000137027
coiled-coil domain containing 125
chr1_+_32521469 0.86 ENSDART00000113818
ENSDART00000152580
neuroligin 4a
chr9_-_21230999 0.86 ENSDART00000150160
ENSDART00000102147
phospholipase A1 member A
chr20_-_31427390 0.86 ENSDART00000007735
uronyl-2-sulfotransferase
chr18_+_7283283 0.85 ENSDART00000141493
si:ch73-86n2.1
chr13_+_30228077 0.85 ENSDART00000100813
ENSDART00000147729
ENSDART00000133404
ribosomal protein S24
chr13_+_23214100 0.85 ENSDART00000163393
sorbin and SH3 domain containing 1
chr1_-_16665044 0.82 ENSDART00000040434
N-acylsphingosine amidohydrolase (acid ceramidase) 1b
chr5_-_33287691 0.82 ENSDART00000004238
ribosomal protein L7a
chr6_-_52400896 0.81 ENSDART00000187624
matrix metallopeptidase 24
chr14_-_44841503 0.81 ENSDART00000179114
si:dkey-109l4.6
chr5_+_27442247 0.79 ENSDART00000184129
lysyl oxidase-like 2b
chr12_-_43435254 0.79 ENSDART00000182723
protein tyrosine phosphatase, receptor type, E, a
chr13_+_41819817 0.78 ENSDART00000185778

chr18_+_13203831 0.76 ENSDART00000032151
coactosin-like F-actin binding protein 1
chr8_-_50287949 0.76 ENSDART00000023639
NK2 transcription factor related 7
chr21_+_22985078 0.76 ENSDART00000156491
lysophosphatidic acid receptor 6b
chr14_+_14224730 0.75 ENSDART00000180112
ENSDART00000184891
ENSDART00000174760
neuroligin 3a
chr23_-_35069805 0.75 ENSDART00000087219

chr5_+_42467867 0.75 ENSDART00000172028
Pim proto-oncogene, serine/threonine kinase, related 58
chr17_+_38476300 0.73 ENSDART00000123298
StAR-related lipid transfer (START) domain containing 9
chr20_+_6630540 0.73 ENSDART00000138361
tensin 3, tandem duplicate 2
chr19_-_5125663 0.73 ENSDART00000005547
ENSDART00000132642
guanine nucleotide binding protein (G protein), beta polypeptide 3b
chr6_-_34008827 0.71 ENSDART00000191183
ENSDART00000003701
ENSDART00000192502
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr20_+_27194833 0.69 ENSDART00000150072
si:dkey-85n7.8
chr1_+_16573982 0.69 ENSDART00000166317
microtubule associated tumor suppressor 1b
chr9_+_6587056 0.67 ENSDART00000193421
four and a half LIM domains 2a
chr11_+_20056732 0.66 ENSDART00000103997
FEZ family zinc finger 2
chr16_+_44314097 0.65 ENSDART00000148684
dihydropyrimidinase
chr9_+_30720048 0.65 ENSDART00000146115
Kruppel-like factor 12b
chr15_+_22267847 0.64 ENSDART00000110665
sperm autoantigenic protein 17
chr9_-_35069645 0.63 ENSDART00000122679
ENSDART00000077908
ENSDART00000077894
ENSDART00000125536
amyloid beta (A4) precursor protein b
chr16_-_44649053 0.62 ENSDART00000184807

chr4_+_15954293 0.61 ENSDART00000132695
si:dkey-117n7.4
chr17_-_20849879 0.61 ENSDART00000088100
ENSDART00000149630
ankyrin 3b
chr9_+_6587364 0.61 ENSDART00000122279
four and a half LIM domains 2a
chr7_+_20019125 0.60 ENSDART00000186391
B-cell CLL/lymphoma 6, member B
chr11_+_25472758 0.59 ENSDART00000011178
opsin 1 (cone pigments), short-wave-sensitive 2
chr15_-_3976035 0.58 ENSDART00000168061
si:ch73-309g22.1
chr8_-_40251126 0.58 ENSDART00000180435
lysine (K)-specific demethylase 2Ba
chr5_+_37785152 0.57 ENSDART00000053511
ENSDART00000189812
myosin Ic, paralog a
chr18_+_22793465 0.56 ENSDART00000149685
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
chr19_-_21832441 0.56 ENSDART00000151272
ENSDART00000151442
ENSDART00000150168
ENSDART00000148797
ENSDART00000128196
ENSDART00000149259
ENSDART00000052556
ENSDART00000149658
ENSDART00000149639
ENSDART00000148424
myelin basic protein a
chr24_-_23671383 0.55 ENSDART00000144193
hepatocyte nuclear factor 4, gamma
chr9_-_30190513 0.55 ENSDART00000137083
interphotoreceptor matrix proteoglycan 2a
chr17_-_29902187 0.54 ENSDART00000009104
estrogen-related receptor beta
chr5_+_22970617 0.53 ENSDART00000192859
high mobility group nucleosomal binding domain 7
chr13_+_30874153 0.53 ENSDART00000112380
ENSDART00000189016
ENSDART00000134809
excision repair cross-complementation group 6
chr19_-_46777963 0.53 ENSDART00000046857
actin binding Rho activating protein b
chr9_-_48701035 0.52 ENSDART00000178332
retinol dehydrogenase 1
chr25_-_16832705 0.50 ENSDART00000171336
ENSDART00000189396
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr6_-_13475439 0.49 ENSDART00000172318
myosin light chain kinase b
chr5_+_58492699 0.48 ENSDART00000181584

chr2_-_34555945 0.48 ENSDART00000056671
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr17_-_28705264 0.47 ENSDART00000076409
ENSDART00000189874
adaptor-related protein complex 4, sigma 1 subunit
chr5_-_1047222 0.46 ENSDART00000181112
methyl-CpG binding domain protein 2
chr14_-_44841335 0.46 ENSDART00000173011
si:dkey-109l4.6
chr7_+_28612671 0.42 ENSDART00000019991
solute carrier family 7, member 6 opposite strand
chr3_-_26341959 0.42 ENSDART00000169344
ENSDART00000142878
ENSDART00000087196
zgc:153240
chr15_-_4152582 0.40 ENSDART00000171942
si:dkey-83h2.5
chr9_-_19699728 0.40 ENSDART00000166780
si:ch211-141e20.2
chr18_+_17786548 0.40 ENSDART00000189493
ENSDART00000146133
si:ch211-216l23.1
chr24_-_23671709 0.39 ENSDART00000164750
hepatocyte nuclear factor 4, gamma
chr16_-_22989262 0.37 ENSDART00000191008
si:dkey-246i14.3
chr6_+_37308716 0.37 ENSDART00000085498
prostaglandin E receptor 3 (subtype EP3)
chr8_-_7474997 0.36 ENSDART00000146555
GATA binding protein 1b
chr24_+_25919809 0.35 ENSDART00000006615
mitogen-activated protein kinase kinase kinase 15
chr22_+_36656680 0.32 ENSDART00000134031
ENSDART00000056169
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr1_+_54835131 0.32 ENSDART00000145070
si:ch211-196h16.4
chr11_-_16152400 0.31 ENSDART00000123665
actin related protein 2/3 complex, subunit 4, like
chr10_-_34889053 0.31 ENSDART00000136966
coiled-coil domain containing 169
chr15_-_4023182 0.29 ENSDART00000190195

chr4_+_5180650 0.29 ENSDART00000067390
fibroblast growth factor 6b
chr20_+_51479263 0.29 ENSDART00000148798
toll-like receptor 5a
chr20_-_26420939 0.29 ENSDART00000110883
A kinase (PRKA) anchor protein 12b
chr24_+_35947077 0.28 ENSDART00000173406
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b
chr4_-_12104421 0.27 ENSDART00000139561
mitochondrial ribosomal protein S33
chr4_-_72609735 0.26 ENSDART00000174299
ENSDART00000159227
si:cabz01054394.6
chr18_+_22793743 0.25 ENSDART00000150106
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
chr8_-_37043900 0.25 ENSDART00000139567
renin binding protein
chr23_-_26521970 0.25 ENSDART00000143712
si:dkey-205h13.1
chr1_+_52130213 0.24 ENSDART00000018817
ring finger protein 11a
chr11_-_30630628 0.23 ENSDART00000103265
zgc:158773
chr16_+_29303971 0.23 ENSDART00000087149
hyaluronan and proteoglycan link protein 2
chr5_-_1047504 0.23 ENSDART00000159346
methyl-CpG binding domain protein 2
chr4_-_28334464 0.23 ENSDART00000123617
cadherin EGF LAG seven-pass G-type receptor 1a
chr10_+_17714866 0.22 ENSDART00000039969
solute carrier family 20 (phosphate transporter), member 1b
chr9_+_30464641 0.21 ENSDART00000128357
gap junction protein, alpha 5a
chr7_-_20758825 0.20 ENSDART00000156717
ENSDART00000182629
ENSDART00000179801
chromodomain helicase DNA binding protein 3
chr24_-_11309477 0.20 ENSDART00000137257
myosin VIIA and Rab interacting protein
chr22_+_30035719 0.20 ENSDART00000192238

chr20_-_26421112 0.19 ENSDART00000183767
ENSDART00000182330
A kinase (PRKA) anchor protein 12b
chr16_+_10346277 0.19 ENSDART00000081092
si:dkeyp-77h1.4
chr18_+_34362608 0.18 ENSDART00000131478
potassium voltage-gated channel, shaker-related subfamily, beta member 1 a
chr20_+_30797329 0.16 ENSDART00000145066
NHS-like 1b
chr6_+_36807861 0.15 ENSDART00000161708
si:ch73-29l19.1
chr15_+_34699585 0.15 ENSDART00000017569
tumor necrosis factor b (TNF superfamily, member 2)
chr1_-_37377509 0.15 ENSDART00000113542
TNFAIP3 interacting protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of atf5a+atf5b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:0060843 lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845)
0.9 2.6 GO:0014814 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.7 2.1 GO:0035992 tendon formation(GO:0035992)
0.6 3.5 GO:0003232 bulbus arteriosus development(GO:0003232)
0.6 2.3 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.5 1.5 GO:0098725 somatic stem cell population maintenance(GO:0035019) symmetric cell division(GO:0098725)
0.5 1.4 GO:0036076 ligamentous ossification(GO:0036076)
0.5 1.4 GO:0070314 G1 to G0 transition(GO:0070314)
0.4 1.1 GO:0003250 cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) endocardial cell development(GO:0060958) cell proliferation involved in heart valve development(GO:2000793)
0.4 1.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.3 1.6 GO:0003210 cardiac atrium formation(GO:0003210)
0.3 0.9 GO:0007414 axonal defasciculation(GO:0007414)
0.3 1.4 GO:0035988 chondrocyte proliferation(GO:0035988)
0.3 0.8 GO:0097264 self proteolysis(GO:0097264)
0.3 2.6 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.3 2.6 GO:0060612 adipose tissue development(GO:0060612)
0.3 1.3 GO:0007508 larval development(GO:0002164) larval heart development(GO:0007508) angiogenesis involved in wound healing(GO:0060055)
0.2 1.4 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.2 1.6 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.2 2.0 GO:0097104 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.2 4.4 GO:0038084 vascular endothelial growth factor signaling pathway(GO:0038084)
0.2 0.8 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.2 1.0 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.2 2.2 GO:2000377 regulation of reactive oxygen species metabolic process(GO:2000377)
0.2 1.6 GO:2001239 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.2 0.5 GO:0032060 bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969)
0.2 2.6 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 1.9 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 2.1 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.1 0.7 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.1 1.3 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 3.4 GO:0032474 otolith morphogenesis(GO:0032474) semicircular canal morphogenesis(GO:0048752)
0.1 1.2 GO:0006007 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 1.4 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 0.4 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.1 0.7 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.1 1.6 GO:0007398 ectoderm development(GO:0007398)
0.1 0.4 GO:0044058 regulation of digestive system process(GO:0044058)
0.1 1.6 GO:0033077 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.1 0.9 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 1.4 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.1 0.5 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 1.8 GO:0007520 myoblast fusion(GO:0007520) pronephric duct development(GO:0039022) nephric duct development(GO:0072176)
0.1 2.3 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.1 1.1 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 0.4 GO:0048532 anatomical structure arrangement(GO:0048532)
0.1 1.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 3.1 GO:0006937 regulation of muscle contraction(GO:0006937)
0.1 1.0 GO:0097324 melanocyte migration(GO:0097324)
0.0 0.1 GO:0034138 toll-like receptor 2 signaling pathway(GO:0034134) toll-like receptor 3 signaling pathway(GO:0034138)
0.0 2.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.5 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.2 GO:1901380 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.5 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.3 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 1.7 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.4 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.0 0.8 GO:2000826 regulation of heart morphogenesis(GO:2000826)
0.0 0.6 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 1.1 GO:0050708 regulation of protein secretion(GO:0050708)
0.0 1.3 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.8 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 1.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.1 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.1 GO:2000179 negative regulation of cell maturation(GO:1903430) positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 0.8 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.8 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 1.1 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.4 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 1.3 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 1.3 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 6.7 GO:0050767 regulation of neurogenesis(GO:0050767)
0.0 0.9 GO:0060914 heart formation(GO:0060914)
0.0 1.5 GO:0048916 posterior lateral line development(GO:0048916)
0.0 1.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 1.5 GO:0031018 endocrine pancreas development(GO:0031018)
0.0 0.1 GO:1990108 protein linear deubiquitination(GO:1990108)
0.0 0.3 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.7 GO:0017144 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.9 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 2.1 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 1.6 GO:0007051 spindle organization(GO:0007051)
0.0 1.4 GO:0070509 calcium ion import(GO:0070509)
0.0 0.6 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.5 GO:0007416 synapse assembly(GO:0007416)
0.0 0.6 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.2 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.7 GO:0006119 oxidative phosphorylation(GO:0006119)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0031673 H zone(GO:0031673)
0.2 2.6 GO:0042627 chylomicron(GO:0042627)
0.1 2.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.6 GO:0060171 stereocilium membrane(GO:0060171)
0.1 1.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 1.6 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 2.0 GO:0031430 M band(GO:0031430)
0.1 1.1 GO:0031045 dense core granule(GO:0031045)
0.1 3.1 GO:0005861 troponin complex(GO:0005861)
0.1 0.5 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.1 3.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.7 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 1.6 GO:0022626 cytosolic ribosome(GO:0022626) cytosolic small ribosomal subunit(GO:0022627)
0.0 2.2 GO:0030141 secretory granule(GO:0030141)
0.0 0.6 GO:0043209 myelin sheath(GO:0043209)
0.0 1.2 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.2 GO:0005871 kinesin complex(GO:0005871)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.7 GO:0005840 ribosome(GO:0005840)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 4.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 1.1 GO:0031201 SNARE complex(GO:0031201)
0.0 1.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.3 GO:0030017 sarcomere(GO:0030017)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0034185 apolipoprotein binding(GO:0034185)
0.7 2.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.5 4.4 GO:0001972 retinoic acid binding(GO:0001972)
0.5 5.7 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.3 2.1 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.3 3.1 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.3 1.6 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.2 0.8 GO:0017064 fatty acid amide hydrolase activity(GO:0017064)
0.2 1.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 2.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 2.2 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.2 0.8 GO:0051430 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 2.7 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 2.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 1.0 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 1.2 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 1.4 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 3.4 GO:0005518 collagen binding(GO:0005518)
0.1 1.1 GO:0045159 myosin II binding(GO:0045159)
0.1 2.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.5 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 1.5 GO:0005112 Notch binding(GO:0005112)
0.1 1.1 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 0.9 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.8 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.6 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.7 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.9 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.6 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.4 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 2.2 GO:0004601 peroxidase activity(GO:0004601)
0.0 1.6 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 1.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 5.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.7 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.3 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 1.5 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.6 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.5 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 5.0 GO:0051015 actin filament binding(GO:0051015)
0.0 0.6 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 2.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.7 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.2 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 2.9 NABA COLLAGENS Genes encoding collagen proteins
0.0 2.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 4.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.5 PID NOTCH PATHWAY Notch signaling pathway
0.0 3.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.8 PID INSULIN PATHWAY Insulin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 3.8 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 0.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 2.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 0.6 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 0.4 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 7.9 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 2.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 0.9 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 2.1 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 2.6 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 3.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 3.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.5 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 1.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides