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PRJNA195909:zebrafish embryo and larva development
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Results for atf3+jdp2b
Z-value: 2.54
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Transcription factors associated with atf3+jdp2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| jdp2b | dr11_v1_chr20_+_46586678_46586692 | -0.89 | 1.3e-03 | Click! |
| atf3 | dr11_v1_chr20_+_37794633_37794633 | 0.28 | 4.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_52442622 Show fit | 4.08 |
ENSDART00000012758
|
zgc:77112 |
|
| chr8_+_42917515 Show fit | 3.72 |
ENSDART00000021715
|
solute carrier family 23 (ascorbic acid transporter), member 2 |
|
| chr8_+_23725957 Show fit | 3.24 |
ENSDART00000104346
|
makorin, ring finger protein, 4 |
|
| chr7_-_51773166 Show fit | 3.14 |
ENSDART00000054591
|
bone morphogenetic protein 15 |
|
| chr17_+_25187226 Show fit | 2.84 |
ENSDART00000148431
|
CLN8, transmembrane ER and ERGIC protein |
|
| chr11_-_44801968 Show fit | 2.79 |
ENSDART00000161846
|
microtubule-associated protein 1 light chain 3 gamma |
|
| chr18_+_14645568 Show fit | 2.79 |
ENSDART00000138995
ENSDART00000147351 |
VPS9 domain containing 1 |
|
| chr5_-_3991655 Show fit | 2.72 |
ENSDART00000159368
|
myosin XIX |
|
| chr10_+_6884123 Show fit | 2.70 |
ENSDART00000149095
ENSDART00000148772 ENSDART00000149334 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 |
|
| chr22_+_17261801 Show fit | 2.70 |
ENSDART00000192978
ENSDART00000193187 ENSDART00000179953 ENSDART00000134798 |
tudor domain containing 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of atf3+jdp2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.8 | GO:0010962 | regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962) |
| 0.1 | 6.4 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800) |
| 0.5 | 5.1 | GO:0043046 | DNA methylation involved in gamete generation(GO:0043046) |
| 0.1 | 4.7 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 0.0 | 4.2 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161) |
| 1.2 | 3.7 | GO:0015882 | L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852) |
| 0.1 | 3.7 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 3.5 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.2 | 3.4 | GO:0035459 | cargo loading into vesicle(GO:0035459) |
| 0.3 | 3.2 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.3 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.4 | 6.7 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 5.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 5.8 | GO:0016604 | nuclear body(GO:0016604) |
| 0.0 | 4.9 | GO:0005764 | lysosome(GO:0005764) |
| 0.0 | 4.8 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 4.0 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 3.9 | GO:0005657 | replication fork(GO:0005657) |
| 0.1 | 3.8 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 3.7 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.7 | GO:2001069 | glycogen binding(GO:2001069) |
| 0.0 | 6.6 | GO:0004518 | nuclease activity(GO:0004518) |
| 0.1 | 6.5 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.0 | 6.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 5.9 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 3.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 3.9 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.2 | 3.6 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.2 | 3.6 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 3.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.9 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.1 | 3.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 3.7 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 3.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 3.4 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 3.0 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.2 | 2.5 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.1 | 2.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 1.8 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 4.3 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 3.2 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.2 | 2.9 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 2.5 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 2.5 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.1 | 2.4 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 2.3 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 2.3 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 2.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |