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PRJNA195909:zebrafish embryo and larva development
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Results for atf1
Z-value: 1.52
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Transcription factors associated with atf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| atf1 | dr11_v1_chr6_-_39521832_39521832 | 0.78 | 1.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_34915886 Show fit | 2.19 |
ENSDART00000141201
ENSDART00000002166 |
cyclin A1 |
|
| chr16_-_42066523 Show fit | 2.07 |
ENSDART00000180538
ENSDART00000058620 |
zona pellucida glycoprotein 3d tandem duplicate 1 |
|
| chr16_-_29387215 Show fit | 1.83 |
ENSDART00000148787
|
S100 calcium binding protein A1 |
|
| chr12_-_22238004 Show fit | 1.75 |
ENSDART00000038310
|
ORMDL sphingolipid biosynthesis regulator 3 |
|
| chr19_+_14454306 Show fit | 1.54 |
ENSDART00000161965
|
zinc finger, DHHC-type containing 18b |
|
| chr7_-_51773166 Show fit | 1.42 |
ENSDART00000054591
|
bone morphogenetic protein 15 |
|
| chr18_+_14633974 Show fit | 1.34 |
ENSDART00000133834
|
VPS9 domain containing 1 |
|
| chr4_-_16628801 Show fit | 1.31 |
ENSDART00000040708
ENSDART00000064009 |
caprin family member 2 |
|
| chr6_+_40992883 Show fit | 1.28 |
ENSDART00000076061
|
transforming growth factor, alpha |
|
| chr3_-_49504023 Show fit | 1.24 |
ENSDART00000168108
|
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a |
Network of associatons between targets according to the STRING database.
First level regulatory network of atf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | GO:0006998 | nuclear envelope organization(GO:0006998) |
| 0.1 | 2.7 | GO:1901800 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800) |
| 0.3 | 2.3 | GO:2000273 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273) |
| 0.1 | 2.1 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.1 | 2.1 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.2 | 2.0 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.4 | 1.8 | GO:0090153 | regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303) |
| 0.1 | 1.8 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.1 | 1.8 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.0 | 1.8 | GO:1904029 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 3.4 | GO:0005730 | nucleolus(GO:0005730) |
| 0.7 | 2.2 | GO:0097124 | cyclin A2-CDK2 complex(GO:0097124) |
| 0.4 | 1.8 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.1 | 1.8 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 1.8 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.1 | 1.7 | GO:0005639 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.1 | 1.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 1.7 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.6 | GO:0016607 | nuclear speck(GO:0016607) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 3.5 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.1 | 3.1 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 2.5 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 2.4 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 2.3 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 2.1 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 2.1 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.1 | 1.9 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.1 | 1.8 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 2.3 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 2.0 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 2.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.9 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 1.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.5 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 1.0 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 0.8 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 1.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 1.8 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 1.7 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.6 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.1 | 1.4 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.2 | 1.0 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.9 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 0.8 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.1 | 0.8 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |